CN102898317B - Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof - Google Patents
Organic amino compounds serving as immunopotentiators, metabolic enhancers or roborants and preparation method and use thereof Download PDFInfo
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- CN102898317B CN102898317B CN201210388154.3A CN201210388154A CN102898317B CN 102898317 B CN102898317 B CN 102898317B CN 201210388154 A CN201210388154 A CN 201210388154A CN 102898317 B CN102898317 B CN 102898317B
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Abstract
The invention discloses it is a kind of as immunopotentiator, metabolic improver, tonic organic amine compound, structural formula is as follows:
(1) R1 is 2- hydroxypropyl; R2 is ethyl; R3 is ethyl; (2) R1 is 2- hydroxypropyl; R2 is hydrogen; R3 is isopropyl; (3) R1 is normal-butyl; R2 is methyl or ethyl; R3 is methyl or ethyl; (4) R1 is normal-butyl; R2 is hydrogen; R3 is isopropyl; (5) R1 is para hydroxybenzene ethyl; R2 is methyl or ethyl; R3 is methyl or ethyl; (6) R1 is para hydroxybenzene ethyl; R2 is hydrogen; R3 is isopropyl. With immunity of organism humidification; Body disease-resistant poison, helminth, bacterium infection, chronic wasting disease adjuvant treatment are helped after immunity of organism enhancing; Body physical efficiency supplement and endurance humidification; Resist various stress reactions; Organism metabolism promotor, tonic; Fat metabolism promotor can be used for reducing blood lipid, weight-reducing.
Description
Technical field
The present invention relates to compound applied technical field, in particular a kind of organic amine compound as immunostimulant, metabolic improver, tonic and its preparation method and application.
Background technology
Virus, as a kind of pathogenic microorganism, can cause the multiple infectious disease of people and various domestic animals and fowls, epiphytotics generation, and its disease caused is many far beyond other microorganism.For the mankind, common acute respiratory infection 90%-95% is caused by virus.According to pertinent data display, viral pathogenesis accounts for the 70%-80% of human infectious disease.As common influenza, mumps, infectious hepatitis, viral enteritis, viral myocarditis, epidemic encephalitis type B, epidemic hemorrhagic fever, zoster, measles and AIDS etc., be all caused by virus.Autogene group can also be integrated into host cell by virus, is the cause of disease of some tumour.New virus also constantly to produce and is occurring, virus is originally easy to again morph, and along with the variation of self, can cause new various disease again.The disease that present virus causes, has strong, the popular wide model of infectivity, case fatality rate high mostly.As broke out in recent years " coronavirus atypical pneumonia ", highly pathogenic H5N1 bird flu, variation swine influenza virus, hand foot mouth disease, " tick stings disease " etc., cause the fear of the mankind.
Virus is very harmful to body, and the disease that virus causes is usually heavy in hand, or even fatal.After Virus entry body, first breed rapidly in the permissive cell at invasion position, and spread to closing in biological cells and tissues, cause local infection focus.Once virus is not suppressed, namely virus entered in lymphocyte and mononuclear phagocyte system by blood breeds, and destroys immunity system and reduces immunizing power, and again invade each organ-tissue of whole body by blood, cause various pathology, thus occur various clinical symptom.Virus, to immune interference and destruction, easily causes various types of many cause of diseases polyinfection, relatively typical in mankind's AIDS; The breeding of pig and respiratory syndrome (blue otopathy), II type PCV-II, Mild type HC, they grow in lymphsystem, badly damaged immunity of organisms; The infectious bursal disease, Marek, avian leukosis, fowl RE hyperplasia disease, chicken infectious anemia etc. of poultry, be damage immunity of organisms equally, cause serious production loss.
