CN102895926B - Moistureproof treatment method for soft capsules - Google Patents
Moistureproof treatment method for soft capsules Download PDFInfo
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- CN102895926B CN102895926B CN201210442324.1A CN201210442324A CN102895926B CN 102895926 B CN102895926 B CN 102895926B CN 201210442324 A CN201210442324 A CN 201210442324A CN 102895926 B CN102895926 B CN 102895926B
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Abstract
The invention provides a moistureproof treatment method for soft capsules. By the method, the problems that soft capsules for filter sticks are in contact with air, continuously absorb moisture from the air and are softened, adhered and the like because of being affected with damp, so that the quality, appearance and application of the soft capsules are influenced are solved, and the requirements that the soft capsules which are embedded in the filter sticks and are used for enhancing aroma and humidifying can be moistureproof and are easy to break are met. According to the method, polyvalent metal salts are added into soft capsule wall materials and are reacted with chitosan, so that water-insoluble chitosan metal salt chelates can be formed through the reaction between the metal salts and the chitosan and are coated on the outer surfaces of the soft capsules, the waterproof performance of the soft capsules is greatly improved, the water resistance and moisture resistance of the soft capsule wall materials are improved, the brittle characteristics of the soft capsules are kept, the retention time of the filter sticks is prolonged, and the influence of an external environment on the quality, appearance and application of the soft capsules is reduced.
Description
Technical field
The present invention relates to the flavouring of cigarette, be specifically related to the post processing field of cigarette filter rod soft capsule wall.
Background technology
Capsule is according to the difference of its shell, conventionally be divided into hard shell capsules and the large class of soft capsule two: hard capsule is that a certain amount of medicine (or medicinal substances extract) and suitable auxiliary material (also can not add auxiliary material) are made to uniform powder or particle, load in empty hard capsule and make; Soft capsule is that a certain amount of medicine (or medicinal substances extract) is dissolved in suitable auxiliary material, use again pressing (or dropping preparation method) to make it to be sealed in spherical or olivary soft capsule, general soft capsule all requires to possess certain suppleness and anti-mechanical pressure ability, and the intensity of wall material is all larger.Soft capsule is the primary raw material taking gelatin, alginate, dextrin etc. as wall material conventionally, these materials have certain hygroscopicity, after contacting with air, the soft capsule shell of preparing with it can constantly from air, absorb moisture, make moist and the phenomenon such as occur softening, bonding, having affected quality, outward appearance and the utilization of soft capsule.
Hard shell capsules is moistureproof main simultaneously at wrappage appearance parcel thin film, and its method is by add polyvinyl alcohol, Arabic gum and polyethylene glycol in retort high-speed shearing machine, after high-speed stirred shearing, makes pre-mixing agent; Take in proportion pre-mixing agent, adding water to stir is made into the aqueous solution, then adopts seed-coating machine to carry out dressing, and capsule after dressing surface is fine and smooth, adhesion is good, moisture effect is obvious.
The moistureproof means of existing soft capsule are mainly to rely on to select the good packaging material of moisture resistance, for example plastics, aluminium foil etc., also have and film-coated method is applied to soft capsule realizes moistureproof report, for example, in the paper " the moistureproof application study of film coating in Chinese medicine capsules " that Chengdu University of Traditional Chinese Medicine dragon Zhang Yu delivers, describe the application of film coating aspect capsule protection against the tide in detail, from the selection of coating material, definite grade of parameter is studied, filter out and be applicable to moistureproof coating material and the technique requiring of capsule, its coating material of selecting mainly comprises following several: hydroxypropyl methylcellulose, PVA filmogen, polyethylene glycol, CAP, ethyl cellulose, acrylic resin etc., by spraying, dry process forms the continuous film of one deck even compact, reach moistureproof effect, but technique relative complex, equipment uses many, and because soft capsule under it is endo-medicine, must consider the disintegrating property of soft capsule, so it is frangible that this soft capsule must be avoided.
