CN102870776A - Soluble concentrate of fructus isopsoraleae chalcone and preparation method of same - Google Patents
Soluble concentrate of fructus isopsoraleae chalcone and preparation method of same Download PDFInfo
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- CN102870776A CN102870776A CN2012103618581A CN201210361858A CN102870776A CN 102870776 A CN102870776 A CN 102870776A CN 2012103618581 A CN2012103618581 A CN 2012103618581A CN 201210361858 A CN201210361858 A CN 201210361858A CN 102870776 A CN102870776 A CN 102870776A
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- isobavachalcone
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- isopsoraleae
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Abstract
A soluble concentrate of fructus isopsoraleae chalcone relates to an agricultural soluble concentrate and comprises the following raw materials in percentage by weight: 0.1-10% of fructus isopsoraleae chalcone, 8-20% of emulsifier and a solvent which is added until the concentrate reaches 100%; the pure fructus isopsoraleae chalcone or the plant extract of fructus isopsoraleae chalcone is mixed with the solvent, stirred and completely dissolved; and then the mixture is added with the emulsifier, stirred, uniformly mixed, supplemented with the solvent to reach 100%, and then kept standing for 4-5 hours. The soluble concentrate of fructus isopsoraleae chalcone is used for preventing plant fungus diseases including rice blast, apple canker, cucumber anthracnose, tomato late blight, pepper anthracnose, cucumber botrytis and rhizoctonia solani kuhn, or used for preventing plant viral diseases including tomato mosaic virus, soybean mosaic virus, tobacco mosaic virus, tobacco virus Y and potato virus Y. The soluble concentrate is well soluble with water, so that the sterilizing effect in practical application is greatly improved; and the content of fructus isopsoraleae chalcone as an effectively component is stable.
Description
Technical field
The present invention relates to a kind of agricultural soluble liquor, particularly relate to a kind of isobavachalcone soluble liquid and preparation method thereof and the application in controlling plant diseases.
Background technology
Agricultural chemicals is being brought into play very important effect in agricultural production.Along with the raising of health of people consciousness, most countries is all paid much attention to the safety of agricultural product, and is very strict to the restriction of residue of pesticide.In order to improve agricultural products in China in the competitiveness of international market, reduce persticide residue, making great efforts the development of new biopesticide has become the task of top priority.Botanical pesticide derives from nature, have free from environmental pollution and agricultural product, comparatively safe to people and livestock, be difficult for developing immunity to drugs, the characteristics such as low toxicity, low-residual, so botanical pesticide has wide market prospects.
For this reason, the applicant has applied for patent of invention " Bavachalcone compounds and Corylifolin controlling plant diseases mix preparation " (2010105652380) in December, 2010.Actual proof said preparation has been received good effect, but the intersolubility of itself and water not satisfactory, have much room for improvement.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and the application in the control corps diseases thereof of soluble liquid isobavachalcone soluble liquid of controlling plant diseases.This kind preparation and glassware for drinking water have good intersolubility, have so greatly improved the bactericidal effect in the practical application, and the stable content of active ingredient isobavachalcone.
The objective of the invention is to be achieved through the following technical solutions:
A kind of isobavachalcone soluble liquid, described liquor is comprised of the raw material of following percentage by weight: isobavachalcone 0.1%～10%, emulsifier 8%～20% complements to 100% with solvent; Its solvent is 1-METHYLPYRROLIDONE or N-chain alkyl pyrrolidones or cyclohexanone or ethylene glycol or dimethyl formamide or methyl alcohol or ethanol, or their mixed solvent; Emulsifier comprises: castor oil polyoxy ethane additive product, calcium dodecyl benzene sulfonate, the sorbitan fatty acid ester APEO, the phenethyl phenol polyethenoxy ether, phenethyl phenol polyethenoxy polyethenoxy ether, aralkyl phenol polyethenoxy ether phosphate, the alkylphenol polyoxyethylene phosphate, alkyl naphthalene sulfonic acid calcium, the aralkyl phenol polyethenoxy ether, sorbitan fatty acid ester, alkyl phenol formaldehyde resin polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether a kind of or their mixture.
Described a kind of isobavachalcone soluble liquid, the raw material of its described isobavachalcone soluble liquid, wherein isobavachalcone is the sterling of isobavachalcone or the plant extracts that contains isobavachalcone.
A kind of preparation method of isobavachalcone soluble liquid, described method comprises following preparation process: with isobavachalcone sterling or isobavachalcone plant extracts and solvent, be stirred to fully dissolving, then add emulsifier for mixing, mix, complement to 100% with solvent at last, leave standstill and got final product in 4～5 hours.
