CN102935259A - Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors - Google Patents
Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors Download PDFInfo
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- CN102935259A CN102935259A CN2012104027199A CN201210402719A CN102935259A CN 102935259 A CN102935259 A CN 102935259A CN 2012104027199 A CN2012104027199 A CN 2012104027199A CN 201210402719 A CN201210402719 A CN 201210402719A CN 102935259 A CN102935259 A CN 102935259A
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Abstract
The invention belongs to the technical field of auxiliary medical devices, and specifically relates to a spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors. The spray type tracheal intubation comprises an airbag injection port, a temperature sensor, a fixed support, a pressure test point outlet, an inflated nozzle with micropores, an airbag, a pressure sensor, a data acquisition module, a tube body of the tracheal intubation, a pressure measurement extension tube, a nozzle extension tube, a temperature measurement extension tube and a computer. The spray type tracheal intubation can spray low temperature protection liquid in tracheae, weaken unevenness of specific heat of tracheae, lung tissues and air, quickly lower the temperature in tracheae and the temperature of lungs, alleviate warm ischemia injury and improve the quality of donor lungs; and the spray type tracheal intubation can monitor the temperature and pressure conditions in tracheae in real time, adjust all parameter indexes in time and guarantee safe and effective cooling of the donor lungs.
Description
Technical field
The invention belongs to medical assistance device technology field, be specifically related to a kind of aerosol type tracheal intubation that the Lungs from Non-Heart-Beating donor lung is transplanted, lung is preserved that is applied to.
Background technology
Brain death donor (the heart beating donor being arranged, heart heating donor, HBD) critical shortage, so the research of Lungs from Non-Heart-Beating donor (non heart heating donor, NHBD) becomes focus.There is the heartbeat blood supply in HBD, and the NHBD donor is then opposite, and there is Warm ischemia injury in various degree in the acardia blood supply, and cooling, the shortening heat Ischemia Time of carrying out as early as possible lungs is requisite measures that lungs are preserved.The doctor can't open the operation that breast is got lung, wound is arranged before obtaining family members' agreement, authorizing; therefore heart beating stop to out breast get lung during this period of time in, noinvasive ground is used ventilated inside gas pipe and is carried out the measure that the NHBD donor lung protects in conjunction with low temperature and be subject to focus of attention.
But the gas cooling extent that previously is blown into low temperature in the research discovery trachea is extremely limited, can't effectively alleviate Warm ischemia injury.Reason may be because the specific heat between trachea, lung tissue and the gas is uneven, and cold air, and especially dried gas can be got warm again after a cold spell rapidly in bronchial tree.How to realize Low Temperature Wet cold aeration in the trachea, effectively alleviate the specific heat inequality, reduce the temperature for lung, become the key of NHBD lung transplantation.
It is uneven to be sprayed the specific heat that cryogenic liquid can weaken between lung tissue and the gas in the trachea, obtained checking in Mice Body, but the mice trachea is tiny, thrusts the sprinkling that trachea can be realized cryogenic liquid by fine needle.For human body, trachea length can not realize by method previously the sprinkling of cryogenic liquid in the trachea considerably beyond mice; And the method for respirator atomizing only can make big airways moistening, can't reach the purpose that reduces trachea, lung tissue and specific heats of gases inequality.Therefore, demand a kind of tracheal cannula of aerosol type urgently, can realize spraying in the trachea low temperature lung preserving liquid body, the specific heat inequality that weakens safely and effectively reduces the lungs temperature, and the biological activity of protection lung inner tissue cell improves for the lung quality.
Summary of the invention
The Lungs from Non-Heart-Beating donor lung is transplanted, the aerosol type tracheal intubation of lung preservation to the purpose of this invention is to provide a kind of novel being applied to, to realize that low temperature lung preserving liquid body is in endotracheal sprinkling, specific heat between reduction trachea, lung tissue and the gas is uneven, reach safely and effectively the lungs temperature in the fast reducing trachea, alleviate NHBD for the lung-heat ischemic injuries, guarantee for the lung quality.
