CN102895384A - Chinese herbal medicine compound preparation for removing pathogenic heat from blood and securing essence and method for preparing Chinese herbal medicine compound preparation - Google Patents
Chinese herbal medicine compound preparation for removing pathogenic heat from blood and securing essence and method for preparing Chinese herbal medicine compound preparation Download PDFInfo
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- CN102895384A CN102895384A CN201210452155XA CN201210452155A CN102895384A CN 102895384 A CN102895384 A CN 102895384A CN 201210452155X A CN201210452155X A CN 201210452155XA CN 201210452155 A CN201210452155 A CN 201210452155A CN 102895384 A CN102895384 A CN 102895384A
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Abstract
The invention relates to a Chinese herbal medicine compound preparation for removing pathogenic heat from blood and securing essence and a method for preparing the Chinese herbal medicine compound preparation for removing pathogenic heat from blood and securing essence. The Chinese herbal medicine compound preparation consists of the following traditional Chinese medicinal materials in parts by weight: 7-30 parts of ox bile powder, 2-10 parts of flos carthami, 4-16 parts of radix glycyrrhizae, 10-40 parts of amur cork tree bark, 2-10 parts of fructus gardeniae, 4-16 parts of fructus piperis longi, 7-30 parts of xiangmo and 4-16 parts of heiyunxiang. The Chinese herbal medicine compound preparation has the main functions for clearing heat and drying dampness, cooling and stopping blood, eliminating putridity and engendering flesh and securing essence, and is used for treating various symptoms including kidney heat, urinary tract infection, hematuria, spermator rhoea, menorrhagia and the like.
Description
Technical field
The present invention relates to a kind of solid pharmaceutical preparations such as powder, tablet, capsule and granule that are prepared from as main active component take several kinds of Chinese medicinal materials and preparation method thereof.Relate in particular to take bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and HEIYUNXIANG totally eight kinds of pharmaceutical preparation and preparation methoies that Chinese crude drug is made as main active component.
Background technology
Kidney-heat syndrome is a kind ofly to act on the hot nephropathy that causes behind the kidney because of blood and pathogenic heat.Record about the treatment febrile disease has just been arranged in " Plain Questions thorn heat piece of writing " of Huangdi's Internal Classics, as: " all calentura of controlling are thorn with the Han Shui of drink, must winter clothing it, occupy only Han Chu, coldness of the body and only also." editor's Yang Shangshan and done to specify, " all febrile disease are sick, with cold treatments, all have four other: one, drink Han Shui and make its endogenous cold; Two, sting and make its arteries and veins cold in the cave; Three, make its exogenous cold with winter clothing, four, make its body cold with Han Ju.With four cold it, make inside and outside the body all cold, therefore calentura is ended also.”
The main cause that causes kidney-heat is because blood and pathogenic heat are invaded and kidney after mixing, and causes the homoiostasis imbalance, digestive function weakness.The disease symptom main manifestations is to be with blood etc. in the pain heating of kidney section, headache and dizzy, urethral orifice causalgia, urine urgency-frequency, the urine.
Along with the quickening of modern society's work and rhythm of life, dog-eat-dog, pressure are greatly the normalities of most people.This state makes that people's mood is smooth, liver-fire is vigorous, thereby causes the heat in blood pathogenic heat, so the kidney-heat syndrome sickness rate is more and more higher.But be not specifically designed in the market the pharmaceutical preparation for the treatment of kidney-heat, the patient is usually used chemicals to treat by doctor trained in Western medicine.And chemicals only takes stopgap measures and can not effect a permanent cure, and more can not fundamentally effectively regulate the function of human organ.
The present invention aims to provide a kind of Traditional Chinese medical theory and Chinese medicine method for making utilized, in conjunction with the modern Chinese medicine production technology, and the compound Chinese medicinal preparation of making as main active component take several kinds of Chinese medicinal materials; Its function and cure mainly and be mainly heat clearing and damp drying, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, controlling nocturnal emission with astringent drugs is used for the treatment of kidney-heat, urinary tract infection, hematuria, seminal emission, through the lower symptom such as too much.
