CN102920886A - Medical composition for treating rheumatoid arthritis and preparation method - Google Patents
Medical composition for treating rheumatoid arthritis and preparation method Download PDFInfo
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- CN102920886A CN102920886A CN2012104731613A CN201210473161A CN102920886A CN 102920886 A CN102920886 A CN 102920886A CN 2012104731613 A CN2012104731613 A CN 2012104731613A CN 201210473161 A CN201210473161 A CN 201210473161A CN 102920886 A CN102920886 A CN 102920886A
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- rhizoma dioscoreae
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- aconiti kusnezoffii
- dioscoreae nipponicae
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Abstract
The invention relates to a medical composition for treating rheumatoid arthritis and a preparation method. The composition is prepared from materials in part by weight as follows: 20-80 parts of prepared kusnezoff monkshood root, 20-80 parts of rhizoma dioscoreae nipponicae, and 20-80 parts of liquorice. The medical composition shown by pharmacology experiment has a good effect for treating rheumatoid arthritis. The preparation method is simple.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to a kind of pharmaceutical composition and preparation method for the treatment of rheumatoid arthritis.
Background technology
Owing to people's rheumatism inflammation that residing environment and living habit cause of living is rather common.What it was constantly positive is encroaching on us, and the suffering of bringing is also well imagined.
Rheumatoid arthritis (Rheumatoid Arthritis, hereinafter to be referred as RA) be that symmetry, polyarthritis take joint on every side is the chronic systemic disease of main manifestations, have that the course of disease is long, touching difficulty more, disability rate is high and be easy to again the characteristics such as recurrence.Clinical typical case shows as metacarpophalangeal joints, carpal pain, swelling and stiff, and joint deformity, dysfunction can appear in middle and advanced stage.Whole world sickness rate is about 1%, the prevalence of China is 0.3 ~ 0.4%, any age all can fall ill, be more common in the 30-50 women in year, disability rate is up to 20% in 1 year, the serious threat mankind's Health and Living quality still belongs to agnogenic " obstinate disease " at home and abroad, and people are called again " not dead cancer ".Although the rheumatoid medicine for the treatment of has much at present, is mostly to belong to NSAID (non-steroidal anti-inflammatory drug) and steroid hormone class, the former has the untoward reaction of GI irritation more, and latter's prolonged application more has the untoward reaction of hemo-hyperadrenocorticism.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of pharmaceutical composition for the treatment of rheumatoid arthritis is provided.
Second purpose of the present invention provides a kind of preparation method for the treatment of the pharmaceutical composition of rheumatoid arthritis.The 3rd purpose of the present invention provides a kind of the treat pharmaceutical composition of rheumatoid arthritis and the pharmaceutical preparation that the acceptable adjuvant of pharmacy is made.
The present invention is achieved through the following technical solutions:
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis is characterized in that being made by following raw material by weight: Radix Aconiti Kusnezoffii Preparata 20-80 part, Rhizoma Dioscoreae Nipponicae 20-80 part and Radix Glycyrrhizae 20-80 part.
Preferably: Radix Aconiti Kusnezoffii Preparata is 40 parts, and described Rhizoma Dioscoreae Nipponicae is 40 parts, and described Radix Glycyrrhizae is 40 parts.
A kind of preparation method for the treatment of the pharmaceutical composition of rheumatism comprises the steps:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20-80 part, Rhizoma Dioscoreae Nipponicae 20-80 part and Radix Glycyrrhizae 20-80 part;
(2) carry out with one of following several modes:
The first: with described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae mix homogeneously and get final product;
The second: described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae are mixed, add the water heating and refluxing extraction 1.5 ~ 2 hours of 6 ~ 10 times of raw materials quality at every turn, extracts 2 ~ 3 times, filter, filtrate is merged, the concentrated extractum that to get gets water extract after the drying and crushing;
The third: described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae are mixed, and the volumetric concentration that at every turn adds 6 ~ 10 times of raw materials quality is 30 ~ 80% ethanol water reflux 1.5 ~ 2 hours, extracts 2 ~ 3 times, filter, filtrate is merged, concentrate and to get extractum, get ethanol extract after the drying and crushing.
The pharmaceutical preparation that the acceptable adjuvant of aforementioned pharmaceutical compositions and pharmacy is made.
Described dosage form is preferably capsule, tablet, granule, pill or powder.
Advantage of the present invention is:
Drug regimen of the present invention shows to have the effect of good treatment rheumatoid arthritis by pharmacological evaluation.Preparation method of the present invention is simple.
The specific embodiment
Used Radix Aconiti Kusnezoffii Preparata among the present invention is the dried root of ranunculaceae plant Aconitum kusnezoffii Reichb Aconitum kusnezoffii Reichb..Preparation process product for Radix Aconiti Kusnezoffii.Hot, bitter, heat; Poisonous.GUIXIN, liver,kidney,spleen warp.Expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's pain, colic of cold type is had a pain and narcotic analgesic.
