CN102885916A - Traditional Chinese medicine composition for oral medication of canine corneal ulcer - Google Patents
Traditional Chinese medicine composition for oral medication of canine corneal ulcer Download PDFInfo
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- CN102885916A CN102885916A CN2012104182029A CN201210418202A CN102885916A CN 102885916 A CN102885916 A CN 102885916A CN 2012104182029 A CN2012104182029 A CN 2012104182029A CN 201210418202 A CN201210418202 A CN 201210418202A CN 102885916 A CN102885916 A CN 102885916A
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Abstract
The invention provides a traditional Chinese medicine composition for oral medication of canine corneal ulcer, which consists of the following components according to parts by weight: 5-500 parts of gentian, 5-500 parts of radix scutellariae, 5-500 parts of Chinese goldthread, 5-500 parts of Gardenia, 5-300 parts of Plantago, 5-250 parts of radix bupleuri, and 5-250 parts of liquorice. According to the technical scheme provided by the invention, the phenomena of photophobia and serous eye secretion increase of dogs can be obviously improved, and the phenomena of eyelid swelling, congestion rubeosis and pain of sick dogs are eliminated; and eye secretions gradually become clear from serosity, the inflammation around eyelids is alleviated, ocular hair is gradually grown, the vision obviously recovers, and the canine corneal ulcer is efficiently cured.
Description
Technical field
The invention belongs to field of traditional Chinese veterinary, especially relate to a kind of Chinese medicine composition for the treatment of the dog corneal ulcer.
Background technology
Keratitis is the common oculopathy of dog class, and the generation of primary disease is many, and there was dampness in the air in season in spring and autumn, and Mosquito Breeding is many, and is dry during winter, more this disease that also easily causes of sand and dust in the air.
Because cornea is positioned at the eyeball front, is the thin film of the top layer of transparent of eyeball, its smooth surface is transparent, without blood vessel, is the refractive media important component part, has dioptric and the tolerant effect of protection ophthalmic; Cornea directly contacts with extraneous, is subject to wound and infection; Do not have vascular tissue on the cornea, be restricted at nutrition supply, metabolism is slower, and the reaction that is inflamed by infection is also more blunt; Simultaneously the cornea quality is transparent, and slight pathological changes just can cause visual deterioration and corneal ulcer in various degree, have in addition cause perforation of cornea.So should in time treat when the cornea inflammation and when ulcer occurring, cause this eye vision forfeiture in order to avoid at the ulcer kitchen range perforation occurs, even secondary panophthalmitis and threat to life.
When the dog class was suffered from Corneal Ulcer, thinner canescence or white casse can appear in one or both sides simultaneously, and the surface forms corneal macula or corneal leukoma, the approximately transparent vesicle of 2mm size of projection appears in individual other anterior corneal surface, corneal dyeing is negative, hypopyon, descemet's membrane bulging.This onset of disease symptom is lighter, and course advancement is slow, and photophobia is only arranged, shed tears, slight foreign body sensation, and basic hospital medical condition and professional standards relative deficiency, easily out in the cold, add that primary disease often has sings and symptoms to separate, and more easily causes mistaken diagnosis.Therefore, if any the crops trauma history, the not swift and violent person of any serpiginous corneal ulcer disease progression, should consider the probability of fungal infection, especially to once using the corneal ulcer of hormone therapy, though with the broad ectrum antibiotic person that also do not prove effective, more should consider fungal infection.With good conditionsily in time do the scraping blade fungal culture, should in time do antifungal and Comprehensive Treatment in case make a definite diagnosis.
Dog suffers from the intractable corneal ulcer, photophobia generally can occur, shed tears and blepharospasm.What corneal epithelium was loose is attached on the corneal stroma, ulcer disunion of a specified duration (the corneal ulcer medical history may reach more than 1 month), and fluorescent staining is positive.
Many the stabbing because of intrusion, sharp instruments such as bump, foreign body and sand and dust of the generation of dog keratoconjunctivitis cause, allergy and corneal nutrition imbalance also can cause this disease.
Primary disease occurs comparatively common clinically, symptom is directly perceived, it is comparatively convenient to diagnose, if but singly take traditional method during clinical treatment, especially for the case of the corneal ulcer that is caused by febrile diseases such as infectious canine hepatitis, canine distemper or traumatic corneal ulcer, usually with anti-inflammation drugs and acupuncture-moxibustion therapy method treatment, use this class methods treatment, the general course for the treatment of is longer, and often onset is very slow, poor effect, even easily cause the blind of dog.
Summary of the invention
In order to overcome above-mentioned deficiency, the invention provides a kind of Chinese medicine composition of oral medication dog corneal ulcer evident in efficacy.
Concrete scheme of the present invention is: a kind of Chinese medicine composition of oral medication dog corneal ulcer, meter comprises following component: Radix Gentianae 5-500 part, Radix Scutellariae 5-500 part, Rhizoma Coptidis 5-500 part, Fructus Gardeniae 5-500 part, Herba Plantaginis 5-300 part, Radix Bupleuri 5-250 part, Radix Glycyrrhizae 5-250 part by weight.
