CN102846650A - Florfenicol compound composition and preparation method thereof - Google Patents
Florfenicol compound composition and preparation method thereof Download PDFInfo
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- CN102846650A CN102846650A CN2012103051769A CN201210305176A CN102846650A CN 102846650 A CN102846650 A CN 102846650A CN 2012103051769 A CN2012103051769 A CN 2012103051769A CN 201210305176 A CN201210305176 A CN 201210305176A CN 102846650 A CN102846650 A CN 102846650A
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Abstract
The invention discloses a florfenicol compound composition and a preparation method thereof. The composition is composed of florfenicol, azithromycin, tylosin, propylene glycol, dimethyl formamide, alpha-pyrrolidone, anhydrous ethanol and polyvinylpyrrolidone (PVP). The preparation method of the composition comprises steps of: 1) adding dimethyl formamide to florfenicol, stirring and dissolving; and sequentially adding propylene glycol, alpha-pyrrolidone and anhydrous ethanol, and stirring to mix evenly; 2) adding azithromycin and tylosin, and stirring to mix evenly; 3) heating with stirring at 40 DEG C, adding polyethylene pyrrole pyrrolidone, dissolving and continuing to stir for 15min; and 4) filtering the obtained solution, inflating nitrogen and encapsulating to obtain the florfenicol compound composition. The compound composition provided by the invention is mainly used in the treatment of swine respiratory diseases, and especially has specific long-term treatment effect and no recurrence on respiratory diseases, such as infectious pleuropneumonia, Haemophilus parasuis, swine plague and asthma.
Description
Technical field
The invention belongs to the veterinary drug technical field, be specifically related to a kind of florfenicol compound and preparation method thereof.
Background technology
Along with the raising of China's its feeding production intensification large-scale degree, Chang Yi causes the popular of various infectious disease.Especially a series of diseases of causing of bacterial infection have been brought very large puzzlement to the raiser clinically.The respiratory tract disease of the pig that is caused by sensitive bacterial mainly contains contagious pleuropneumonia, haemophilus parasuis, pig lung plague, the disease etc. of breathing.
Porcine contagious pleuropneumonia is a kind of serious contagious infection sexually transmitted disease (STD) of the respiratory diseases in pigs that caused by Actinobacillus pleuropneumoniae, take hemorrhagic, gangrenosum acne, fiber disposition pleuropneumonia as feature, cause the height dyspnea of pig, acute sepsis occurs and sudden death.Haemophilus parasuis causes pig polyserositis and arthritis, and mainly the child care stage after the pig wean falls ill, and usually sees the pig in 5～8 ages in week, and sickness rate is 10～15%, and mortality rate can reach 50% when serious.The existence of haemophilus parasuis can aggravate the clinical symptoms of porcine respiratory, causes the suppurative bronchopneumonia of fiber disposition.Usually haemophilus parasuis is regarded as the Secondary cases pathogen, after viral disease infects, Haemophilus parasuis is occured easily, make the state of an illness complicated.Pig lung plague (swine pasteurellosis) is by the caused a kind of acute infectious disease of multiple lethal pasteurellosis bacillus, and characteristic symptoms is breathed for the childbirth sample, extremely swelling of bottleneck throat, and breathing is the devil, collapse, high heat, mortality rate is up to about 50%.Mycoplasma pneumoniae of swine claims again mycoplasmal pneumonia of swine, is a kind of chronic respiratory tract disease that is caused by mycoplasma hyopneumoniae.Ill pig clinically main manifestations is cough, asthma, and growth retardation, feed conversion rate is low.
Respiratory diseases in pigs is that upper common disease is produced in livestock rearing, pig all can infect regardless of size, kind, age etc., and infected pigs's enormous amount, the efficiency of feed utilization of ill pig is low, daily gain can not reach standard, and marketing time is postponed, and consumption cost increases, and mortality rate increases, and causes serious economic loss to the raiser.
Summary of the invention
The purpose of this invention is to provide a kind of florfenicol compound, the porcine respiratory disease that primary treatment is caused by sensitive bacterial.