At some special dimensions, for example pre-buried for flavouring in filter stick, the soft capsule of humidification, belong to frangible soft capsule, there is certain intensity and fragility, the capsule material fragmentation of capsule under finger extruding, core liquid discharges, change mouthfeel and experience, there is humectation, flavouring, reducing tar and reducing harm function, it requires capsule wall material not only to possess good humidity resistance, also should possess breakable feature, so above-mentioned dampproof method is not also suitable for filter stick soft capsule, need to find one can make cigarette filter rod soft capsule both moistureproof, do not affect the processing method of its serviceability simultaneously.
Summary of the invention
Can constantly from air, absorb moisture for solving after filter stick contacts with air with soft capsule, make moist and occur softening, the phenomenon such as bonding, affect the quality of soft capsule, the problem of outward appearance and utilization, meet in filter stick pre-buried for flavouring simultaneously, the soft capsule of humidification can either be moistureproof, and breakable requirement, the object of the present invention is to provide a kind of moistureproof processing method of soft capsule, by add auxiliary material in soft capsule wall material, and coordinate corresponding processing means, improve the water-fast and humidity resistance of soft capsule wall material, keep the frangible characteristic of soft capsule, extend the holding time of the type filter stick, reduce the quality of external environment to soft capsule, the impact of outward appearance and utilization.
For achieving the above object, the present invention adopts following technological means, and a kind of moistureproof processing method of soft capsule, is characterized in that, comprises the following steps:
1. the preparation of soft capsule, prepares wall material raw material according to a conventional method, comprises sizing material excipient, plasticizer, additives and water, adds the calcium chloride that accounts for glue weight 0.1%-10% after making glue, then adopts conventional steps to make soft capsule;
2. the soft capsule preparing is put into and configured the chitosan solution that concentration is 0.1%-2%, at room temperature stir 1-30min, make shitosan react film forming with calcium chloride;
3. by step 2. soft capsule after treatment put into the dehydrating agent 1-30min that dewaters;
4. by step 3. soft capsule after treatment put into stir with the drying equipment of air-blast device be dried process 1-24 hour, be 30%-45%RH by space humidity control;
5. by step 4. in soft capsule standing and drying 24-48 hour after treatment, be 30%-45%RH by space humidity control, obtain having the soft capsule of good humidity resistance.
Described sizing material excipient is as any one or more combinations in gelatin, alginate, dextrin.
Described plasticizer is any in glycerine, sorbierite.
Described additives are spices, opacifier etc.
Described dehydrating agent is ethanol.
Described chitosan solution can be water soluble chitosan solution or the chitosan solution that uses organic acid configuration.
The preparation method of described soft capsule is that emulsion becomes any of embrane method, pressing, coetrusion.
Beneficial effect of the present invention is, by add calcium chloride in soft capsule wall material, and by itself and chitosan reaction, the two reaction can form water-fast chitin metal salt chelate, be wrapped in the appearance of soft capsule, greatly increase the water resistance of soft capsule, guarantee that soft capsule can not absorb because of contacting with air moisture from air, make moist and occur softening, the phenomenon such as bonding, affect the quality of soft capsule, the problem of outward appearance and utilization, meet soft capsule and kept frangible characteristic, extend the holding time of the type filter stick, reduce the quality of external environment to soft capsule, the impact of outward appearance and utilization, after testing, after preserving in equivalent environment, the shell water content of soft capsule of the present invention is much smaller than conventional soft capsule, crushing performance, obviously be better than conventional soft capsule.
Detailed description of the invention
Embodiment 1
The step of the present embodiment is as follows:
1. adopting gelatin is main wall material raw material, adds glycerine and spices, opacifier, adds the calcium chloride that accounts for glue weight 0.3% after making glue, and with soft capsule pressing process, to be made into loading amount be the soft capsule of 500mg and be dried processing;
2. preparing concentration with the acetic acid solution that concentration is 0.2% is 0.5% chitosan solution, and the soft capsule preparing is put into chitosan solution, at room temperature stirs 15min, and mixing speed forms good mobile being advisable in solution with soft capsule;
3. by step 2. soft capsule after treatment put into the ethanol 3min that dewaters;
4. by step 3. soft capsule after treatment to be placed in humidity be that the rotating cage of 35%RH is dried and processes 5 hours;
5. by step 4. in soft capsule after treatment be the soft capsule that in 35%RH space, standing and drying obtains having good humidity resistance for 36 hours in humidity.
