CN102885916B - A kind of Chinese medicine composition of oral medication dog corneal ulcer - Google Patents

A kind of Chinese medicine composition of oral medication dog corneal ulcer Download PDF

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Publication number
CN102885916B
CN102885916B CN201210418202.9A CN201210418202A CN102885916B CN 102885916 B CN102885916 B CN 102885916B CN 201210418202 A CN201210418202 A CN 201210418202A CN 102885916 B CN102885916 B CN 102885916B
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dog
radix
corneal ulcer
corneal
chinese medicine
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CN102885916A (en
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裴毅
王洪杰
刘志辉
苏永鹏
黄健
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Shengshi Jialian (Tianjin) Biotechnology Co., Ltd.
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SRICK (TIANJIN) BIO-TECHNOLOGY Co Ltd
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Abstract

The invention provides a kind of Chinese medicine composition of oral medication dog corneal ulcer, count by weight, comprise following component: Radix Gentianae 5-500 part, Radix Scutellariae 5-500 part, Rhizoma Coptidis 5-500 part, Fructus Gardeniae 5-500 part, Herba Plantaginis 5-300 part, Radix Bupleuri 5-250 part, Radix Glycyrrhizae 5-250 part.Technical scheme provided by the invention can significantly improve suffer from the photophobia of dog, serosity discharge of eye increases phenomenon, sick dog eyelid swelled, congested flushing, pain phenomenon disappear; Discharge of eye transfers to limpid gradually from serosity, the red and swollen phenomenon of surrounding eyelids alleviates, and the ocular hair sloughed grows gradually, and vision is obviously replied, and effectively cures dog corneal ulcer.

