CN102886102A - Mirror movement neuromodulation system - Google Patents
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Abstract
The invention discloses a mirror movement neuromodulation system, which comprises a plurality of lead biological signal amplifiers, a microcomputer controller, a plurality of lead functional electric stimulators and a micro-current direct-current constant-current stimulator. The principle that functional electric stimulation and transcranial direct-current electric stimulation techniques and mirror movement neurons participate in movement control is applied comprehensively, the biological signal amplifiers, the functional electric stimulators for simulating integrated electromyography envelope signal control, and the micro-current direct-current constant-current stimulator are integrated through the microcomputer controller, myoelectric activity envelope signals are generated by processing myoelectric signals of a plurality of muscle groups which move functionally by using an uninjured side limb, and the plurality of functional electric stimulators are modulated and controlled, so that the same mirror action is generated by the plurality of muscle groups of an injured limb on an opposite side according to uninjured side myoelectric information, brain functional regulation and reconstruction are realized, the plasticity of neuronal synapsis and the recovery of neurological functions are facilitated, and the treatment effect of sports rehabilitation is achieved.
Description
Technical field
The present invention relates to neural rehabilitation technique field, relate in particular to a kind of mirror movements neuromodulation system for hemiplegia patient treatment behind apoplexy and the central nervous system injury.
Background technology
Central nervous system pathological change usually causes the human motion dysfunction, and modal is inclined to one side side quadriplegia, affects greatly patient's work and life, and has also brought white elephant for family and society.
Traditional medical rehabilitation means mainly are that its Therapeutic Method and therapeutic effect are limited by acupuncture, massage, physical exercise therapy and the passive treatment of physical therapy.In recent years along with scientific research and the development of neuroscience and clinical rehabilitation medicine, the nervimotion therapy of some new nervous physiology theories and delayed ischemic neurological deficits is successively proposed, such as the regeneration of nerve injury, reconstruction, function compensation is theoretical, motor relearning is theoretical, functional electric stimulation (FES), biofeedback therapy, the new Therapeutic Method such as therapy, transcranial magnetic stimulation therapy, robot assisted treatment are observed in forced movement therapy, motion imagination therapy, action, and utilize recently visual feedback, see the strong lateral movement of mirror the mirror movements therapy.These treatments have often only utilized the partial nerve movement mechanism to promote rehabilitation, and curative effect is unsatisfactory.Neural controlled motion is sensation, motion driving, emotion, the common result who regulates in multi-functional, the multiple neural feedback of memory loop, therefore will increase neural rehabilitation and will transfer more neuron participation as far as possible.
Mirror neuron is the in recent ten years new discovery of Neuroscience Research, at first found that the monkey class just had discharge activities to make the mirror image nerve of echopraxia when seeing action in 1996, application magnetic resonance in 1998 and transcranial magnetic stimulation technology find that again the human brain multiple location equally also has mirror neuron system.Studies have shown that the mirror image nervous system is the neuro-physiological mechanism of movement observation, the imagination, imitation, study and nerve function rebuilding.
A kind of ancient and new electrotherapy method of re-recognizing, rediscovering through cranium galvanic stimulation (tDCS).Use the noinvasive weak current, regulate the tranquillization level of brain nervous cell transmembrane potential with the model of action of electric field polarization, the local potential of the cell that affects the nerves changes excited threshold value, and positive polar stimulation can make nerve excitability increase, and negative pole stimulates inhibition function of nervous system.With negative pole stimulate strong side brain, positive polar stimulation Ipsilateral brain can direct excited Ipsilateral brain, suppress strong side cortex to the inhibition of Ipsilateral.
Summary of the invention
Main purpose of the present invention provides a kind of take the mirror movements neuromodulation as main rehabilitation system, be intended to utilize more motion assist mechanism to realize the brain function regulation and control and rebuild, promote the plasticity of nerve synapse and the rehabilitation of function of nervous system, improve central hemiplegic patient's therapeutic effect.
