CN102905755B - 可耐受的微创性皮肤电穿孔装置 - Google Patents

可耐受的微创性皮肤电穿孔装置 Download PDF

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Publication number
CN102905755B
CN102905755B CN201180011473.6A CN201180011473A CN102905755B CN 102905755 B CN102905755 B CN 102905755B CN 201180011473 A CN201180011473 A CN 201180011473A CN 102905755 B CN102905755 B CN 102905755B
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CN
China
Prior art keywords
electromotive force
tissue
delivered
voltage generator
electrode
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CN201180011473.6A
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English (en)
Chinese (zh)
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CN102905755A (zh
Inventor
K.布罗德里克
J.麦科伊
S.V.坎梅雷
林峰
R.克杰肯
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Inovio Pharmaceuticals Inc
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Inovio Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201180011473.6A 2010-03-01 2011-03-01 可耐受的微创性皮肤电穿孔装置 Active CN102905755B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30942210P 2010-03-01 2010-03-01
US61/309422 2010-03-01
US61/309,422 2010-03-01
PCT/US2011/026701 WO2011109406A1 (en) 2010-03-01 2011-03-01 A tolerable and minimally invasive skin electroporation device

Publications (2)

Publication Number Publication Date
CN102905755A CN102905755A (zh) 2013-01-30
CN102905755B true CN102905755B (zh) 2016-03-09

Family

ID=44542539

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180011473.6A Active CN102905755B (zh) 2010-03-01 2011-03-01 可耐受的微创性皮肤电穿孔装置

Country Status (14)

Country Link
US (2) US11565107B2 (cg-RX-API-DMAC10.html)
EP (1) EP2542300B1 (cg-RX-API-DMAC10.html)
JP (1) JP5706451B2 (cg-RX-API-DMAC10.html)
KR (1) KR101872408B1 (cg-RX-API-DMAC10.html)
CN (1) CN102905755B (cg-RX-API-DMAC10.html)
AU (1) AU2011223753B2 (cg-RX-API-DMAC10.html)
CA (1) CA2789736A1 (cg-RX-API-DMAC10.html)
DK (1) DK2542300T3 (cg-RX-API-DMAC10.html)
EA (1) EA025705B1 (cg-RX-API-DMAC10.html)
ES (1) ES2594498T3 (cg-RX-API-DMAC10.html)
MX (1) MX2012009986A (cg-RX-API-DMAC10.html)
PL (1) PL2542300T3 (cg-RX-API-DMAC10.html)
PT (1) PT2542300T (cg-RX-API-DMAC10.html)
WO (1) WO2011109406A1 (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3473296T3 (da) 2011-06-28 2020-11-09 Inovio Pharmaceuticals Inc Minimalt invasiv dermal elektroporeringsenhed
AU2015203882C1 (en) * 2011-06-28 2017-09-21 Inovio Pharmaceuticals, Inc. A minimally invasive dermal electroporation device
EP3010582B1 (en) 2013-06-21 2021-04-28 Newsouth Innovations Pty Limited Method and apparatus for close-field electroporation
CN104689478A (zh) * 2013-12-09 2015-06-10 深圳市瑞吉思科技有限公司 细胞再生仪
CN103861202B (zh) 2014-03-18 2016-06-01 苏州壹达生物科技有限公司 一种利用空心电极针电穿孔给药的装置
DK3277368T3 (da) * 2015-03-31 2020-07-27 Oncosec Medical Inc Systemer til forbedret vævsregistreringsbaseret elektroporering
PT3397337T (pt) 2015-12-30 2020-11-24 Inovio Pharmaceuticals Inc Dispositivo de eletroporação com conjunto de agulhas destacável com sistema de bloqueio
US11390840B2 (en) * 2016-09-30 2022-07-19 University Of Florida Research Foundation, Inc. Systems and methods including porous membrane for low-voltage continuous cell electroporation
CN107890608A (zh) * 2017-12-01 2018-04-10 王嘉浩 淋巴细胞增升仪
CN113613711B (zh) * 2019-02-04 2024-09-17 新泽西州立罗格斯大学 使用微电极进行组织电转移的装置
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
BR102019013578A2 (pt) * 2019-06-28 2021-01-05 Eqt Equipamentos E Tecnologia Ltda. Ponta aplicadora de eletroporação para procedimento de eletroquimioterapia
EP4121161A4 (en) 2020-03-20 2024-10-16 Inovio Pharmaceuticals, Inc. VACUUM-ASSISTED ELECTROPORATION DEVICES AND CORRESPONDING SYSTEMS AND METHODS
KR102576604B1 (ko) 2021-02-16 2023-09-08 주식회사 밀알 의료용 정밀 약물주입 및 전기천공 융합 전극
KR20220159203A (ko) 2021-05-25 2022-12-02 주식회사 밀알 의료용 정밀 약물주입 및 전기천공 융합 전극