Summary of the invention
The object of the present invention is to provide a kind of compound preparation of making as main active component take several kinds of Chinese medicinal materials and preparation method thereof.Specifically, exactly take bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and HEIYUNXIANG totally eight kinds of compound medicinal formulations that Chinese crude drug is made as main active component, be mainly used in clinically heat clearing and damp drying, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, controlling nocturnal emission with astringent drugs, be used for the treatment of kidney-heat, urinary tract infection, hematuria, seminal emission, through the lower symptom such as too much.
The present invention is except main active component is bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and eight kinds of Chinese crude drugs of HEIYUNXIANG, also comprise the adjuvant commonly used that pharmaceutical preparation is required, such as diluent, binding agent, wetting agent, disintegrating agent, lubricant and correctives etc.
Content of the present invention is made bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and eight kinds of Chinese crude drugs of HEIYUNXIANG the compound medicinal formulation except comprising, also comprises the production technology of using common drug pharmaceutical adjunct useful in preparing drug formulations.
The objective of the invention is to be finished by following technical proposals.
A kind of compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs is characterized in that mainly being comprised of by weight the following traditional Chinese medicines material:
Bilein 7-30 part
Flos Carthami 2-10 part
Radix Glycyrrhizae 4-16 part
Cortex Phellodendri 10-40 part
Fructus Gardeniae 2-10 part
Fructus Piperis Longi 4-16 part
XIANGMO(sic) 7-30 part
HEIYUNXIANG 4-16 part
Add the required adjuvant commonly used of appropriate amount of drug preparation, diluent, binding agent, wetting agent, disintegrating agent, lubricant or correctives are made powder, tablet, capsule or granule.
The present invention preferably fills a prescription and mainly is comprised of by weight the following traditional Chinese medicines material:
15 parts of bileins
5 parts on Flos Carthami
8 parts in Radix Glycyrrhizae
20 parts of Cortex Phellodendris
5 parts of Fructus Gardeniaes
8 parts of Fructus Piperis Longi
15 parts of XIANGMO(sic)
8 parts of HEIYUNXIANG
Add the required adjuvant commonly used of appropriate amount of drug preparation, diluent, binding agent, wetting agent, disintegrating agent, lubricant or correctives are made powder, tablet, capsule and granule.
Production technology of the present invention:
1) takes by weighing above-mentioned 8 flavor Chinese crude drugs by recipe quantity, clean respectively, pulverize, sieve;
2) with above-mentioned 8 flavor Chinese crude drug fine powder sterilizations;
3) get respectively fine powder 1/3 amount after the above-mentioned 8 flavor Chinese crude drugs sterilizations, in material-compound tank, mix, fully stirred 30 minutes, make mix homogeneously, mix 1/3 amount 1 time, 8 flavor Chinese crude drug fine powders are all mixed minutes for 3 times;
4) 2 parts in the 8 flavor Chinese crude drug fine powders that mix for above-mentioned 3 times are mixed in material-compound tank, fully stirred 30 minutes, make and mix fully; The above-mentioned 8 flavor Chinese crude drug fine powders that more remaining 1/3 amount mixed add in the material-compound tank, fully stir 30 minutes, make and mix fully, get the always dark fine powder that closes;
5) will always drift along or through that to close fine powder moistening with the alcoholic solution of 75-85%, add successively required pharmaceutic adjuvant, fully stir 30 minutes, make mix homogeneously; Wet granulation, dry rear granulate;
6) gained granule direct packaging becomes powder, capsule and granule finished product; Or repressed in blocks, sugar coating gets the tablet finished product.
Required pharmaceutic adjuvant in the production technology of the present invention refers to diluent, binding agent, wetting agent, disintegrating agent, lubricant or correctives.
Diluent refers to one or more in starch, pregelatinized Starch, lactose, dextrin, microcrystalline Cellulose, mannitol, Sorbitol, calcium sulfate, the calcium bisulfate.