The development of antibiotic research makes a lot of bacteriosis be easy to control, and virus just becomes unprecedented outstanding cause of disease.In a century in the past, struggle from two approach with virus infection.One be development vaccine, comprise deactivation vaccine, Attenuate vaccine, subunit seedling etc., make body produce antibody in advance, prevention poisoning intrusion, but some viruses when having made vaccine appoint so can invade body; Two is development specificity antivirus medicines, and progress is always very slow on the one hand for this.Past 30 Years is to the research explanation of mammalian virus, virus strictly parasitizes in cell, host cell enzyme system is relied on to breed, medicine is difficult to enter cell on the one hand, affecting viral metabolism process simultaneously on the other hand, may also disturb normal cell metabolism process, medicine is difficult to reach efficient specificity, and side effect is little again.Gene integration also may be entered host cell by virus, hides for a long time, reactivates under certain conditions, and the variability of virus is also higher than bacterium in addition, and these all increase the difficulty of antiviral research.
In any case, the alternative antiviral drug of present clinical medicine is considerably less, drug effect neither be determined very much, existing antiviral, as Aminodiamantane, iodoxuridine, virazole, acyclovir, sulfated polysaccharides etc., can not solve the infection of the ubiquitous reproductive and respiratory syndrome virus of current swinery, PCV-II and Pestivirus suis substantially.Above-mentioned virus causes the sub-health status of swinery, causes polytype bacillary secondary infection, causes a large amount of direct economic loss, and as Sow abortion, piggy mortality ratio is high, swine growth degradation, swinery stress reaction are high.
Before high-efficiency broad spectrum antiviral drug is not invented, we improve body physical efficiency and immunizing power by enhancing body resistance against diseases, are that another better solves the strategy of virus infection problem.But for now, the medicine that effectively can promote immunity of organisms is little, and Western medicine only has several, and great majority are Chinese medicine, but Chinese medicine generally needs long-term prescription just effective, so it is extremely urgent to study broad-spectrum high-efficiency and low-toxicity medicament for immunity enhancement of new generation.
Summary of the invention
The method of the present invention's chemosynthesis obtains the new organic amine compound of a class, and experiment proves that this compounds has following pharmacological action and application: (1) immunity of organism enhancement; (2) immunity of organism helps body disease-resistant poison, parasite, bacteriological infection, chronic wasting disease assisting therapy after strengthening; (3) body physical efficiency is supplemented and endurance enhancement; (4) anti-various stress reaction; (5) organism metabolism promotor, tonic; (6) metabolism of fat promotor, can be used for reducing blood-fat, fat-reducing.
Be used as an organic amine compound for immunostimulant, metabolic improver, tonic, its structural formula is as follows:
be liquid under normal temperature, can with sour salify, be solid crystals after salify;
(1) R
1for 2-hydroxypropyl; R
2for ethyl; R
3for ethyl;
(2) R
1for 2-hydroxypropyl; R
2for hydrogen; R
3for sec.-propyl;
(3) R
1for normal-butyl; R
2for methyl or ethyl; R
3for methyl or ethyl;
(4) R
1for normal-butyl; R
2for hydrogen; R
3for sec.-propyl;
(5) R
1for para hydroxybenzene ethyl; R
2for methyl or ethyl; R
3for methyl or ethyl;
(6) R
1for para hydroxybenzene ethyl; R
2for hydrogen; R
3for sec.-propyl.
Described organic amine compound, the described acid used for salify comprises hydrochloric acid, sulfuric acid, acetic acid, citric acid, succsinic acid, succinic acid, Whitfield's ointment, paraacetaminobenzoic acid.
The application of described organic amine compound, prepares the application in immunostimulant, antiviral, metabolic improver, tonic, reducing blood-fat, the human drugs of weight losing function and healthcare products.
The application of described organic amine compound, prepares the application in immunostimulant, the veterinary medicine of antiviral, metabolic improver, tonic function and healthcare products.
The application of described organic amine compound, prepares the application in immunostimulant, the fishing medicine of antiviral, metabolic improver, tonic function and healthcare products.
This compounds can be developed into the medicine of the relevant pharmacological action being applied to the mankind, Mammals, hydrocoles etc., healthcare products.
