CN102935259B - Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors - Google Patents
Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors Download PDFInfo
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- CN102935259B CN102935259B CN201210402719.9A CN201210402719A CN102935259B CN 102935259 B CN102935259 B CN 102935259B CN 201210402719 A CN201210402719 A CN 201210402719A CN 102935259 B CN102935259 B CN 102935259B
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Abstract
The invention belongs to the technical field of auxiliary medical devices, and specifically relates to a spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors. The spray type tracheal intubation comprises an airbag injection port, a temperature sensor, a fixed support, a pressure test point outlet, an inflated nozzle with micropores, an airbag, a pressure sensor, a data acquisition module, a tube body of the tracheal intubation, a pressure measurement extension tube, a nozzle extension tube, a temperature measurement extension tube and a computer. The spray type tracheal intubation can spray low temperature protection liquid in tracheae, weaken unevenness of specific heat of tracheae, lung tissues and air, quickly lower the temperature in tracheae and the temperature of lungs, alleviate warm ischemia injury and improve the quality of donor lungs; and the spray type tracheal intubation can monitor the temperature and pressure conditions in tracheae in real time, adjust all parameter indexes in time and guarantee safe and effective cooling of the donor lungs.
Description
Technical field
The invention belongs to medical assistance device arts, be specifically related to a kind of aerosol type tracheal intubation being applied to spinning without mandrel lung transplantation, lung preservation.
Background technology
Brain death donor (having heart beating donor, heart heating donor, HBD) critical shortage, therefore the research of spinning without mandrel (non heart heating donor, NHBD) becomes focus.There is heartbeat blood supply in HBD, NHBD donor is then contrary, acardia blood supply, there is Warm ischemia injury in various degree, carry out the cooling of lungs as early as possible, shortening heat Ischemia Time is the requisite measure that lungs are preserved.Doctor cannot open the operation that breast is got lung, carried out having wound before obtaining family members' agreement, authorizing; therefore heart beating stop to out breast get lung during this period of time in, non-invasively apply the ventilated inside gas pipe measure of carrying out the protection of NHBD donor lung in conjunction with low temperature and receive focus of attention.
But the gas cooling extent that the past research discovery tracheal strips is blown into low temperature is extremely limited, effectively cannot alleviate Warm ischemia injury.Reason may be because trachea, specific heat between lung tissue and gas are uneven, and cold air, and especially dry gas can be got warm again after a cold spell rapidly in bronchial tree.How to realize tracheal strips Low Temperature Wet cold aeration, effectively alleviate specific heat inequality, reduce the temperature for lung, become the key of NHBD lung transplantation.
Tracheal strips is sprayed cryogenic liquid, and can to weaken specific heat between lung tissue and gas uneven, obtain checking, but mice trachea is tiny, thrusts by fine needle the sprinkling that trachea can realize cryogenic liquid in Mice Body.For human body, air tubing length, considerably beyond mice, does not realize the sprinkling of tracheal strips cryogenic liquid by method previously; And the method for respirator atomization only can make big airways moistening, the object reducing trachea, lung tissue and specific heats of gases inequality cannot be reached.Therefore, urgently a kind of tracheal cannula of aerosol type, can realize tracheal strips and spray low temperature lung preserving liquid body, weaken specific heat inequality safely and effectively, reduce lungs temperature, and the biological activity of protection lung inner tissue cell, improves for lung quality.
Summary of the invention
The object of this invention is to provide a kind of novel aerosol type tracheal intubation being applied to spinning without mandrel lung transplantation, lung preservation, to realize low temperature lung preserving liquid body in endotracheal sprinkling, weaken trachea, specific heat between lung tissue and gas is uneven, reduce tracheal strips and lungs temperature fast safely and effectively, alleviate NHBD for lung-heat ischemic injuries, ensure for lung quality.
The aerosol type tracheal intubation being applied to spinning without mandrel lung transplantation, lung preservation provided by the invention, specifically comprises: air bag injection port 1, temperature sensor 2, fixed support 3, pressure-measuring-point outlet 4, expand band micropore nozzle 5, air bag 6, pressure transducer 7, data acquisition module 8, the pipe shaft 9 of tracheal intubation, piezometry extension tube 10, nozzle extension tube 11, temperature measuring extension tube 12, and computer; Wherein:
The pipe shaft 9 of tracheal intubation forms the body supports of aerosol type tracheal intubation, provides the passage that low temperature is ventilated, and cryogenic gas is transported to trachea, lungs are inner, reaches the effect reducing lungs temperature; Air bag 6 is looped around the fore-end of tracheal intubation pipe shaft 9, and be connected with air bag injection port 1 by thin pipe, air is injected to air bag 6 by air bag injection port 1, air bag 6 is expanded, ensure tracheal intubation when in use tracheal strips without gas leakage, withdrawing air then makes air bag 6 sunken, causes tracheal strips to leak gas; Air bag 6 does not communicate with tracheal intubation pipe shaft 9, when air bag 6 is in inflated condition, can change endotracheal pressure and gas leakage degree by regulating the filling degree of air bag.