Binding agent refers to one or more in starch slurry, hydroxy methocel, polyvidone, gelatin, the Polyethylene Glycol.
Wetting agent refers to ethanol.
Disintegrating agent refers to one or more in Sodium Hydroxymethyl Stalcs, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, the polyvinylpolypyrrolidone.
Lubricant refers to one or more in magnesium stearate, Pulvis Talci, micropowder silica gel, the hydrogenated vegetable oil.
Correctives refers to one or more in menthol, Aspartane, saccharin sodium, the sucralose.
The pharmacological function of each active component is among the present invention:
Bilein: liver heat removing and eyesight improving, function of gallbladder promoting relieving constipation, removing toxic substances and promoting subsidence of swelling.
Flos Carthami: warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, lochia.Radix Glycyrrhizae: be longer than and relieve inflammation or internal heat, with heat-clearing and toxic substances removing, nourishing the lung to arrest cough power wins.Be used for phlegm-heat cough, laryngopharynx swelling and pain.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication is except the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria.
Fructus Gardeniae: pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.
Fructus Piperis Longi: be used for coldness and pain in the epigastrium, vomit, have loose bowels, migraine.
XIANGMO(sic): have hemostasis, the confession effect of detumescence is spitted blood epistaxis, metrorrhagia and metrostaxis in order to treatment.HEIYUNXIANG: have the effects such as reducing swelling and alleviating pain, wound healing.
Major function of the present invention cures mainly and is heat clearing and damp drying, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, controlling nocturnal emission with astringent drugs, is used for the treatment of kidney-heat, urinary tract infection, hematuria, seminal emission, through the lower symptom such as too much.Through its clinical cure 19 examples, produce effects 34 examples, effective 11 examples, invalid 3 examples, total effective rate 94.03% are added up in 67 routine kidney-heat syndrome patient clinical treatments.Illustrate that the present invention has higher curative effect aspect the treatment kidney-heat syndrome.During the clinical treatment observation, the 67 routine patients rear obvious untoward reaction of all not finding of taking medicine shows that toxic and side effects of the present invention is low, and is safe and effective.
Characteristics of the present invention are:
1, the compound preparation of innovation.
With bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and HEIYUNXIANG totally eight kinds of Chinese crude drugs adopt Chinese medicine preparation technologies, make the compound medicinal formulation of innovation, comprise powder, tablet, capsule and granule.
2, the production technology of innovation
Production technology of the present invention combines Chinese medicine concocting method and advanced modern Chinese medicine preparation technology.In preparation compound medicinal formulation process of the present invention, both used the Chinese medicine processing procedure, crude drug directly is used as medicine, and has kept all effective ingredient of Chinese crude drug; Adopt again the advanced preparation technology of modern Chinese medicine such as sugar coating etc., avoided the shortcoming that is difficult to take of traditional Chinese patent medicine, improved the compliance of clinical practice.
3, medicament curative effect enhancement.
The present invention is owing to adopting the processing procedure of Chinese medicine, and crude drug directly is used as medicine, and has avoided modern extraction process and the loss of the active component that may cause, so that all active components of 8 kinds of Chinese crude drugs all keep, has strengthened curative effect of medication.
4, clinical application range is extensive.
Bilein, Flos Carthami, Radix Glycyrrhizae, Cortex Phellodendri, Fructus Gardeniae, Fructus Piperis Longi, XIANGMO(sic) and 8 kinds of direct crude drugs of Chinese crude drug of HEIYUNXIANG are used as medicine in the present invention, and 8 kinds of Chinese crude drug the monarch and his subjects are clearly demarcated, effect is complemented each other, given full play to the compound recipe advantage of China's Chinese medicine, can be used for clinically heat clearing and damp drying, cooling blood for hemostasis, removing the necrotic tissue and promoting granulation, controlling nocturnal emission with astringent drugs, treatment kidney-heat, urinary tract infection, hematuria, seminal emission, through lower many symptoms such as too much.