In order to achieve the above object, the present invention proposes a kind of mirror movements neuromodulation system, comprising: some bio-signals amplifiers that lead, the information of the surface electromyogram signal when being used for gathering strong side limb activity;
Microcomputer controller is used for described surface electromyogram signal is processed, and forms the dynamic myoelectricity envelope shape command signal of analog integration;
Some functional electrical stimulatos that lead are used for the dynamic myoelectricity envelope shape command signal according to described strong side limbs analog integration, stimulate the mirror movements of the similar synchronous of offside affected limb generation with the image current of equal proportion motion.
Preferably, described some bio-signals amplifiers that lead have detecting electrode, and described detecting electrode is attached to the respective muscle position of the strong side limbs of patient; Described some functional electrical stimulatos that leads have stimulating electrode, and described stimulating electrode is attached to the corresponding muscle position of patient's affected limb.
Preferably, this system also comprises: processor, be connected between described bio-signals amplifier and the microcomputer controller, and be used for that described surface electromyogram signal is carried out AD conversion, amplification, rectification, filtering and integrating circuit and process.
Preferably, described microcomputer controller mode that described surface electromyogram signal is processed comprises: AD conversion, digital filtering and wavelet analysis are processed.
Preferably, this system also comprises: little current DC constant current stimulator, be connected with described microcomputer controller, its anodal head position that connects the leather Representative Region of affected limb, negative pole connects the corresponding head surface of strong side, is used for when the periphery limbs produce mirror movements the collaborative brain leather neuron that stimulates of little current DC electricity irritation of head, regulate and increase the irritability of Ipsilateral brain, jointly promote the recovery of impaired cortex hormone function.
What preferably, described little current DC constant current stimulator was selected is high voltage operational amplifier and constant-current source circuit.
Preferably, the stimulating current of described little current DC constant current stimulator is less than 5mA.
Preferably, described microcomputer controller also is used for time-delay and triggers described functional electrical stimulato, makes the time-delay of affected limb muscular irritation time synchronized, produces the phase alternation motion of strong side limbs and affected limb.
Preferably, described bio-signals amplifier is low noise high impedance instrument amplifier; What described microcomputer controller was selected is the ARM series monolithic.
Preferably, the information of described surface electromyogram signal comprises one of following at least: the activity sequential between the amplitude of electromyographic signal, waveform, activity time, intermittent time, each muscle group.
A kind of mirror movements neuromodulation system that the present invention proposes, integrated application FES, tDCS technology and mirror movements neuron participate in the principle of motor control, utilize bio-signals amplifier, the functional electrical stimulato of simulation myoelectricity integration envelope signal control, little current DC constant current stimulator is under the integration of microcomputer controller, integrated, utilize strong side limbs to carry out the electromyographic signal of some muscle groups of functional activation, through amplifying, rectification, filtering, sampling and Mathematical treatment, produce the myoelectrical activity envelope signal of some functional activity muscle groups, and modulate and control some functional electric stimulations that lead with this, make some muscle groups of the ill limbs of offside according to the activity intensity of strong pleural muscle electricity, Strength Changes, contraction time, intermittent time, the mirror image action that the activity timing sequence generating is same, without mirror, the patient can see and feel that the movable or functional mirror image of the synchronous mirror of bilateral limbs is movable, give full play to patient's mirror image neural, sensory nerve, nervus motorius and motion idea, the nervus centraliss such as motor feedback, the reflex arcs such as peripheral nervous, realize the brain function regulation and control and rebuild, promote the plasticity of nerve synapse, promote the rehabilitation of function of nervous system, thereby reach the therapeutic effect of athletic rehabilitation.
Description of drawings
Fig. 1 is the structured flowchart of mirror movements neuromodulation of the present invention system preferred embodiment;
Fig. 2 is the work process schematic diagram of mirror movements neuromodulation of the present invention system.
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.
