CN102935023B - Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors - Google Patents
Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors Download PDFInfo
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- CN102935023B CN102935023B CN201210402486.2A CN201210402486A CN102935023B CN 102935023 B CN102935023 B CN 102935023B CN 201210402486 A CN201210402486 A CN 201210402486A CN 102935023 B CN102935023 B CN 102935023B
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Abstract
The invention belongs to the technical field of auxiliary medical devices, and specifically relates to a noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors. The device comprises two solenoid valves, a minitype membrane pump, two semiconductor refrigeration modules, a lung preserving fluid tank, a cooling water tank, a radiating coil tube, a fan, a water temperature controller and a water pump, and is divided into three systems, namely a low temperature aerating system, a low temperature lung preserving fluid supply system and a radiating system, wherein the low temperature aerating system carries out low temperature aeration in tracheae, the low temperature lung preserving fluid supply system supplies low temperature lung preserving fluid in the tracheae, and the radiating system carries out circulatory radiating on the two refrigeration modules. The noninvasive endotracheal cooling device can provide low temperature air with high flow capacity under the precondition of noninvasive operation, simultaneously feed high pressure low temperature lung preserving fluid into the tracheae, reduce the heat exchange coefficient, weaken unevenness of specific heat, quickly lower the temperature in the tracheae and the temperature of lungs, alleviate warm ischemia injury and improve the quality of donor lungs.
Description
Technical field
The invention belongs to medical assistance device technology field, be specifically related to a kind of heat sink in the trachea that Lungs from Non-Heart-Beating donor lung is transplanted, lung is preserved that is applied to, especially confirm to authorize at donor and open before breast gets lung, the interior heat sink of noninvasive trachea that can provide.
Background technology
Latter stage at end, unique effective Therapeutic Method of pulmonary disease was lung transplant.Clinical lung transplant operation quantity increases less at present, stagnation, main cause is that brain death donor (has heart beating donor, heart heating donor, HBD) critical shortage, therefore numerous scholars invest sight the research of Lungs from Non-Heart-Beating donor (non heart heating donor, NHBD).But HBD exists heartbeat blood supply, NHBD donor is contrary, and acardia blood supply exists Warm ischemia injury in various degree, As time goes on and gradually loses function, is not suitable for carrying out lung transplant again.Warm ischemia injury time length determines the quality for lung quality, and cooling, the shortening heat Ischemia Time of carrying out as early as possible lungs is requisite measures that lungs are preserved.Doctor cannot open the operation that breast is got lung, had wound before obtaining family members' agreement, authorizing; therefore heart beating stop to out breast get lung during this period of time in; how noinvasive cooling under the prerequisite of not violating ethics, the Lung protection that alleviates Warm ischemia injury are most important, become the key of NHBD lung transplantation.
Lungs upwards communicate with the external world by trachea, form branch spline structure downwards by tapered bronchus, and whole bronchiolus terminalis expands and is formed into alveolar, and bronchus branch spline structure and alveolar have formed pulmonary parenchyma jointly.Ambient atmos enters in pulmonary parenchyma by trachea, arrives whole end alveolar, carries out herein the blood oxygen exchange of human body, completes the physiological action of breathing.Lungs are special organs, because the survival of irradiation in all of pulmonary parenchyma cells does not depend on merely circumfusion oxygen supply, can also utilize oxygen in alveolar to carry out cell oneself breathing; After body death, the lung tissue certain hour of still surviving, this is its place different from other organs, is also the theoretical basis that ventilated inside gas pipe lung is preserved.Low temperature is the requisite measure that organ is preserved, and can reduce cellular metabolism, and enzymatic activity and energy consumption, slow down cell death, alleviates Warm ischemia injury.
Therefore, the measure that noinvasive ground application ventilated inside gas pipe carries out the protection of NHBD donor lung in conjunction with low temperature has been subject to focus of attention, but previously research to find to be blown in trachea the gas cooling extent of low temperature extremely limited, cannot effectively alleviate Warm ischemia injury.Reason may be due to the specific heat inequality between trachea, lung tissue and gas, and cold air, especially dry gas can be got warm again after a cold spell rapidly in bronchial tree, therefore needs to change the ventilating mode of this type, reduction specific heat inequality, reaches the object of fast cooling.
How under the prerequisite of not violating ethics, to weaken the specific heat inequality between trachea, lung tissue and gas; noinvasive, reduce in trachea rapidly and the temperature of lungs becomes the key of NHBD for lung quality; therefore; the urgently a kind of cooling protection device that can simultaneously realize above-mentioned requirements; alleviate Warm ischemia injury, improve for lung quality.
Summary of the invention
The object of the present invention is to provide one can alleviate NHBD for lung-heat ischemic injuries, guarantee the interior heat sink of noinvasive trachea that Lungs from Non-Heart-Beating donor lung is preserved that is applied to for lung quality.