The aerosol type tracheal intubation that is applied to the transplanting of Lungs from Non-Heart-Beating donor lung, lung preservation provided by the invention specifically comprises: air bag injection port 1, temperature sensor 2, fixed support 3, nozzle 5 with micropore is expanded in pressure-measuring-point outlet 4, air bag 6, pressure transducer 7, data acquisition module 8, the pipe shaft 9 of tracheal intubation, piezometry extension tube 10, nozzle extension tube 11, temperature measuring extension tube 12, and computer; Wherein:
The pipe shaft 9 of tracheal intubation consists of the body supports of aerosol type tracheal intubation, and the passage of low temperature ventilation is provided, and cryogenic gas is transported to trachea, lungs inside, reaches the effect that reduces the lungs temperature; Air bag 6 is looped around the fore-end of tracheal intubation pipe shaft 9, and be connected with air bag injection port 1 by thin pipe, inject air by air bag injection port 1 to air bag 6, so that air bag 6 expands, trachea is interior without gas leakage when in use to guarantee tracheal intubation, the suction air causes gas leakage in the trachea then so that air bag 6 is sunken; Air bag 6 does not communicate with tracheal intubation pipe shaft 9, when air bag 6 is in inflated condition, can change endotracheal pressure and gas leakage degree by the filling degree of regulating air bag.
Front end at tracheal intubation pipe shaft 9 is fixed on its top to nozzle 5, temperature sensor 2 and the pressure-measuring-point outlet 4 of expanding with micropore by fixed support 3, and draws from the hole of the sidewall of pipe shaft 9 by nozzle extension tube 11, temperature measuring extension tube 12, piezometry extension tube 10.Wherein fixed support 3 hollows can not affect the ventilation of this device center tube.
The nozzle 5 that expands with micropore is the coaxitron structure with tracheal intubation pipe shaft 9, the end of this nozzle 5 is positioned at tracheal intubation pipe shaft 9 foremost, and end expands, and forms convex semicircles shape structure, there are a plurality of micropores its inside, guarantees that low temperature lung preserving liquid body is sprayed in the trachea with vaporific graininess; Expand and be connected with the front end of micropore nozzle 5 with nozzle extension tube 11, nozzle extension tube 11 is drawn from the sidewall of pipe shaft 9; Temperature sensor 2 is positioned at the front end of tracheal intubation pipe shaft 9, and the temperature sense of position is provided, and temperature sensor 2 is connected with temperature measuring extension tube 12 front ends, and temperature measuring extension tube 12 is drawn from the sidewall of pipe shaft 9, and is connected with data acquisition module 8; Pressure-measuring-point outlet 4 is positioned at the front end of tracheal intubation pipe shaft 9, the pressure sensitive of position is provided, pressure-measuring-point outlet 4 is connected with the front end of piezometry extension tube 12, and piezometry extension tube 12 is drawn from the sidewall of pipe shaft 9, then successively Bonding pressure sensor 7 and data acquisition module 8; Data acquisition module 8 connects computers, and computer provides the conversion of temperature, pressure data according to the data that data acquisition module 8 collects, can the endotracheal temperature of Real Time Monitoring, pressure changes.
Compared with prior art, the advantage and the beneficial effect that have of the present invention:
The present invention can realize hypothermic protective solution in endotracheal sprinkling, and the trachea that can weaken, lung tissue and the specific heats of gases are uneven, reaches the lungs temperature in the fast reducing trachea, alleviates Warm ischemia injury, improves for the lung quality; Temperature and pressure condition are in time adjusted the parameters index in can the Real-Time Monitoring trachea, guarantee to lower the temperature safely and effectively for lung.
Description of drawings
Fig. 1 is apparatus of the present invention structural diagrams.
