CN102836287A - Chinese medicinal ointment for treating scar and preparation method thereof - Google Patents
Chinese medicinal ointment for treating scar and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal ointment for treating scar and a preparation method of the Chinese medicinal ointment. The Chinese medicinal ointment comprises 30-50% of Chinese medicine extract and 50-70% of matrix, wherein the Chinese medicine extract is extracted from red-rooted salvia, gallnut, garden balsam stem, cape jasmine bark, rheum lidjiangense, rheum wittrochii, peach kernel, lilac daphne root, caudate desmodium root, native copper processed with vinegar, dormant insect, leech, borneol, camphor, olibanum and myrrh; and the matrix comprises povidone, glycerol, aerosol, chitosan, poval, table vinegar and purified water. The Chinese medicinal ointment is applicable to patients with scars, has the functions of relieving pruritus and pain and fading scar color, gradually reducing the area of a scar and smoothening scars, is safe and reliable and has no side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine ointment of treating cicatrix and preparation method thereof.
Background technology
Cicatrix is the mode of appearance of caused normal skin tissue after the various wounds and the general designation of tissue pathologies change, and it is a product inevitable in the human body processes of wound repair.In a broad sense, there is not scar tissue just not have the healing of wound yet.But cicatrix growth surpasses certain limit, and various complication will take place, and such as the destruction of profile and functional activity obstacle etc., brings huge human body misery and psychic pain to the patient, the cicatrix of especially burning, leaving over after the scald, severe trauma.Both at home and abroad the world of medicine has carried out long-term a large amount of safety, the safe and effective procedure of experimentation in the hope of finding one can shorten the damage phase, promote wound healing that is deep into cell, molecule and gene level from tissue.The method of using at present mainly contains: oral drug therapy, injection of drug, laser therapy etc.; Oral drug therapy and injection of drug are dispeled cicatrix of skin can produce certain side effect and untoward reaction; Like headache, stomachache, feel sick, vomiting etc., it is relatively more expensive that the cicatrix of skin expense is dispeled in laser therapy, therapeutic effect is undesirable; There is pigmentation in various degree in above-mentioned therapy or takes off mistake after treatment simultaneously, and what have also can produce situation such as recurrence, regeneration.
Summary of the invention
The objective of the invention is deficiency for solving the problems of the technologies described above; A kind of Chinese medicine ointment of treating cicatrix and preparation method thereof is provided, and Chinese medicine ointment is used for the restorative treatment of various cicatrixs, and is safe and reliable, have no side effect; Can effectively alleviate pruritus; Alleviating pain, desalination cicatrix color reduces the area of cicatrix gradually and becomes level and smooth.
The present invention is the deficiency that solves the problems of the technologies described above; The technical scheme that is adopted is: a kind of Chinese medicine ointment of treating cicatrix; Described ointment is made up of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is: Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is by Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl., Rheum forrestii Diels, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa, Radix Desmodii Caudati; Vinegar Pyritum (processed), Eupolyphaga Seu Steleophaga, Hirudo; Borneolum Syntheticum, Camphora, Olibanum and Myrrha are formed, and the ratio of weight and number that each medical material adds is respectively: 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts in Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of Eupolyphaga Seu Steleophaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas;
Described substrate is made up of polyvidone, glycerol, micropowder silica gel, chitosan, polyvinyl alcohol, tablet vinegar and purified water, and the ratio of weight and number that each raw material adds is respectively: 40～70 parts of 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans, 1～5 part of polyoxyethylene alcohol, 5～10 parts of tablet vinegar and purified water;
Be used for the method for preparing of the Chinese medicine ointment of scar treatment, it is characterized in that: method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts in Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of Eupolyphaga Seu Steleophaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 200～400 orders, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 10～100% ethanol soaks; Alcoholic acid addition is soaked after 12～48 hours for 1.2～1.5 times of immersion medical material volume, and the concentration that adds 3～10 times of immersion medical material original volumes again is 10～100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 10～15 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 200～400 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 5～10 parts of 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans and tablet vinegar, subsequent use;
(2), with in the polyvidone and 10～20 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 60～70 ℃, stirred 30～60 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 30～50 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water; Add in the agitated reactor; Stirred 1～2 minute, and added the pure oil solution that above-mentioned steps (3) makes again, be warmed up to 40～70 ℃; Stirred 2～10 minutes, and stopped to stir and static 2～5 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 2～10 minutes, make substrate;
(three), preparation Chinese medicine ointment
Get the Chinese medicine extract of 30～50% above-mentioned steps () preparations and the substrate of 50～70% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45～55 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 20～40 minutes, promptly make Chinese medicine ointment.