Heat sink in the noinvasive trachea that is applied to the preservation of Lungs from Non-Heart-Beating donor lung provided by the invention, merge low temperature lung preserving liquid body in endotracheal input by low temperature ventilation in trachea, weaken the specific heat inequality between trachea, lung tissue and gas, reach in fast reducing trachea and the object of lungs temperature, thereby alleviate NHBD for lung-heat ischemic injuries, guarantee for lung quality.Its system structure as shown in Figure 1.This device is by the first electromagnetic valve 1, the second electromagnetic valve 2, Miniature diaphragm pump 3, the first semiconductor refrigerating modules 4, the second semiconductor refrigerating module 5, lung preserving liquid body water tank 6, circulating cooling water tank 7, radiator coil tube 8, blower fan 9, circulating water temperature controller 10, water circulating pump 11 forms; Be divided into 3 systems: low temperature aerating system, low temperature lung preserving liquid body feed system and cooling system; Wherein:
The second semiconductor refrigerating module 5 forms low temperature aerating system, and the gas that extraneous high-pressure air source provides enters semiconductor refrigerating module 5 by pipeline, obtains cryogenic gas; Cryogenic gas enters in trachea through the outlet 13 of semiconductor refrigerating module 5, realizes low temperature ventilation in trachea;
Lung preserving liquid body water tank 6 connects the first electromagnetic valve 1, then connects successively Miniature diaphragm pump 3 and the first semiconductor refrigerating module 4, the first semiconductor refrigerating modules 4 and be provided with outlet 12; Before the second electromagnetic valve 2 is arranged on Miniature diaphragm pump 3, in parallel with the first electromagnetic valve 1, second electromagnetic valve 2 other ends lead to ambient air; More than form low temperature lung preserving liquid body feed system; Lung preserving liquid body water tank 6 provides lung preserving liquid body, after the first electromagnetic valve 1 and the second electromagnetic valve 2 regulation and control, then enters successively Miniature diaphragm pump 3 and the first semiconductor refrigerating module 4, obtains low temperature lung preserving liquid body; This low temperature lung preserving liquid body is input in trachea by the outlet 12 of the first semiconductor refrigerating module 4, realizes the supply to low temperature lung preserving liquid body in trachea;
The setting of the first electromagnetic valve 1, the second electromagnetic valve 2 is in order to prevent that low temperature lung preserving liquid body straying quatity from too much causing lungs edema, is arranged on the front end of Miniature diaphragm pump 3.Wherein the first electromagnetic valve 1 import is connected to low temperature lung preserving liquid body stream; the second electromagnetic valve 2 connects gas flow path; the switching of two electromagnetic valves is by microcomputerized control; guarantee to only have at every turn the two one of for path; as long as control both opening/closing times; just can allow Organ Preservation Solution quantity delivered form pulsed control, easy to operate.
Miniature diaphragm pump 3 provides lung preserving liquid body mobile power support, orders about lung preserving liquid direction of flow semiconductor refrigerating module 4, and the latter provides fast-refrigerating, and the low temperature lung preserving liquid body after cooling is input in trachea by connecting low temperature lung preserving liquid body outlet 12.
Circulating cooling water tank 7, radiator coil tube 8, blower fan 9, circulating water temperature controller 10, water circulating pump 11 forms cooling system; The first semiconductor refrigerating module 4, the second semiconductor refrigerating module 5 are connected to cooling system by corresponding pipeline respectively, the heat producing in 2 semiconductor refrigerating modules is left, to guarantee two semiconductor refrigerating module consecutive low temperature runnings, continue to provide cryogenic gas and low temperature lung preserving liquid body in endotracheal input.Specifically:
The left side of circulating cooling water tank 7 is connected with circulating water temperature controller 10 and water circulating pump 11 successively, and then is connected to respectively the hot junction of the first semiconductor refrigerating module 4 and the second semiconductor refrigerating module 5; Circulating cooling water tank 7 provides cold water source, and circulating water temperature controller 10 and water circulating pump 11 provide respectively adjustable control and the mobile power support of cold water of temperature; Right side at cyclic water tank 7 is connected with one end of radiator coil tube 8, carries out exchange heat by radiator coil tube 8, and heat is discharged; Radiator coil tube 8 connecting fans 2, blower fan 2 can accelerate heat radiation; The other end of radiator coil tube 8 is connected with the cold junction of the first semiconductor refrigerating module 4 and the second semiconductor refrigerating module 5 respectively, realizes circulation cooling.
