CN102895456A - Drug for treating polycystic ovarian syndrome - Google Patents
Drug for treating polycystic ovarian syndrome Download PDFInfo
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- CN102895456A CN102895456A CN2011102079207A CN201110207920A CN102895456A CN 102895456 A CN102895456 A CN 102895456A CN 2011102079207 A CN2011102079207 A CN 2011102079207A CN 201110207920 A CN201110207920 A CN 201110207920A CN 102895456 A CN102895456 A CN 102895456A
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Abstract
The invention relates to a drug for treating polycystic ovarian syndrome. The drug is characterized by comprising an oral medicine and an enema medicine, wherein the oral medicine comprises 15 g of common curculigo rhizome, 10 g of epimedium, 15 g of common cnidium fruit, 15 g of medicinal morinda root, 15 g of dodder, 15 g of glossy privet fruit, 15 g of medlar, 10 g of prepared rhizome of rehmannia, 15 g of angelica, 15 g of szechwan lovage rhizome, 15 g of salvia miltiorrhiza, 15 g of dangshen, 15 g of stir-fried ovate atractylodes root, 15 g of tuckahoe, 30 g of common yam rhizome, 15 g of pinellia, 12 g of seasoned orange peel, and 15 g of officinal magnolia bark, and the enema medicine comprises 15 g of peach seed, 10 g of safflower, 15 g of common burreed tuber, 12 g of cassiabarktree twig, 15 g of trumpetweed, 15 g of speranskia tuberculata, 15 g of common selfheal spike, 15 g of Chinese honeylocust spine, 15 g of szechwan lovage rhizome, 15 g of seaweed, and 15 g of kelp. According to the present invention, treatment philosophy of combination of the oral medicine and the enema medicine is adopted, and blood circulation activating, blood stasis dissipating, swelling subsiding, and stagnation eliminating are adopted to reduce intumescent ovary and thin ovarian follicle, such that ovulation easily occurs.
Description
Technical field
The present invention relates to Chinese herbal medicine and medication, specifically a kind of efficacy result is good, the medicine of the treatment polycystic ovarian syndrome that has no side effect.
Background technology
As everyone knows, polycystic ovarian syndrome is the comparatively common E﹠M disorder disease of adolescence and the women of child-bearing age, its sickness rate is about 5%-10%, take persistence ovulation failure or anovulation, excessive androgen, many capsules of ovary sample change and insulin resistant as feature.Reproductive function obstacle and abnormal carbohydrate metabolism and a kind of special disease of depositing.Main clinical manifestation is the symptom of the Developmental and Metabolic Disorder such as the reproductive function obstacles such as delayed menstrual cycle, amenorrhea, infertile, ovary increase and obesity, acne, hirsutism.Because the mechanism of its genesis it be unclear that so far, therefore in the clinical real difficult and complicated illness that belongs to.
The medicine of modern medicine treatment polycystic ovarian syndrome, the main antagonism androgen (Diane 35 commonly used) and gonadal hormone artificial cycle and raising insulin sensitivity (metformin) of adopting treated, TCM Gynecology then often uses merely kidney and spleen invigorating, the promoting blood flow to regulate menstruation treatment, though these methods are effective in cure, but still aobvious many drawbacks: many patients suffer from the sensitivity of said medicine side effect are difficult to adhere to enough courses for the treatment of; Other has many patients to talk " hormone " complexion changed, refuses to take the hormone therapy scheme, moreover the more important thing is simple hormone scheme or use merely oral medicinal herb, and clinical effectiveness is difficult to the greatest extent people's will really, therefore be called difficult and complicated illness.Again because of its age of onset early, the high and patient of sickness rate examines with infertile and first, it is heavy that doctor and patient is all felt responsibility, the method for the produce effects of trip so numerous doctor seek assiduously.
Summary of the invention
Purpose of the present invention is intended to overcome the deficiency of above-mentioned technology, a kind of warming the kidney to invigorate YANG, spleen invigorating dehumidifying, promoting blood circulation to remove obstruction in the collateral are provided, the balance of recovering between " kidney-menses-punching is appointed-uterus " is improved gonad function, and then recovers the medicine of the treatment polycystic ovarian syndrome of normal menstrual cycle.