Description

A kind of Chinese medicine composition of oral medication dog corneal ulcer
Technical field
The invention belongs to field of traditional Chinese veterinary, especially relate to a kind of Chinese medicine composition for the treatment of dog corneal ulcer.
Background technology
Keratitis is the common oculopathy of dog class, and the generation of primary disease is many, and in season in spring and autumn, there was dampness in the air, and Mosquito Breeding is many, dry during winter, and in air, sand and dust are more also easily causes this disease.
Because cornea is positioned at before eyeball, be the thin film of the layer of transparent of eyeball foremost, its smooth surface is transparent, without blood vessel, is refractive media important component part, the effect having dioptric and protect ophthalmic tolerant; Cornea directly and extraneous contact, is subject to wound and infection; Cornea does not have vascular tissue, nutrition supply is restricted, metabolism is comparatively slow, and the reaction that is inflamed by infecting is also more blunt; Simultaneously cornea quality is transparent, and slight pathological changes just can cause visual deterioration in various degree and corneal ulcer, and what have even causes perforation of cornea.So should treat in time when working as corneal inflammation and occur ulcer, in order to avoid cause this eye vision to be lost in ulcer stove generation perforation, even secondary panophthalmitis and threat to life.
When dog class suffers from Corneal Ulcer, can there is thinner canescence or white casse in one or both sides simultaneously, and surface forms corneal macula or corneal leukoma, other anterior corneal surface individual occurs that projection is about the transparent vesicle of 2mm size, corneal dyeing is negative, hypopyon, descemet's membrane bulging.This onset of disease symptom is comparatively light, and course advancement is slow, only has photophobia, sheds tears, slight foreign body sensation, and basic hospital medical condition and professional standards relative deficiency, easily out in the cold, add that primary disease often has sings and symptoms to be separated, more easily cause mistaken diagnosis.Therefore, if any crops trauma history, the not swift and violent person of any serpiginous corneal ulcer disease progression, the probability of fungal infection should be considered, especially to the corneal ulcer once using hormone therapy, though also not prove effective person with broad ectrum antibiotic, more fungal infection should be considered.With good conditionsily do scraping blade fungal culture in time, antifungal and Comprehensive Treatment should be done in time once make a definite diagnosis.
Dog suffers from intractable corneal ulcer, generally there will be photophobia, sheds tears and blepharospasm.What corneal epithelium was loose is attached on corneal stroma, ulcer disunion of a specified duration (corneal ulcer medical history may reach more than 1 month), and fluorescent staining is positive.
The generation of dog keratoconjunctivitis many because clashing into, intrusion, the sharp instrument such as foreign body and sand and dust stab and cause, allergy and corneal dystrophy also can cause this disease.
Primary disease occurs comparatively common clinically, symptom is directly perceived, diagnosis more for convenience, if but clinical treatment time singly take traditional method, especially for the case of the corneal ulcer caused by the febrile disease such as infectious canine hepatitis, canine distemper or traumatic corneal ulcer, usual anti-inflammation drugs and acupuncture-moxibustion therapy method treatment, use these class methods to treat, the general course for the treatment of is longer, and often onset is very slow, poor effect, even easily causes the blind of dog.
Summary of the invention
In order to overcome above-mentioned deficiency, the invention provides a kind of Chinese medicine composition of oral medication dog corneal ulcer evident in efficacy.
Concrete scheme of the present invention is: a kind of Chinese medicine composition of oral medication dog corneal ulcer, count by weight, comprise following component: Radix Gentianae 5-500 part, Radix Scutellariae 5-500 part, Rhizoma Coptidis 5-500 part, Fructus Gardeniae 5-500 part, Herba Plantaginis 5-300 part, Radix Bupleuri 5-250 part, Radix Glycyrrhizae 5-250 part.
During concrete use, count by weight, mixed by above-mentioned Chinese medicine composition, be 1:4-15 with the ratio of added water, decoction is removed slag, and considers gavaging, 1-2 times/day according to sick dog size, and being used in conjunction 5 ~ 7 days is a course for the treatment of.
Further, above-mentioned Chinese medicine composition, counts by weight and is made up of following component: Radix Gentianae 150 parts, Radix Scutellariae 200 parts, Rhizoma Coptidis 150 parts, Fructus Gardeniae 200 parts, Herba Plantaginis 150 parts, Radix Bupleuri 150 parts, 100 parts, Radix Glycyrrhizae.
During concrete use, add water 8000ml, decoct to 6500ml, seriously ill meat dog gavages by force according to size 20 ~ 50ml, 1 times/day, is used in conjunction 5 ~ 7 days.
In clinical trial, choose 46 routine keratoconjunctivitises and suffer from dog, use scheme provided by the invention to treat:
1) incidence
In 46 routine sick dogs, from build, in the majority with small-sized dog, be 34 examples, account for 74% of total morbidity number, its Zhong jing bar dog 22 example, Chinese sharpei 7 example, rich U.S. dog 3 example, Bulldog and Shih Tzu 1 example.From age of onset, in the majority with adult dogs, be 32 examples, account for 70% of total morbidity number, wherein 1 ~ 3 years old dog 28 example, more than 3 years old dog 4 example.From morbidity season, in the majority with spring and autumn morbidity, be 30 examples, account for 66% of total morbidity number.
2) clinical symptoms
Trouble dog their early stage shows as photophobia more, serosity discharge of eye increases, and sick dog eyelid swelled, congested flushing, pain, canescence spray appears in Central corneal.Along with the prolongation of the course of disease, discharge of eye transfers purulence to from serosity gradually, and surrounding eyelids is obviously red and swollen, and occurs depilation.Time seriously, upper palpebra inferior is bonded together by purulent secretion, and Central corneal spray becomes dense, finally occurs ulcer stove, visual deterioration, blind time serious finally.
3) clinical diagnosis