Rhizoma Dioscoreae Nipponicae described in the present invention is the dry rhizome of Dioscoreaceae plant Dioscorea nipponica Mak. Ningpo Yam Rhizome Dioscorea nipponica Makino.Sweet, bitter, warm.Wind-damp dispelling, pain relieving, relaxing muscles and tendons to promote blood circulation, relieving cough and asthma eliminates the phlegm.Be used for rheumatic arthritis, lumbago and skelalgia, numbness, urov disease, injury from falling down, lumbar sprain and QI divergeny, chronic bronchitis, cough and asthma.
Used Radix Glycyrrhizae among the present invention is the dry foundation rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Sweet, flat.GUIXIN, lung, spleen, stomach warp.But invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmaceutical composition of the present invention, utilize traditional Chinese medical science compatibility theory with 3 flavor medical material prescriptions after, can significantly treat rheumatoid arthritis, for clinical application provides a kind of safer reliably new selection.
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and the Radix Glycyrrhizae 80g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 2
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and the Radix Glycyrrhizae 60g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 3
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and the Radix Glycyrrhizae 20g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 4
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and the Radix Glycyrrhizae 40g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 5
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 60g, Rhizoma Dioscoreae Nipponicae 60g and the Radix Glycyrrhizae 60g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 6
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following raw material:
Take by weighing respectively and to pulverize, cross Radix Aconiti Kusnezoffii Preparata 80g, Rhizoma Dioscoreae Nipponicae 80g and the Radix Glycyrrhizae 20g of 160 mesh sieves, mix homogeneously and get final product.
Embodiment 7
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and Radix Glycyrrhizae 80g;
(2) raw material is mixed, added 720ml distilled water heating and refluxing extraction 1.5 hours at every turn, extract 2 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 8
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and Radix Glycyrrhizae 60g;
(2) raw material is mixed, added 980ml distilled water heating and refluxing extraction 1.5 hours at every turn, extract 3 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 9
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and Radix Glycyrrhizae 20g;
(2) raw material is mixed, added 600ml distilled water heating and refluxing extraction 2 hours at every turn, extract 2 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 10
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and Radix Glycyrrhizae 40g;
(2) raw material is mixed, added 1080ml distilled water heating and refluxing extraction 2 hours at every turn, extract 3 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 11
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 60g, Rhizoma Dioscoreae Nipponicae 60g and Radix Glycyrrhizae 60g;
(2) raw material is mixed, added 1440ml distilled water heating and refluxing extraction 1.5 hours at every turn, extract 2 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 12
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 80g, Rhizoma Dioscoreae Nipponicae 80g and Radix Glycyrrhizae 20g;
(2) raw material is mixed, added 1080ml distilled water heating and refluxing extraction 1.5 hours at every turn, extract 3 times, filter, filtrate is merged, concentrate and to get extractum, get water extract after the drying and crushing.
Embodiment 13
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and Radix Glycyrrhizae 80g;
(2) raw material is mixed, added the 720g volumetric concentration at every turn and be 30% ethanol water heating and refluxing extraction 1.5 hours, extracts 2 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.
Embodiment 14
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and Radix Glycyrrhizae 60g;
(2) raw material is mixed, added the 980g volumetric concentration at every turn and be 40% ethanol water heating and refluxing extraction 1.5 hours, extracts 3 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.
Embodiment 15
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20g, Rhizoma Dioscoreae Nipponicae 20g and Radix Glycyrrhizae 20g;
(2) raw material is mixed, added the 600g volumetric concentration at every turn and be 50% ethanol water heating and refluxing extraction 2 hours, extracts 2 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.
Embodiment 16
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 40g, Rhizoma Dioscoreae Nipponicae 40g and Radix Glycyrrhizae 40g;
(2) raw material is mixed, added the 1080g volumetric concentration at every turn and be 60% ethanol water heating and refluxing extraction 2 hours, extracts 3 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.
Embodiment 17
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 60g, Rhizoma Dioscoreae Nipponicae 60g and Radix Glycyrrhizae 60g;
(2) raw material is mixed, added the 1440g volumetric concentration at every turn and be 80% ethanol water heating and refluxing extraction 1.5 hours, extracts 2 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.
Embodiment 18
A kind of pharmaceutical composition for the treatment of rheumatoid arthritis, make with following method:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 80g, Rhizoma Dioscoreae Nipponicae 80g and Radix Glycyrrhizae 20g;
(2) raw material is mixed, added the 1080g volumetric concentration at every turn and be 70% ethanol water heating and refluxing extraction 1.5 hours, extracts 3 times, filter, filtrate is merged, the concentrated extractum that to get gets ethanol extract after the drying and crushing.(ethanol is not in scope)
Adopt the acceptable adjuvant of Pharmaceutical composition adding pharmacy of embodiment 1-18 can make respectively tablet, powder, granule, capsule according to a conventional method.