Be fixed on its top by fixed support 3 expanding the band nozzle 5 of micropore, temperature sensor 2 and pressure-measuring-point outlet 4 in the front end of tracheal intubation pipe shaft 9, and drawn from the hole of the sidewall of pipe shaft 9 by nozzle extension tube 11, temperature measuring extension tube 12, piezometry extension tube 10.Wherein fixed support 3 hollow, can not affect the ventilation of this device center tube.
Expand and be with the nozzle 5 of micropore and tracheal intubation pipe shaft 9 to be coaxitron structure, the end of this nozzle 5 is positioned at tracheal intubation pipe shaft 9 foremost, and end expands, and forms convex semicircles shape structure, there is multiple micropore its inside, ensures that low temperature lung preserving liquid body is sprayed into tracheal strips with mist particles shape; The band micropore nozzle 5 that expands is connected with the front end of nozzle extension tube 11, and nozzle extension tube 11 is drawn from the sidewall of pipe shaft 9; Temperature sensor 2 is positioned at the front end of tracheal intubation pipe shaft 9, provides the temperature sense of position, and temperature sensor 2 is connected with temperature measuring extension tube 12 front end, and temperature measuring extension tube 12 is drawn from the sidewall of pipe shaft 9, and is connected with data acquisition module 8; Pressure-measuring-point outlet 4 is positioned at the front end of tracheal intubation pipe shaft 9, the pressure sensitive of position is provided, pressure-measuring-point outlet 4 is connected with the front end of piezometry extension tube 12, and piezometry extension tube 12 is drawn from the sidewall of pipe shaft 9, then Bonding pressure sensor 7 and data acquisition module 8 successively; Data acquisition module 8 connects computer, the data that computer collects according to data acquisition module 8, provides the conversion of temperature, pressure data, can monitor endotracheal temperature, pressure change in real time.
Compared with prior art, the advantage that has of the present invention and beneficial effect:
The present invention can realize hypothermic protective solution in endotracheal sprinkling, can weaken trachea, lung tissue and specific heats of gases inequality, reduce tracheal strips and lungs temperature fast, alleviate Warm ischemia injury, improve for lung quality; Can Real-Time Monitoring tracheal strips temperature and pressure condition, adjustment parameters index in time, ensures to lower the temperature safely and effectively for lung.
Accompanying drawing explanation
Fig. 1 is apparatus of the present invention structural diagrams.
Number in the figure: 1 is air bag injection port, 2 is temperature sensor, and 3 is fixed support, and 4 is pressure-measuring-point outlet, 5 for expanding band micropore nozzle, 6 is air bag, and 7 is pressure transducer, and 8 is data acquisition module, 9 is tracheal intubation pipe shaft, 10 is piezometry extension tube, and 11 is nozzle extension tube, and 12 is temperature measuring extension tube.
Detailed description of the invention
Apparatus of the present invention insert spinning without mandrel tracheal strips in use, spray low temperature lung preserving liquid body while providing ventilation, weaken lung tissue and specific heats of gases inequality, reduce tracheal strips and lungs temperature fast.Concrete operations are as follows:
1, low temperature lung preserving liquid body pumps into nozzle extension tube 11 by high-pressure pump; by expanding, the rear formation of band micropore nozzle 5 is vaporific to be sprayed in trachea, lungs; the band micropore nozzle 5 that expands can make liquid form the fine mist particles of about 10 μm; this nozzle 5 is coaxitron structure with tracheal intubation pipe shaft 9; extend into pipe, to guarantee that protection liquid subparticle is uniformly distributed at lung inner surface with cold airflow.
2, cryogenic gas is pumped into the centre of tracheal intubation pipe shaft 9 by air pump, by spraying, the low temperature lung preserving liquid body nebulized dispels trachea further, lungs are inner, effective reduction lung tissue and specific heats of gases inequality, take away amount of heat, reduce trachea and lungs internal temperature.
3, temperature sensor 2 and pressure receptor 7 are all connected to data acquisition module 8, and data acquisition module 8 connects computer.Computer, according to temperature, pressure in the device front end collected, realizes Real-Time Monitoring, and adjusts the filling degree of air bag 6 in time as required, the parameters index of high-pressure pump, air pump, ensures to lower the temperature safely and effectively for lung.