Second purpose of the present invention provides a kind of preparation method of florfenicol compound.
In order to realize above purpose, the technical solution adopted in the present invention is: a kind of florfenicol compound, the composition of this compound and parts by weight are: 10 parts of florfenicols, 3～5 parts of azithromycins, 1～2 part of tylosin, 30～40 parts of propylene glycol, 15～20 parts of dimethyl formamides, 25～30 parts of alpha-pyrrolidones, 8～10 parts of dehydrated alcohol, 2～3 parts of polyvinylpyrrolidones.
Described polyvinylpyrrolidone is high molecular polymer PVP K30.
A kind of preparation method of florfenicol compound comprises the following steps:
1) get dimethyl formamide and add the florfenicol stirring and dissolving, after add successively propylene glycol, alpha-pyrrolidone, absolute ethyl alcohol and stirring to mix homogeneously;
2) adding azithromycin, tylosin are stirred to mix homogeneously;
3) 40 ℃ of heated and stirred add polyvinylpyrrolidone again, and insulation reaction continues after the dissolving to stir 15min, makes abundant chelating between polyvinylpyrrolidone and the medicine;
4) with the gained solution filter, rush nitrogen, embedding namely gets the florfenicol compound.
The holding conditions of this compound is: shading, and airtight, preserve in cool dark place.Florfenicol compound of the present invention, drug dose is pressed weighing machine, but the direct injection use, intramuscular injection is once measured and is every kg body weight domestic animal 20～25mg.
Florfenicol in the compound of the present invention is the broad spectrum antibiotic of the special-purpose chloromycetin of a kind of veterinary drug, is mainly used in the bacterial disease of pig, chicken and fish due to the sensitive bacterial, and is especially evident in efficacy to respiratory system infection and intestinal infection.The Antibacterial Mechanism of florfenicol mainly is by being combined with the 50S ribosomal subunit, Profilin matter is synthesized required key enzyme-peptidy transeferace, thereby stoped specifically the receptors bind on aminoacyl tRNA and the ribosome, suppressed the prolongation of peptide chain and tropina can not be synthesized.This product has a broad antifungal spectrum all has potent to gram positive bacteria and gram negative bacteria and mycoplasma.Florfenicol targeting location performance medicine utmost point effect acts on organism, and consumption is little, instant effect, long half time, blood drug level is high, can the long period keep blood drug level.
Azithromycin in the compound of the present invention is a kind of antibiotic of Macrolide, it is a kind of broad ectrum antibiotic that after the erythromycin structure is modified, obtains, belong to Macrolide second filial generation antibiotic, be applicable to the transmissible disease due to respiratory tract, skin soft-tissue infection and the chlamydia due to the sensitive organism.
Tylosin in the compound of the present invention is a kind of macrolide antibiotics that obtains from the culture fluid of streptomyces fradiae, because of its intestinal absorption good, the body internal diffusion is fast, blood drug level is high, multiplex clinically mainly have good inhibitory action to multiple gram positive bacteria in the medicine use, also part gram negative bacteria, knee bacterium, spirillum had inhibitory action, and the anticoccidial effect, be mainly used in preventing and treating the livestock and poultry mycoplasma disease.So unique advantage is at the special-purpose antibiotic of poultry, additive capacity is little, can not bring the cross resistance problem to the mankind.
Polyvinylpyrrolidone in the compound prescription of the present invention is PVP K30, mainly plays long-acting slow-release, cosolvent and stabilizing agent in compositions.PVP K30 is high molecular polymer, and metabolism is slow in vivo, thereby said composition is slowly absorbed in animal body until absorb fully, reaches long-acting purpose, uses polyvinylpyrrolidone that the stability of compositions has also been improved a lot.
The present invention adopts florfenicol, azithromycin and tylosin to make long-acting compound, the respiratory tract disease of primary treatment pig, especially the respiratory tract diseases such as contagious pleuropneumonia, haemophilus parasuis, pig lung plague, the disease of breathing have special long-acting therapeutic effect, be difficult for recurrence, make numerous raisers aspect raising, reduce cost, greatly improved economic benefit.
