CN102872313B - Traditional Chinese medicine qi-tonifying and kidney-nourishing decoction for treating henoch-schonlein purpura nephritis - Google Patents
Traditional Chinese medicine qi-tonifying and kidney-nourishing decoction for treating henoch-schonlein purpura nephritis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine qi-tonifying and kidney-nourishing decoction for treating the henoch-schonlein purpura nephritis. The henoch-schonlein purpura nephritis belongs to the category of the traditional Chinese medicine such as 'blood trouble', 'purpura', 'hematuria', 'edema' and the like, and is a disease for injuring the kidney caused by anaphylactoid purpura. The traditional Chinese medicine qi-tonifying and kidney-nourishing decoction selects the raw materials such as gynura divaricata, clerodendrum fortunatum root, clinopodium megalanthum, henry clematis root, astragalus mongholicus, silverweed cinquefoil root, swertia mileensis, ciliate desert-grass, ginseng, root of szechwan-yunnan sanicle, rhizoma anemarrhenae, dried rehamnnia root and madder. The raw materials are decocted into decoction by the academy to be taken by patients. The clinical test shows that the cure rate, the total effective rate, the microscopic hematuria negative turning mean time and the urine protein negative turning mean time of the traditional Chinese medicine qi-tonifying and kidney-nourishing decoction are obviously better than those of a control group, so that the traditional Chinese medicine qi-tonifying and kidney-nourishing decoction is worth popularizing and using.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine QI invigorating nourishing kidney soup for the treatment of Henoch Schonlein purpura nephritis.
Background technology
Anaphylactoid purpura is also referred to as schonlein-Henoch purpura, it is a kind of blood capillary allergy hemorrhage, may be relevant with the autoimmune damage of blood vessel, anaphy lactoid purpura nephritis is the kidney damage that is caused by anaphylactoid purpura, brings out mainly due to factors such as microorganism, medicine or foods.Up to the present without specific medicament and Therapeutic Method, still take symptomatic treatment as main, adrenocortical hormone and immunosuppressant are effective to purpura, but undesirable to the henoch Schonlein purpura nephritis curative effect, and doctor trained in Western medicine there is no fruitful therapy at present.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine QI invigorating nourishing kidney soup for the treatment of Henoch Schonlein purpura nephritis.Henoch Schonlein purpura nephritis belongs to the categories such as motherland's medical science " blood disorder ", " purpura ", " hematuria ", " edema ", is a kind of disease that is caused kidney damage by anaphylactoid purpura.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine QI invigorating nourishing kidney soup of this treatment Henoch Schonlein purpura nephritis is made by the Chinese medicine of following weight portion: Radix et Rhizoma Gynurae divaricatae 13-15 part, Radix Clerodendri Fortunati 15-20 part, Herba Stellariae paniculigerae 15-20 part, Radix Clematidis Henryi 14-16 part, Radix Astragali 14-16 part, Radix potentillae anserinae 15-18 part, Herba Swertiae yunnanensis 15-20 part, Phtheirospermum tenuisectum Bur.et Franch. 17-20 part, Radix Ginseng 10-12 part, Radix Saniculae Astrantifoliae 15-17 part, Rhizoma Anemarrhenae 10-13 part, Radix Rehmanniae 9-12 part, Radix Rubiae 16-18 part.
Preferably, 14 parts of Radix et Rhizoma Gynurae divaricataes, 18 parts of Radix Clerodendri Fortunatis, 18 parts of Herba Stellariae paniculigeraes, 15 parts of Radix Clematidis Henryi, 15 parts of the Radixs Astragali, 16 parts of Radix potentillae anserinae, 19 parts of Herba Swertiae yunnanensiss, 19 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 11 parts of Radix Ginsengs, 16 parts of Radix Saniculae Astrantifoliae, 12 parts of the Rhizoma Anemarrhenaes, 11 parts in the Radix Rehmanniae, 17 parts in Radix Rubiae.
In the side: Radix et Rhizoma Gynurae divaricatae: clearing away heat and cooling blood, dissipating blood stasis for subsidence of swelling.Radix Clerodendri Fortunati: heat-clearing and toxic substances removing, cooling blood and relieving pain.Herba Stellariae paniculigerae: activating QI to eliminate phlegm, promoting blood circulation and hemostasis, clear long-pending detoxifcation.Radix Clematidis Henryi: promoting flow of QI and blood, anti-inflammation.The Radix Astragali: QI invigorating is given birth to sun, and benefit is consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer life.