Soft capsule prepared by above-mentioned pressing process with do not carry out the moistureproof soft capsule of processing 25 DEG C of temperature, humidity is in 80%RH space, to detect effect as table 1:
Table 1
Embodiment 2
The step of the present embodiment is as follows:
1. adopting gelatin, gellan gum, dextrin is main wall material raw material, add glycerine and spices, opacifier, after making glue, add the calcium chloride that accounts for glue weight 0.2%, with coetrusion soft capsule pill dripping machine, to be made into diameter be the circular soft capsule of 3.6mm and be dried processing;
2. preparing concentration with water soluble chitosan is 0.5% chitosan solution, by step 1. in the soft capsule of preparation put into chitosan solution, at room temperature stir 3min, mixing speed forms good mobile being advisable in solution with soft capsule;
3. by step 2. soft capsule after treatment put into the ethanol 2min that dewaters;
4. by step 3. soft capsule after treatment put into that to be placed in humidity be that the rotating cage of 35%RH is dried and processes 3 hours;
5. by step 4. in the soft capsule after treatment space that is 35%RH in humidity standing and drying within 36 hours, obtain having the soft capsule of good humidity resistance.
Soft capsule prepared by above-mentioned coetrusion technique with do not carry out the moistureproof soft capsule of processing 25 DEG C of temperature, humidity is in 80%RH space, to detect effect as table 2:
Table 2
Embodiment 3
The step of the present embodiment is as follows:
1. adopting alginate, dextrin is main wall material raw material, adds glycerine and spices, opacifier, adds the calcium chloride that accounts for glue weight 3% after making glue, and by emulsion film forming legal system, to make diameter be the circular soft capsule of 3.6mm and be dried processing;
2. preparing concentration with water soluble chitosan is 0.8% chitosan solution, by step 1. in the soft capsule of preparation put into chitosan solution after cleaning with distilled water, at room temperature stir 2min, mixing speed forms good mobile being advisable in solution with soft capsule;
3. by step 2. soft capsule after treatment put into the ethanol 1min that dewaters;
4. by step 3. soft capsule after treatment put into that to be placed in humidity be that the rotating cage of 40%RH is dried and processes 3 hours;
5. by step 4. in the soft capsule after treatment space that is 40%RH in humidity standing and drying within 36 hours, obtain having the soft capsule of good humidity resistance.
Above-mentioned emulsion is become to soft capsule prepared by membrane process craft and do not carry out the moistureproof soft capsule of processing 25 DEG C of temperature, and humidity is in 80%RH space, to detect effect as table 3:
Table 3
Embodiment 4
The step of the present embodiment is as follows:
1. adopting gelatin is main wall material raw material, adds sorbierite and spices, opacifier, adds the calcium chloride that accounts for glue weight 0.1% after making glue, and with soft capsule pressing process, to be made into loading amount be the soft capsule of 300mg and be dried processing;
2. preparing concentration with the acetic acid solution that concentration is 0.2% is 2% chitosan solution, and the soft capsule preparing is put into chitosan solution, at room temperature stirs 30min, and mixing speed forms good mobile being advisable in solution with soft capsule;
3. by step 2. soft capsule after treatment put into the ethanol 30min that dewaters;
4. by step 3. soft capsule after treatment to be placed in humidity be that the rotating cage of 45%RH is dried and processes 24 hours;
5. by step 4. in soft capsule after treatment be the soft capsule that in 45%RH space, standing and drying obtains having good humidity resistance for 48 hours in humidity.
Soft capsule prepared by above-mentioned pressing process with do not carry out the moistureproof soft capsule of processing 25 DEG C of temperature, humidity is in 80%RH space, to detect effect as table 4:
Table 4
Embodiment 5
The step of the present embodiment is as follows:
1. adopting alginate, dextrin is main wall material raw material, adds glycerine and spices, opacifier, adds the calcium chloride that accounts for glue weight 10% after making glue, and the circular soft capsule that is 3.6mm with the diameter of emulsion film forming legal system system is also dried processing;
2. preparing concentration with water soluble chitosan is 2% chitosan solution, by step 1. in the soft capsule of preparation put into chitosan solution after cleaning with distilled water, at room temperature stir 1min, mixing speed forms good mobile being advisable in solution with soft capsule;
3. by step 2. soft capsule after treatment put into the ethanol 1min that dewaters;
4. by step 3. soft capsule after treatment put into that to be placed in humidity be that the rotating cage of 40%RH is dried and processes 3 hours;
5. by step 4. in the soft capsule after treatment space that is 40%RH in humidity standing and drying within 36 hours, obtain having the soft capsule of good humidity resistance.