Embodiment 19
The antiinflammatory of the present composition is tested---and xylol causes the inhibitory action of mice ear
Experimental agents: pharmaceutical composition of the present invention; Prick punching ten triplex pills
Laboratory animal: kunming mice, 18～22g.
Experimental technique: get 64 of healthy kunming mices,
Weigh, divide at random 8 groups, 8 every group, that is: blank is organized (normal saline group), and positive controls (prick punching ten triplex pill groups, 3g/kg), compositions administration group of the present invention.Below respectively organize medication and be gavage, once a day, continuous 5d.Under etherization 100% dimethylbenzene 0.1ml is evenly coated in two sides, mouse right ear front and back behind the last administration 45min, left ear compares.1.5h after mice taken off neck put to death, cut two ears along the auricle baseline, lay round auricle at the same position of left and right sides ear respectively with 9mm diameter card punch, calculate inhibitory rate of intumesce, comparison between organizing.
Experimental result sees Table 1.
Table 1 compositions xylol of the present invention causes the inhibitory action of mice ear
Annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01
The experiment proved that the mice ear due to the compositions xylol of various embodiments of the present invention has obvious inhibitory action.
Embodiment 20
The antiinflammatory experiment of the present composition---ovalbumin is caused the inhibitory action of mice foot swelling
Experimental agents: pharmaceutical composition of the present invention; Prick punching ten triplex pills
Laboratory animal: kunming mice, 18～22g.
Experimental technique: get 64 of healthy mices,
Weigh, be divided at random 8 groups, blank group (normal saline group), positive controls (prick punching ten triplex pill groups, 3g/kg), compositions administration group of the present invention, continuously gastric infusion 5d.Behind last administration 1h, every left back toes subcutaneous injection 10% ovalbumin liquid 0.1ml of mice.30min, 1h, 3h, 5h measure respectively left back toes thickness once (toes central thickness under with vernier caliper measurement mice ankle joint) after the inflammation in causing subsequently, calculate swelling.
Experimental result sees Table 2.
Table 2 compositions of the present invention causes the inhibitory action of mice foot swelling to ovalbumin
Annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01
The experiment proved that the compositions of various embodiments of the present invention has obvious inhibitory action to the mice ear due to the ovalbumin.
Embodiment 21
The analgesic experiment of the present composition---Dichlorodiphenyl Acetate causes the inhibitory action of mouse writhing experiment
Experimental agents: pharmaceutical composition of the present invention; Prick punching ten triplex pills;
Laboratory animal: kunming mice, 18～22g.
Experimental technique: get 64 of white mice,
Weigh, be divided at random 8 groups, 8 every group, be divided into blank group (normal saline group), positive controls (is pricked punching 13 flavor groups, 3g/kg), compositions administration group of the present invention, gavage 5 days, behind the last administration 1h, the acetum 0.4mL of lumbar injection 0.6% records respectively the time (pain threshold) that the writhing number of times appears in mice, and observes the writhing response number of times of each Mus in 15min.Writhing response show as the abdominal part indent, body twist, hind leg stretches, hips up etc.
Experimental result sees Table 3.
Table 3 compositions Dichlorodiphenyl Acetate of the present invention causes the inhibitory action of mouse writhing experiment
Annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01
The experiment proved that the mouse writhing number of times due to the compositions Dichlorodiphenyl Acetate of various embodiments of the present invention has obvious inhibitory action.
Embodiment 22
The analgesic experiment of the present composition---on the impact of female mice hot plate induced pain
Experimental agents: pharmaceutical composition of the present invention; Prick punching ten triplex pills;
Laboratory animal: kunming mice, 18～22g.
Experimental technique: get the female property mice of body weight 18 ~ 22g, press hot plate method and before experiment, measure 64 of the mice of pain threshold in 5s ~ 30s at the hot plate dolorimeter, be divided into immediately 8 groups by body weight: model group, Zha Chong group, drug regimen high and low dose group of the present invention.The foot reaction to occur licking as observation index, in administration in the time of the 5th day, measure respectively the pain threshold behind administration 0.5h, 1h, 1.5h, the 2h.Compare the variation of the threshold of pain, administration front and back, and press (after the medication-the front average pain threshold of medication)/the front on average pain threshold of medication * 100% calculating threshold of pain raising percentage rate.Each is organized date processing and uses SPSS statistical software Treatment Analysis, and difference adopts one factor analysis of variance between its average.