The specific embodiment
Should be appreciated that specific embodiment described herein only in order to explain the present invention, is not intended to limit the present invention.
It is historical that mirror neuron system is found existing more than ten years.When the mankind see a kind of new behavior, when imitateing this behavioral activity, one group of special cells of brain premotor area has electric discharge phenomena, and therefore named is mirror neuron, makes their own action no matter be, still see that others makes same action, mirror neuron all can be activated, and its function is to help human motion study, and simulation is imitated, being the important anatomical physiology basis that the nervus motorius network is rebuild, also is the basis of understanding other people behavior.
Present discovery mirror neuron is widely distributed brain, and premotor cortex, top, temporal lobe and island leaf all can be seen a large amount of mirror neurons.Also have in addition a class mirror image neuron, when observing new element, behavior, language, countenance and body gesture, activate.Another kind of mirror neuron then activates when the idea of going to be familiar with when people's attempt after just now observing.Mirror neuron activated when the idea of initiatively being familiar with, imitating, learning as people strengthened, and when cortical excitability improved, the activity of mirror image nerve can make the motor function improvement of limbs.
The mirror image therapy also is a kind of new athletic rehabilitation Therapeutic Method: for example: mirror is placed in the middle of the limbs of both sides with certain angle; the pathological changes limbs be cannot see at the mirror reverse side; make the patient watch strong side limbs in the mirror attentively; to make patient both sides limbs that mirror image is movable simultaneously; because affected limb is hidden by mirror all the time; the patient see the pathological changes limbs can activity in mirror freely; be the non-invasive neural study method for reconstructing that a kind of patient initiatively participates in, effective to the rehabilitation of hemiplegic patient behind apoplexy and the central nervous system injury.
TDCS also is a new technique of re-recognizing, and both combine to use and can strengthen therapeutic effect.
The present invention just is being based on above-mentioned principle, adopt bilateral active exercise and strong lateral wall to help Ipsilateral mirror movements and auxiliary thinking through the cranium galvanic stimulation, take full advantage of multiple nervimotion modulation scheme, active exercise, action observation, mirror movements, imagery motion, biofeedback motion, bilateral movement body sense reflection, functional electric stimulation, integrating through cranium HVDC Modulation technology, is a kind of brand-new neural rehabilitation Comprehensive Treatment technology.The present invention gives full play to reflex arc, little direct currents such as nervus centralis, peripheral nervous such as patient's mirror image nerve, sensory nerve, nervus motorius and motion idea, movable body sense feedback the cerebral cortex function is modulated, realize the modulation of Ipsilateral brain and rebuild, promote the plasticity of nerve synapse, promote the rehabilitation of function of nervous system, thereby reach the therapeutic effect of athletic rehabilitation.
Particularly, as shown in Figure 1, preferred embodiment of the present invention proposes a kind of mirror movements neuromodulation system, be mainly used in treating rehabilitation training and the treatment of central hemiplegic patient, this mirror movements neuromodulation system comprises: some bio-signals amplifiers that lead 1, microcomputer controller 2, some functional electrical stimulatos that leads 3, wherein:
The input of bio-signals amplifier 1 has detecting electrode 11, the input of functional electrical stimulato 3 has stimulating electrode 31, the detecting electrode 11 of the input of some bio-signals amplifiers that lead 1 and the stimulating electrode 31 of some functional electrical stimulatos that lead 3, form with lamellar is attached to respectively strong side (measurement myoelectricity), Ipsilateral is muscle group body surface position one to one, the detecting electrode 11 that is bio-signals amplifier 1 is attached to the respective muscle position that the patient is good for the side limbs, and the stimulating electrode 31 of functional electrical stimulato 3 is attached to the corresponding muscle position of patient's affected limb.
The information of the surface electromyogram signal when bio-signals amplifier 1 is used for gathering strong side limb activity, the information of this surface electromyogram signal comprises the activity sequential between the amplitude of electromyographic signal, waveform, activity time, intermittent time, each muscle group etc.