Pharmacological experiment proves: this product can improve body specificity and non-specific immunity simultaneously; Promote human body energy metabolism and flowing, promote that Body development decomposes and utilize, be conducive to synthesis and the storage of ATP; The physical efficiency load of body can be increased, the stress reaction under anti-various environment unfavourable condition; The antivirus action of this product is not direct virus replication, but is realized opposing poisoning intrusion and and breeding by enhancing body specificity and non-specific immunity.
A further object of the invention, is to provide the application of this organic amine compound in people's medicine and people's healthcare products.
A further object of the invention, is to provide the application of this organic amine compound in veterinary drug and animal health product.
A further object of the invention, is to provide the application of this organic amine compound in fishing medicine.
Compared with prior art, the present invention has following advantage:
(1) carboxylate salt of this organic amine compound, can be added in cultivated animals (pig, rabbit, cattle and sheep, poultry, fishes and shrimps etc.) feed, the immunological competence of cultivated animals can be strengthened, improve resistance against diseases, make the few sick few medication of cultivated animals, replace the antibiotic interpolation of part to use, improve animal product quality, reduce antibiotic remains in product.
(2) carboxylate salt of this organic amine compound, can be added in cultivated animals (pig, rabbit, cattle and sheep, poultry, fishes and shrimps etc.) feed, promotes cultivated animals growth, improve food conversion ratio, improve breeding performonce fo animals, reduce production cost, improve fanning economics.
(3) this organic amine compound has certain antiobesity action, reduces blood cholesterol and blood fat, promotes that body fat decomposes, exploit person reducing blood-fat, the relevant medicine of fat-reducing and healthcare products great potential.
Accompanying drawing explanation
Fig. 1 is 1-diethylin-2-propyl alcohol
1h-NMR composes;
Fig. 2 is 1-diethylin-2-propyl alcohol
13c-NMR composes;
Fig. 3 is sec.-propyl n-butylamine
1h-NMR composes;
Fig. 4 is sec.-propyl n-butylamine
13c-NMR composes;
Fig. 5 is 4-(2-isopropylamino) ethylphenol
1h-NMR composes;
Fig. 6 is 4-(2-isopropylamino) ethylphenol
13c-NMR composes;
Embodiment
The specific embodiment provided below in conjunction with contriver is to further illustrate beneficial effect and the application of organic amine compound of the present invention.
Embodiment 1
Structure for reagent product sec.-propyl n-butylamine is as follows:
The isolated perfusion experiment of the frog heart and the mouse heart
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 (mol ratio, lower same) salify.
The frog heart and mouse core make isolated ventricular perfusion, by the pollex of polygraph record ventricular muscles, 0.05% organic slat solution has cardiotonic, cardiotonic is increased more obvious with test solution concentration, and under high density, (5%) is also safe to heart, does not suppress the pollex of heart.
The experiment of rabbits infestines motion
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
Prepared by rabbits infestines, be placed in maxwell bath cup, with the wriggling of polygraph record myenteron, containing the Tai Shi solution of 0.05% organic amine salt, have the effect strengthening unstriated muscle and wriggle, myenteron wriggling strength and amplitude increase, the wriggling time obviously extends, but peristalsis frequency does not significantly increase.
The hungry endurance experiment of small white mouse
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
Small white mouse stops throwing in food, freely drinks the 0.1% organic amine salt aqueous solution, can strengthen the ability of the resistance to hunger of small white mouse, increases the survival time, and this effect realizes by accelerating body fat decomposition energy supply.
Obese rat model is set up and weight-reducing experiment
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
By giving the nutritional imbalance diet of rat height fat high calorie, set up obese model, obese rat freely drinks the 0.1% organic amine salt aqueous solution, proves to have obvious antiobesity action.
Small white mouse physical efficiency Enhancement test
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
Small white mouse freely drinks the 0.1% organic amine salt aqueous solution, and Ganderwa is one week, can extend small white mouse frozen water swimming time.
Small white mouse cold-hot stress tests
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
Small white mouse freely drinks the 0.1% organic amine salt aqueous solution, and Ganderwa is one week.Small white mouse is placed in 42 DEG C respectively, 5 DEG C of environment, have and improve mouse opposing cold stress, heat stress effect, extends mouse survival time in extreme circumstances.