Citations (6)

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US5968006A (en) * 1997-11-04 1999-10-19 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US20020010412A1 (en) * 1996-07-03 2002-01-24 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US20020193833A1 (en) * 1999-03-25 2002-12-19 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US20060084938A1 (en) * 1998-07-13 2006-04-20 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
CN101370553A (zh) * 2006-02-11 2009-02-18 基因特伦尼克斯公司 用于单针体内电穿孔的装置和方法
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法

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US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US6277116B1 (en) * 1994-05-06 2001-08-21 Vidaderm Systems and methods for shrinking collagen in the dermis
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
WO1998043702A2 (en) 1997-04-03 1998-10-08 Iacob Mathiesen Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
CA2294793A1 (fr) 1997-06-30 1999-01-14 Rhone-Poulenc Rorer S.A. Amelioration du transfert d'acide nucleique dans le muscle strie et combinaison permettant la mise en oeuvre du procede
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
WO2000044438A1 (en) 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US20070016268A1 (en) 2000-01-07 2007-01-18 John Carter Percutaneous electrode array
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
AU2003226605A1 (en) * 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US20060036210A1 (en) 2004-06-30 2006-02-16 Lei Zhang Modular electroporation device with disposable electrode and drug delivery components
US20100168501A1 (en) * 2006-10-02 2010-07-01 Daniel Rogers Burnett Method and apparatus for magnetic induction therapy
EP2111252A4 (en) 2007-01-31 2010-12-01 Adam Heller MANAGEMENT OF PAIN BY ELECTROCHEMICAL PATHWAY

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Publication number Priority date Publication date Assignee Title
US20020010412A1 (en) * 1996-07-03 2002-01-24 Spectrx, Inc. Multiple mechanical microporation of skin or mucosa
US5968006A (en) * 1997-11-04 1999-10-19 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US20060084938A1 (en) * 1998-07-13 2006-04-20 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US20020193833A1 (en) * 1999-03-25 2002-12-19 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
CN101370553A (zh) * 2006-02-11 2009-02-18 基因特伦尼克斯公司 用于单针体内电穿孔的装置和方法
CN101563132A (zh) * 2006-10-17 2009-10-21 Vgx药品公司 电穿孔装置及用其进行哺乳动物细胞电穿孔的方法

Also Published As

Publication number Publication date
ES2594498T3 (es) 2016-12-20
JP2013521058A (ja) 2013-06-10
EP2542300A4 (en) 2013-11-13
KR101872408B1 (ko) 2018-06-28
EA201201203A1 (ru) 2013-04-30
EP2542300B1 (en) 2016-08-10
CA2789736A1 (en) 2011-09-09
US12491361B2 (en) 2025-12-09
US11565107B2 (en) 2023-01-31
JP5706451B2 (ja) 2015-04-22
AU2011223753A1 (en) 2012-09-13
DK2542300T3 (en) 2016-11-28
US20130066296A1 (en) 2013-03-14
KR20130020662A (ko) 2013-02-27
US20230145532A1 (en) 2023-05-11
PL2542300T3 (pl) 2017-06-30
WO2011109406A1 (en) 2011-09-09
PT2542300T (pt) 2016-11-14
MX2012009986A (es) 2012-11-21
BR112012021805A2 (pt) 2016-05-17
EA025705B1 (ru) 2017-01-30
AU2011223753B2 (en) 2014-06-26
EP2542300A1 (en) 2013-01-09
CN102905755A (zh) 2013-01-30
HK1181339A1 (zh) 2013-11-08

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Application publication date: 20130130

Assignee: Beijing Apollo Saturn Biomedical Technology Co.,Ltd.

Assignor: INOVIO PHARMACEUTICALS, Inc.

Contract record no.: X2022990000903

Denomination of invention: Tolerable minimally invasive skin electroporation device

Granted publication date: 20160309

License type: Exclusive License

Record date: 20221108