CN102948419B - Termite killing drug compound combination - Google Patents
Termite killing drug compound combination Download PDFInfo
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- CN102948419B CN102948419B CN201210436785.8A CN201210436785A CN102948419B CN 102948419 B CN102948419 B CN 102948419B CN 201210436785 A CN201210436785 A CN 201210436785A CN 102948419 B CN102948419 B CN 102948419B
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- termite
- sulfluramid
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Abstract
The present invention relates to termite killing drug compound combination, which is prepared by compounding 1-40 parts by weight of sulfluramid and 1-20 parts by weight of chlorfenapyr. The present invention provides a termite killing drug compound combination, wherein different action mechanisms on termites of sulfluramid and chlorfenapyr are adopted to improve virulence transmission capacity and killing capacity on the termites by the drug, a co-toxicity index of the compound agent is more than 100, the highest co-toxicity index is 175, and a significant synergistic effect is provided. The compound combination has the following advantages that: (1) a significant synergistic effect is provided for the termites, and prevention and control effects are increased; (2) compared with the existing agents, the compound combination provides a better termite group killing effect; and (3) toxicity is low, and application cost of the compound combination is lower than application cost of the single agent.
Description
Technical field
The present invention relates to agriculture chemical compounding technical field, be specifically related to a kind of termite is had to a synergistic effect kill white-ant drug compounded combination.
Background technology
Termite is one of worldwide insect, very wide in the distribution of China.Termite damage can cause house collapse, destroys home decoration, and heritage archive is impaired, and trees, the large quantities of death of crops even can cause the dike piping of rivers, reservoir, the serious consequence such as subside.The economic loss being caused by termite damage every year is according to statistics up to 2,000,000,000 ~ 2,500,000,000.
Agriculture chemical compounding can improve control efficiency, reduction agricultural chemicals usage amount, expanding prevention object, reduce reagent toxicity and delay the advantages such as pesticide resistance generation.Termite classifies as sanitary insect pest in China, kills termite medicament and belongs to hygienic insecticide.According to statistics, at present there is kind more than 30 by the termite pharmaceutical products of killing of agriculture chemical registration, but compound drug only has two kinds, be respectively killing termite paste, soaking and 12% boric acid (7%), copper sulphate (5%) soluble concentrate of control rot fungi and termite are processed in brushing for timber of 0.8% tetramethrin and 0.04% alpha-cypermethrin, proportion is less than 7%.But in whole Information for pesticide Product Registration, the kind of annual complex preparation registration (factory time) accounts for more than 60%, and single dose only account for 40% less than, have larger market prospects so kill the research and development of termite compound drug.In addition, about pulvis and the bait formulation of control termites, according to statistics, up to now, the pulvis of registering by the Ministry of Agriculture of China has 2 kinds, is respectively 0.5% chloro-cyanide pyrethrin insecticide pulvis and 0.5% fipronil insecticidal pulvis; Bait formulation has 3 kinds, is respectively the compound medicine of 0.5% HEXAFLUMURON, 0.1% fluorine pyridine urea and tetramethrin and alpha-cypermethrin.The pulvis of alternative termite control and bait formulation kind quantity are few, can not meet actual termite control requirements of one's work.
Sulfluramid (sulfluramid) is Organic fluoride insecticides, and its mechanism of action is the respiration that suppresses harmful insect, stops APP to produce with high-octane ATP by oxidative phosphorylation process, thereby causes insect death.In termite control, due to the chronic effect mechanism of sulfluramid, sulfluramid is mainly as bait formulation.Relevant sulfluramid is that the pulvis of effective ingredient or the research of bait formulation or patent also have report, for example: the big light of the artificial hair of invention, notification number is CN1505931, the day for announcing is on 06 23rd, 2004; Invent artificial Zhang Songsheng, Zhao Jin etc., notification number is CN101352168, and the day for announcing is on 01 28th, 2009; Invention people is Wu Hua, Huang Hong, and notification number is CN1947515, and the day for announcing is on 04 18th, 2007; Invention people is Korean and Japanese farmland, Chen Jinghua, and notification number is CN101015294, and the day for announcing is on 08 15th, 2007.