Beneficial effect
1, Chinese medicine ointment of the present invention is applicable to all cicatrix patients, has the pruritus of alleviating, and lenitive effect, and can desalinate the cicatrix color reduces the area of cicatrix gradually and becomes level and smooth, safe and reliable, has no side effect.
2, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, Olibanum, Myrrha have the hemostasis convergence in the Chinese medicine preparation of Chinese medicine ointment of the present invention, promote the effect of wound healing; Itea orientalis Hemsl., Rheum forrestii Diels, Radix Genkwa, Radix Desmodii Caudati, Eupolyphaga Seu Steleophaga, Hirudo, vinegar Pyritum (processed), have and nourish blood and blood, the effect of promoting the circulation of blood dissipating blood stasis analgesic therapy, and can improve local microcirculation, and strengthen local blood fortune, improve wound nutrition; The hemostasis of can regulating the flow of vital energy of Borneolum Syntheticum, Camphora, vinegar, the clots absorbing analgesic therapy, removing the necrotic tissue and promoting granulation has the anabolic effect of improvement.All medicines share, and have the effect of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, elimination cicatrix, are used for the treatment of cicatrix of skin, and big scar is diminished, the hardness deliquescing, and little scar is eliminated, and local function is recovered.
3, the matrix components of Chinese medicine ointment of the present invention, chitosan are to be obtained through deacetylation by the chitin that nature extensively exists, and chemical name is polydextrose amine (1-4)-2-amino-B-D glucose; Its chemical constitution is similar with cellulose, in low PH scope, can dissolve the heavy-gravity macromolecule cation gel solution of formation; Have good film property, the present technique scheme is a major ingredient with the chitosan, is equipped with adjuvants such as micropowder silica gel, polyvidone; The substrate resilient flexibility for preparing is good; Cooperate Chinese medicine extract, be used for clinical various skin injury treatment, effect is very good.
The specific embodiment
Through a plurality of embodiment the method for preparing of first aid dressing of the present invention is further specified below, but present embodiment does not mean that any restriction of the present invention.
Embodiment 1
A kind of method for preparing of treating the Chinese medicine ointment of cicatrix, method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 20 parts of 50 parts of Radix Salviae Miltiorrhizaes, 55 parts of Galla Chinensiss, 25 parts of Herba speranskiae tuberculataes, 20 parts of itea orientalis Hemsl., 60 parts of Rheum forrestii Diels, 65 parts of Radix et Rhizoma Rhei Wittrockiis, 40 parts in Semen Persicae, 20 parts of Radix Genkwa, 70 parts of Radix Desmodii Caudatis, 20 parts of vinegar Pyritum (processed), 35 parts of Eupolyphaga Seu Steleophaga, 30 parts of Hirudos, 8 parts of Borneolum Syntheticums, 12 parts of Camphoras, 40 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 200 order, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 10% ethanol soaks; Alcoholic acid addition is soaked after 48 hours for 1.5 times of immersion medical material volume, and the concentration that adds 3 times of immersion medical material original volumes again is 100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 10 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 400 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 5 parts of polyvidones, 40 parts of purified water, 1 part of polyvinyl alcohol, 30 parts of glycerol, 15 parts of micropowder silica gels, 8 parts of chitosans, 5 parts of tablet vinegar, subsequent use;
(2), with in the polyvidone and 10 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 60 ℃, stirred 60 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 30 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water, add in the agitated reactor, stirred 1～2 minute; Add the pure oil solution that above-mentioned steps (3) makes again; Be warmed up to 40 ℃, stirred 10 minutes, stop to stir and static 5 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 10 minutes, make substrate;