Radix potentillae anserinae: invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst, vigorate qi and replenish the blood.Herba Swertiae yunnanensis: the liver heat removing function of gallbladder promoting, except damp and clearing heat.Phtheirospermum tenuisectum Bur.et Franch.: tranquilizing by nourishing the heart, hemostasis.Radix Ginseng: strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind.Radix Saniculae Astrantifoliae: invigorating the lung and the kidney.The Rhizoma Anemarrhenae: clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.The Radix Rehmanniae: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Radix Rubiae: enrich blood and invigorate blood circulation, expelling wind and removing dampness, softening the hard mass removing mass.
Preparation method according to a conventional method decocting becomes juice.
Clinical data
Physical data is originally organized the diagnostic criteria of equal anaphy lactoid purpura nephritis, and 136 examples are the out-patient, is divided at random treatment group and matched group, treatment group 84 examples, male 44 examples, women 40 examples; Age 4-15 year, average 9.5 years old; The course of disease 5～28d, average 14.5d.Albuminuria positive 42 examples, albuminuria (+) 20 examples wherein, (++) 16 examples, (+++) 6 examples; Simple hematuria person's 30 examples; 12 examples that albuminuria and hematuria all have.Matched group 52 examples, male 28 examples, women 24 examples, 5～13 years old age, average 8.5 years old; The course of disease 4～25d, average 14.0d, albuminuria positive 28 examples, albuminuria (+) 14 examples wherein, (++) 10 examples, (+++) 4 examples; Simple hematuria person's 20 examples; 4 examples that albuminuria and hematuria all have; Two groups of data no difference of science of statistics (P＞0.05) have comparability.
The Therapeutic Method treatment group is taken QI invigorating nourishing kidney Chinese medicinal decoction of the present invention, and 1 dose/d, decocting divides clothes 2 times, and the consumption of person below 5 years old reduces by half.Matched group is with persantin 3～5mg/kg/d, and minutes 3 times oral; Cimetidine 5mg/kg/d, minutes 2 times are oral, and two groups of equal 10 weeks are a course for the treatment of.
Criterion of therapeutical effect (1) is cured: clinical symptoms, sign complete obiteration, renal function and routine urinalysis are normal.(2) produce effects: clinical symptoms, sign complete obiteration, normal renal function, routine urinalysis mile abnormality (urine protein ±～+), Urine sediments analyzer (erythrocyte＜5/HP).(3) take a turn for the better: clinical symptoms, sign disappear, and normal renal function, routine urinalysis be front the improvement.(4) invalid: treatment is more than 3 months, and indices is without improvement.
(1) two group of patient treatment of therapeutic outcome after course for the treatment of curative effect relatively see Table 1.
Table 1 liang group patient treatment is curative effect relatively (%) after course for the treatment of
Two groups of total effective rate differences (P＜0.01)
(2) two groups of patient's microscopic hematurias are turned out cloudy, urine protein is turned out cloudy average time relatively sees Table 2.
Two groups of patient's microscopic hematurias table 2 of turning out cloudy
Two groups are compared (P＜0.01)
Can find out treatment group from table 1, table 2, cure rate, total effective rate, microscopic hematuria are turned out cloudy, urine protein is turned out cloudy, and compare average time, obviously is better than matched group, and statistics has significant difference (P＜0.05).
The specific embodiment
Embodiment one: take by weighing Radix et Rhizoma Gynurae divaricatae 14g, Radix Clerodendri Fortunati 18g, Herba Stellariae paniculigerae 18g, Radix Clematidis Henryi 15g, Radix Astragali 15g, Radix potentillae anserinae 16g, Herba Swertiae yunnanensis 19g, Phtheirospermum tenuisectum Bur.et Franch. 19g, Radix Ginseng 11g, Radix Saniculae Astrantifoliae 16g, Rhizoma Anemarrhenae 12g, Radix Rehmanniae 11g, Radix Rubiae 17g.Agent/d, decocting divide clothes 2 times.