Capillary is aryl pyrrole compounds, has stomach toxicity and certain action of contace poison and systemic activity, is a kind of preinsecticide, itself to insect without toxic action.After insect's food-taking or contact capillary, in insect bodies, under the effect of mixed-functional oxidase, change the chemical combination with insecticidal activity into, its target is the mitochondria in insect bodies cell, and mode of action novelty is middle low-toxin farm chemicals.Capillary is the insecticidal/acaricidal agent of a class broad-spectrum high efficacy, for vegetables, fruit tree, cotton, tea tree etc., can effectively prevent and treat diamond-back moth, imported cabbageworm, vegetable aphid, mite, thrips etc., about the patent of capillary single dose and built agent has more report, for example capillary and beta-cypermethrin, invent artificial sieve just grand, Zhu Weifeng etc., notification number is CN1961671, the day for announcing is on 05 16th, 2007, capillary and Acetamiprid, invent artificial Zhang Yan, You Wenli, notification number is CN101518254, the day for announcing is on 09 02nd, 2009, capillary and HEXAFLUMURON, invention people is Ge Yaolun, notification number is CN101228878, the day for announcing is on 07 30th, 2008, capillary and second worm nitrile, invention people is Zhu Weifeng, Kong Jian etc., notification number is CN101480185, the day for announcing is on 07 15th, 2009 etc., but have no correlative study report and the patent of capillary and sulfluramid.
Capillary and sulfluramid are non-anti-repelling properties, chronic virulence to termite, but their mechanism of action difference, the also difference of poisoning symptom showing, the former is slower to the speed of knocking down of termite, after drug treating, in short time, the ability of creeping of (in general 2 days) termite is not significantly affected, termite is short from the required time of the death of going down, not obvious the dwindling of poisoning and dead polypide, in termite control, this is beneficial to takes the propagation in ant group and the diffusion to medicine virulence of malicious termite, thereby kills preferably whole ant group; The knock down speed of the latter to termite, after drug treating, in the short time, termite is knocked down by medicine, and termite has lost the ability of creeping, and termite is longer from the required time of the death of going down, poisoning and dead polypide obviously dwindles, and this is unfavorable takes malicious termite and in ant group, medicament virulence is transmitted.
Summary of the invention
The object of this invention is to provide one and kill white-ant drug compounded combination, utilize the sulfluramid mechanism of action different to termite with capillary, improve termite to the virulence transmission capacity of medicament and knock down power, have obvious synergistic effect.
The object of the invention is to be achieved through the following technical solutions:
One is killed white-ant drug compounded combination, and described combination is composited by sulfluramid and capillary.
Preferably, described sulfluramid and capillary ratio of weight and number be 1 ~ 40:1 ~ 20; Preferred, described sulfluramid and capillary ratio of weight and number be 5:1 or 20:1.
Beneficial effect of the present invention is:
1, compared with single dose, the present invention has synergistic effect to termite, can improve control efficiency, and the co-toxicity coefficient of built agent is all greater than 100, and the highest reaches 175;
2, can overcome sulfluramid to the termite shortcoming of knockdown effect faster, be beneficial to the virulence transmission of termite to medicament, more effectively kill whole ant group;
3, compared with existing available pulvis, pulvis is processed in the present invention, due to long without anti-repelling properties, the time of knocking down to termite, so better to the insect killing effect of termite colony;
4,, compared with single dose, two kinds of single dose combinations can reduce application cost;
5, capillary, sulfluramid are middle low-toxin farm chemicals, use safety, meet environmental requirement.
Embodiment
Following experiment and operational instances are further to explanation of the present invention, should not be used as limitation of the present invention.The present invention adopts the method for indoor bioassay, and co-toxicity coefficient and the synergy multiple of the built agent of mensuration different proportion to termite, to determine whether built agent has synergistic effect.
Reagent agent: sulfluramid (98%) is provided by state's every household agricultural chemicals Product Quality Verification Centers, and capillary (98.1%) is provided by Shanghai Pesticide Research Institute.
For examination insect: formosanes (Coptotermes sp.) is picked up from Xuancheng Profile, anhui Province, raise with pine piece, after indoor separation raised at least 1 week for test.
Embodiment 1: the toxicity test of single dose to termite
Assay method: the mother liquor that respectively sulfluramid and the former medicine of capillary is made into about 1000ppm with acetone.The mother liquor of two kinds of medicines is diluted to series concentration with acetone.Pipette liquid 1ml with pipette, drip at filter paper (Ф 90mm) above, form even medicine film, after naturally drying, put into clean culture dish (Ф 90mm).Drip 1ml deionized water, drop into 30 worker ants, continuous contact.Each concentration in triplicate, and is established blank, observes and record poisoning symptom and the death toll of termite every day, and test is carried out under 28 ± 1 ℃, dark condition, and notes keeping the moistening of filter paper.
Experiment effect: the termite borer population of death every day is cumulative, calculate the cumulative mortality of termite after different number of days, take the logarithm value of drug concentration as independent variable X, be dependent variable Y the probit value of the average cumulative lethality of (96h) after 4 days, calculate the virulence regression equation of medicine with EXCELL, obtain the LC of two kinds of medicines
50value, the results are shown in Table 1.The LC of capillary
50value is for 1.211mg/L, sulfluramid be 16.143mg/L, capillary to the virulence of termite than the height of sulfluramid, after 96h, to the virulence of termite, the former is the latter 13 times.