Number in the figure: 1 is the air bag injection port, 2 are temperature sensor, and 3 is fixed support, and 4 are the pressure-measuring-point outlet, 5 for expanding the band micropore nozzle, 6 is air bag, and 7 is pressure transducer, and 8 is data acquisition module, 9 is the tracheal intubation pipe shaft, 10 are the piezometry extension tube, and 11 is nozzle extension tube, and 12 are the temperature measuring extension tube.
The specific embodiment
Apparatus of the present invention are inserted in the Lungs from Non-Heart-Beating donor trachea in use, spray low temperature lung preserving liquid body when ventilation is provided, and reduction lung tissue and the specific heats of gases are uneven, reach the lungs temperature in the fast reducing trachea.Concrete operations are as follows:
1, low temperature lung preserving liquid body pumps into nozzle extension tube 11 by high-pressure pump; by expanding vaporific being sprayed in trachea, the lungs of band micropore nozzle 5 rear formation; expand and to make liquid form fine vaporific granule about 10 μ m with micropore nozzle 5; this nozzle 5 is the coaxitron structure with tracheal intubation pipe shaft 9; extend into trachea inside, to guarantee the protecting liquid subparticle evenly to distribute at the lung inner surface with cold airflow.
2, cryogenic gas is pumped into the centre of tracheal intubation pipe shaft 9 by air pump, the low temperature lung preserving liquid body that sprinkling is nebulized further dispels trachea, lungs are inner, effectively reduction lung tissue and the specific heats of gases are uneven, take away amount of heat, reduce trachea and lungs internal temperature.
3, temperature sensor 2 and pressure receptor 7 all are connected to data acquisition module 8, and data acquisition module 8 connects computer.Computer is realized Real-Time Monitoring according to temperature, pressure in the device front end that collects, and in time adjusts as required the filling degree of air bag 6, and the parameters index of high-pressure pump, air pump guarantees to lower the temperature safely and effectively for lung.
4, give air bag 6 inflations by air bag injection port 1, adjust endotracheal pressure and gas leakage degree according to the full state of air bag, avoid too high pressure damage, guarantee the space discharge of heat between trachea and tracheal intubation pipe shaft 9.
By this device, carry out the sprinkling of low-temperature protection liquid when can realize ventilated inside gas pipe, the specific heat of reduction trachea, lung tissue and gas is uneven, so that for the lung effective temperature-reducing; By corresponding temperature, pressure receptor, data acquisition module, can the endotracheal temperature of Real-Time Monitoring, pressure changes, in time adjust the hypothermic protective solution that pumps into and temperature, the pressure parameter of cryogenic gas, realize for the lung cooling saferly.
Claims (1)
1. one kind is applied to the aerosol type tracheal intubation that the Lungs from Non-Heart-Beating donor lung is preserved, it is characterized in that by air bag injection port (1), temperature sensor (2), fixed support (3), pressure-measuring-point outlet (4), expand nozzle (5), air bag (6), pressure transducer (7), data acquisition module (8), the pipe shaft (9) of tracheal intubation, piezometry extension tube (10), nozzle extension tube (11), temperature measuring extension tube (12) with micropore, and computer forms; Wherein:
The pipe shaft of tracheal intubation (9) consists of the body supports of aerosol type tracheal intubation, and the passage of low temperature ventilation is provided, and cryogenic gas is transported to trachea, lungs inside, reaches the effect that reduces the lungs temperature; Air bag (6) is looped around the fore-end of the pipe shaft (9) of tracheal intubation, and be connected with air bag injection port (1) by thin pipe, inject air by air bag injection port (1) to air bag (6), so that air bag (6) expands, trachea is interior without gas leakage when in use to guarantee tracheal intubation, the suction air causes gas leakage in the trachea then so that air bag (6) is sunken; Air bag (6) can change endotracheal pressure and gas leakage degree by the filling degree of regulating air bag when being in inflated condition;
