CN102830162A - Harmful microparticle detection device before clinical use of injection - Google Patents
Harmful microparticle detection device before clinical use of injection Download PDFInfo
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- CN102830162A CN102830162A CN2012103158395A CN201210315839A CN102830162A CN 102830162 A CN102830162 A CN 102830162A CN 2012103158395 A CN2012103158395 A CN 2012103158395A CN 201210315839 A CN201210315839 A CN 201210315839A CN 102830162 A CN102830162 A CN 102830162A
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Abstract
The invention discloses a harmful microparticle detection device before clinical use of an injection. The harmful microparticle detection device comprises an infusion bottle to be detected, a comparison infusion bottle, a dot type ultrasonic receiving transducer, a comparison ultrasonic transducer, a detection ultrasonic transducer, a high-accuracy telescopic mechanism, a detection device shell, a water inlet electromagnetic valve, a drainage electromagnetic valve, an infusion bottle bracket, a clamping mechanism, a centrifugal motor, a microprocessor, a touch screen, a multi-channel ultrasonic signal generating and receiving module, a high-speed A/D (Analog/Digital) conversion module, an electromagnetic valve control module, a telescopic mechanism driving control module and a centrifugal motor driving control module. According to the technical scheme, non-contact, non-invasion and non-damage harmful microparticle detection with a measuring error correction function can be realized on the basis of a triple medium ultrasonic back scattering and centrifugal settling technology; and the harmful microparticle detection device has a simple structure and is low in cost.
Description
Technical field
The present invention relates to a kind of pick-up unit of relevant medical injection agent, particularly a kind of injection faces with preceding particulates emission pick-up unit.
Background technology
The particulates emission of indication is meant and is present in injection in the present technique scheme, the visual particulate matter that can observe under rated condition, its particle diameter or length usually＞50 μ m.Big quantity research proves that particulates emission can produce potential serious harm, like inflammatory reaction, granuloma, tumour, the reaction of thermal source appearance etc.Particulate will cause local vascular to stop up more greatly or too much to cause thrombus in the transfusion, so that blood supply insufficiency or produce oedema or phlebitis because of anoxic." 2010 editions regulations of Chinese pharmacopoeia: to contained particulate matter in the injection, 50 μ m above for detecting.If there is a kind of conveniently device to detect the particulates emission more than the 50 μ m before by nursery work person in clinical use, screen out non-compliant injection, patient's drug safety is played last barrier action, be to have very much clinical value.
For the particulates emission in the injection, common pick-up unit and relate to detection method lamp test and light scattering method are arranged.Lamp test is easier, practical, it is low to detect cost, is applicable to most of kinds, but that check result is influenced by artificial subjectivity is bigger.Comprising proofer's technical merit, detect gimmick, condition, degree of fatigue, eyesight, it is higher that psychological conditions etc., loss are influenced by subjectivity, can not guarantee that unacceptable product all detects.Light scattering method is comparatively objective, and cost is high, the use kind is few, parameter is provided with shortcomings such as undue influence testing result but exist at present.
It is wide that ultrasound wave has frequency band range; Penetrability is good; Can in coloured and opaque material, propagate; Advantages such as the fast and cost of measuring speed is cheap relatively, and ultrasonic mechanism of transmission in containing particle-liquid is closely related with particle grain size, can be used as the grain diameter information carrier and realize the deleterious particle detection.In 2 ~ 20MHz of routine ultrasonic frequency range; Hyperacoustic wavelength of in parenteral solution, propagating is bigger than the grain diameter of 50 μ m; Also be that size factor ka is generally less than 0.5; This moment, ultrasonic backscattering acoustic pressure will preferably adopt the ultrasonic backscattering method to detect grain diameter significantly greater than the forward scattering acoustic pressure.
Existing ultrasonic backscattering method particle detection method all is to be based upon on the model of ultrasound wave through solid-liquid two-fold media plane, and supposes that tested granule density is low to moderate and in detecting area, has only individual particle to pass through.Therefore in this type detection method, the ultrasound emission probe must be fixed on the outer wall of measurand, thereby can't detect the grain diameter that drops on the acoustic pressure near field region; Also there is the scholar to propose liquid to be measured is detected grain diameter and guarantees the single pass individual particle through the special tubule that ultrasonic probe is housed; But this class methods efficient is lower and need transformed measurand and container, can't implement non-intruding and nondestructive detection to the detected object that is similar to bottled injection and so on.In addition, consider that the relation curve right and wrong of size factor ka and backscattering acoustic pressure are dull, under the constant situation of ultrasound emission frequency, the monambiguity of its testing result also is difficult to guarantee, can not draws testing result accurately.
In view of this, the inventor combines to be engaged in ultrasound examination particulate area research work experience for many years, and the defective of above-mentioned technical field is studied for a long period of time, and this case produces thus.
Summary of the invention
The object of the present invention is to provide a kind of injection to face with preceding particulates emission pick-up unit; Based on triple media ultrasonic backscatterings and centrifugal settling technology; The particulates emission that can realize noncontact, non-intruding, non-destructive, has measuring error debugging functions detects; And it is simple in structure, with low cost.