A kind of isobavachalcone soluble liquid, its described isobavachalcone soluble liquid is used for the fungal diseases of plants such as control rice blast, apple canker, cucumber anthracnose, tomato late blight, pepper anthracnose, gray mold of cucumber, rice sheath blight disease, or is used for the viral diseases of plants of control Tomato yellow mosaic virus, soybean Mosaic, tobacco mosaic virus disease, tobacco potato Y virus disease.
Advantage of the present invention and effect are:
1. a kind of isobavachalcone soluble liquid of the present invention is a kind of botanical biological pesticide, the patent of invention " Bavachalcone compounds and Corylifolin controlling plant diseases mix preparation " (2010105652380) of this invention and early stage in December, 2010 application is different, in " Bavachalcone compounds and Corylifolin mix preparation controlling plant diseases ", isobavachalcone and Corylifolin soluble liquid are the mix preparations of two kinds of active ingredients, emphasize both proportions, and the solvent that is used for dissolving active ingredient is water and ethanol.Active ingredient of the present invention is the isobavachalcone single dose, and solvent for use is 1-METHYLPYRROLIDONE, N-chain alkyl pyrrolidones, cyclohexanone, ethylene glycol, dimethyl formamide, methyl alcohol, ethanol, also can be their mixed solvent.This kind preparation and glassware for drinking water have good intersolubility, have so greatly improved the bactericidal effect in the practical application, and the stable content of active ingredient isobavachalcone.
2. isobavachalcone soluble liquid of the present invention can use in paddy rice, apple and various vegetables, be used for the fungal diseases of plants such as control rice blast, apple canker, cucumber anthracnose, tomato late blight, pepper anthracnose, gray mold of cucumber, rice sheath blight disease, can also be used for the important plant diseases such as control Tomato yellow mosaic virus, soybean Mosaic, tobacco mosaic virus disease, tobacco potato Y virus disease.The effect of the viral diseases of plants such as the fungal diseases of plants such as control rice blast, apple canker, pepper anthracnose, gray mold of cucumber and Tomato yellow mosaic virus is better than the main flow kind in the existing market, has great market application potential.
3. advantage of the present invention is as follows:
(1) bactericidal effect is good: the isobavachalcone soluble liquid is better than main flow kind in the existing market to the control efficiency of the fungal diseases of plants such as rice blast, apple canker, pepper anthracnose, gray mold of cucumber and viral diseases of plants.
(2) fungicidal spectrum is wide: the isobavachalcone soluble liquid not only can be used for the fungal diseases of plants such as control rice blast, apple canker, rice sheath blight disease, tomato late blight, pepper anthracnose, gray mold of cucumber, can also be used for the viral diseases of plants such as control Tomato yellow mosaic virus, soybean Mosaic, tobacco mosaic virus disease, tobacco potato Y virus disease.
(3) without pesticide resistance: botanical pesticide multiaction site, phytopathogen is difficult for developing immunity to drugs to medicament.
(4) noresidue, environmentally safe: isobavachalcone is natural products, takes from nature, is easy to degraded.Have the characteristics such as efficient, low toxicity, noresidue, therefore, the isobavachalcone soluble liquid is a kind of biopesticide of environmental protection.
(5) good stability: through the proportion research of a large amount of isobavachalcone, solvent and emulsifier, make each composition and ratio of isobavachalcone soluble liquid scientific and reasonable, show isobavachalcone soluble liquid good stability provided by the invention through study on the stability, can long preservation.
Description of drawings
Fig. 1 is isobavachalcone structural formula of the present invention.
Embodiment
Be elaborated below in conjunction with part embodiment of the present invention.
Isobavachalcone of the present invention (isobavachalcone) molecular formula: C
20H
20O
4
Example 1:0.1% isobavachalcone soluble liquid:
0.1% isobavachalcone soluble liquid is made by the raw material of following percentage by weight: isobavachalcone sterling 0.1%, cyclohexanone 39.9%, ethanol 50%, sorbitan fatty acid ester APEO 10%.
Example 2:0.4% isobavachalcone soluble liquid:
0.4% isobavachalcone soluble liquid is made by the raw material of following percentage by weight: isobavachalcone sterling 0.4%, 1-METHYLPYRROLIDONE 53.6%, ethylene glycol 36%, castor oil polyoxy ethane additive product 6%, sorbitan fatty acid ester APEO 4%.
Example 3:1% isobavachalcone soluble liquid;
1% isobavachalcone soluble liquid is made by the raw material of following percentage by weight: contain the plant extracts 25% of 4% isobavachalcone, N-chain alkyl pyrrolidones 45%, dimethyl formamide 22%, phenethyl phenol polyethenoxy polyethenoxy ether 8%.
Example 4:5% isobavachalcone soluble liquid:
5% isobavachalcone soluble liquid is made by the raw material of following percentage by weight: contain the plant extracts 50% of 10% isobavachalcone, cyclohexanone 20%, methyl alcohol 15%, calcium dodecyl benzene sulfonate 5%, aralkyl phenol polyethenoxy ether phosphate 10%.