During concrete the use, meter mixes above-mentioned Chinese medicine composition by weight, with the ratio of adding entry be 1:4-15, decoction is removed slag, and gavages as one feels fit according to sick dog size, 1-2 times/day, being used in conjunction 5 ~ 7 days is a course for the treatment of.
Further, above-mentioned Chinese medicine composition is counted by weight by following component and is formed: 150 parts of Radix Gentianae, 200 parts of Radix Scutellariaes, 150 parts of Rhizoma Coptidis, 200 parts of Fructus Gardeniaes, 150 parts of Herba Plantaginis, 150 parts of Radix Bupleuri, 100 parts in Radix Glycyrrhizae.
During concrete the use, add entry 8000ml, fry in shallow oil to 6500ml, seriously ill meat dog gavages with 20 ~ 50ml by force according to size, 1 times/day, is used in conjunction 5 ~ 7 days.
In the clinical trial, choose 46 routine keratoconjunctivitises and suffer from dog, use scheme provided by the invention to treat:
1) incidence
In the 46 routine sick dogs, in the majority with small-sized dog from build, be 34 examples, account for 74% of total morbidity number, its Zhong jing bar dog 22 examples, Chinese sharpei 7 examples, rich U.S. dog 3 examples, Bulldog and Shih Tzu 1 example.From age of onset, in the majority with adult dogs, be 32 examples, account for 70% of total morbidity number, 1～3 years old dog 28 example wherein, dog 4 examples more than 3 years old.From morbidity season, in the majority with the spring and autumn morbidity, be 30 examples, account for 66% of total morbidity number.
2) clinical symptoms
Trouble dog their early stage shows as photophobia more, the serosity discharge of eye increases, sick dog eyelid swelled, and congested flushing, pain, the canescence spray appears in cornea central authorities.Along with the prolongation of the course of disease, discharge of eye transfers purulence to from serosity gradually, and is obviously red and swollen around the eyelid, and depilation occurs.When last serious, upper palpebra inferior is bonded together by purulent secretion, and cornea central authorities spray becomes dense, the ulcer kitchen range finally occurs, and visual deterioration is blind when serious.
3) clinical diagnosis
Can make being diagnosed as corneal ulcer from the clinical manifestation of suffering from dog, such as the increasing and progressively transfer purulence to from serosity of secretions, the pain of eyelid and congested swelling, the cornea surface is from ulcer when serious of the cloud thing of initial appearance, perforation etc.
4) therapeutic outcome
Above-mentioned 46 examples are suffered from dog, use Chinese medicine composition provided by the invention to treat, therapeutic effect is obvious, all cures.Wherein for the dog of their early stage, adopt and to take effect in above method 1-3 days, ill more serious dog, general 3-5 days rear visible positive effects, treatment 1-2 week recovery from illness.
Beneficial effect of the present invention is: effectively cure the dog corneal ulcer, significantly improve photophobia, the serosity discharge of eye of suffering from dog and increase phenomenon, sick dog eyelid swelled, congested flushing, pain phenomenon disappear.Discharge of eye transfers to limpid gradually from serosity, red and swollen phenomenon alleviates around the eyelid, and the ocular hair of sloughing is grown gradually, and vision is obviously replied.
The specific embodiment
The invention will be further described below by specific embodiment, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
3 the monthly age Shih Tzu, cornea of left eye is haze, shed tears, caligation, ill first quarter moon is had a surplus, use this programme to treat: Radix Gentianae 45g, Radix Scutellariae 60g, Rhizoma Coptidis 45g, Fructus Gardeniae 60g, Herba Plantaginis 45g, Radix Bupleuri 45g, Radix Glycyrrhizae 30g, add water 2000ml, fry in shallow oil to 1500ml, 25ml gavages by force, 1-2 times/day, be used in conjunction 5 ~ 7 days.Cornea gradual change indigo plant after 1 week for the treatment of, symptom all disappears after 2 weeks.
Embodiment 2
1 year old Beijing dog, because of external force damage cornea of left eye, rear formation total corneal cloud father-in-law, white can not be looked thing such as mist, use this programme to treat: Radix Gentianae 30g, Radix Scutellariae 40g, Rhizoma Coptidis 30g, Fructus Gardeniae 40g, Herba Plantaginis 30g, Radix Bupleuri 30g, Radix Glycyrrhizae 20g, add water 1500ml, fry in shallow oil to 800ml, 30ml gavages by force, 1-2 times/day, be used in conjunction 5 ~ 7 days.After treating for 1 week, the cloud father-in-law is disappeared to the red size of core, has recovered vision.
Embodiment 3
Suffer from dog and show as Corneal Ulcer, thinner canescence or white casse appear in one or both sides simultaneously, and the surface forms corneal macula or corneal leukoma, the approximately transparent vesicle of 2mm size of projection appears in individual other anterior corneal surface, corneal dyeing is negative, hypopyon, descemet's membrane bulging.Use this programme to treat: Radix Gentianae 50g, Radix Scutellariae 65g, Rhizoma Coptidis 50g, Fructus Gardeniae 65g, Herba Plantaginis 50g, Radix Bupleuri 50g, Radix Glycyrrhizae 35g, add water 2000ml, fry in shallow oil to 1500ml, 35ml gavages by force, 1-2 times/day, is used in conjunction 5 ~ 7 days.Take a turn for the better after 1 week, after 2 weeks of taking medicine continuously, transference cure.