To achieve these goals, technical scheme of the present invention is following:
A kind of injection faces with preceding particulates emission pick-up unit, comprises infusion bottle to be measured, comparison infusion bottle, the ultrasonic receiving transducer of point type, comparison ultrasonic transducer, detects ultrasonic transducer, high precision telescoping mechanism, pick-up unit shell, entering water electromagnetic valve, drain solenoid valve, infusion bottle carriage and clamp system, centrifugal motor, microprocessor, touch-screen, the generation of channel ultrasonic signal and receiver module, high-speed a/d modular converter, solenoid control module, telescoping mechanism drive control module and centrifugal motor-driven control module.
Wherein, Infusion bottle to be measured is an infusion bottle of the same type with the comparison infusion bottle; Equate with bottleneck height in vertical direction at the bottom of its bottle; The axial line of the axial line of comparison infusion bottle and vertical range and the infusion bottle to be measured of comparison ultrasonic transducer equates with the vertical range that detects ultrasonic transducer, infusion bottle to be measured and compare the subpoint of infusion bottle axial line in base plane, and ultrasonic transducer and detection ultrasonic transducer are 4 summits of certain rectangle on this plane at the subpoint of base plane; The high precision telescoping mechanism is fixedly connected through T type straight-bar with comparison ultrasonic transducer, detection ultrasonic transducer each other; The horizontal level of flexible each ultrasonic transducer of scalable through horizontal direction, high precision telescoping mechanism are fixed on the pick-up unit shell and with telescoping mechanism drive control module electricity and link to each other; Compare ultrasonic transducer and detect ultrasonic transducer employing homotype ultrasonic transducer, the comparison ultrasonic transducer all takes place with the channel ultrasonic signal with the detection ultrasonic transducer and the receiver module electricity links to each other; Infusion bottle to be measured is fixed by infusion bottle carriage and clamp system respectively with the comparison infusion bottle; The output shaft of centrifugal motor is fixedly connected with infusion bottle carriage and clamp system and can drives its rotation; Centrifugal motor is fixed on the bottom of pick-up unit shell and links to each other with centrifugal motor-driven control module electricity, and the clamp operation of infusion bottle carriage and clamp system is also by centrifugal motor-driven control module control; The ultrasonic receiving transducer of point type is fixed on the bottle wall place of the inside of comparison infusion bottle near comparison ultrasonic transducer one side; And its vertical height equates that with the comparison ultrasonic transducer other end of the ultrasonic receiving transducer of point type takes place to link to each other with the receiver module electricity with the channel ultrasonic signal; The pick-up unit side wall of outer shell that entering water electromagnetic valve and inlet pipeline are placed in capable of storing water leans on top, and drain solenoid valve is placed in the pick-up unit side wall of outer shell and leans on the bottom, all links to each other with solenoid control module electricity; The channel ultrasonic signal takes place to link to each other with the high-speed a/d modular converter with the output of receiver module; The output of high-speed a/d modular converter links to each other with microprocessor, and microprocessor links to each other with touch-screen, the generation of channel ultrasonic signal and receiver module, high-speed a/d modular converter, solenoid control module, telescoping mechanism drive control module and centrifugal motor-driven control module respectively; But touch-screen input feature vector information, demonstration particulates emission evaluation result, and can characteristic information and log-on message be sent to microprocessor.
Further, said comparison ultrasonic transducer and the ultrasonic transducer that detects the ultrasonic transducer employing,, wideband ultrasonic transducer focusing for concave spherical surface.Because the transonic model in the present technique scheme is the triple media areal models of liquid-solid-liquid, can know that from the transonic theory this will make the intensity of ultrasonic reflection echo weakened.For this reason, for better realizing the technique effect of present technique scheme, the comparison ultrasonic transducer in the present technique scheme all adopts the concave spherical surface focused transducer with the detection ultrasonic transducer, to guarantee the sound field intensity of detection zone; Simultaneously; Bottle wall thickness and matter material according to infusion bottle; Frequency f 0 when producing total transmissivity when calculating ultrasound wave through the triple media of liquid-solid-liquid plane; It is neighbouring to guarantee the ultrasonic reflection echo strength, so ultrasonic transducer all adopts the wideband ultrasonic transducer with the detection ultrasonic transducer to this frequency to adjust Frequency for Ultrasonic Energy Transducer.
Further, said detection ultrasonic transducer is also 2 the above ultrasonic transducers compositions on vertical base plane that form a line, and wherein topmost ultrasonic transducer is identical with the height of comparison ultrasonic transducer.Like this, when detecting, make the slow stepping rotation of centrifugal driven by motor infusion bottle to be measured,, just can obtain bottle comprehensive information of interior parenteral solution particle size distribution according to the amplitude and the number of ratio signal.