Example 5:10% isobavachalcone soluble liquid:
10% isobavachalcone soluble liquid is made by the raw material of following percentage by weight: the plant extracts 20% that contains 50% isobavachalcone, cyclohexanone 40%, ethanol 20%, alkyl phenol formaldehyde resin polyoxyethylene ether 12%, polyoxyethylene nonylphenol ether 6%, calcium dodecyl benzene sulfonate 2%.
Example 6: the indoor pot efficiency test result who is used for the control rice blast according to example 1～5 gained isobavachalcone soluble liquid is as follows:
Table 1 isobavachalcone soluble liquid is to the indoor pot efficiency test of rice blast
| Reagent agent | Extension rate | Preventive effect (%) |
| Example 1 | 400 | 73.00 |
| Example 2 | 400 | 80.20 |
| Example 3 | 600 | 85.89 |
| Example 4 | 1000 | 85.07 |
| Example 5 | 2000 | 96.30 |
| 40% Isoprothiolane missible oil | 400 | 65.91 |
| Blank | Water | - |
Adopt the method for artificial infection, liquid sprays the rice shoot of 3～4 leaf phases, to spray clear water as blank, processes for every kind and repeats 3 times.The result shows, example 1～5 gained isobavachalcone soluble liquid all is better than main flow kind 40% Isoprothiolane missible oil in the existing market to the control efficiency of rice blast.
Example 7: the indoor pot efficiency test result who is used for the control gray mold of cucumber according to example 1～5 gained isobavachalcone soluble liquid is as follows:
Table 2 isobavachalcone soluble liquid is to the indoor pot efficiency test of gray mold of cucumber
| Reagent agent | Extension rate | Preventive effect (%) |
| Example 1 | 600 | 68.00 |
| Example 2 | 600 | 73.70 |
| Example 3 | 800 | 85.00 |
| Example 4 | 1000 | 88.07 |
| Example 5 | 2000 | 94.52 |
| 40% Shi Jiale suspending agent | 600 | 67.73 |
| Blank | Water | - |
24h sprays medicament behind the artificial indoor inoculation botrytis cinerea pers, to spray clear water as blank, processes for every kind and repeats 3 times.The result shows, example 1～5 gained isobavachalcone soluble liquid all is better than main flow kind 40% Shi Jiale suspending agent in the existing market to the control efficiency of gray mold of cucumber.
Example 8: the indoor pot experiment result who is used for the control pepper anthracnose according to example 1～5 gained isobavachalcone soluble liquid is as follows:
Table 3 isobavachalcone soluble liquid is to the indoor pot efficiency test of pepper anthracnose
| Reagent agent | Extension rate | Preventive effect (%) |
| Example 1 | 600 | 61.00 |
| Example 2 | 600 | 68.70 |
| Example 3 | 800 | 75.23 |
| Example 4 | 1000 | 90.17 |
| Example 5 | 2000 | 95.02 |
| 70% thiophanate methyl wetting powder | 600 | 57.10 |
| Blank | Water | - |
Adopt spore suspension spray inoculation method inoculation in seedling stage Colletotrichum capsici, spray medicament behind the 24h, to spray clear water as blank, every processing 6 young plants repeat 3 times.The result shows, example 1～5 gained isobavachalcone soluble liquid all is better than main flow kind 70% thiophanate methyl wetting powder in the existing market to the control efficiency of pepper anthracnose.
Example 9: as follows for the field test results of preventing and treating apple canker according to example 1～5 gained isobavachalcone soluble liquid:
The different extension rates of 5 kinds of example medicaments and 200 times of liquid of contrast medicament dilution are processed the scab place.Processed rear 24 days, most sick scar director goes out green new organization, simultaneously, the survey showed that in 24 days, and no matter each example medicament is scraped to control is processed or scraping article is processed control efficiency and all is better than the principal item-40% asomate wetting powder (table 4) of preventing and treating at present apple canker.
Table 4 isobavachalcone soluble liquid is to the field control effect of apple canker
Example 10: the indoor pot experiment result who is used for the control Tomato yellow mosaic virus according to example 1～5 gained isobavachalcone soluble liquid is as follows:
Indoor pot experiment is the result show, when extension rate was 500 times, example 1～5 gained isobavachalcone soluble liquid all was better than contrasting the control efficiency of medicament virus A to protective effect, passivation and the therapeutic action of Tomato yellow mosaic virus.As seen, the isobavachalcone soluble liquid has good control efficiency to Tomato yellow mosaic virus, and is better than antiviral kind virus A commonly used at present.