The specific embodiment
Embodiment 1,
Take by weighing respectively bilein 90g, Flos Carthami 30g, Radix Glycyrrhizae 48g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 48g, XIANGMO(sic) 90g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 1000 bags of powders are made in directly embedding.
Embodiment 2,
Take by weighing respectively bilein 90g, Flos Carthami 30g, Radix Glycyrrhizae 48g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 48g, XIANGMO(sic) 90g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, add pharmaceutic adjuvant, tabletting, make 1000 tablets of tablets, sugar coating gets finished product.
Embodiment 3,
Take by weighing respectively bilein 90g, Flos Carthami 30g, Radix Glycyrrhizae 48g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 48g, XIANGMO(sic) 90g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 1000 capsules are made in directly embedding.
Embodiment 4,
Take by weighing respectively bilein 90g, Flos Carthami 30g, Radix Glycyrrhizae 48g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 48g, XIANGMO(sic) 90g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 1000 bags of granules are made in directly embedding.
Embodiment 5,
Take by weighing respectively bilein 9kg, Flos Carthami 3kg, Radix Glycyrrhizae 4.8kg, Cortex Phellodendri 12kg, Fructus Gardeniae 3kg, Fructus Piperis Longi 4.8kg, XIANGMO(sic) 9kg and HEIYUNXIANG 4.8kg totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 100000 bags of powders are made in directly embedding.
Embodiment 6,
Take by weighing respectively bilein 9kg, Flos Carthami 3kg, Radix Glycyrrhizae 4.8kg, Cortex Phellodendri 12kg, Fructus Gardeniae 3kg, Fructus Piperis Longi 4.8kg, XIANGMO(sic) 9kg and HEIYUNXIANG 4.8kg totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, add pharmaceutic adjuvant, tabletting, make 100000 tablets of tablets, sugar coating gets finished product.
Embodiment 7,
Take by weighing respectively bilein 9kg, Flos Carthami 3kg, Radix Glycyrrhizae 4.8kg, Cortex Phellodendri 12kg, Fructus Gardeniae 3kg, Fructus Piperis Longi 4.8kg, XIANGMO(sic) 9kg and HEIYUNXIANG 4.8kg totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 100000 capsules are made in directly embedding.
Embodiment 8,
Take by weighing respectively bilein 9kg, Flos Carthami 3kg, Radix Glycyrrhizae 4.8kg, Cortex Phellodendri 12kg, Fructus Gardeniae 3kg, Fructus Piperis Longi 4.8kg, XIANGMO(sic) 9kg and HEIYUNXIANG 4.8kg totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 100000 bags of granules are made in directly embedding.
Embodiment 9,
Take by weighing respectively bilein 50g, Flos Carthami 60g, Radix Glycyrrhizae 48g, Cortex Phellodendri 200g, Fructus Gardeniae 30g, Fructus Piperis Longi 48g, XIANGMO(sic) 60g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 1000 bags of powders are made in directly embedding.
Embodiment 10,
Take by weighing respectively bilein 90g, Flos Carthami 20g, Radix Glycyrrhizae 90g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 90g, XIANGMO(sic) 60g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, add pharmaceutic adjuvant, tabletting, make 1000 tablets of tablets, sugar coating gets finished product.
Embodiment 11,
Take by weighing respectively bilein 90g, Flos Carthami 30g, Radix Glycyrrhizae 30g, Cortex Phellodendri 220g, Fructus Gardeniae 40g, Fructus Piperis Longi 48g, XIANGMO(sic) 90g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory.
Embodiment 12,
Take by weighing respectively bilein 60g, Flos Carthami 20g, Radix Glycyrrhizae 48g, Cortex Phellodendri 120g, Fructus Gardeniae 30g, Fructus Piperis Longi 30g, XIANGMO(sic) 150g and HEIYUNXIANG 48g totally 8 kinds of Chinese crude drugs by inventory, according to aforementioned " production technology of the present invention " described step, behind the granulate, 1000 bags of granules are made in directly embedding.