4, give air bag 6 by air bag injection port 1 to inflate, adjust endotracheal pressure and gas leakage degree according to the expanded state of air bag, avoid too high stress injury, ensure that heat is discharged from the space between trachea and tracheal intubation pipe shaft 9.
By this device, carry out the sprinkling of low-temperature protection liquid while can realizing ventilated inside gas pipe, the specific heat weakening trachea, lung tissue and gas is uneven, makes for lung effective temperature-reducing; By corresponding temperature, pressure receptor, data acquisition module, can the endotracheal temperature of Real-Time Monitoring, pressure change, adjust temperature, the pressure parameter of hypothermic protective solution and the cryogenic gas pumped in time, realize saferly confession lung lower the temperature.
Claims (1)
1. the aerosol type tracheal intubation being applied to spinning without mandrel lung and preserving, it is characterized in that by air bag injection port (1), temperature sensor (2), fixed support (3), pressure-measuring-point export (4), expand band micropore nozzle (5), air bag (6), pressure transducer (7), data acquisition module (8), tracheal intubation pipe shaft (9), piezometry extension tube (10), nozzle extension tube (11), temperature measuring extension tube (12), and computer composition; Wherein:
Tracheal intubation pipe shaft (9) forms the body supports of aerosol type tracheal intubation, provides the passage that low temperature is ventilated, and cryogenic gas is transported to trachea, lungs are inner, reaches the effect reducing lungs temperature; Air bag (6) is looped around the fore-end of tracheal intubation pipe shaft (9), and be connected with air bag injection port (1) by thin pipe, by air bag injection port (1) to air bag (6) injection air, air bag (6) is expanded, ensure tracheal intubation when in use tracheal strips without gas leakage, withdrawing air then makes air bag (6) sunken, causes tracheal strips to leak gas; When air bag (6) is in inflated condition, endotracheal pressure and gas leakage degree can be changed by regulating the filling degree of air bag;
By fixed support (3), nozzle (5), temperature sensor (2) and pressure-measuring-point outlet (4) are fixed on its top in the front end of tracheal intubation pipe shaft (9); Wherein, nozzle (5) and tracheal intubation pipe shaft (9) are coaxitron structure, the end of this nozzle (5) is positioned at tracheal intubation pipe shaft (9) foremost, end expands, form convex semicircles shape structure, there is multiple micropore its inside, ensures that low temperature lung preserving liquid body is sprayed into tracheal strips with mist particles shape; Nozzle (5) is connected with the front end of nozzle extension tube (11), and nozzle extension tube (11) is drawn from the sidewall of tracheal intubation pipe shaft (9); Temperature sensor (2) is positioned at the front end of tracheal intubation pipe shaft (9), the temperature sense of position is provided, temperature sensor (2) is connected with temperature measuring extension tube (12) front end, temperature measuring extension tube (12) is drawn from the sidewall of tracheal intubation pipe shaft (9), and is connected with data acquisition module (8); Pressure-measuring-point outlet (4) is positioned at the front end of tracheal intubation pipe shaft (9), the pressure sensitive of position is provided, pressure-measuring-point outlet (4) is connected with the front end of piezometry extension tube (10), piezometry extension tube (10) is drawn from the sidewall of tracheal intubation pipe shaft (9), then Bonding pressure sensor (7) and data acquisition module (8) successively; Data acquisition module (8) connects computer; Computer provides the conversion of temperature, pressure data, and the endotracheal temperature of monitoring, pressure change in real time.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210402719.9A CN102935259B (en) | 2012-10-22 | 2012-10-22 | Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210402719.9A CN102935259B (en) | 2012-10-22 | 2012-10-22 | Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors |
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| CN102935259A CN102935259A (en) | 2013-02-20 |
| CN102935259B true CN102935259B (en) | 2014-12-24 |
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| CN111880842B (en) * | 2020-06-22 | 2023-08-22 | 东北大学 | Method and device for switching instructions, electronic equipment and storage medium |
| CN111939411A (en) * | 2020-08-21 | 2020-11-17 | 道琪康医学科技(苏州)有限公司 | System and method for monitoring and judging air leakage of airway seal during trachea cannula ventilation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098622A (en) * | 2004-11-12 | 2008-01-02 | 多尔灿德气动股份有限公司 | Composition for cold preservation and perfusion of organs |
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| EP2285211B1 (en) * | 2008-05-06 | 2019-07-24 | XVIVO Perfusion AB | Apparatus for housing an organ during evaluation and preservation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098622A (en) * | 2004-11-12 | 2008-01-02 | 多尔灿德气动股份有限公司 | Composition for cold preservation and perfusion of organs |
Non-Patent Citations (1)
| Title |
|---|
| 无心跳供体肺原位降温保护系统的研究;彭富裕等;《制冷学报》;20120831;第33卷(第4期);第74-78页 * |
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