The present invention can reach by following measure.
A kind of medicine for the treatment of polycystic ovarian syndrome, it is characterized in that being formed by oral medicine and enema, oral medicine is by Rhizoma Curculiginis, Herba Epimedii, Fructus Cnidii, Radix Morindae Officinalis, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis forms, the weight of above-mentioned composition is respectively Rhizoma Curculiginis 15g in every pair of medicine, Herba Epimedii 10g, Fructus Cnidii 15g, Radix Morindae Officinalis 15g, Semen Cuscutae 15g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Radix Rehmanniae Preparata 10g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Radix Salviae Miltiorrhizae 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Poria 15g, Rhizoma Dioscoreae 30g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 12g, Cortex Magnoliae Officinalis 15g, enema is by Semen Persicae, Flos Carthami, rhizoma sparganic, Ramulus Cinnamomi, the Herba Lycopi, Herba speranskiae tuberculatae, Spica Prunellae, Spina Gleditsiae, Rhizoma Chuanxiong, Sargassum, Thallus Laminariae (Thallus Eckloniae) forms, the weight of above-mentioned composition is respectively Semen Persicae 15g in every pair of medicine, Flos Carthami 10g, rhizoma sparganic 15g, Ramulus Cinnamomi 12g, Herba Lycopi 15g, Herba speranskiae tuberculatae 15g, Spica Prunellae 15g, Spina Gleditsiae 15g, Rhizoma Chuanxiong 15g, Sargassum 15g, Thallus Laminariae (Thallus Eckloniae) 15g, above-mentioned oral medicine and enema all adopt the decocting method of Chinese herbal medicine to extract medicinal liquid for oral administration and coloclysis medicinal liquid.
Modern pharmacology shows, many kidney-nourishing tcm drugs have Estrogenicity-like effect, Rhizoma Curculiginis, Herba Epimedii, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis warming the kidney to invigorate YANG, dispelling cold and dehumidification, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Fructus Lycii enriching yin and nourishing kidney are nourished blood, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae invigorating the spleen for eliminating dampness, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, the Cortex Magnoliae Officinalis removing dampness and eliminating phlegm of regulating the flow of vital energy, all medicines share, and play altogether the merit of enriching yin and nourishing kidney, invigorating the spleen for eliminating dampness, blood circulation promoting and blood stasis dispelling.The traditional Chinese medical science is thought: kidney storing essence is the congenital foundation.Kidney has Yinyang, is the residence of extreme misery, the residence nephroyin and nephroyang, and through this in kidney, entirely rely the executing of kidney water through water, only have kidney qi to contain, could the menarche, conception vessel is logical, taichong channel is contained, regular menstrual cycle.Polycystic ovarian syndrome be because of kidney-menses-punching appoint-uterus between due to the disequilibrium, so collaborative, maximize favourable factors and minimize unfavourable ones, the pathogenesis that hits, satisfactory for result.And more emphasis be in conjunction with the Chinese medicine promoting blood circulation and breaking stagnation when the invention reside in above-mentioned treatment, the decoct of dispersing swelling and dissipating binds, every night retention enema, Semen Persicae, Flos Carthami, rhizoma sparganic, Herba Lycopi, Rhizoma Chuanxiong are all the product of promoting blood circulation and breaking stagnation in the side, the Ramulus Cinnamomi dispelling cold by warming the meridian, Spica Prunellae, Spina Gleditsiae, Herba speranskiae tuberculatae resolving the hard mass; Sargassum, Thallus Laminariae (Thallus Eckloniae) are the product of hard masses softening and resolving.