Embodiment two: take by weighing Radix et Rhizoma Gynurae divaricatae 13g, Radix Clerodendri Fortunati 15g, Herba Stellariae paniculigerae 15g, Radix Clematidis Henryi 14g, Radix Astragali 14g, Radix potentillae anserinae 15g, Herba Swertiae yunnanensis 15g, Phtheirospermum tenuisectum Bur.et Franch. 17g, Radix Ginseng 10g, Radix Saniculae Astrantifoliae 15g, Rhizoma Anemarrhenae 10g, Radix Rehmanniae 9g, Radix Rubiae 16g.Agent/d, decocting divide clothes 2 times.
Embodiment example three: take by weighing Radix et Rhizoma Gynurae divaricatae 15g, Radix Clerodendri Fortunati 20g, Herba Stellariae paniculigerae 20g, Radix Clematidis Henryi 16g, Radix Astragali 16g, Radix potentillae anserinae 18g, Herba Swertiae yunnanensis 20g, Phtheirospermum tenuisectum Bur.et Franch. 20g, Radix Ginseng 12g, Radix Saniculae Astrantifoliae 17g, Rhizoma Anemarrhenae 13g, Radix Rehmanniae 12g, Radix Rubiae 18g.Agent/d, decocting divide clothes 2 times.
Claims (2)
1. Chinese medicine QI invigorating nourishing kidney soup for the treatment of Henoch Schonlein purpura nephritis, it is characterized in that this Chinese medicine QI invigorating nourishing kidney soup made by the Chinese medicine of following weight portion: Radix et Rhizoma Gynurae divaricatae 13-15 part, Radix Clerodendri Fortunati 15-20 part, Herba Stellariae paniculigerae 15-20 part, Radix Clematidis Henryi 14-16 part, Radix Astragali 14-16 part, Radix potentillae anserinae 15-18 part, Herba Swertiae yunnanensis 15-20 part, Phtheirospermum tenuisectum Bur.et Franch. 17-20 part, Radix Ginseng 10-12 part, Radix Saniculae Astrantifoliae 15-17 part, Rhizoma Anemarrhenae 10-13 part, Radix Rehmanniae 9-12 part, Radix Rubiae 16-18 part, preparation method according to a conventional method decocting becomes juice.
2. a kind of Chinese medicine QI invigorating nourishing kidney soup for the treatment of Henoch Schonlein purpura nephritis according to claim 1 is characterized in that this Chinese medicine QI invigorating nourishing kidney soup made by the Chinese medicine of following weight portion: 14 parts of Radix et Rhizoma Gynurae divaricataes, 18 parts of Radix Clerodendri Fortunatis, 18 parts of Herba Stellariae paniculigeraes, 15 parts of Radix Clematidis Henryi, 15 parts of the Radixs Astragali, 16 parts of Radix potentillae anserinae, 19 parts of Herba Swertiae yunnanensiss, 19 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 11 parts of Radix Ginsengs, 16 parts of Radix Saniculae Astrantifoliae, 12 parts of the Rhizoma Anemarrhenaes, 11 parts in the Radix Rehmanniae, 17 parts in Radix Rubiae.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103860965A (en) * | 2014-04-02 | 2014-06-18 | 张利民 | Medicament for treating henoch-schonlein purpura nephritis |
| CN104208530A (en) * | 2014-09-15 | 2014-12-17 | 伏淼 | Traditional Chinese medicine preparation for treating infantile henoch-schonlein purpura nephritis |
| CN104623364A (en) * | 2015-01-20 | 2015-05-20 | 张玉玲 | Traditional Chinese medicine for treating anaphylactoid purpura caused by qi dysfunction in blood control |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1682982A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | Yishenkangshuai pill for treating chronic nephrosis and renal failure |
| CN102648969A (en) * | 2012-04-24 | 2012-08-29 | 李雯 | Complex Chinese medicine preparation for reinforcing kidney |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682982A (en) * | 2005-02-22 | 2005-10-19 | 黄资源 | Yishenkangshuai pill for treating chronic nephrosis and renal failure |
| CN102648969A (en) * | 2012-04-24 | 2012-08-29 | 李雯 | Complex Chinese medicine preparation for reinforcing kidney |
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