The specific embodiment
Below in conjunction with the specific embodiment the present invention is elaborated:
Embodiment 1
The florfenicol compound of present embodiment, compound recipe consists of: florfenicol 10g, azithromycin 5g, tylosin 2g, propylene glycol 40g, dimethyl formamide 15g, alpha-pyrrolidone 25g, dehydrated alcohol 10g, polyvinylpyrrolidone 3g.
The preparation method of florfenicol compound may further comprise the steps:
1) get dimethyl formamide 15g, add 10g florfenicol stirring and dissolving, after add successively propylene glycol 40g, alpha-pyrrolidone 25g, dehydrated alcohol 10g is stirred to mix homogeneously;
2) add azithromycin 5g, tylosin 2g and be stirred to mix homogeneously;
3) 40 ℃ of heated and stirred add 3g PVP K30 again, and insulation reaction continues after the dissolving to stir 15min, makes abundant chelating between PVP K30 and the medicine;
4) with the gained solution filter, rush nitrogen, embedding namely gets the florfenicol compound.
Embodiment 2
The florfenicol compound of present embodiment, compound recipe consists of: florfenicol 10g, Azithromycin 4 g, tylosin 1.5g, propylene glycol 35g, dimethyl formamide 17g, alpha-pyrrolidone 28g, dehydrated alcohol 9g, polyvinylpyrrolidone 2.5g.
The preparation method of florfenicol compound may further comprise the steps:
1) get dimethyl formamide 17g, add 10g florfenicol stirring and dissolving, after add successively propylene glycol 35g, alpha-pyrrolidone 28g, dehydrated alcohol 9g is stirred to mix homogeneously;
2) add Azithromycin 4 g, tylosin 1.5g and be stirred to mix homogeneously;
3) 40 ℃ of heated and stirred add 2.5g PVP K30 again, and insulation reaction continues after the dissolving to stir 15min, makes abundant chelating between PVP K30 and the medicine;
4) with the gained solution filter, rush nitrogen, embedding namely gets the florfenicol compound.
Embodiment 3
The florfenicol compound of present embodiment, compound recipe consists of: florfenicol 10g, azithromycin 3g, tylosin 1g, propylene glycol 30g, dimethyl formamide 20g, alpha-pyrrolidone 30g, dehydrated alcohol 8g, polyvinylpyrrolidone 2g.
The preparation method of florfenicol compound may further comprise the steps:
1) get dimethyl formamide 20g, add 10g florfenicol stirring and dissolving, after add successively propylene glycol 30g, alpha-pyrrolidone 30g, dehydrated alcohol 8g is stirred to mix homogeneously;
2) add azithromycin 3g, tylosin 1g and be stirred to mix homogeneously;
3) 40 ℃ of heated and stirred add 2g PVP K30 again, and insulation reaction continues after the dissolving to stir 15min, makes abundant chelating between PVP K30 and the medicine;
4) with the gained solution filter, rush nitrogen, embedding namely gets the florfenicol compound.
Zoopery
The sick swinery body that mycoplasmal pneumonia of swine occurs has been made a definite diagnosis through means such as the clinical symptoms consultation of doctors, laboratory diagnosises in certain pig farm, Henan, and the clinical symptoms performance is obvious: cough, and rhinorrhea, loss of appetite etc., laboratory diagnosis is mycoplasma pneumonia.Random choose is 100 from sick swinery, male and female has concurrently, pig individual weight and the mental status selected are similar, be divided into 4 groups, the florfenicol compound and the commercially available florfenicol injection that use embodiment 1～3 to make are treated, the drug dose of compound of the present invention is 20mg/kg, and injection is used.Outcome record is as follows:
Treatment situation statistical table
Claims (3)
1. florfenicol compound, it is characterized in that: the composition of this compound and parts by weight are: 10 parts of florfenicols, 3～5 parts of azithromycins, 1～2 part of tylosin, 30～40 parts of propylene glycol, 15～20 parts of dimethyl formamides, 25～30 parts of alpha-pyrrolidones, 8～10 parts of dehydrated alcohol, 2～3 parts of polyvinylpyrrolidones.