Table 5 isobavachalcone soluble liquid is to the control efficiency of Tomato yellow mosaic virus
Example 11: dispersiveness and the stability of example 1～5 gained isobavachalcone soluble concentrate are very, and cold storage, thermodynamic stability are good.The isobavachalcone soluble liquid does not freeze without crystallization at 0 ± 1 ℃ of lower 7d that stores, and the bottom is without precipitation.At 54 ± 2 ℃ of lower 14d that store, analyze active constituent content, resolution ratio all is lower than 5%.
The stability of table 6 isobavachalcone soluble concentrate
Annotate: the medicament percentage composition is mass fraction.
Claims (4)
1. an isobavachalcone soluble liquid is characterized in that, described liquor is comprised of the raw material of following percentage by weight: isobavachalcone 0.1%～10%, and emulsifier 8%～20% complements to 100% with solvent; Its solvent is 1-METHYLPYRROLIDONE or N-chain alkyl pyrrolidones or cyclohexanone or ethylene glycol or dimethyl formamide or methyl alcohol or ethanol, or their mixed solvent; Emulsifier comprises: castor oil polyoxy ethane additive product, calcium dodecyl benzene sulfonate, the sorbitan fatty acid ester APEO, the phenethyl phenol polyethenoxy ether, phenethyl phenol polyethenoxy polyethenoxy ether, aralkyl phenol polyethenoxy ether phosphate, the alkylphenol polyoxyethylene phosphate, alkyl naphthalene sulfonic acid calcium, the aralkyl phenol polyethenoxy ether, sorbitan fatty acid ester, alkyl phenol formaldehyde resin polyoxyethylene ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene nonylphenol ether a kind of or their mixture.
2. a kind of isobavachalcone soluble liquid according to claim 1, it is characterized in that, the raw material of described isobavachalcone soluble liquid, wherein isobavachalcone is the sterling of isobavachalcone or the plant extracts that contains isobavachalcone.
3. the preparation method of an isobavachalcone soluble liquid, it is characterized in that, described method comprises following preparation process: with isobavachalcone sterling or isobavachalcone plant extracts and solvent, be stirred to fully dissolving, then add emulsifier for mixing, mix, complement to 100% with solvent at last, leave standstill and got final product in 4～5 hours.
4. isobavachalcone soluble liquid, it is characterized in that, described isobavachalcone soluble liquid is used for the fungal diseases of plants such as control rice blast, apple canker, cucumber anthracnose, tomato late blight, pepper anthracnose, gray mold of cucumber, rice sheath blight disease, or is used for the viral diseases of plants of control Tomato yellow mosaic virus, soybean Mosaic, tobacco mosaic virus disease, tobacco potato Y virus disease.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843127A (en) * | 2006-05-16 | 2006-10-11 | 沈阳化工学院 | Plant source bacteriocide for agriculture |
| CN101215229A (en) * | 2008-01-02 | 2008-07-09 | 沈阳化工学院 | Bavachalcone compounds capable of resisting plant epiphyte disease |
| CN101824039A (en) * | 2009-03-06 | 2010-09-08 | 北京卓越同创药物研究院 | Active ingredient for corylifolinin and preparation method thereof |
| CN102037963A (en) * | 2010-11-30 | 2011-05-04 | 沈阳化工大学 | Bavachalcone compounds and bavachin mixed preparation for preventing and controlling plant diseases |
-
2012
- 2012-09-26 CN CN201210361858.1A patent/CN102870776B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843127A (en) * | 2006-05-16 | 2006-10-11 | 沈阳化工学院 | Plant source bacteriocide for agriculture |
| CN101215229A (en) * | 2008-01-02 | 2008-07-09 | 沈阳化工学院 | Bavachalcone compounds capable of resisting plant epiphyte disease |
| CN101824039A (en) * | 2009-03-06 | 2010-09-08 | 北京卓越同创药物研究院 | Active ingredient for corylifolinin and preparation method thereof |
| CN102037963A (en) * | 2010-11-30 | 2011-05-04 | 沈阳化工大学 | Bavachalcone compounds and bavachin mixed preparation for preventing and controlling plant diseases |
Non-Patent Citations (3)
| Title |
|---|
| 关丽杰等: "0.1%异补骨脂查耳酮乳油防治水稻稻瘟病药效试验", 《农药》 * |
| 杨荣平等: "HPLC测定复方补骨脂缓释片中补骨脂香豆素类和黄酮类成分的含量", 《中成药》 * |
| 郭武棣: "《液体制剂》", 31 January 2004, 化学工业出版社 * |
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Effective date of registration: 20180427 Address after: 110027 -6, eight East Road, Shensi, Shenyang economic and Technological Development Zone, Liaoning, China. 9 Patentee after: Shenyang with the same biological pesticide Co., Ltd. Address before: No. 11, economic and Technological Development Zone, Shenyang, Liaoning Province, Liaoning Patentee before: Shenyang University of Chemical Technology |
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