Adopt the present technique scheme; The present invention obtains following useful technique effect: the first, and utilize triple media ultrasound wave backscattering methods to detect deleterious particle, can realize non-intrusion type, non-damage type and non-contact measurement; And illuminance is not required, and it is preferable to detect effect; The second, utilize centrifugal settling to change surveyed area, make detection method not influenced by object concentration to be measured etc., improve detection efficiency and accuracy rate; The 3rd, can detect at acoustic pressure maximal point place, detection sensitivity is high; Four, multi-frequency ultrasound emission echo receive mode capable of using makes that the monotonicity of ultrasonic scattering intensity and size factor ka is better, thereby has guaranteed the detection monambiguity; The 5th; Employing is equipped with to inject in advance and is contained 50 μ m standard microparticle parenteral solutions, bottle matter and infusion bottle to be measured comparison infusion bottle 2 of the same type as comparison material; Both avoided adopting the lower defective of absolute value calibration measuring method reliability; Make it the accuracy of detection height, applicability is good, coincide again " in the Chinese pharmacopoeia 2010 editions " to contained particulate matter in the injection, 50 μ m above for detecting " regulation; The 6th, consider the deviation on the two infusion bottle bottle wall thickness, with error compensation coefficient k compensation sound wave transmission decay, thereby have the function of particulates emission measuring error correction when detecting; The 7th, the present technique scenario-frame is simple, with low cost, can realize the better detecting effect simultaneously.
In order further to explain technical scheme of the present invention, the present invention is done further detailed description below in conjunction with accompanying drawing and embodiment.
Description of drawings
Fig. 1 is a kind of structural representation of the present invention;
Fig. 2 is a kind of side structure synoptic diagram of the present invention;
Fig. 3 is ultrasound echo signal synoptic diagram, wherein label declaration: 1 inceptive impulse signal, 2 outer blank wall reflected signals, 3 inner bottle wall reflected signals, 4 particulate backscatter signals.
Embodiment
Below in conjunction with accompanying drawing to enforcement further detailed description of the present invention.
Like Fig. 1, shown in Figure 2; A kind of injection faces with preceding particulates emission pick-up unit, comprises the ultrasonic receiving transducer of infusion bottle to be measured 1, comparison infusion bottle 2, point type 3, comparison ultrasonic transducer 4, detects ultrasonic transducer 5, high precision telescoping mechanism 6, pick-up unit shell 7, entering water electromagnetic valve 8, drain solenoid valve 9, infusion bottle carriage and clamp system 10, centrifugal motor 11, microprocessor 12, touch-screen 13, channel ultrasonic signal take place and receiver module 14, high-speed a/d modular converter 15, solenoid control module 16, telescoping mechanism drive control module 17 and centrifugal motor-driven control module 18.
In addition, above-mentioned comparison ultrasonic transducer 4 and the ultrasonic transducer that detects ultrasonic transducer 5 employings,, wideband ultrasonic transducer focusing for concave spherical surface.Because the transonic model in the present technique scheme is the triple media areal models of liquid-solid-liquid, can know that from the transonic theory this will make the intensity of ultrasonic reflection echo weakened.For this reason, for better realizing the technique effect of present technique scheme, the comparison ultrasonic transducer in the present technique scheme all adopts the concave spherical surface focused transducer with the detection ultrasonic transducer, to guarantee the sound field intensity of detection zone; Simultaneously; Bottle wall thickness and matter material according to infusion bottle; Frequency f 0 when producing total transmissivity when calculating ultrasound wave through the triple media of liquid-solid-liquid plane; It is neighbouring to guarantee the ultrasonic reflection echo strength, so ultrasonic transducer all adopts the wideband ultrasonic transducer with the detection ultrasonic transducer to this frequency to adjust Frequency for Ultrasonic Energy Transducer.
In addition, said detection ultrasonic transducer 5 is also 2 the above ultrasonic transducers compositions on vertical base plane that form a line, and wherein topmost ultrasonic transducer is identical with the height of comparison ultrasonic transducer 4.Like this, when detecting, make the slow stepping rotation of centrifugal driven by motor infusion bottle to be measured,, just can obtain bottle comprehensive information of interior parenteral solution particle size distribution according to the amplitude and the number of ratio signal.
The implementation step of present technique scheme is following:
A kind of injection faces with preceding particulates emission detection method, comprises the early-stage preparations step, the drain step of intaking, detects preparation process and make the detection step.
Wherein early-stage preparations step; Be meant infusion bottle 1 to be measured and comparison infusion bottle 2 are separately fixed on the infusion bottle carriage and clamp system 10 separately; Contain the parenteral solution A of certain volume in the infusion bottle to be measured and possibly contain other particulates emissions; Comparison infusion bottle 2 includes the comparison liquid that is made up of pure parenteral solution A and equally distributed 50 μ m glass microballoon particles of equal volume; The ultrasonic receiving transducer 3 of point type is fixed on the bottle wall place of the inside of comparison infusion bottle 2 near comparison ultrasonic transducer one side, and its vertical height equates that with comparison ultrasonic transducer 4 other end of the ultrasonic receiving transducer 3 of point type takes place to link to each other with receiver module 14 electricity with the channel ultrasonic signal; On touch-screen 13, importing infusion bottle (can be infusion bottle only to be measured; Also can be to be measured with the contrast two infusion bottles) characteristic information (such as characteristic informations such as this soda-lime glass infusion bottle model, capacity, matter material, size and wall thickness in the present embodiment); Click the work of operation icon detection starting device, touch-screen 13 sends to microprocessor 12 with characteristic information and enabling signal; The centrifugal motor-driven control module 18 output signals of microprocessor 12 controls; Infusion bottle carriage and clamp system 10 are moved infusion bottle 1 to be measured and comparison infusion bottle 2 are clamped, centrifugal motor 11 startups of microprocessor 12 controls and running can make particle stop after the time from the t that the bottle heart fully moves to bottle wall then.