2. florfenicol compound according to claim 1, it is characterized in that: described polyvinylpyrrolidone is high molecular polymer PVP K30.
3. the preparation method of a florfenicol compound as claimed in claim 1 or 2 is characterized in that: comprise the following steps:
1) get dimethyl formamide and add the florfenicol stirring and dissolving, after add successively propylene glycol, alpha-pyrrolidone, absolute ethyl alcohol and stirring to mix homogeneously;
2) adding azithromycin, tylosin are stirred to mix homogeneously;
3) 40 ℃ of heated and stirred add polyvinylpyrrolidone again, and insulation reaction continues after the dissolving to stir 15min, makes abundant chelating between polyvinylpyrrolidone and the medicine;
4) with the gained solution filter, rush nitrogen, embedding namely gets the florfenicol compound.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103143019A (en) * | 2013-03-15 | 2013-06-12 | 湖南泰谷生物科技股份有限公司 | Compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection and preparation method thereof |
| CN103432153A (en) * | 2013-08-13 | 2013-12-11 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
| CN103505469A (en) * | 2013-07-29 | 2014-01-15 | 山东德州神牛药业有限公司 | Special compound levorgyration florfenicol injection for animal and preparation method thereof |
| CN108904514A (en) * | 2018-07-26 | 2018-11-30 | 日照市牧邦畜牧科技有限公司 | A kind of long stable effect compound solution of diclazuril and its preparation process |
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
| CN111759854A (en) * | 2020-07-10 | 2020-10-13 | 四川成邦药业有限公司 | Injection composition for treating respiratory diseases of animals and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103143019A (en) * | 2013-03-15 | 2013-06-12 | 湖南泰谷生物科技股份有限公司 | Compound preparation for treating porcine contagious pleuropneumonia and respiratory tract mixed infection and preparation method thereof |
| CN103505469A (en) * | 2013-07-29 | 2014-01-15 | 山东德州神牛药业有限公司 | Special compound levorgyration florfenicol injection for animal and preparation method thereof |
| CN103505469B (en) * | 2013-07-29 | 2015-08-26 | 山东德州神牛药业有限公司 | A kind of special compound levorgyration florfenicol injection for animal and preparation method thereof |
| CN103432153A (en) * | 2013-08-13 | 2013-12-11 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
| CN103432153B (en) * | 2013-08-13 | 2015-04-22 | 潍坊富邦药业有限公司 | Novel prescription of injection for treating infectious pleuropneumonia of livestock and preparation technology thereof |
| CN108904514A (en) * | 2018-07-26 | 2018-11-30 | 日照市牧邦畜牧科技有限公司 | A kind of long stable effect compound solution of diclazuril and its preparation process |
| CN109464435A (en) * | 2018-11-30 | 2019-03-15 | 河南师范大学 | It is a kind of for preventing and treating the pharmaceutical composition of fish liver inflammation |
| CN109464435B (en) * | 2018-11-30 | 2021-06-29 | 河南师范大学 | Pharmaceutical composition for preventing and treating fish liver inflammation |
| CN111759854A (en) * | 2020-07-10 | 2020-10-13 | 四川成邦药业有限公司 | Injection composition for treating respiratory diseases of animals and preparation method thereof |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 Xingang, Henan, Zhengzhou, Hong Kong airport on the eastern side of the road on the eastern side of Zhengzhou Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
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Effective date of registration: 20211214 Address after: 463000 Zhumadian Industrial Park, Henan Province Patentee after: HENAN HOUYI PHARMACY CO.,LTD. Address before: 451162 Henan Zhengzhou Zhengzhou airport comprehensive economic experimentation area, Xingang Avenue East Patentee before: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. |
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