(three), preparation ointment
Get the Chinese medicine extract of 30% above-mentioned steps () preparation and the substrate of 70% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 40 minutes, promptly make ointment;
Embodiment 2
A kind of method for preparing of treating the Chinese medicine ointment of cicatrix, method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 40 parts of 55 parts of Radix Salviae Miltiorrhizaes, 60 parts of Galla Chinensiss, 20 parts of Herba speranskiae tuberculataes, 25 parts of itea orientalis Hemsl., 65 parts of Rheum forrestii Diels, 60 parts of Radix et Rhizoma Rhei Wittrockiis, 35 parts in Semen Persicae, 25 parts of Radix Genkwa, 65 parts of Radix Desmodii Caudatis, 40 parts of vinegar Pyritum (processed), 40 parts of Eupolyphaga Seu Steleophaga, 35 parts of Hirudos, 10 parts of Borneolum Syntheticums, 15 parts of Camphoras, 35 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 400 order, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 100% ethanol soaks; Alcoholic acid addition is soaked after 12 hours for 1.2 times of immersion medical material volume, and the concentration that adds 3 times of immersion medical material original volumes again is 100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 15 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 200 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 8 parts of polyvidones, 70 parts of purified water, 2 parts of polyvinyl alcohol, 35 parts of glycerol, 25 parts of micropowder silica gels, 12 parts of chitosans, 7 parts of tablet vinegar, subsequent use;
(2), with in the polyvidone and 20 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 70 ℃, stirred 30 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 50 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water, add in the agitated reactor, stirred 2 minutes; Add the pure oil solution that above-mentioned steps (3) makes again; Be warmed up to 40 ℃, stirred 10 minutes, stop to stir and static 2 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 10 minutes, make substrate;
(three), preparation ointment
Get the Chinese medicine extract of 50% above-mentioned steps () preparation and the substrate of 50% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 40 minutes, promptly make ointment;
Embodiment 3
A kind of method for preparing of treating the Chinese medicine ointment of cicatrix, method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 30 parts of 65 parts of Radix Salviae Miltiorrhizaes, 70 parts of Galla Chinensiss, 30 parts of Herba speranskiae tuberculataes, 40 parts of itea orientalis Hemsl., 50 parts of Rheum forrestii Diels, 70 parts of Radix et Rhizoma Rhei Wittrockiis, 30 parts in Semen Persicae, 35 parts of Radix Genkwa, 55 parts of Radix Desmodii Caudatis, 35 parts of vinegar Pyritum (processed), 20 parts of Eupolyphaga Seu Steleophaga, 40 parts of Hirudos, 12 parts of Borneolum Syntheticums, 10 parts of Camphoras, 30 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 400 order, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 50% ethanol soaks; Alcoholic acid addition is soaked after 36 hours for 1.2 times of immersion medical material volume, and the concentration that adds 3 times of immersion medical material original volumes again is 100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 12 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 400 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 7 parts of polyvidones, 50 parts of purified water, 3 parts of polyvinyl alcohol, 40 parts of glycerol, 32 parts of micropowder silica gels, 10 parts of chitosans, 8 parts of tablet vinegar, subsequent use;
(2), with in the polyvidone and 20 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 65 ℃, stirred 60 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 30 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water, add in the agitated reactor, stirred 1～2 minute; Add the pure oil solution that above-mentioned steps (3) makes again; Be warmed up to 40 ℃, stirred 10 minutes, stop to stir and static 5 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 10 minutes, make substrate;