Compared with prior art, tool of the present invention has the following advantages and beneficial effect:
The present invention can, under noinvasive operational hypothesis, provide high flow capacity cryogenic gas, simultaneously input high pressure low temperature lung preserving liquid body in trachea, reduce heat exchange coefficient, weaken specific heat inequality, can fast reducing trachea in and lungs temperature, alleviate Warm ischemia injury, improve for lung quality.This device can also be transported to lungs inside by protective gas or liquid medicine composition, and collaborative antagonism NHBD is for lung-heat ischemic injuries.
Accompanying drawing explanation
Fig. 1 is plant system drawing.
Fig. 2 is device circuit figure.
Number in the figure: 1 is the first electromagnetic valve, 2 is the second electromagnetic valve, 3 is Miniature diaphragm pump, 4 is the first semiconductor refrigerating module, 5 is the second semiconductor refrigerating module, and 6 is lung preserving liquid body water tank, and 7 is circulating cooling water tank, 8 is radiator coil tube, 9 is blower fan, and 10 is circulating water temperature controller, and 11 is water circulating pump, 12 is the outlet of low temperature lung preserving liquid body, and 13 is cryogenic gas outlet.
The specific embodiment
High flow capacity gas is passed through the cooling cryogenic gas that becomes fast by the present invention, and directly send into pulmonary by trachea; Meanwhile, adopt pulse mode to carry a small amount of lung preserving liquid body and refrigerating gas together to enter pulmonary.This is specific heat inequality between the interior heat exchange coefficient of favourable enhancing lung, reduction lung tissue and gas not only, can also protect the biological activity of lung inner tissue cell.The present invention can, under noinvasive operational hypothesis, implement fast cooling to NHBD for lung original position, alleviates Warm ischemia injury, improves NHBD for lung quality.
Elaborate embodiment of the present invention below in conjunction with legend.Be illustrated in figure 1 the system principle schematic diagram of apparatus of the present invention.
High-pressure air source provides high flow capacity gas, carries out coolingly fast through the second semiconductor refrigerating module 5, obtains cryogenic gas and is input to trachea inside; Lung preserving liquid body in lung preserving liquid body water tank 6 provides power support by Miniature diaphragm pump 3, is transported in the first semiconductor refrigerating module 4, carries out cooling fast therein; The first semiconductor refrigerating module 4 connects the outlet of low temperature lung preserving liquid body, extends into the inner appropriate depth of trachea, to guarantee that this liquid enters in trachea, lung tissue with low-temperature airflow; For preventing from protecting liquid straying quatity too much to cause the problems such as edema, at two electromagnetic valves of micro pump front end assembling, guarantee to only have at every turn the two one of be path, just can make the control of lung preserving liquid body quantity delivered formation pulsed as long as control both opening/closing times; Cryogenic gas follows the low temperature lung preserving liquid body of input in trachea can weaken specific heat inequality, reduces heat exchange coefficient, takes away amount of heat by trachea, the evaporation of lung surface liquid composition, can realize the fast cooling on trachea, lung surface.
Working properly for guaranteeing the first semiconductor refrigerating module 4 in system, the second semiconductor refrigerating module 5, the present invention adopts mode air-cooled and that water-cooled combines, carry out cooling to the hot junction of quasiconductor refrigeration module, the water-cooled coil pipe that is semiconductor refrigerating module 4,5 hot junctions is by cyclic water tank 7, carry out heat exchange through water circulating pump 11 cooling, its coolant water temperature is monitored by circulating water temperature controller 10.Less for guaranteeing as far as possible the water temperature of cyclic water tank 7, before recirculated water enters water tank, adopt blower fan 9 to dispel hot coil 8 surfaces, carry out auxiliary temperature-reducing.In order to meet different operating modes and clinical demand, two semiconductor refrigerating modules adopt respectively micro computer independence control sequence, and its design parameter can relatively independent work.
This device provides the air of high flow capacity by high-pressure air source, oxygen and other protective gas that can merge different flow mix jointly; This device can add various ingredients in lung preserving liquid body water tank, is transported to trachea, lungs inside simultaneously, better brings into play the effect of medicine.
According to the concrete structure of apparatus of the present invention and function, those skilled in the art person can design corresponding electrical schematic diagram.Fig. 2 is electrical schematic diagram example of the present invention.
This device makes trachea, the inner surperficial liquid component evaporation of lungs take away amount of heat under the prerequisite of not violating ethics and noinvasive operation, can realize the fast cooling of trachea, lungs, alleviate Warm ischemia injury, guarantee that NHBD, for lung quality, is conducive to extensively carrying out of clinical lung transplant operation.