Embodiment 4
One capital bar dog, public dog, 5 years old, body weight 8.3kg, clinical examination finds that cornea of left eye has a diameter 6mm ulcer kitchen range, ulcer is centered close to the CC upper part of slightly taking back, to be the volcano shape of the mouth as one speaks outstanding to the eyeball outer surface for cornea tissue around the ulcer kitchen range, and color is light blue, and several dendroid blood vessels are from cornea and sclera junction to the ulcer range edge, almost be covered with whole cornea, at the existing lightpink granulation tissue hyperplasia of ulcer kitchen range base portion.Other clinical symptoms and check result: 39.8 ℃ of body temperature, hyperfunction, the yellowish or reddish urine of drink wish, stool are thick soft, owner described this dog and began to occur anorexia before 2 week, cornea of left eye becomes blueness overnight before 1 week, use afterwards the Chloramphenicol Eye Drop eye dripping, cornea is only tapered to by large stretch of blueness and is being blue near the CC position, obviously outwards gave prominence to but should locate cornea tissue, suffered from eye because trouble dog refusal eye dripping and warp forelimb commonly used is scratched afterwards, and caused this state of an illness sharply to worsen.
Blood test: erythrocyte 4.93 * 10
12/ L, leukocyte 10.27 * 10
9/ L, ALT 276U/L, ALP1033U/L.
Diagnosis: suspect that in conjunction with clinical symptoms and hematological results this dog suffers from infectious canine hepatitis, adopt CAV quick diagnosis reagent kit testing result positive, make a definite diagnosis this dog and suffer from infectious canine hepatitis, because the keratitis that virus causes does not obtain in time comprehensively treating in addition exopathogenic factor and antibacterial secondary infection, causes keratitis to develop into corneal ulcer.
Use this programme to treat: Radix Gentianae 45g, Radix Scutellariae 60g, Rhizoma Coptidis 45g, Fructus Gardeniae 60g, Herba Plantaginis 45g, Radix Bupleuri 45g, Radix Glycyrrhizae 30g, add water 2000ml, fry in shallow oil to 1500ml, 25ml gavages by force, 1-2 times/day, is used in conjunction 5 ~ 7 days.Take a turn for the better after 1 week, after 2 weeks of taking medicine continuously, transference cure.
Above preferred embodiment of the present invention is had been described in detail, but described content only is preferred embodiment of the present invention, can not be considered to be used to limiting practical range of the present invention.All equalizations of doing according to the present patent application scope change and improve etc., all should still belong within the patent covering scope of the present invention.
Claims (2)
1. the Chinese medicine composition of an oral medication dog corneal ulcer, it is characterized in that counting by weight, comprise following component: Radix Gentianae 5-500 part, Radix Scutellariae 5-500 part, Rhizoma Coptidis 5-500 part, Fructus Gardeniae 5-500 part, Herba Plantaginis 5-300 part, Radix Bupleuri 5-250 part, Radix Glycyrrhizae 5-250 part.
2. Chinese medicine composition as claimed in claim 1 is characterized in that counting by weight by following component and forms: 150 parts of Radix Gentianae, 200 parts of Radix Scutellariaes, 150 parts of Rhizoma Coptidis, 200 parts of Fructus Gardeniaes, 150 parts of Herba Plantaginis, 150 parts of Radix Bupleuri, 100 parts in Radix Glycyrrhizae.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210418202.9A CN102885916B (en) | 2012-10-26 | 2012-10-26 | A kind of Chinese medicine composition of oral medication dog corneal ulcer |
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| CN201210418202.9A CN102885916B (en) | 2012-10-26 | 2012-10-26 | A kind of Chinese medicine composition of oral medication dog corneal ulcer |
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| CN102885916B CN102885916B (en) | 2015-11-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121012A (en) * | 2007-08-08 | 2008-02-13 | 李金山 | Traditional Chinese medicine for treating external oculopathy eye disease |
| CN101167890A (en) * | 2007-09-20 | 2008-04-30 | 吴月 | Traditional Chinese medicine for treating superficial punctuate keratitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101121012A (en) * | 2007-08-08 | 2008-02-13 | 李金山 | Traditional Chinese medicine for treating external oculopathy eye disease |
| CN101167890A (en) * | 2007-09-20 | 2008-04-30 | 吴月 | Traditional Chinese medicine for treating superficial punctuate keratitis |
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Effective date of registration: 20190102 Address after: No. 38 Huafeng Road, Beichen Economic and Technological Development Zone, Tianjin 300400 Patentee after: Shengshi Jialian (Tianjin) Biotechnology Co., Ltd. Address before: No. 27 Samsung Road, Zhongbei Industrial Park, Xiqing District, Tianjin 300380 Patentee before: Srick (Tianjin) Bio-Technology Co., Ltd. |
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