The dynamic myoelectricity envelope shape command signal that some functional electrical stimulatos that lead 3 are used for according to described analog integration stimulates the affected limb of strong side limbs offside to produce the mirror movements of equal proportion synchronous with the equal proportion image current.Stimulate offside mirror image muscle to produce the equal proportion synchronous by the equal proportion image current, when the Ipsilateral muscle contraction, both produced real mirror movements, make again Ipsilateral muscle obtain functional exercise, make the somesthetic sensibility sensors such as intramuscular tendon, muscle-spindle excited, participate in the feedback regulation in sensation nervus motorius loop and the reconstruction of reflex arc, better promote the rehabilitation of Ipsilateral nervus motorius function.
For better effects on surface electromyographic signal is processed, the present embodiment mirror movements neuromodulation system further comprises: processor 4, this processor 4 is connected between described bio-signals amplifier 1 and the microcomputer controller 2, is used for that described surface electromyogram signal is carried out AD conversion, amplification, rectification, filtering and integrating circuit and processes.
The information such as activity sequential between the amplitude of the electromyographic signal on the strong side limb muscle surface of bio-signals amplifier 1 collection, waveform, activity time, intermittent time, each muscle group.Afterwards with collected 4 amplifications of information process processor, Filtering Processing, consider and remove the frequency irrelevant with signal, through over commutation and integrating circuit, signal is changed through AD, in mathematical processing methods such as microcomputer controller 2 interior employing wavelet analysises, form the analog integration network signal movable consistent with strong pleural muscle meat, use sort signal as the control instruction signal, the output of the functional electrical stimulato 3 of regulation and control respective channel makes affected limb produce the synchronous mirror motion.
In addition, for the collaborative brain leather neuron that stimulates, the present embodiment mirror movements neuromodulation system further comprises little current DC constant current stimulator 5, this little current DC constant current stimulator 5 is connected with described microcomputer controller 2, the positive pole of little current DC constant current stimulator 5 connects the head position of the cortical representation of affected limb, increase irritability and the blood flow of Ipsilateral brain, negative pole connects the corresponding head surface of strong side, suppresses strong side hemisphere to the inhibition of Ipsilateral.Be used for when the periphery limbs produce mirror movements, little current DC electricity irritation of head is worked in coordination with stimulates brain leather neuron, regulates and increase the irritability of Ipsilateral brain, jointly promotes the recovery of impaired cortex hormone function.
Because, the bilateral brain is mutually coordination and interinhibitive to the control of motor function, after one-sided brain brain motor function damage, Ipsilateral cortex disappears to the inhibition of strong side brain, and strong lateral movement cortex is to the inhibitory action enhancing of Ipsilateral motor cortex, the normal excited function of recovery that is unfavorable for Ipsilateral brain injured nerve, therefore need with the corticocerebral irritability of little electric current regulation and control bilateral, suppress strong side brain to the inhibition of Ipsilateral with cathodal current, strengthen the corticocerebral irritability of Ipsilateral, with the mirror movements treatment effect collaborative and the increase curative effect is arranged.
What the above-mentioned little current DC constant current stimulator 5 of the present embodiment was selected is high voltage operational amplifier and constant-current source circuit, and this instrument has the function that stimulates through the cranium direct electric current.The stimulating current of described little current DC constant current stimulator 5 is less than 5mA.
Described bio-signals amplifier 1 can adopt low noise high impedance instrument amplifier, and this instrument has various bioelectrical signals measuring abilities, can detect electrocardio, brain electricity and electromyogram signal.
What described microcomputer controller 2 was selected is the ARM series monolithic, and this instrument has quick, high-precision mathematical operation function.
Above-mentioned microprocessor 4 can adopt the analog integration electric stimulator with microcomputer controller 2, what this analog integration electric stimulator was selected is operational amplifier, through high-frequency diode arrangement, digital filtering, micro computer wavelet analysis, detect and smoothing processing through peak value, obtain the surface electromyogram signal of real-time synchronization.This instrument has checking with EMG method, analysis and myoelectricity envelope signal abstraction function.