Virulence to termite after table 1 medicine single dose 96h
Embodiment 2: the toxicity test of compound drug to termite
Assay method: be used in respectively the maximum concentration of capillary and sulfluramid in single dose toxicity test and be mixed into by a certain percentage two yuan of built agents (concrete ratio is in table 2) of different proportionings (active ingredient ratio), be then down diluted to 4-5 concentration by geometric ratio principle.Pipette 1ml liquid with pipette and evenly drip on filter paper (Φ 9cm), form medicine film, after naturally drying, put into clean culture dish (Φ 9cm).Drip 1ml redistilled water, drop into 30 formosanes worker ants, continuous contact.Each concentration in triplicate, and is established blank, and observe and record poisoning symptom and the death toll of termite every day, and obtain the LC of various built agents
50value, co-toxicity coefficient and synergy multiple.Test is carried out under 28 ± 1 ℃, dark condition, and notes keeping the moistening of filter paper.
Implementation result: built agent is cumulative to the dead borer population of termite every day, calculate the cumulative mortality of termite after different number of days, take the logarithm value of drug concentration as independent variable X, be dependent variable Y the probit value of the average cumulative lethality of (96h) after 4 days, calculate the virulence regression equation of compound drug with EXCELL, obtain the LC of the built agent of sulfluramid and capillary different proportion
50value.Obtain co-toxicity coefficient and the synergy multiple of built agent by the abundant method of Sun Yun, specifically see following formula.
The percentage composition of B medicine in the toxicity index × mixture of percentage composition+B medicine of A medicine in the toxicity index × mixture of theoretical toxicity index=A medicine of mixture
Virulence to termite after the built agent 96h of table 2 different proportion
The LC of different built agents to termite
50the co-toxicity coefficient of value and built agent, synergy multiple are in table 2.The co-toxicity coefficient of the built agent that the effective ingredient ratio of sulfluramid and capillary is 1 ~ 40:1 ~ 20 is all greater than 100, synergy multiple is greater than 0, show that built agent all has synergistic effect to termite, wherein sulfluramid: capillary is that the ratio of 5:1 and 20:1 is when composite, their co-toxicity coefficient is respectively 175 and 154, synergy multiple is 0.75 and 0.54, has significant synergistic effect.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but do any variation in its shape or structure; every have identical with a application or akin technical scheme, within all dropping on protection scope of the present invention.
Claims (3)
1. kill a white-ant drug compounded combination, it is characterized in that: described combination is by sulfluramid and capillary is composite forms, wherein the weight fraction of sulfluramid and capillary is than being 1:20-40:1.
2. the white-ant drug compounded combination of killing according to claim 1, is characterized in that: the weight fraction of described sulfluramid and capillary is than being 5:1.
3. the white-ant drug compounded combination of killing according to claim 1, is characterized in that: the weight fraction of described sulfluramid and capillary is than being 20:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210436785.8A CN102948419B (en) | 2012-11-06 | 2012-11-06 | Termite killing drug compound combination |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210436785.8A CN102948419B (en) | 2012-11-06 | 2012-11-06 | Termite killing drug compound combination |
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| CN102948419A CN102948419A (en) | 2013-03-06 |
| CN102948419B true CN102948419B (en) | 2014-06-11 |
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| CN201210436785.8A Expired - Fee Related CN102948419B (en) | 2012-11-06 | 2012-11-06 | Termite killing drug compound combination |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104604928A (en) * | 2015-02-06 | 2015-05-13 | 南京市白蚁防治研究所 | Compound medicine for synergy for killing termites |
| CN105994279A (en) * | 2016-06-22 | 2016-10-12 | 叶松 | Composition for preventing and treating phytomyza horticola goureau and preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2009298776A (en) * | 2008-05-14 | 2009-12-24 | Nippon Nohyaku Co Ltd | Termite controlling composition |
| NZ576293A (en) * | 2009-04-17 | 2010-11-26 | Zelam Ltd | Insecticidal composition and Method |
| CN101536695A (en) * | 2009-04-23 | 2009-09-23 | 南通功成精细化工有限公司 | Synergistic white ant killing compound and application thereof |
| CN101536688A (en) * | 2009-04-23 | 2009-09-23 | 南通功成精细化工有限公司 | Application of chlorfenapyr synergistic preparation |
| ES2468794T3 (en) * | 2009-08-20 | 2014-06-17 | Bayer Cropscience Ag | Sulfide derivatives substituted with 3-triazolylphenyl as acaricides and insecticides |
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