(three), preparation ointment
Get the Chinese medicine extract of 40% above-mentioned steps () preparation and the substrate of 60% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 40 minutes, promptly make ointment;
Embodiment 4
A kind of method for preparing of treating the Chinese medicine ointment of cicatrix, method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 35 parts of 70 parts of Radix Salviae Miltiorrhizaes, 65 parts of Galla Chinensiss, 40 parts of Herba speranskiae tuberculataes, 30 parts of itea orientalis Hemsl., 70 parts of Rheum forrestii Diels, 50 parts of Radix et Rhizoma Rhei Wittrockiis, 20 parts in Semen Persicae, 40 parts of Radix Genkwa, 50 parts of Radix Desmodii Caudatis, 30 parts of vinegar Pyritum (processed), 30 parts of Eupolyphaga Seu Steleophaga, 20 parts of Hirudos, 15 parts of Borneolum Syntheticums, 8 parts of Camphoras, 20 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 400 order, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 80% ethanol soaks; Alcoholic acid addition is soaked after 24 hours for 1.4 times of immersion medical material volume, and the concentration that adds 3 times of immersion medical material original volumes again is 100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 10 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 400 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 10 parts of polyvidones, 60 parts of purified water, 5 parts of polyvinyl alcohol, 50 parts of glycerol, 40 parts of micropowder silica gels, 15 parts of chitosans, 10 parts of tablet vinegar, subsequent use;
(2), with in the polyvidone and 15 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 60 ℃, stirred 60 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 45 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water, add in the agitated reactor, stirred 1～2 minute; Add the pure oil solution that above-mentioned steps (3) makes again; Be warmed up to 40 ℃, stirred 10 minutes, stop to stir and static 5 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 10 minutes, make substrate;
(three), preparation ointment
Get the Chinese medicine extract of 45% above-mentioned steps () preparation and the substrate of 55% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 40 minutes, promptly make ointment;
Zoopery
Further specify the therapeutic effect of first aid adjuvant of the present invention through following experimental technique, concrete test method is: get 3 of commercially available piglets, and every heavy 10～15kg, random number is A, B, C.Respectively at spinal column both sides, back and totally 4 position depilations of cervical region health symmetry of every piglet, and under anesthesia, do the otch that is about 5cm, reach the flesh layer deeply, after the hemostasis, use 3-0 silk suture wound at the depilation position of every piglet.
This test is divided into two groups: (1), negative control group, (2), medication group;
(1), negative control group: the cervical region of the cervical region of the cervical region of piglet A and left side, back wound, piglet B and left side, back wound, piglet C and left side, back wound; After negative control group makes and disinfects in alcohol, direct sew up wound.
(2), medication group: the cervical region of the cervical region of the cervical region of piglet A and right side, back wound, piglet B and right side, back wound, piglet C and right side, back wound; Disinfect wound earlier in alcohol, card applies Chinese medicine ointment in the wound then, changed once in per three days, and be a course of treatment, adopt the iodine disinfection wound when changing dressings, to off-test at every turn.
Two, result of the test
1, observed result
Three porkling healths of postoperative are good, do not have diarrhoea, and untoward reaction such as refusing to eat are movable normal.
A, postoperative 3 days
Negative control group: the incrustation of part wound, the part wound fluid is more, and wound circumference is red and swollen.