Breeding of Broiler Chicks is tested
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
One monthly age broiler chicken, is divided into blank group and experimental group.Experimental group is with supplying reagent product spice, and containing supplying reagent product 0.1% in experimental group feed, other system component of feed is consistent.Feeding time is one month, and two monthly age broiler chicken are weighed, broiler growth and efficiency of feed utilization during experiment with computing.Experiment proves can improve broiler growth rate 11.3% for reagent product, improves efficiency of feed utilization 9.4%.
Pigling immunity determination experiment
For reagent product: the organic amine salt of sec.-propyl n-butylamine and paraacetaminobenzoic acid 1:1 salify.
60 age in days piglets, with supplying reagent product spice, containing supplying reagent product 0.1% in feed, feeding time is one month, measures body fluid and the cellular immunity of pig during 90 age in days.Experiment proves can improve body antibody-producing ability (improve associated antibodies molecular amounts in blood, antibody response level improves) for reagent product, can improve macrophage in body phagocytic activity (carbon particle clearance test) simultaneously.
Embodiment 2
The synthesis of 1-diethylin-2-propyl alcohol:
Synthetic method: the diethylamine adding 0.2mol in the 250mL four-hole boiling flask that agitator, reflux condensing tube and two dropping funnels are housed, the 1-chloro-2-propanol of 0.1mol is slowly dripped under heating in water bath, drip the aqueous sodium hydroxide solution 20ml of 40% again, control total time for adding 2h, then boiling reflux 1h, cools to obtain thick product.Filtering sodium-chlor, filtrate stratification, water phase separated and organic phase, aqueous phase extracted with diethyl ether 3 times, extraction liquid and organic phase merge, dried overnight.The distillation of filtering siccative obtains product.
With reference to figure 1 and Fig. 2, structured data:
1h-NMR (400MHz, CDCl
3) δ 1.0 (m, 9H) 2.4 (t, 4H) 2.6 (d, 1H) 3.4 (m, 1H) 4.8 (s, 1H);
13c-NMR (400MHz, CDCl
3) δ 13.3 (2C) 21.7 (1C) 47.7 (2C) 61.5 (1C) 66.5 (1C).
Embodiment 3
The synthesis of sec.-propyl n-butylamine:
Synthetic method: the isopropylamine adding 0.2mol in the 250mL four-hole boiling flask that agitator, reflux condensing tube and dropping funnel are housed, the 1-n-butyl bromide of 0.1mol is slowly dripped under heating in water bath, drip the aqueous sodium hydroxide solution 20ml of 40% again, control total time for adding 2h, then boiling reflux 1h, cools to obtain thick product.Filtering sodium-chlor, filtrate stratification, water phase separated and organic phase, aqueous phase extracted with diethyl ether 3 times, extraction liquid and organic phase merge, dried overnight.The distillation of filtering siccative obtains product.
With reference to figure 3 and Fig. 4, structured data:
1h-NMR (400MHz, CDCl
3) δ 0.9 (t, 3H) 1.1 (d, 6H) 1.3 (m, 4H) 2.0 (s, 1H) 2.5 (t, 2H) 3.0 (m, 1H);
13c-NMR (400MHz, CDCl
3) δ 13.8 (1C) 20.1 (1C) 23.7 (2C) 61.5 (1C) 33.0 (1C) 46.8 (1C) 48.7 (1C).
Embodiment 4
The synthesis of 4-(2-isopropylamino) ethylphenol
Synthetic method: the isopropylamine adding 0.2mol in the 250mL four-hole boiling flask that agitator, reflux condensing tube and dropping funnel are housed, 4-(2 '-chlorine) ethylphenol of 0.1mol is slowly added under heating in water bath, drip the aqueous sodium hydroxide solution 20ml of 40% again, control total time for adding 2h, then boiling reflux 1h, separate out solid after cooling, suction filtration obtains thick product.Product is obtained with appropriate solvent recrystallization.