The drain step of wherein intaking is meant; After centrifugal motor 11 stops; Microprocessor 12 driving solenoid control modules 16 are sent signal opens entering water electromagnetic valve 8, in the pick-up unit shell of capable of storing water, injects pure water at least to the water level that can flood all ultrasonic transducers; After detecting end, microprocessor 12 driving solenoid control modules 16 are sent signal makes drain solenoid valve 9 open the pure water in the emptying pick-up unit shell.
Wherein detecting preparation process is meant; After centrifugal motor 11 stops; Microprocessor 12 will be compared the place, acoustic pressure maximum value Zmax place that ultrasonic transducer 4 moves to this transducer through drive control module 17 and high precision telescoping mechanism 6; The ultrasonic receiving transducer 3 of point type
distance in the i.e. distance comparison infusion bottle 2; Be connected with comparison ultrasonic transducer 4 horizontal fixed owing to detect ultrasonic transducer 5, detect ultrasonic transducer 5 and also move to the Zmax place synchronously; Microprocessor 12 infusion bottle characteristic information (like information such as matter material, wall thickness) through obtaining from touch-screen 13, calculate that ultrasound wave can be realized the frequency values of total transmissivity in triple media and according to the nearest frequency values of ultrasonic transducer characteristic selected distance centre frequency as benchmark transmission frequency f0; Because the bottle wall of comparison infusion bottle 2 and infusion bottle 1 to be measured possibly exist different; Microprocessor 12 is according to comparison infusion bottle 2 and the deviation information of infusion bottle 1 to be measured on the bottle wall thickness, calculates consequent acoustic wave transmission decay and it is compensated with an error compensation coefficient k.
Wherein making the detection step is meant; Microprocessor 12 control ultrasonic transducers 4, detect ultrasonic transducer 5 respectively by reference frequency
, 1.5
and 0.75
emission pulse ultrasonic; Write down these 3 scatter echo measured values respectively and its stack is obtained comparing scattering pressure V0 and scattering pressure V1 to be measured; Microprocessor 12 obtains the particulates emission testing result of related detection zone grain diameter with respect to the information such as size of 50 μ m standard particulates through ratio k * V1/V0, simultaneously this result is shown through touch-screen 13 and makes acousto-optic and report to the police.
In addition; The t time is meant in the said early-stage preparations step; Microprocessor 12 goes out particulate moves to bottle wall from the bottle heart maximum required time
according to the movement velocity formula of particulate in centrifugal field in conjunction with other essential feature coaptation that obtains from touch-screen 13:
；
Wherein
is the angular velocity of rotation of centrifugal motor 11;
is particle diameter;
is particle density;
is parenteral solution density;
is parenteral solution viscosity,
be the radius (characteristic parameter that partly can't accurately foresee can get its upper lower limit value) of the infusion bottle bottle heart to inwall.
In addition, following in the said detection preparation process through the formula of the total transmissivity reference frequency
of microprocessor 12 calculating ultrasound waves in triple media:
Wherein
is ultrasonic propagation velocity in the bottle wall;
(supposes the incident of the vertical bottle of ultrasound wave wall here for the thickness of bottle wall; And the ultrasonic propagation velocity in parenteral solution and the pure water equates that this assumed conditions can satisfy generally speaking).
In addition, maximum value Zmax in the said detection preparation process is to demarcate through calculation procedure and actuation step; Said calculation procedure is meant; Microprocessor 12 is according to detecting the benchmark transmission frequency f0 that obtains in the preparation process; Calculate theoretical acoustic pressure maximum value Zg (the acoustic pressure maximum value of a far and near intersection of this transducer acoustic pressure in other words of concave spherical surface focused transducer; Owing to be that this value is a calculated value; Have discrepancy with actual, need as near following method actual measurement maximum value position this distance) and apart from Zg place acoustic pressure decay distance
and
of 3dB; Said actuation step is meant; Microprocessor 12 control telescoping mechanism drive control modules 17 send signal; Drive high precision telescoping mechanism 6 drive comparison ultrasonic transducers 4 and move to the ultrasonic receiving transducer 3 of point type
distance in the distance comparison infusion bottle 2; And with certain speed to infusion bottle near up to moving to
distance; Comparison ultrasonic transducer 4 is by sending the identical pulse ultrasonic wave of intensity certain interval time when moving; A plurality of sound pressure information that the ultrasonic receiving transducer 3 of point type will receive take place through the channel ultrasonic signal and receiver module 14 passes to microprocessor 12 with high-speed a/d modular converter 15; Set up the curve of sound pressure and distance through the series data that collects, the position of finding out maximal point is maximum value
.Thereby realize the automatic focus of acoustic pressure maximal point, detection sensitivity is high.