Experimental result sees Table 4.
Table 4 compositions of the present invention is to the analgesic activity intensity (hot plate method) (x ± s, n=8) of mice
Annotate: compare with the normal saline group
*P＜0.05,
*P＜0.01
The experiment proved that the compositions of various embodiments of the present invention is to the mice threshold of pain effect of being significantly improved due to the hot plate.
Brief summary:
The antiinflammatory experimentation shows that pharmaceutical composition of the present invention can significantly alleviate the mice ear that dimethylbenzene causes, alleviates the mice toes swelling due to the random albumin, has preferably antiinflammatory action.
Analgesic experiment studies show that in the writhing experiment, the present composition can reduce the writhing number of times of the mice due to the acetic acid significantly, and in hot plate method, pharmaceutical composition of the present invention can obviously prolong the latency of pain response of mice, has preferably analgesic activity.
In sum, the present composition has stronger effect aspect anti-inflammatory and antalgic, utilize traditional Chinese medical science compatibility theory with 3 flavor prescriptions after, for the clinical application of resisting rheumatoid arthritis provides a kind of new selection.
Claims (6)
1. a pharmaceutical composition for the treatment of rheumatoid arthritis is characterized in that being made by following raw material by weight: Radix Aconiti Kusnezoffii Preparata 20-80 part, Rhizoma Dioscoreae Nipponicae 20-80 part, Radix Glycyrrhizae 20-80 part.
2. pharmaceutical composition according to claim 1, the described Radix Aconiti Kusnezoffii Preparata of its feature is 40 parts, and described Rhizoma Dioscoreae Nipponicae is 40 parts, and described Radix Glycyrrhizae is 40 parts.
3. a preparation method for the treatment of the pharmaceutical composition of rheumatoid arthritis is characterized in that comprising the steps:
(1) takes by weighing respectively pulverizing, cross the raw material of 160 mesh sieves: Radix Aconiti Kusnezoffii Preparata 20-80 part, Rhizoma Dioscoreae Nipponicae 20-80 part and Radix Glycyrrhizae 20-80 part;
(2) carry out with one of following several modes:
The first: with described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae mix homogeneously and get final product;
The second: described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae are mixed, add the water heating and refluxing extraction 1.5 ~ 2 hours of 6 ~ 10 times of raw materials quality at every turn, extracts 2 ~ 3 times, filter, filtrate is merged, the concentrated extractum that to get gets water extract after the drying and crushing;
The third: described raw material Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Nipponicae and Radix Glycyrrhizae are mixed, and the volumetric concentration that at every turn adds 6 ~ 10 times of raw materials quality is 30 ~ 80% ethanol water reflux 1.5 ~ 2 hours, extracts 2 ~ 3 times, filter, filtrate is merged, concentrate and to get extractum, get ethanol extract after the drying and crushing.
4. method according to claim 3 is characterized in that described Radix Aconiti Kusnezoffii Preparata is 40 parts, and described Rhizoma Dioscoreae Nipponicae is 40 parts, and described Radix Glycyrrhizae is 40 parts.
5. claim 1 or 2 described pharmaceutical compositions and the acceptable adjuvant of the pharmacy pharmaceutical preparation of making.
6. pharmaceutical preparation according to claim 5 is characterized in that dosage form is capsule, tablet, granule, pill or powder.
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| CN2012104731613A CN102920886A (en) | 2012-11-20 | 2012-11-20 | Medical composition for treating rheumatoid arthritis and preparation method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
| CN102579899A (en) * | 2012-03-05 | 2012-07-18 | 宁夏紫荆花制药有限公司 | Traditional Chinese medical composition for spur pain elimination and preparation method thereof |
| CN102631429A (en) * | 2012-04-26 | 2012-08-15 | 天津大学 | Medicinal composition for treating rheumatoid arthritis and preparation method thereof |
-
2012
- 2012-11-20 CN CN2012104731613A patent/CN102920886A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101254284A (en) * | 2007-02-26 | 2008-09-03 | 北京亚东生物制药有限公司 | Rheumatism treating medicine combination, preparation and quality control method |
| CN102579899A (en) * | 2012-03-05 | 2012-07-18 | 宁夏紫荆花制药有限公司 | Traditional Chinese medical composition for spur pain elimination and preparation method thereof |
| CN102631429A (en) * | 2012-04-26 | 2012-08-15 | 天津大学 | Medicinal composition for treating rheumatoid arthritis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 《山东中医杂志》 19980131 柳全文等 "穿山龙的成分、药理及临床应用研究概况" 第29-31页 1-6 第17卷, 第1期 * |
| 柳全文等: ""穿山龙的成分、药理及临床应用研究概况"", 《山东中医杂志》 * |
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Application publication date: 20130213 |