The treatment theory that the present invention adopts oral medicine to combine with enema, wherein oral medicine has the effect of blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, enema is used for the treatment of pelvic inflammatory disease, pelvic lump and so on, and it is used all primary disease, and the two is in conjunction with passing through blood circulation promoting and blood stasis dispelling, and dispersing swelling and dissipating binds is to dwindle the ovary of enlargement, the attenuate ovarian follicle wall is in order to ovulation.Have following advantage: 1. the medicinal liquid per rectum is local directly absorbs, and can play a role very soon, makes the medicine focus of going directly, the focus local drug concentration improves, can effectively improve the blood circulation of pelvic cavity and even ovary, inflammation-inhibiting and hamartoplasia are to the effect of the ovary of enlargement performance dispersing swelling and dissipating binds; 2. the product of blood circulation promoting and blood stasis dispelling dispersing swelling and dissipating binds gastrointestinal reaction for oral administration is large, and burden of liver is heavy, yet primary disease is longer again the course for the treatment of, thus can't Long-term Oral, and retention enema can be avoided this fraud fully.3. drug enema is avoided gastroenterol hepatol first pass effect, has both alleviated burden of liver, avoids again lowering the efficacy of a drug, even if in the time of can't adhering to oral medication for some reason, retention enema still can be carried out.
The specific embodiment
Below the invention will be further described.
A kind of medicine for the treatment of polycystic ovarian syndrome, it is characterized in that being formed by oral medicine and enema, oral medicine is by Rhizoma Curculiginis, Herba Epimedii, Fructus Cnidii, Radix Morindae Officinalis, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis forms, the weight of above-mentioned composition is respectively Rhizoma Curculiginis 15g in every pair of medicine, Herba Epimedii 10g, Fructus Cnidii 15g, Radix Morindae Officinalis 15g, Semen Cuscutae 15g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Radix Rehmanniae Preparata 10g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Radix Salviae Miltiorrhizae 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Poria 15g, Rhizoma Dioscoreae 30g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 12g, Cortex Magnoliae Officinalis 15g, enema is by Semen Persicae, Flos Carthami, rhizoma sparganic, Ramulus Cinnamomi, the Herba Lycopi, Herba speranskiae tuberculatae, Spica Prunellae, Spina Gleditsiae, Rhizoma Chuanxiong, Sargassum, Thallus Laminariae (Thallus Eckloniae) forms, the weight of above-mentioned composition is respectively Semen Persicae 15g in every pair of medicine, Flos Carthami 10g, rhizoma sparganic 15g, Ramulus Cinnamomi 12g, Herba Lycopi 15g, Herba speranskiae tuberculatae 15g, Spica Prunellae 15g, Spina Gleditsiae 15g, Rhizoma Chuanxiong 15g, Sargassum 15g, Thallus Laminariae (Thallus Eckloniae) 15g, above-mentioned oral medicine and enema all adopt the decocting method of Chinese herbal medicine to extract medicinal liquid for oral administration and coloclysis medicinal liquid.
Modern pharmacology shows, many kidney-nourishing tcm drugs have Estrogenicity-like effect, Rhizoma Curculiginis, Herba Epimedii, Fructus Cnidii, Semen Cuscutae, Radix Morindae Officinalis warming the kidney to invigorate YANG, dispelling cold and dehumidification, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Fructus Ligustri Lucidi, Fructus Lycii enriching yin and nourishing kidney are nourished blood, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae invigorating the spleen for eliminating dampness, the Rhizoma Pinelliae Pericarpium Citri Reticulatae Cortex Magnoliae Officinalis removing dampness and eliminating phlegm of regulating the flow of vital energy, all medicines share, and play altogether the merit of enriching yin and nourishing kidney, invigorating the spleen for eliminating dampness, blood circulation promoting and blood stasis dispelling.The traditional Chinese medical science is thought: kidney storing essence is the congenital foundation.Kidney has Yinyang, is the residence of extreme misery, the residence nephroyin and nephroyang, and through this in kidney, entirely rely the executing of kidney water through water, only have kidney qi to contain, could the menarche, conception vessel is logical, taichong channel is contained, regular menstrual cycle.Polycystic ovarian syndrome be because of kidney-menses-punching appoint-uterus between due to the disequilibrium, so collaborative, maximize favourable factors and minimize unfavourable ones, the pathogenesis that hits, satisfactory for result.And more emphasis be in conjunction with the Chinese medicine promoting blood circulation and breaking stagnation when the invention reside in above-mentioned treatment, the decoct of dispersing swelling and dissipating binds, every night retention enema, Semen Persicae, Flos Carthami, rhizoma sparganic, Herba Lycopi, Rhizoma Chuanxiong are all the product of promoting blood circulation and breaking stagnation in the side, the Ramulus Cinnamomi dispelling cold by warming the meridian, Spica Prunellae, Spina Gleditsiae, Herba speranskiae tuberculatae resolving the hard mass; Sargassum, Thallus Laminariae (Thallus Eckloniae) are the product of hard masses softening and resolving.