Claims (9)
1. compound Chinese medicinal preparation that is used for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs is characterized in that mainly being comprised of by weight the following traditional Chinese medicines material:
Bilein 7-30 part
Flos Carthami 2-10 part
Radix Glycyrrhizae 4-16 part
Cortex Phellodendri 10-40 part
Fructus Gardeniae 2-10 part
Fructus Piperis Longi 4-16 part
XIANGMO(sic) 7-30 part
HEIYUNXIANG 4-16 part
Its preparation method is:
1) takes by weighing above-mentioned 8 flavor Chinese crude drugs by recipe quantity, clean respectively, pulverize, sieve;
2) with above-mentioned 8 flavor Chinese crude drug fine powder sterilizations;
3) get respectively fine powder 1/3 amount after the above-mentioned 8 flavor Chinese crude drugs sterilizations, in material-compound tank, mix, fully stirred 30 minutes, make mix homogeneously, mix 1/3 amount 1 time, 8 flavor Chinese crude drug fine powders are all mixed minutes for 3 times;
4) 2 parts in the 8 flavor Chinese crude drug fine powders that mix for above-mentioned 3 times are mixed in material-compound tank, fully stirred 30 minutes, make and mix fully; The above-mentioned 8 flavor Chinese crude drug fine powders that more remaining 1/3 amount mixed add in the material-compound tank, fully stir 30 minutes, make and mix fully, get the always dark fine powder that closes;
5) will always drift along or through that to close fine powder moistening with the alcoholic solution of 75-85%, add successively required pharmaceutic adjuvant, fully stir 30 minutes, make mix homogeneously; Wet granulation, dry rear granulate;
6) gained granule direct packaging becomes powder, capsule and granule finished product; Or repressed in blocks, sugar coating gets the tablet finished product.
2. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 1 is characterized in that mainly being comprised of by weight the following traditional Chinese medicines material:
15 parts of bileins
5 parts on Flos Carthami
8 parts in Radix Glycyrrhizae
20 parts of Cortex Phellodendris
5 parts of Fructus Gardeniaes
8 parts of Fructus Piperis Longi
15 parts of XIANGMO(sic)
8 parts of HEIYUNXIANG
Add the required adjuvant commonly used of appropriate amount of drug preparation, diluent, binding agent, wetting agent, disintegrating agent, lubricant or correctives are made powder, tablet, capsule or granule.
3. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 1, it is characterized in that: required pharmaceutic adjuvant refers to diluent, binding agent, wetting agent, disintegrating agent, lubricant or correctives in its preparation method.
4. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: diluent refers to one or more in starch, pregelatinized Starch, lactose, dextrin, microcrystalline Cellulose, mannitol, Sorbitol, calcium sulfate, the calcium bisulfate.
5. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: binding agent refers to one or more in starch slurry, hydroxy methocel, polyvidone, gelatin, the Polyethylene Glycol.
6. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: wetting agent refers to ethanol.
7. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: disintegrating agent refers to one or more in Sodium Hydroxymethyl Stalcs, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose, the polyvinylpolypyrrolidone.
8. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: lubricant refers to one or more in magnesium stearate, Pulvis Talci, micropowder silica gel, the hydrogenated vegetable oil.
9. the compound Chinese medicinal preparation for the clearing away heat and cooling blood controlling nocturnal emission with astringent drugs according to claim 3, it is characterized in that: correctives refers to one or more in menthol, Aspartane, saccharin sodium, the sucralose.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103394056A (en) * | 2013-07-19 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing liquorice and preparation method thereof |
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2012
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Non-Patent Citations (2)
| Title |
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| 中华人民共和国药典委员会: "《中华人民共和国卫生部药品标准.蒙药分册》", 31 December 1998 * |
| 刘续芳，等: "蒙药黄柏八味散微生物限度检查方法验证", 《中国民族医药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103394056A (en) * | 2013-07-19 | 2013-11-20 | 苏州市天灵中药饮片有限公司 | Traditional Chinese medicine containing liquorice and preparation method thereof |
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Application publication date: 20130130 |