In addition, the theoretical acoustic pressure maximum value Zg of said concave spherical surface focused transducer and following apart from the calculation procedure apart from Zl and Zr of Zg place acoustic pressure decay 3dB: microprocessor 12 calculates concave spherical surface focused transducer acoustic pressure axial distribution expression formula according to reference frequency
:
Wherein
is the characteristic acoustic impedance of sound bearing medium;
velocity amplitude when vibrating for sound source;
is the distance of bin
to observation station;
hyperacoustic angular frequency,
is hyperacoustic wave number.Wherein the relation curve of
and
can be drawn by following formula, and available thus numerical method is confirmed axial acoustic pressure maximum position
;
Wherein
is the focal length of concave spherical surface focused transducer;
is the spherical crown radius of concave spherical surface focused transducer;
is resonance frequency, and then
and
can be drawn by following formula:
In addition; Comparison infusion bottle 2 obtains through following method with the deviation information of infusion bottle 1 to be measured on the bottle wall thickness in the said detection preparation process: microprocessor 12 control ratios to ultrasonic transducer 4, detect ultrasonic transducer 5 by reference frequency
transmission test pulse, then according to ultrasonic transducer 4, the position difference that detects on the time shaft of interior outer blank wall reflected signal in the echoed signal that ultrasonic transducer 5 receives obtains infusion bottle 1 to be measured and compares the deviation information of infusion bottle 2 on the bottle wall thickness.(in the present embodiment, comparison ultrasonic transducer 4, to detect the echoed signal that ultrasonic transducer 5 receives as shown in Figure 3, comprises 1 respectively, the inceptive impulse signal; 2, outer blank wall reflected signal; 3, inner bottle wall reflected signal and 4, particulate backscatter signals, the wherein interior distance of outer blank wall reflected signal on time shaft comprised a bottle wall thickness information).
In addition, the error compensation coefficient k obtains through following manner in the said detection preparation process: the ultrasonic transmission attenuation coefficient
that is caused by the bottle wall thickness deviation calculates through following formula:
Wherein
is the wave number in comparison infusion bottle or the infusion bottle bottle wall medium to be measured;
is comparison infusion bottle or infusion bottle bottle wall thickness to be measured; Be the acoustic characteristic impedance of pure water,
for comparing the acoustic characteristic impedance of infusion bottle or infusion bottle bottle wall medium to be measured.
And k = ratio of the infusion bottle
/ analyte infusion bottle
.
In addition, detecting ultrasonic transducer 5 can be also 2 the above ultrasonic transducers compositions on vertical base plane that form a line, and wherein topmost ultrasonic transducer is identical with the height of comparison ultrasonic transducer 4; At this moment; Microprocessor 12 control ultrasonic transducers 4, detect ultrasonic transducer 5 respectively by reference frequency
, 1.5
and 0.75
emission pulse ultrasonic; Write down these 3 scatter echo measured values respectively and intercepting of particulate backscatter signals part and stack obtained the comparison scattering pressure
and the scattering pressure to be measured
of this point, microprocessor 12 through ratio
obtain the surveyed area grain diameter with respect to 50
size information of standard particle diameter.
In addition; No matter detecting ultrasonic transducer 5 is single or a plurality of ultrasonic transducers; Other steps are constant; The centrifugal motor 11 of microprocessor 12 controls rotates with certain speed in the interval time of ultrasonic transducer 4, detection ultrasonic transducer 5 emission pulse ultrasonics slowly, according to the amplitude and the number of ratio signal, just can record the comprehensive information of parenteral solution particle size distribution in the infusion bottle to be measured and provide the particulates emission evaluation result.
The principle of work of present technique scheme is following:
The deleterious particle origin cause of formation in the injection (is example with the glass transfusion bottle) and characteristic are complicated; Possibly be external pollutants such as cilium, metal fillings, chips of glass; It also possibly be endogenic solid; As: the sediment that exists in the raw material or separate out by the insolubles that incompatibility produces, crystallization etc., its concentration is unpredictable, this can't guarantee the surveyed area low concentration individual particle supposition of ultrasonic backscattering particle detection method.In order to address this problem, adopt centrifugal motor 11 to drive infusion bottle 1 to be measured and parenteral solution high speed rotating wherein in the present technique scheme.Can know that by the centrifugal settling principle liquid of forming suspension system is different because of density with particle suspensions, in centrifugal force field, relative motion will take place, thereby make suspension system obtain separate and subside.When suspension system is done gyration, the suspension that density is big (solid particle) will outwards move along turning radius direction under the effect of inertial centrifugal force.Behind certain hour, the particle aggregation in the parenteral solution and is arranged by grain size near the inwall near infusion bottle 1 to be measured in vertical direction, bulky grain below.Simultaneously, in certain range of size, can be similar to and think, have only individual particle to exist in this scope.And because particle is pressed close to a bottle wall, the influence of concentration factor almost can be ignored.This moment, surveyed area low concentration individual particle assumed conditions satisfied, and can use the ultrasonic backscattering method to detect the grain diameter of bottle wall annex.