The myoelectricity bio signal of polylith muscle when the present embodiment is moved by the strong side limb function of multi-lead biological amplifier collection, become analog integration myoelectricity envelope signal by rectifying and wave-filtering and Computer Processing, as the command signal that stimulates the some respective muscle mirror movementses of offside, modulation multi-lead functional electric stimulation drives the mirror movements of affected limb respective muscle, because strong side cortex nervus motorius can produce the mutual inhibition to Ipsilateral brain motor region, anelectrode with little current DC constant current stimulator 5 stimulates the Ipsilateral brain, negative electrode places the scalp position of strong side brain motor region, reduce strong side brain to the inhibition of Ipsilateral brain, improve Ipsilateral cerebral nerve irritability.Brain mirror neuron active mechanism during present technique simulation human body study motion, excite mirror neuron movable, allow patient initiatively participate in, transfer the bilateral brain movable simultaneously, be a kind of non-invasive neural Active Learning reconstruction technique, help patient's injured nerve reconstruction and rehabilitation.
Below in conjunction with Fig. 2 the operation principle of the present embodiment is elaborated as follows:
During use, detecting electrode 11 and stimulating electrode 31 are attached to respectively patient's strong side and the corresponding muscle of Ipsilateral position, when the strong side limbs of patient moving, 11 information of collecting strong side limb muscle surface electromyogram signal of the detecting electrode of biological amplifier input, through amplifying, rectification, the processing of filtering and integrating circuit, again through the AD conversion of microcomputer controller 2 self, the Mathematical treatment such as digital filtering and wavelet analysis, produce the strong integration envelope electromyographic signal of pleural muscle group when functional activity, modulation is used for the output of the functional electrical stimulato 3 of affected limb, in order to produce the mirror movements of affected limb.
With the following little electric current of little current DC constant current stimulator 5 output 5mA, with positive polar stimulation Ipsilateral brain head movement district, negative pole stimulates strong side brain corresponding sports district simultaneously.When the periphery limbs produce mirror movements, the collaborative brain leather neuron that stimulates of little current DC electricity irritation of head, the irritability of adjusting and increase Ipsilateral brain promotes the answer of impaired cortex hormone function jointly.
In addition, microcomputer controller 2 can also be delayed time and be triggered described functional electrical stimulato 3, makes the time-delay of affected limb muscular irritation time synchronized, produces the phase alternation motion of strong side limbs and affected limb.
Particularly, the present invention can utilize the functional electric physiological activity of strong nervus lateralis muscle, the motion of control offside diseased muscles generation synchronous mirror, also can trigger by time-delay, the asynchronous Coordinating Activity during as functional lock by the asynchronous stimulation Ipsilateral of signal sequence of strong each passage of side, simulation bilateral limbs suppress alternately, shrink in turn, as upper limb, the in turn alternating movement of lower limb of walking, finish walking function.
Embodiment of the invention mirror movements neuromodulation system, integrated application FES, tDCS technology and mirror movements neuron participate in the principle of motor control, utilize bio-signals amplifier 1, the functional electrical stimulato 3 of simulation myoelectricity integration envelope signal control, little current DC constant current stimulator 5 is under the integration of microcomputer controller 2, integrated, utilize strong side limbs to carry out the electromyographic signal of some muscle groups of functional activation, through amplifying, rectification, filtering, sampling and Mathematical treatment, produce the myoelectrical activity envelope signal of some functional activity muscle groups, and modulate and control some functional electric stimulations that lead with this, make some muscle groups of the ill limbs of offside according to the activity intensity of strong pleural muscle electricity, Strength Changes, contraction time, intermittent time, the mirror image action that the activity timing sequence generating is same, without mirror, the patient can see and feel that the movable or functional mirror image of the synchronous mirror of bilateral limbs is movable, fully activate with transfer patient mirror image neural, sensory nerve, nervus motorius and motion drive idea, the nervus centraliss such as motor feedback, the peripheral nervous reflex arc, participate in realizing the brain function regulation and control and rebuild, promote the plasticity of nerve synapse, promote the rehabilitation of function of nervous system, thereby reach the therapeutic effect of athletic rehabilitation.