The present invention gives clomiphene 50mg, once a day in menstruation or hormone withdrawal bleeding the 5th day, serve on 5 days and namely stop, give simultaneously oral medicine and take orally and the enema coloclysis, oral medicine is take the kidney and spleen invigorating removing dampness as main, enema is with promoting blood circulation and breaking stagnation, and hard masses softening and resolving is main.
Model case.
Case 1: patient clump XX, woman 30 years old, first visit on May 17 in 2009: married 5 years, the man and wife lives together and does not practise contraception and unpregnancy.Menstruation is gradual delays more than 5 years.Patient's menstruation tide 15 the beginning of the year, the 2-3 month, once the menstrual cycle rule was about 28-30 days after 17 years old, through amount, color is all normal, painless warp, the unknown cause menstruation is delayed gradually over nearly 5 years, do not wait April in January to three, reduces gradually through amount, at every turn only about three days, and only use 2-3 sheet sanitary towel every day, body weight increases nearly 30 jin, ultrasound diagnosis uterus position normal in size, bilateral ovaries increases, left side 38*29mm, right side 33*29mm, and be polycystic change.LH/FSH 〉=2.0 meet the diagnosis of polycystic ovarian syndrome substantially.Give Progesterone 20mg intramuscular injection, be used in conjunction 3 days, treat the 5th day beginning of hormone withdrawal bleeding, give clomiphene 50mg once a day, be used in conjunction 5 days, give simultaneously Chinese medicine Rhizoma Curculiginis 15g, Herba Epimedii 12g, Fructus Cnidii 15g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Semen Cuscutae 15g, Radix Rehmanniae Preparata 10g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 20g, Radix Salviae Miltiorrhizae 30g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Poria 15g, Rhizoma Dioscoreae 30g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Cortex Magnoliae Officinalis 15g takes orally and retention-enema treatment: Semen Persicae 15g, Flos Carthami 10g, rhizoma sparganic 12g, Ramulus Cinnamomi 12g, Herba Lycopi 15g, Herba speranskiae tuberculatae 15g, Spica Prunellae 15g, Rhizoma Chuanxiong 15g, Sargassum 15g, after Thallus Laminariae (Thallus Eckloniae) 15g. treats January, menstruation is risen on time, before increase through amount, be extended down to 5 days menstrual period, treat half a year continuously, patient's menstruation normal, body weight cuts about 12 jin.Existing conceived 24 weeks.
Case 2, the old XX of patient, woman 28 years old, the worker of the court, first visit in July 10 in 2010, the 3 years unpregnancies of marrying.Patient's menstruation is delayed nearly ten years, 4-6 month delegation, and gradual obesity is more obvious over nearly 5 years, and body weight increases nearly 10Kg, and is medical before 5 years, through coherence check, namely is diagnosed as polycystic ovarian syndrome, do not give at that time treatment.Married before 3 years, the man and wife lives together, contraception and unpregnancy, the year before at the court's reproductive center through androgen antagonist, HCG, HMG ovulation treatment and artificial gravidity assisting, conceived spontaneous abortion during to 24 week, after this gestation more.Existing patient's menstruation is 3-5 month delegation still, height 160cm, and body weight 65kg, LH/FSH＞2.0, ultrasound diagnosis, bilateral ovaries all increases, and LOV:42*34mm, ROV:38*29mm, every side ovary be visible 7-8 little follicle all.Comprehensive indices patient meets the diagnosis of polycystic ovarian syndrome.Treatment is still given the 5th day beginning of hormone withdrawal bleeding and is given clomiphene 50mg, once a day, serve on 5 days, give simultaneously that Kidney-supplementing is invigorated blood circulation, the agent of invigorating the spleen for eliminating dampness: Rhizoma Curculiginis 15g, Herba Epimedii 12g, Radix Morindae Officinalis 15g, Fructus Cnidii 15g, Semen Cuscutae 15g, Rhizoma Drynariae 15g, Fructus Psoraleae 10g, Herba Cynomorii 12g, Herba Cistanches 18g, Radix Angelicae Sinensis 15g, Fructus Lycii 15g, Radix Rehmanniae Preparata 10g, Colla Corii Asini 12g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Poria 15g, Semen Lablab Album 30g, Radix Salviae Miltiorrhizae 15g, Rhizoma Chuanxiong 30g; And give simultaneously promoting blood circulation and breaking stagnation, the agent retention enema of dispersing swelling and dissipating binds: Semen Persicae 10g, Flos Carthami 10g, rhizoma sparganic 15g, Rhizoma Curcumae 15g, Herba Lycopi 15g, Spica Prunellae 20g, Spina Gleditsiae 15g, Herba speranskiae tuberculatae 15g, Sargassum 15g, Thallus Laminariae (Thallus Eckloniae) 15g.Get its decoct 50ml, about 38 ℃ of temperature, just before going to bed retention enema, Chinese medicine can with the card plus-minus, so be used to order two months cycles for the treatment of, conceived 9 weeks of patient.