But because the thickness of bottle wall is less than ultrasonic acoustic pressure near field length; If detect by existing ultrasonic backscattering method; Ultrasonic transducer need be installed on bottle wall; Thereby make particle to be detected drop on the acoustic pressure near field region, fluctuation acutely can't guarantee the monambiguity and the validity of testing result because acoustic pressure is in the near field region.For this reason; The present technique scheme will be compared ultrasonic transducer 4, and (both connect together with detecting ultrasonic transducer 5; Same moved further) is designed to scalable form; Automatically make zone to be detected drop on the acoustic pressure maximum value place of a far and near intersection of acoustic pressure through the position of regulating transducer, acoustic pressure detects contrast and is accomplished by the ultrasonic receiving transducer 3 of point type that is fixed in the comparison infusion bottle 2.
In addition, can be known by the ultrasonic scattering theory that the relation between ultrasonic scattering intensity and the size factor ka is non-monotonic quantity within the specific limits, and ka is relevant with grain diameter and ultrasonic wavelength, this will cause the monambiguity of testing result to guarantee.For this reason, the present invention has in use adopted multi-frequency ultrasound emission echo receive mode, to guarantee the monotonicity of ultrasonic scattering intensity and size factor ka.Find that under study for action the frequency f 0 during with total transmissivity is a benchmark, in the echoed signal that receives after the multi-frequency ultrasound emission of stack 1.5f0 and 0.75f0 frequency, the monotonicity of ultrasonic scattering intensity and size factor ka is better, can guarantee to detect monambiguity.
In addition, because in the ultrasonic backscattering detection, the factor that influences ultrasonic scattering intensity is more, adopt the method reliability of absolute value calibration measurements lower.In the present invention, for guaranteeing detecting reliability, in comparison infusion bottle 2, inject the parenteral solution that contains 50 μ m standard microparticles in advance and be used as comparison material.Comparison ultrasonic transducer 4 adopts the homotype ultrasonic transducers with detection ultrasonic transducer 5, is divided by the detection numerical value of standard liquid injection and parenteral solution to be measured, can draw the information that whether contains deleterious particle.
In addition, though infusion bottle to be measured 1 and comparison infusion bottle 2 belong to infusion bottle of the same type, a bottle wall thickness can not guarantee measure-alike, and the difference of bottle wall thickness also can influence the validity of surveyed area selection and cause detecting error simultaneously.For this reason; Microcontroller 12 is through drawing the wall thickness variation information of 2 infusion bottles to ultrasonic transducer 4 and the ultrasonic reflection echo data analysis that detects ultrasonic transducer 5 receptions; And it is treated to a certain error coefficient by the certain mathematical method; Testing result is revised, to guarantee the reliability of testing result.
Be that example specifies with " the interior deleterious particle of infusion bottle detects after adding the sulphadiazine injection in 10% glucose infusion liquid " below:
Add the sulphadiazine injection in 10% glucose infusion liquid, be prone to separate out drug crystallization particulate (particulates emission) owing to the pH value changes, this drug crystallization particulate can cause the depletion of transfusion patient peripheral vessels and deadly dying.Here the injection that proposes through the present invention faces with preceding particulates emission detection method and installs this injection is detected.
Parenteral solution in the infusion bottle 1 to be measured is to add the sulphadiazine injection in 10% glucose infusion liquid, and infusion bottle is a 3A type soda-lime glass infusion bottle, 250ml, body external diameter 66mm, bottle wall thickness 2mm.Infusion bottle 1 to be measured is fixed on infusion bottle carriage and the clamp system 10.Comparison infusion bottle 2 is selected A type soda-lime glass infusion bottle for use, fills 10% glucose infusion liquid that 250ml contains even distribution 50 μ m glass microballoon particles in the bottle.To compare infusion bottle 2 equally is fixed on infusion bottle carriage and the clamp system 10.At touch-screen 13, can select the Kunlun on-state touch-screen TPC 1062KS here for use, on import characteristic informations such as soda-lime glass infusion bottle model, capacity, matter material, wall thickness, click the work of operation icon detection starting device.Touch-screen 13 sends to microprocessor 12 with characteristic information and enabling signal, the DSP class microprocessor that the preference data processing power is strong here.Microprocessor 12 can be extrapolated particle movement near