With reference to figure 5 and Fig. 6, structured data:
1h-NMR:(400MHz, CDCl
3), δ 1.1 (d, 6H) 2.0 (s, 1H) 2.7 (t, 2H) 2.8 (t, 2H) 3.0 (m, 1H) 6.9 (q, 4H) 9.4 (s, 1H)
13C-NMR：(400MHz，CDCl
3)，δ23.7(2C)35.9(1C)48.7(2C)115.8(2C)128.1(1C)130.2(2C)155.7(1C)
Should be understood that, for those of ordinary skills, can be improved according to the above description or convert, and all these improve and convert the protection domain that all should belong to claims of the present invention.
Claims (1)
1. a purposes for sec.-propyl n-butylamine, is characterized in that, this compound is for the preparation of the human drugs or the healthcare products that are used as immunostimulant.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293192A1 (en) * | 1987-05-27 | 1988-11-30 | Exxon Chemical Patents Inc. | Diesel fuel composition |
| US5705681A (en) * | 1994-02-07 | 1998-01-06 | Witco Corporation | Diquaternary compounds useful as bleach activators |
| CN1962032A (en) * | 2005-11-09 | 2007-05-16 | 南化集团研究院 | Solvent and method for simultaneous removal of hydrogen sulphide and carbon dioxide |
| CN101050205A (en) * | 2007-05-15 | 2007-10-10 | 武汉大学 | Compound containing cation radical of piperazidine, synthetic method, and application |
| CN101121702A (en) * | 2007-07-30 | 2008-02-13 | 浙江大学 | Phenoxy indanone derivatives containing alkylamino side-chain, preparation method and use thereof |
| CN101209973A (en) * | 2006-12-26 | 2008-07-02 | 中国科学院兰州化学物理研究所 | Bronsted acidic ion liquid using polyamine as cation and preparation method thereof |
| CN101948392A (en) * | 2010-08-25 | 2011-01-19 | 南京泽朗医药科技有限公司 | Preparation method of hordenine |
| CN102424645A (en) * | 2011-07-29 | 2012-04-25 | 湖南大学 | Method for synthesizing aromatic amide and aromatic methanol |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE044427T2 (en) * | 2007-01-22 | 2019-10-28 | Arkema France | Process for making foundry shaped cores and for casting metals |
-
2012
- 2012-10-12 CN CN201210388154.3A patent/CN102898317B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0293192A1 (en) * | 1987-05-27 | 1988-11-30 | Exxon Chemical Patents Inc. | Diesel fuel composition |
| US5705681A (en) * | 1994-02-07 | 1998-01-06 | Witco Corporation | Diquaternary compounds useful as bleach activators |
| CN1962032A (en) * | 2005-11-09 | 2007-05-16 | 南化集团研究院 | Solvent and method for simultaneous removal of hydrogen sulphide and carbon dioxide |
| CN101209973A (en) * | 2006-12-26 | 2008-07-02 | 中国科学院兰州化学物理研究所 | Bronsted acidic ion liquid using polyamine as cation and preparation method thereof |
| CN101050205A (en) * | 2007-05-15 | 2007-10-10 | 武汉大学 | Compound containing cation radical of piperazidine, synthetic method, and application |
| CN101121702A (en) * | 2007-07-30 | 2008-02-13 | 浙江大学 | Phenoxy indanone derivatives containing alkylamino side-chain, preparation method and use thereof |
| CN101948392A (en) * | 2010-08-25 | 2011-01-19 | 南京泽朗医药科技有限公司 | Preparation method of hordenine |
| CN102424645A (en) * | 2011-07-29 | 2012-04-25 | 湖南大学 | Method for synthesizing aromatic amide and aromatic methanol |
Non-Patent Citations (1)
| Title |
|---|
| A structure-activity study of sympathomimetic amines onthe beta-adrenoceptors of guinea-pig trachea;LORIS A. CHAHL;《British Journal of Pharmacology》;19721231;第53卷(第3期);第513页表2第17条记录 * |
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