The treatment theory that the present invention adopts oral medicine to combine with enema, wherein oral medicine has the effect of blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, enema is used for the treatment of pelvic inflammatory disease, pelvic lump and so on, and it is used all primary disease, the two is in conjunction with passing through blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds is to dwindle the ovary of enlargement, the attenuate ovarian follicle wall reaches 70% in order to ovulation, cure rate, and effective percentage reaches 99%.Have following advantage: 1. the medicinal liquid per rectum is local directly absorbs, and can play a role very soon, makes the medicine focus of going directly, the focus local drug concentration improves, can effectively improve the blood circulation of pelvic cavity and even ovary, inflammation-inhibiting and hamartoplasia are to the effect of the ovary of enlargement performance dispersing swelling and dissipating binds; 2. the product of blood circulation promoting and blood stasis dispelling dispersing swelling and dissipating binds gastrointestinal reaction for oral administration is large, and burden of liver is heavy, yet primary disease is longer again the course for the treatment of, thus can't Long-term Oral, and retention enema can be avoided this fraud fully.3. drug enema is avoided gastroenterol hepatol first pass effect, has both alleviated burden of liver, avoids again lowering the efficacy of a drug, even if in the time of can't adhering to oral medication for some reason, retention enema still can be carried out.
Claims (1)
1. medicine for the treatment of polycystic ovarian syndrome, it is characterized in that being formed by oral medicine and enema, oral medicine is by Rhizoma Curculiginis, Herba Epimedii, Fructus Cnidii, Radix Morindae Officinalis, Semen Cuscutae, Fructus Ligustri Lucidi, Fructus Lycii, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Poria, Rhizoma Dioscoreae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis forms, the weight of above-mentioned composition is respectively Rhizoma Curculiginis 15g in every pair of medicine, Herba Epimedii 10g, Fructus Cnidii 15g, Radix Morindae Officinalis 15g, Semen Cuscutae 15g, Fructus Ligustri Lucidi 15g, Fructus Lycii 15g, Radix Rehmanniae Preparata 10g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Radix Salviae Miltiorrhizae 15g, Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae (parched) 15g, Poria 15g, Rhizoma Dioscoreae 30g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 12g, Cortex Magnoliae Officinalis 15g, enema is by Semen Persicae, Flos Carthami, rhizoma sparganic, Ramulus Cinnamomi, the Herba Lycopi, Herba speranskiae tuberculatae, Spica Prunellae, Spina Gleditsiae, Rhizoma Chuanxiong, Sargassum, Thallus Laminariae (Thallus Eckloniae) forms, the weight of above-mentioned composition is respectively Semen Persicae 15g in every pair of medicine, Flos Carthami 10g, rhizoma sparganic 15g, Ramulus Cinnamomi 12g, Herba Lycopi 15g, Herba speranskiae tuberculatae 15g, Spica Prunellae 15g, Spina Gleditsiae 15g, Rhizoma Chuanxiong 15g, Sargassum 15g, Thallus Laminariae (Thallus Eckloniae) 15g, above-mentioned oral medicine and enema all adopt the decocting method of Chinese herbal medicine to extract medicinal liquid for oral administration and coloclysis medicinal liquid.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272144A (en) * | 2013-05-24 | 2013-09-04 | 孙炳云 | Medicine for treating polycystic ovarian syndrome |