Soft capsule prepared by above-mentioned coetrusion technique with do not carry out the moistureproof soft capsule of processing 25 DEG C of temperature, humidity is in 80%RH space, to detect effect as table 5:
Table 5.
Claims (8)
1. a moistureproof processing method for soft capsule, is characterized in that, comprises the following steps:
1. the preparation of soft capsule, prepares wall material raw material according to a conventional method, comprises sizing material excipient, plasticizer, additives and water, adds the calcium chloride that accounts for glue weight 0.1%-10% after making glue, then makes soft capsule by conventional method;
2. the soft capsule preparing is put into and configured the chitosan solution that concentration is 0.1%-2%, at room temperature stir 1-30min, make shitosan react film forming with calcium chloride;
3. by step 2. soft capsule after treatment put into the dehydrating agent 1-30min that dewaters;
4. by step 3. soft capsule after treatment put into stir with the drying equipment of air-blast device be dried process 1-24 hour, be 30%-45%RH by space humidity control;
5. by step 4. in soft capsule standing and drying 24-48 hour after treatment, be 30%-45%RH by space humidity control, obtain having the soft capsule of good humidity resistance.
2. the moistureproof processing method of a kind of soft capsule according to claim 1, is characterized in that, described plasticizer is any in glycerine, sorbierite.
3. the moistureproof processing method of a kind of soft capsule according to claim 1, is characterized in that, described additives are spices, opacifier.
4. the moistureproof processing method of a kind of soft capsule according to claim 1, is characterized in that, described dehydrating agent is ethanol.
5. the moistureproof processing method of a kind of soft capsule according to claim 1, is characterized in that, described sizing material excipient is any one or more combinations in gelatin, alginate, dextrin.
6. according to the moistureproof processing method of a kind of soft capsule described in claim 1-5 any one, it is characterized in that, described chitosan solution is water soluble chitosan solution or the chitosan solution that uses organic acid configuration.
7. the moistureproof processing method of a kind of soft capsule according to claim 1, is characterized in that, the preparation method of described soft capsule is that emulsion becomes any of embrane method, pressing, coetrusion.
8. the moistureproof processing method of a kind of soft capsule according to claim 5, is characterized in that, the preparation method of described soft capsule is that emulsion becomes any of embrane method, pressing, coetrusion.
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| CN110710707A (en) * | 2018-07-11 | 2020-01-21 | 湖南中烟工业有限责任公司 | Method for preparing composite low-temperature cigarette with stable nicotine release |
| US11849756B2 (en) | 2016-07-11 | 2023-12-26 | Philip Morris Products S.A. | Hydrophobic capsule |
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| CN104172471A (en) * | 2014-07-16 | 2014-12-03 | 江西中烟工业有限责任公司 | Brittle capsule with ginseng characteristic aroma as well as preparation method and application thereof |
| CN105536658B (en) * | 2016-01-04 | 2016-10-12 | 云南巴菰生物科技有限公司 | A kind of preparation method of cigarette moisture-resisting capsule |
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| NO20021592D0 (en) * | 2002-04-04 | 2002-04-04 | Fmc Biopolymer As | Polysaccharide Capsules and Method of Preparation thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1415290A (en) * | 2002-10-22 | 2003-05-07 | 南京长澳医药科技有限公司 | Diclofenac natrium slowly released capsule and its preparation method |
| CN102266310A (en) * | 2011-07-21 | 2011-12-07 | 佛山市隆信医药科技有限公司 | Dihydroergotoxine mesylate sustained-release capsule and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11849756B2 (en) | 2016-07-11 | 2023-12-26 | Philip Morris Products S.A. | Hydrophobic capsule |
| CN110710707A (en) * | 2018-07-11 | 2020-01-21 | 湖南中烟工业有限责任公司 | Method for preparing composite low-temperature cigarette with stable nicotine release |
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