needed maximum time t (characteristic parameter that partly can't accurately foresee can be got its upper lower limit value) the bottle wall according to the movement velocity formula of particulate in centrifugal field in conjunction with other essential feature parameter.The centrifugal motor-driven control module 18 output signals of microprocessor 12 controls make carriage and clamp system 10 actions, and infusion bottle 1 to be measured is clamped.Start centrifugal motor 11 (that select for use is the two wires stepper motor 57HS09 of Shenzhen Lei Sai company, and rotating speed is controlled at about 800r/min) then here and rotate the t time.After centrifugal motor 11 stopped, microprocessor 12 driving solenoid control modules 16 are sent signal opened entering water electromagnetic valve 8, in pick-up unit, injects pure water to predetermined water level.Microprocessor 12 subsequently through information calculations such as known infusion bottle matter material, wall thickness can realize total transmissivity frequency values and according to ultrasonic transducer characteristic selected distance centre frequency nearest as benchmark transmission frequency f0, and calculate thus the concave spherical surface focused transducer theoretical acoustic pressure maximum value Zg and apart from Zg place acoustic pressure decay 3dB apart from Zl and Zr.Microprocessor 12 control telescoping mechanism drive control modules 17 send signal; Drive high precision telescoping mechanism 6 (the preferred left-handed ball screw of 1605P5 level here; Degree of regulation is about 0.025mm) drive comparison ultrasonic transducer 4 and move to the ultrasonic receiving transducer 3 about Zl distance of point type in the distance comparison infusion bottle 2, move to the Zr place with certain speed.Comparison ultrasonic transducer 4 is by sending the identical pulse ultrasonic wave of intensity certain interval time when moving; A plurality of sound pressure information that the ultrasonic receiving transducer 3 of point type will receive take place through the channel ultrasonic signal and receiver module 14 passes to microprocessor 12 with high-speed a/d modular converter 15; Set up the curve of sound pressure and distance, can find out the position Zmax of maximal point.Microprocessor 12 will be compared ultrasonic transducer 4 through drive control module 17 and high precision telescoping mechanism 6 subsequently and move to the Zmax place; Be connected with comparison ultrasonic transducer 4 horizontal fixed owing to detect ultrasonic transducer 5, detect ultrasonic transducer 5 and also move to the Zmax place synchronously.Then, microprocessor 12 control ratios to ultrasonic transducer 4, detect ultrasonic transducer 5 by the pulse of reference frequency f0 transmission test, comparison ultrasonic transducer 4, to detect the echoed signal that ultrasonic transducer 5 receives as shown in Figure 3, comprises 1 respectively, the inceptive impulse signal; 2, outer blank wall reflected signal; 3, inner bottle wall reflected signal and 4, particulate backscatter signals.The distance of wherein interior outer blank wall reflected signal on time shaft comprised bottle wall thickness information; Microprocessor 12 is according to different bottles of wall thickness of comparison infusion bottle 2 and infusion bottle 1 to be measured, calculates consequent acoustic wave transmission and decays and it is compensated with an error compensation coefficient k.Demarcation apart from Zmax and penalty coefficient k after; Microprocessor 12 control ratios are pressed reference frequency f0,1.5 f0 and 0.75 f0 emission pulse ultrasonic respectively to ultrasonic transducer 4, detection ultrasonic transducer 5; Write down these 3 scatter echo measured values respectively and its stack is obtained comparing scattering pressure V0 and scattering pressure V1 to be measured, can obtain the size of this some place grain diameter with respect to 50 μ m standard particulates by k*V1/V0 (also can adopt other amplitude-frequency analytical approach).Be made up of a plurality of ultrasonic transducers on the vertical direction owing to detect ultrasonic transducer 5, one-shot measurement can obtain a plurality of grain diameter information on the vertical direction.If the centrifugal motor 11 of control rotates with certain speed in the interval time of comparison ultrasonic transducer 4, detection ultrasonic transducer 5 emission pulse ultrasonics slowly; Then can obtain the comprehensive information of diameter of particle in the injection to be measured and provide the particulates emission evaluation result, but this result shows and sound and light alarm through touch-screen 13.After detecting end, microprocessor 12 driving solenoid control modules 16 are sent signal makes drain solenoid valve 9 open the pure water in the emptying pick-up unit.
The above is merely specific embodiment of the present invention, is not the restriction to this case design, and all equivalent variations of doing according to the design key of this case all fall into the protection domain of this case.