Front end at the pipe shaft (9) of tracheal intubation is fixed on its top to nozzle (5), temperature sensor (2) and pressure-measuring-point outlet (4) by fixed support (3); Wherein, nozzle (5) is the coaxitron structure with tracheal intubation pipe shaft (9), the pipe shaft (9) that the end of this nozzle (5) is positioned at tracheal intubation foremost, end expands, form convex semicircles shape structure, there are a plurality of micropores its inside, guarantees that low temperature lung preserving liquid body is sprayed in the trachea with vaporific graininess; Nozzle (5) is connected with the front end of nozzle extension tube (11), and nozzle extension tube (11) is drawn from the sidewall of pipe shaft (9); Temperature sensor (2) is positioned at the front end of the pipe shaft (9) of tracheal intubation, the temperature sense of position is provided, temperature sensor (2) is connected with temperature measuring extension tube (12) front end, temperature measuring extension tube (12) is drawn from the sidewall of pipe shaft (9), and is connected with data acquisition module (8); Pressure-measuring-point outlet (4) is positioned at the front end of tracheal intubation pipe shaft (9), the pressure sensitive of position is provided, pressure-measuring-point outlet (4) is connected with the front end of piezometry extension tube (10), piezometry extension tube (10) is drawn from the sidewall of pipe shaft (9), then successively Bonding pressure sensor (7) and data acquisition module (8); Data acquisition module (8) connects computer; Computer provides the conversion of temperature, pressure data, and the endotracheal temperature of Real Time Monitoring, pressure change.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210402719.9A CN102935259B (en) | 2012-10-22 | 2012-10-22 | Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210402719.9A CN102935259B (en) | 2012-10-22 | 2012-10-22 | Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors |
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| CN102935259A true CN102935259A (en) | 2013-02-20 |
| CN102935259B CN102935259B (en) | 2014-12-24 |
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| CN201210402719.9A Active CN102935259B (en) | 2012-10-22 | 2012-10-22 | Spray type tracheal intubation applied to preservation of lungs from non-heart-beating donors |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111880842A (en) * | 2020-06-22 | 2020-11-03 | 东北大学 | Instruction switching method and device, electronic equipment and storage medium |
| CN111939411A (en) * | 2020-08-21 | 2020-11-17 | 道琪康医学科技(苏州)有限公司 | System and method for monitoring and judging air leakage of airway seal during trachea cannula ventilation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098622A (en) * | 2004-11-12 | 2008-01-02 | 多尔灿德气动股份有限公司 | Composition for cold preservation and perfusion of organs |
| WO2009136838A1 (en) * | 2008-05-06 | 2009-11-12 | Igelösa Transplantation Science Ab | Apparatus for housing an organ during evaluation and preservation |
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2012
- 2012-10-22 CN CN201210402719.9A patent/CN102935259B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101098622A (en) * | 2004-11-12 | 2008-01-02 | 多尔灿德气动股份有限公司 | Composition for cold preservation and perfusion of organs |
| WO2009136838A1 (en) * | 2008-05-06 | 2009-11-12 | Igelösa Transplantation Science Ab | Apparatus for housing an organ during evaluation and preservation |
Non-Patent Citations (1)
| Title |
|---|
| 彭富裕等: "无心跳供体肺原位降温保护系统的研究", 《制冷学报》, vol. 33, no. 4, 31 August 2012 (2012-08-31), pages 74 - 78 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111880842A (en) * | 2020-06-22 | 2020-11-03 | 东北大学 | Instruction switching method and device, electronic equipment and storage medium |
| CN111880842B (en) * | 2020-06-22 | 2023-08-22 | 东北大学 | Method and device for switching instructions, electronic equipment and storage medium |
| CN111939411A (en) * | 2020-08-21 | 2020-11-17 | 道琪康医学科技(苏州)有限公司 | System and method for monitoring and judging air leakage of airway seal during trachea cannula ventilation |
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| CN102935259B (en) | 2014-12-24 |
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