Claims (1)
1. be applied to the interior heat sink of noinvasive trachea that Lungs from Non-Heart-Beating donor lung is preserved, it is characterized in that this device is made up of the first electromagnetic valve (1), the second electromagnetic valve (2), Miniature diaphragm pump (3), the first semiconductor refrigerating module (4), the second semiconductor refrigerating module (5), lung preserving liquid body water tank (6), circulating cooling water tank (7), radiator coil tube (8), blower fan (9), circulating water temperature controller (10) and water circulating pump (11); Be divided into 3 systems: low temperature aerating system, low temperature lung preserving liquid body feed system and cooling system; Wherein:
The second semiconductor refrigerating module (5) forms low temperature aerating system, and the gas that extraneous high-pressure air source provides, enters semiconductor refrigerating module (5) by pipeline, obtains cryogenic gas; Cryogenic gas is input in trachea through the outlet (13) of semiconductor refrigerating module (5), realizes carrying out low temperature ventilation in trachea;
Lung preserving liquid body water tank (6) connects the first electromagnetic valve (1), then connects successively Miniature diaphragm pump (3) and the first semiconductor refrigerating module (4); The second electromagnetic valve (2) is arranged on Miniature diaphragm pump (3) before, in parallel with the first electromagnetic valve (1), and the second electromagnetic valve (2) other end leads to ambient air; The above lung preserving liquid body water tank (6), the first electromagnetic valve (1), the second electromagnetic valve (2), Miniature diaphragm pump (3) and the first semiconductor refrigerating module (4) composition low temperature lung preserving liquid body feed system; Lung preserving liquid body water tank (6) provides lung preserving liquid body, after the first electromagnetic valve (1) and the second electromagnetic valve (2) regulation and control, then enters successively Miniature diaphragm pump (3) and the first semiconductor refrigerating module (4), obtains low temperature lung preserving liquid body; This low temperature lung preserving liquid body is input in trachea by the outlet (12) of the first semiconductor refrigerating module (4), realizes the supply to low temperature lung preserving liquid body in trachea; Described at Miniature diaphragm pump (3) the first electromagnetic valve (1) and the second electromagnetic valve (2) before, guarantee to only have at every turn the two one of for path, and control both opening/closing time, make lung preserving liquid body quantity delivered form pulsed control;
Circulating cooling water tank (7), radiator coil tube (8), blower fan (9), circulating water temperature controller (10) and water circulating pump (11) composition cooling system; The left side of circulating cooling water tank (7) is connected with circulating water temperature controller (10) and water circulating pump (11) successively, and then is connected to respectively the hot junction of the first semiconductor refrigerating module (4) and the second semiconductor refrigerating module (5); Circulating cooling water tank (7) provides cold water source, and circulating water temperature controller (10) and water circulating pump (11) provide respectively adjustable control and the mobile power support of cold water of temperature; Right side at cyclic water tank (7) is connected with one end of radiator coil tube (8), carries out exchange heat by radiator coil tube (8), and heat is discharged; Blower fan (2) is for accelerating heat radiation; The other end of radiator coil tube (8) is connected with the cold junction of the first semiconductor refrigerating module (4) and the second semiconductor refrigerating module (5) respectively, realizes the circulation cooling to two refrigeration modules; Wherein, the first semiconductor refrigerating module (4) and the second semiconductor refrigerating module (5) adopt respectively the control of micro computer independence control sequence.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210402486.2A CN102935023B (en) | 2012-10-22 | 2012-10-22 | Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors |
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| CN201210402486.2A CN102935023B (en) | 2012-10-22 | 2012-10-22 | Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors |
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| CN102935023A CN102935023A (en) | 2013-02-20 |
| CN102935023B true CN102935023B (en) | 2014-07-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130347A (en) * | 1994-07-12 | 1996-09-04 | 伊莱亚斯有限公司 | Method to refrigerate a jacket for keeping a transplant organ cold |
| CN202908928U (en) * | 2012-10-22 | 2013-05-01 | 同济大学附属上海市肺科医院 | Non-invasive intratracheal cooling device applied to preservation of non heart heating donor lung |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001104362A (en) * | 1999-10-13 | 2001-04-17 | Yukio Kuniyoshi | Sinus node cooling device and heart beat restraint system using it |
| US20070162097A9 (en) * | 2004-03-16 | 2007-07-12 | Rojas Arturo R | Patient cooling system and method |
| EP2192879B1 (en) * | 2007-09-27 | 2016-05-04 | Critical Care Research, Inc. | Portable apparatus and method for the administration of heat exchange in the lungs of a mammal |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130347A (en) * | 1994-07-12 | 1996-09-04 | 伊莱亚斯有限公司 | Method to refrigerate a jacket for keeping a transplant organ cold |
| CN202908928U (en) * | 2012-10-22 | 2013-05-01 | 同济大学附属上海市肺科医院 | Non-invasive intratracheal cooling device applied to preservation of non heart heating donor lung |
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| JP特开2001-104362A 2001.04.17 |
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