| CN103446403A (en) * | 2013-09-07 | 2013-12-18 | 马玉玲 | Traditional Chinese medicine preparation for treating polycystic ovarian syndrome |
| CN103599240A (en) * | 2013-11-14 | 2014-02-26 | 苏宏英 | Oral liquid for treating polycystic ovarian syndrome |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167850A (en) * | 2007-10-20 | 2008-04-30 | 徐究竟 | Medicine for treating polycystic ovary syndrome and preparation technology thereof |
| CN101496862A (en) * | 2009-03-19 | 2009-08-05 | 王新民 | Chinese medicinal composition for treating infertility and preparation method thereof |
| CN101549139A (en) * | 2009-04-07 | 2009-10-07 | 孙逊 | Polycyst remove |
| CN101919953A (en) * | 2010-06-03 | 2010-12-22 | 宋丽峰 | Traditional Chinese medicine combination menstruation-regulating soup for treating polycystic ovary syndrome |
-
2011
- 2011-07-25 CN CN201110207920.7A patent/CN102895456B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167850A (en) * | 2007-10-20 | 2008-04-30 | 徐究竟 | Medicine for treating polycystic ovary syndrome and preparation technology thereof |
| CN101496862A (en) * | 2009-03-19 | 2009-08-05 | 王新民 | Chinese medicinal composition for treating infertility and preparation method thereof |
| CN101549139A (en) * | 2009-04-07 | 2009-10-07 | 孙逊 | Polycyst remove |
| CN101919953A (en) * | 2010-06-03 | 2010-12-22 | 宋丽峰 | Traditional Chinese medicine combination menstruation-regulating soup for treating polycystic ovary syndrome |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845342A (en) * | 2012-12-03 | 2014-06-11 | 浙江大学 | Composite drug for treating adolescent polycystic ovarian syndrome (PCOS)-insulin resistance (IR) |
| CN103272144A (en) * | 2013-05-24 | 2013-09-04 | 孙炳云 | Medicine for treating polycystic ovarian syndrome |
| CN104107313A (en) * | 2013-07-27 | 2014-10-22 | 成都绿迪科技有限公司 | Traditional Chinese medicine composition used for treating kidney-deficiency liver-depression type breast distention before menstruation |
| CN103446403A (en) * | 2013-09-07 | 2013-12-18 | 马玉玲 | Traditional Chinese medicine preparation for treating polycystic ovarian syndrome |
| CN103599240A (en) * | 2013-11-14 | 2014-02-26 | 苏宏英 | Oral liquid for treating polycystic ovarian syndrome |
| CN104147551A (en) * | 2014-09-02 | 2014-11-19 | 马俊安 | Traditional Chinese medicine for treating polycystic ovarian syndrome |
| CN104906448A (en) * | 2015-06-30 | 2015-09-16 | 河南中医学院 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome |
| CN104906448B (en) * | 2015-06-30 | 2018-08-14 | 河南中医学院 | A kind of Chinese medicine composition for treating Stein-Leventhal syndrome |
| CN105168701A (en) * | 2015-10-30 | 2015-12-23 | 张英杰 | Traditional Chinese medicine composite for treating polycystic ovarian syndrome |
| CN105250975A (en) * | 2015-11-18 | 2016-01-20 | 张剑 | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof |
| CN105535466A (en) * | 2016-01-25 | 2016-05-04 | 青岛云天生物技术有限公司 | Pharmaceutical composition for treating pubescent polycystic ovarian syndrome |
| CN105535199A (en) * | 2016-02-22 | 2016-05-04 | 林立朋 | Pharmaceutical preparation for treating polycystic ovarian syndromes accompanied with mammary gland hyperplasia |
| CN108853427A (en) * | 2018-08-02 | 2018-11-23 | 中山大学附属第医院 | A kind of Chinese medicinal formulae for treating overweight/obesity type Stein-Leventhal syndrome |
| CN111317777A (en) * | 2020-05-08 | 2020-06-23 | 河南中医药大学 | Traditional Chinese medicine decoction for treating kidney deficiency and phlegm dampness type polycystic ovarian syndrome infertility |
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