The medication group: the wound incrustation, inflammatory reaction is lighter, and wound circumference does not have obvious redness;
B, postoperative 6 days
Negative control group: the most of incrustation of wound, wound circumference is red and swollen slightly, and suture reaction is heavier;
The medication group: epidermal area is healing basically, does not have redness, and the part wound has
Suture reaction;
C, postoperative 9,12,15,18,21,24,27,30 days
Negative control group: wound healing is good, visible significantly healing line;
The medication group: wound healing is good;
2, the histology changes
A, postoperative 3 days
Negative control group: epidermal area and skin corium do not heal, and visible part is organized internal hemorrhage in the skin corium, and fibroblast quantity is few, and inflammatory cell is more;
The medication group: epidermal area and skin corium do not heal, visible more fibroblast and inflammatory cell in the skin corium;
B, postoperative 6 days
Negative control group: epidermal area heals basically, and fibroblast in the wound skin corium is spindle shape, and quantity is few, and is sparse, and nucleus is little, and more inflammatory cell is arranged;
The medication group: epidermal area is healing basically, and visible more fibroblast is spindle shape in the skin corium, and nucleus is bigger;
C, postoperative 9 days
Each organizes wound healing basically
Negative control group: above respectively to organize quantity few for value-added fibroblast in the skin corium, and newborn collagen is also few;
Medication group: visible more fibroblast of skin corium and new crude rubber original fiber;
D, postoperative 12,30 days
Negative control group: the cicatrix of wound healing is bigger;
The medication group: cicatrix is little in the healing of wound;
Claims (3)
1. Chinese medicine ointment of treating cicatrix, it is characterized in that: described ointment is made up of Chinese medicine extract and substrate, and the percentage by weight of Chinese medicine extract and substrate is: Chinese medicine extract 30～50%, substrate 50～70%;
The crude drug of described Chinese medicine extract is by Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl., Rheum forrestii Diels, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa, Radix Desmodii Caudati; Vinegar Pyritum (processed), Eupolyphaga Seu Steleophaga, Hirudo; Borneolum Syntheticum, Camphora, Olibanum and Myrrha are formed, and the ratio of weight and number that each medical material adds is respectively: 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts in Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of Eupolyphaga Seu Steleophaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas.
2. a kind of Chinese medicine ointment of treating cicatrix as claimed in claim 1; It is characterized in that: described substrate is made up of polyvidone, glycerol, micropowder silica gel, chitosan, polyvinyl alcohol, tablet vinegar and purified water, and the ratio of weight and number that each raw material adds is respectively: 40～70 parts of 5～10 parts of polyvidones, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans, 1～5 part of polyoxyethylene alcohol, 5～10 parts of tablet vinegar and purified water.
3. the method for preparing that is used for the Chinese medicine ointment of scar treatment as claimed in claim 1, it is characterized in that: method for preparing is following:
(one), preparation Chinese medicine extract
(1), by weight; Get 20～40 parts of 50～70 parts of Radix Salviae Miltiorrhizaes, 50～70 parts of Galla Chinensiss, 20～40 parts of Herba speranskiae tuberculataes, 20～40 parts of itea orientalis Hemsl., 50～70 parts of Rheum forrestii Diels, 50～70 parts of Radix et Rhizoma Rhei Wittrockiis, 20～40 parts in Semen Persicae, 20～40 parts of Radix Genkwa, 50～70 parts of Radix Desmodii Caudatis, 20～40 parts of vinegar Pyritum (processed), 20～40 parts of Eupolyphaga Seu Steleophaga, 20～40 parts of Hirudos, 8～15 parts of Borneolum Syntheticums, 8～15 parts of Camphoras, 20～40 parts of Olibanums and Myrrhas, subsequent use;
(2), with the vinegar Pyritum (processed), Borneolum Syntheticum, Camphora, Olibanum and the Myrrha that take out in the step (1), pulverize separately to 200～400 orders, subsequent use;
(3), with the Radix Salviae Miltiorrhizae, Galla Chinensis, Herba speranskiae tuberculatae, itea orientalis Hemsl. and the Rheum forrestii Diels mix homogeneously that take out in the step (1), pulverize the back and cross 10 mesh sieves, the medical material after will sieving is then inserted in the percolator; Adding concentration and be 10～100% ethanol soaks; Alcoholic acid addition is soaked after 12～48 hours for 1.2～1.5 times of immersion medical material volume, and the concentration that adds 3～10 times of immersion medical material original volumes again is 10～100% ethanol; Carry out percolation, it is subsequent use to collect percolate;