Claims (3)
1. an injection faces with preceding particulates emission pick-up unit, it is characterized in that: comprise infusion bottle to be measured, comparison infusion bottle, the ultrasonic receiving transducer of point type, comparison ultrasonic transducer, detect ultrasonic transducer, high precision telescoping mechanism, pick-up unit shell, entering water electromagnetic valve, drain solenoid valve, infusion bottle carriage and clamp system, centrifugal motor, microprocessor, touch-screen, the generation of channel ultrasonic signal and receiver module, high-speed a/d modular converter, solenoid control module, telescoping mechanism drive control module and centrifugal motor-driven control module;
Wherein, Infusion bottle to be measured is an infusion bottle of the same type with the comparison infusion bottle; Equate with bottleneck height in vertical direction at the bottom of its bottle; The axial line of the axial line of comparison infusion bottle and vertical range and the infusion bottle to be measured of comparison ultrasonic transducer equates with the vertical range that detects ultrasonic transducer, infusion bottle to be measured and compare the subpoint of infusion bottle axial line in base plane, and ultrasonic transducer and detection ultrasonic transducer are 4 summits of certain rectangle on this plane at the subpoint of base plane; The high precision telescoping mechanism is fixedly connected through T type straight-bar with comparison ultrasonic transducer, detection ultrasonic transducer each other; The horizontal level of flexible each ultrasonic transducer of scalable through horizontal direction, high precision telescoping mechanism are fixed on the pick-up unit shell and with telescoping mechanism drive control module electricity and link to each other; Compare ultrasonic transducer and detect ultrasonic transducer employing homotype ultrasonic transducer, the comparison ultrasonic transducer all takes place with the channel ultrasonic signal with the detection ultrasonic transducer and the receiver module electricity links to each other; Infusion bottle to be measured is fixed by infusion bottle carriage and clamp system respectively with the comparison infusion bottle; The output shaft of centrifugal motor is fixedly connected with infusion bottle carriage and clamp system and can drives its rotation; Centrifugal motor is fixed on the bottom of pick-up unit shell and links to each other with centrifugal motor-driven control module electricity, and the clamp operation of infusion bottle carriage and clamp system is also by centrifugal motor-driven control module control; The ultrasonic receiving transducer of point type is fixed on the bottle wall place of the inside of comparison infusion bottle near comparison ultrasonic transducer one side; And its vertical height equates that with the comparison ultrasonic transducer other end of the ultrasonic receiving transducer of point type takes place to link to each other with the receiver module electricity with the channel ultrasonic signal; The pick-up unit side wall of outer shell that entering water electromagnetic valve and inlet pipeline are placed in capable of storing water leans on top, and drain solenoid valve is placed in the pick-up unit side wall of outer shell and leans on the bottom, all links to each other with solenoid control module electricity; The channel ultrasonic signal takes place to link to each other with the high-speed a/d modular converter with the output of receiver module; The output of high-speed a/d modular converter links to each other with microprocessor, and microprocessor links to each other with touch-screen, the generation of channel ultrasonic signal and receiver module, high-speed a/d modular converter, solenoid control module, telescoping mechanism drive control module and centrifugal motor-driven control module respectively; But touch-screen input feature vector information, demonstration particulates emission evaluation result, and can characteristic information and log-on message be sent to microprocessor.
2. a kind of injection as claimed in claim 1 faces with preceding particulates emission pick-up unit, it is characterized in that: said comparison ultrasonic transducer and the ultrasonic transducer that detects the ultrasonic transducer employing,, wideband ultrasonic transducer focusing for concave spherical surface.
3. according to claim 1 or claim 2 a kind of injection faces with preceding particulates emission pick-up unit; It is characterized in that: said detection ultrasonic transducer is also 2 the above ultrasonic transducers compositions on vertical base plane that form a line, and wherein topmost ultrasonic transducer is identical with the height of comparison ultrasonic transducer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315839.5A CN102830162B (en) | 2012-08-31 | 2012-08-31 | Harmful microparticle detection device before clinical use of injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210315839.5A CN102830162B (en) | 2012-08-31 | 2012-08-31 | Harmful microparticle detection device before clinical use of injection |
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| Publication Number | Publication Date |
|---|---|
| CN102830162A true CN102830162A (en) | 2012-12-19 |
| CN102830162B CN102830162B (en) | 2014-06-25 |
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| CN201210315839.5A Expired - Fee Related CN102830162B (en) | 2012-08-31 | 2012-08-31 | Harmful microparticle detection device before clinical use of injection |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608715A (en) * | 1970-02-06 | 1971-09-28 | Brockway Glass Co Inc | Method and apparatus for inspecting liquids |
| CN85202399U (en) * | 1985-06-17 | 1986-07-16 | 吉林市科学技术研究所 | Detector for corpuscle in infusion |
| DE19944047A1 (en) * | 1999-09-14 | 2001-04-12 | Georg F Wagner | Device for measuring concentration/density and particles has ultrasonic transducers operating at different frequencies, whereby the highest frequency is about double the lowest |
| CN101169364A (en) * | 2007-09-27 | 2008-04-30 | 上海理工大学 | Method and device for measuring discrete state granule graininess distribution |
| CN202748344U (en) * | 2012-08-31 | 2013-02-20 | 绍兴文理学院 | Device for detecting harmful particles of injection before use |
-
2012
- 2012-08-31 CN CN201210315839.5A patent/CN102830162B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3608715A (en) * | 1970-02-06 | 1971-09-28 | Brockway Glass Co Inc | Method and apparatus for inspecting liquids |
| CN85202399U (en) * | 1985-06-17 | 1986-07-16 | 吉林市科学技术研究所 | Detector for corpuscle in infusion |
| DE19944047A1 (en) * | 1999-09-14 | 2001-04-12 | Georg F Wagner | Device for measuring concentration/density and particles has ultrasonic transducers operating at different frequencies, whereby the highest frequency is about double the lowest |
| CN101169364A (en) * | 2007-09-27 | 2008-04-30 | 上海理工大学 | Method and device for measuring discrete state granule graininess distribution |
| CN202748344U (en) * | 2012-08-31 | 2013-02-20 | 绍兴文理学院 | Device for detecting harmful particles of injection before use |
Non-Patent Citations (1)
| Title |
|---|
| 侯怀书等: "基于中低频超声波的纳米颗粒粒径测量", 《机械工程材料》 * |
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| CN102830162B (en) | 2014-06-25 |
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