The present invention is as a kind of innovative means of novel exercise therapy, simple, easy to learn, be easy to do, efficiently, safety, increased a kind of new Therapeutic Method for the nervimotion rehabilitation.The phase alternation that simultaneously the present invention can also make the time-delay of Ipsilateral muscular irritation time synchronized by computer control programming, produce strong side and affected limb moves, suppresses alternately being synchronized with the movement and asynchronous movement of motion, mirror movements, coordination.
The above only is the preferred embodiments of the present invention; be not so limit claim of the present invention; every equivalent structure or equivalent flow process conversion that utilizes description of the present invention and accompanying drawing content to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present invention.
Claims (10)
1. a mirror movements neuromodulation system is characterized in that, comprising:
Some bio-signals amplifiers that lead, the information of the surface electromyogram signal when being used for gathering strong side limb activity;
Microcomputer controller is used for described surface electromyogram signal is processed, and forms the dynamic myoelectricity envelope shape command signal of analog integration;
Some functional electrical stimulatos that lead are used for the dynamic myoelectricity envelope shape command signal according to described analog integration, stimulate the affected limb of strong side limbs offside to produce the mirror movements of equal proportion synchronous with the equal proportion image current.
2. mirror movements neuromodulation according to claim 1 system is characterized in that, described some bio-signals amplifiers that lead have detecting electrode, and described detecting electrode is attached to the respective muscle position of the strong side limbs of patient; Described some functional electrical stimulatos that leads have stimulating electrode, and described stimulating electrode is attached to the corresponding muscle position of patient's affected limb.
3. mirror movements neuromodulation according to claim 2 system, it is characterized in that, also comprise: processor, be connected between described bio-signals amplifier and the microcomputer controller, be used for that described surface electromyogram signal is carried out AD conversion, amplification, rectification, filtering and integrating circuit and process.
4. mirror movements neuromodulation according to claim 3 system is characterized in that, the mode that described microcomputer controller is processed described surface electromyogram signal comprises: AD conversion, digital filtering and wavelet analysis are processed.
5. mirror movements neuromodulation according to claim 4 system, it is characterized in that, also comprise: little current DC constant current stimulator, be connected with described microcomputer controller, its anodal head position that connects the leather Representative Region of affected limb, negative pole connects the corresponding head surface of strong side, be used for when the periphery limbs produce mirror movements, the collaborative brain leather neuron that stimulates of little current DC electricity irritation of head, regulate and increase the irritability of Ipsilateral brain, jointly promote the recovery of impaired cortex hormone function.
6. mirror movements neuromodulation according to claim 5 system is characterized in that, what described little current DC constant current stimulator was selected is high voltage operational amplifier and constant-current source circuit.
7. mirror movements neuromodulation according to claim 6 system is characterized in that, the stimulating current of described little current DC constant current stimulator is less than 5mA.
8. each described mirror movements neuromodulation system according to claim 1-7, it is characterized in that, described microcomputer controller also is used for time-delay and triggers described functional electrical stimulato, make the time-delay of affected limb muscular irritation time synchronized, produce the phase alternation motion of strong side limbs and affected limb.
9. mirror movements neuromodulation according to claim 8 system is characterized in that, described bio-signals amplifier is low noise high impedance instrument amplifier; What described microcomputer controller was selected is the ARM series monolithic.
10. mirror movements neuromodulation according to claim 1 system is characterized in that, it is one of following that the information of described surface electromyogram signal comprises at least: the activity sequential between the amplitude of electromyographic signal, waveform, activity time, intermittent time, each muscle group.
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