Can make from the clinical manifestation of suffering from dog and be diagnosed as corneal ulcer, increasing and progressively transferring purulence to from serosity as secretions, the pain of eyelid and congested swelling, cornea surface is from the initial cloud thing occurred to ulcer time serious, perforation etc.
4) therapeutic outcome
Suffer from dog to above-mentioned 46 examples, use Chinese medicine composition provided by the invention to treat, therapeutic effect is obvious, all cures.Wherein for the dog of their early stage, adopt within above method 1-3 days, can take effect, ill more serious dog, general 3-5 days visible positive effects afterwards, treatment 1-2 week recovery from illness.
Beneficial effect of the present invention is: effectively cure dog corneal ulcer, and the photophobia, the serosity discharge of eye that significantly improve trouble dog increase phenomenon, and sick dog eyelid swelled, congested flushing, pain phenomenon disappear.Discharge of eye transfers to limpid gradually from serosity, the red and swollen phenomenon of surrounding eyelids alleviates, and the ocular hair sloughed grows gradually, and vision is obviously replied.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
3 the monthly age Shih Tzu, cornea of left eye is haze, shed tears, caligation, ill first quarter moon is had a surplus, this programme is used to treat: Radix Gentianae 45g, Radix Scutellariae 60g, Rhizoma Coptidis 45g, Fructus Gardeniae 60g, Herba Plantaginis 45g, Radix Bupleuri 45g, Radix Glycyrrhizae 30g, add water 2000ml, decocts to 1500ml, 25ml and gavage by force, 1-2 times/day, is used in conjunction 5 ~ 7 days.Treat cornea gradual change after 1 week blue, after 2 weeks, symptom all disappears.
Embodiment 2
1 year old Beijing dog, because of external force damage cornea of left eye, rear formation total corneal cloud father-in-law, white, as mist, can not look thing, this programme is used to treat: Radix Gentianae 30g, Radix Scutellariae 40g, Rhizoma Coptidis 30g, Fructus Gardeniae 40g, Herba Plantaginis 30g, Radix Bupleuri 30g, Radix Glycyrrhizae 20g, add water 1500ml, decocts to 800ml, 30ml and gavage by force, 1-2 times/day, is used in conjunction 5 ~ 7 days.After treating 1 week, cloud father-in-law is disappeared to the red size of core, has recovered vision.
Embodiment 3
Suffer from dog and show as Corneal Ulcer, there is thinner canescence or white casse in one or both sides simultaneously, and surface forms corneal macula or corneal leukoma, other anterior corneal surface individual occurs that projection is about the transparent vesicle of 2mm size, corneal dyeing is negative, hypopyon, descemet's membrane bulging.This programme is used to treat: Radix Gentianae 50g, Radix Scutellariae 65g, Rhizoma Coptidis 50g, Fructus Gardeniae 65g, Herba Plantaginis 50g, Radix Bupleuri 50g, Radix Glycyrrhizae 35g, add water 2000ml, and decoct and gavage by force to 1500ml, 35ml, 1-2 times/day, is used in conjunction 5 ~ 7 days.Take a turn for the better after 1 week, after taking medicine continuously 2 weeks, transference cure.
Embodiment 4
One capital bar dog, public dog, 5 years old, body weight 8.3kg, clinical examination finds that cornea of left eye has a diameter to be about 6mm ulcer stove, ulcer is centrally located at CC upper position slightly to the left, around ulcer stove, cornea tissue is that the volcano shape of the mouth as one speaks is outstanding to eyeball outer surface, and color is light blue, and several dendroid blood vessels are from cornea and sclera junction to ulcer range edge, almost be covered with whole cornea, have lightpink granulation tissue hyperplasia at ulcer stove base portion.Other clinical symptoms and check result: body temperature 39.8 DEG C, drink for hyperfunction, yellowish or reddish urine, stool thick soft, owner describes this dog and started to occur anorexia before 2 weeks, before 1 week, cornea of left eye becomes blue overnight, use Chloramphenicol Eye Drop eye dripping afterwards, it is being only blue near CC position that cornea is tapered to by large stretch of blueness, but this place's cornea tissue obviously outwardly, afterwards owing to suffering from dog refusal eye dripping and suffering from eye through conventional forelimb scratching, this state of an illness is caused sharply to worsen.
Blood test: erythrocyte 4.93 × 10 12/ L, leukocyte 10.27 × 10 9/ L, ALT276U/L, ALP1033U/L.
Diagnosis: suspect that this dog suffers from infectious canine hepatitis in conjunction with clinical symptoms and hematological results, CAV quick diagnosis reagent kit testing result is adopted to be positive, make a definite diagnosis this dog and suffer from infectious canine hepatitis, the keratitis caused due to virus does not obtain comprehensively treating exopathogenic factor and antibacterial secondary infection in addition in time, causes keratitis to develop into corneal ulcer.
This programme is used to treat: Radix Gentianae 45g, Radix Scutellariae 60g, Rhizoma Coptidis 45g, Fructus Gardeniae 60g, Herba Plantaginis 45g, Radix Bupleuri 45g, Radix Glycyrrhizae 30g, add water 2000ml, and decoct and gavage by force to 1500ml, 25ml, 1-2 times/day, is used in conjunction 5 ~ 7 days.Take a turn for the better after 1 week, after taking medicine continuously 2 weeks, transference cure.
Above preferred embodiment of the present invention has been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should still belong within patent covering scope of the present invention.

Claims (1)

1. the Chinese medicine composition of an oral medication dog corneal ulcer, it is characterized in that counting by weight, be made up of following component: Radix Gentianae 30-50 part, Radix Scutellariae 40-65 part, Rhizoma Coptidis 30-50 part, Fructus Gardeniae 40-65 part, Herba Plantaginis 30-50 part, Radix Bupleuri 30-50 part, Radix Glycyrrhizae 20-35 part.
CN201210418202.9A 2012-10-26 2012-10-26 A kind of Chinese medicine composition of oral medication dog corneal ulcer Expired - Fee Related CN102885916B (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101121012A (en) * 2007-08-08 2008-02-13 李金山 Traditional Chinese medicine for treating external oculopathy eye disease
CN101167890A (en) * 2007-09-20 2008-04-30 吴月 Traditional Chinese medicine for treating superficial punctate keratitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101121012A (en) * 2007-08-08 2008-02-13 李金山 Traditional Chinese medicine for treating external oculopathy eye disease
CN101167890A (en) * 2007-09-20 2008-04-30 吴月 Traditional Chinese medicine for treating superficial punctate keratitis

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