(4), be ground into coarse powder after the Eupolyphaga Seu Steleophaga that takes out in the step (1), Hirudo, Radix et Rhizoma Rhei Wittrockii, Semen Persicae, Radix Genkwa and Radix Desmodii Caudati mixed, place extraction pot then, add purified water and decoct; The addition of purified water is 10～15 times of decocting herbs weight; Extraction time is 2 hours, extracts altogether 3 times, each after-filtration that finishes that extracts; Extracting solution with 3 extractions merges at last, and is subsequent use;
(5), percolate that step (3) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the alcohol extraction thick paste that makes is subsequent use;
(6), extracting solution that step (4) is collected sends in the vacuum decompressioning and concentrating tank, being evaporated to density is 1.10～1.30g/cm
3Thick paste, density measurement is carried out in the time of 50 ℃, reclaims solvent simultaneously, the water that makes is carried thick paste, and is subsequent use;
(7), alcohol extraction thick paste that step (5) is made, water that step (6) makes carry the medicated powder mix homogeneously of thick paste and step (2) preparation, is ground into 200～400 purpose fine powders after the oven dry, promptly makes Chinese medicine extract;
(two), preparation substrate
(1), by weight, get 5～10 parts of 5～10 parts of polyvidones, 40～70 parts of purified water, 1～5 part of polyvinyl alcohol, 30～50 parts of glycerol, 15～40 parts of micropowder silica gels, 8～15 parts of chitosans and tablet vinegar, subsequent use;
(2), with in the polyvidone and 10～20 parts of adding agitated reactors of purified water that take out in the step (1), be warming up to 60～70 ℃, stirred 30～60 minutes, make it abundant swelling, obtain the polyvidone swelling solution, subsequent use;
(3), polyvinyl alcohol that takes out in the step (1) and glycerol are added in the agitated reactor, be warmed up to 70 ℃, stirring 30min, mix homogeneously obtains pure oil solution, and is subsequent use;
(4), with 30～50 parts of the micropowder silica gel of taking out in the step (1), chitosan, tablet vinegar and purified water; Add in the agitated reactor; Stirred 1～2 minute, and added the pure oil solution that above-mentioned steps (3) makes again, be warmed up to 40～70 ℃; Stirred 2～10 minutes, and stopped to stir and static 2～5 minutes; Again the mixed solution in the agitated reactor is warming up to 50 ℃ afterwards, adds the polyvidone swelling solution that above-mentioned steps (2) makes, stirred 2～10 minutes, make substrate;
(three), preparation Chinese medicine ointment
Get the Chinese medicine extract of 30～50% above-mentioned steps () preparations and the substrate of 50～70% above-mentioned steps (two) preparation by weight percentage; Earlier substrate is added in the agitated reactor, make the substrate in the agitated reactor be warming up to 45～55 ℃, again Chinese medicine extract is added in the agitated reactor, stirred 20～40 minutes, promptly make Chinese medicine ointment.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189332A (en) * | 2014-07-31 | 2014-12-10 | 牛拥军 | Traditional Chinese medicine for treating scars and preparation method of traditional Chinese medicine |
| CN104398936A (en) * | 2014-11-05 | 2015-03-11 | 青岛华仁技术孵化器有限公司 | Dermatitis treatment ointment |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1162467A (en) * | 1996-04-12 | 1997-10-22 | 鞍山钢铁集团公司 | External use medicine for curing scars |
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2012
- 2012-09-14 CN CN201210339580.8A patent/CN102836287B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1162467A (en) * | 1996-04-12 | 1997-10-22 | 鞍山钢铁集团公司 | External use medicine for curing scars |
Non-Patent Citations (1)
| Title |
|---|
| 闫宏山等: "瘢痕的中医药治疗及其研究现状", 《中国美容医学》, vol. 15, no. 09, 28 September 2006 (2006-09-28), pages 1093 - 1095 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189332A (en) * | 2014-07-31 | 2014-12-10 | 牛拥军 | Traditional Chinese medicine for treating scars and preparation method of traditional Chinese medicine |
| CN104189332B (en) * | 2014-07-31 | 2018-08-21 | 牛拥军 | Chinese medicine and preparation method thereof for treating scar |
| CN104398936A (en) * | 2014-11-05 | 2015-03-11 | 青岛华仁技术孵化器有限公司 | Dermatitis treatment ointment |
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