CN102824232B - Anti-oxidation artificial joint prosthesis and preparation method thereof - Google Patents
Anti-oxidation artificial joint prosthesis and preparation method thereof Download PDFInfo
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- CN102824232B CN102824232B CN201210308999.7A CN201210308999A CN102824232B CN 102824232 B CN102824232 B CN 102824232B CN 201210308999 A CN201210308999 A CN 201210308999A CN 102824232 B CN102824232 B CN 102824232B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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Abstract
The invention relates to an anti-oxidation artificial joint prosthesis and a preparation method thereof. The joint prosthesis comprises metal acetabulum and a polyethylene lining, wherein the inner side of the metal acetabulum is provided with a porous structure; the polyethylene lining is embedded into the metal acetabulum; and a mixture of ultrahigh-molecular-weight polyethylene and an antioxidant constituting the polyethylene lining permeate into holes, so that the polyethylene lining and the metal acetabulum are combined tightly. The preparation method comprises the following steps of: adding the antioxidant and ultrahigh-molecular-weight polyethylene resin powder into an organic solvent, and drying to obtain mixture powder; putting the mixture powder into semispherical metal acetabulum, heating to turn the mixture powder into a melt, pressurizing with a pestle-shaped male die to make the mixture melt go deep into the holes on the metal acetabulum, cooling, pressurizing continually for 1-72 hours, cooling to the normal temperature, and demolding to obtain a prosthesis blank; and precisely cutting the prosthesis blank, grinding and polishing to obtain a finished product. The prosthesis prepared by using the method contains a powerful antioxidant, and has a high crosslinking degree; and the wear resistance of the prosthesis is enhanced.
Description
Technical field
The present invention relates to a kind of antioxidation Manmade joint prosthesis and its preparation method, particularly relate to a kind of antioxidation manual acetabulum and preparation method thereof, this prosthese is applicable to joint replacement, belongs to and is implanted into medical instruments field.
Background technology
Ultra-high molecular weight polyethylene, due to the wearability of its excellence, good mechanical property and biocompatibility, starts for artificial joint liner length of load bearing material the sixties in last century.The manufacture method of each parts of artificial joint is of a great variety, and manufacture method for artificial joint mechanical property and wearing and tearing have important impact.Traditional method is that the ultra-high molecular weight polyethylene of compression molding or plunger extrusion molding is cut into specific prosthetic element, becomes artificial joint with other assembling parts.During row joint replacement, need be chimeric with hardware by polyethylene elements with special operation tool.In order to ensure that polyethylene liner is stablized for a long time in acetabular bone, usually need the position-limit mechanism of Design and manufacture complexity on metal acetabulum and polyethylene liner.In addition, in traditional artificial hip joint, there are at least two frictional interfaces between polyethylene liner and metal ball-head, between polyethylene liner and metal acetabulum, because polyethylene liner is not often fixed, these two rubbing surfaces all can carry out relative motion, thus wear and tear, producing a large amount of abrasive dusts, is the main cause causing Periprosthe bone to dissolve.
Ultra-high molecular weight polyethylene and hardware integral molding techniques have unique advantage.Application number be US2004/0098127 A1 patent discloses a kind of similar " integral type " manual acetabulum and manufacture method thereof: pass through hot compression molding, ultra-high molecular weight polyethylene melt is forced the metal acetabulum inwall embedding porous, form the integral type acetabular bone of physics occlusion.Its advantage is: the hole formation " interpenetrating structure " of polythene material and metal, becomes as a whole, and do not need other Design and manufacture position-limit mechanism, production efficiency improves greatly; In addition, decrease the sliding friction surface of ultra-high molecular weight polyethylene and metal acetabulum, avoid back side wearing and tearing, be beneficial to and reduce rate of depreciation and abrasive dust quantity.
No matter be which kind of prosthese, after making finished product, before implant into body, have to pass through sterilization treatment, and irradiation sterilization is one of important method.In addition, in order to improve the abrasion resistance properties of prosthese, usually ultra-high molecular weight polyethylene is carried out cross-linking radiation.Irradiation sterilization and cross-linking radiation all can produce free radical, cause polyethylene to be oxidized in stock's phase with after implanting.Below respectively from the technical background that two the aspect introductions of irradiation sterilization and cross-linking radiation are relevant.
Artificial joint manufacturer main in early days generally adopts radiated by gamma-ray sterilizing in atmosphere, and preserves at air atmosphere intermediate package.In atmosphere during irradiation, polyethylene molecular chain is by dissociation, and the free radical of generation is combined with oxygen molecule rapidly, form peroxy radical, bring out the reactions such as waterfall type oxidation-chain interruption-radical transfer, constantly cause Polyethylene Chain to be oxidized, fracture, degraded, the strength of materials and toughness significantly reduce.Namely there is serious oxidation in such artificial joint, particularly polyethylene lower surface degree of oxidation is the highest, takes second place in surface after storage exceedes a year and a half.The artificial joint of irradiation sterilization implant 5-10 time, the oxygen molecule dissolved in knuckle synovia can invade polyethylene prosthese with knuckle synovia, react with the alkyl diradical in polyethylene, generate peroxy radical, peroxy radical causes polyethylene molecular chain generation waterfall type oxidation reaction, particularly lower surface that maximum oxidation occurs, fatigue toughness reduces, easy generation lamellar is peeled off, and causing prosthese to occur to loosen, dislocate, is the one of the main reasons causing prosthese (particularly knee-joint prosthesis) to be overhauled.
Polyethylene prosthese is placed in vacuum or hypoxia or oxygen-free atmosphere cross-linking radiation, the oxidation of the generating material when irradiation can be avoided, avoid or reduce the generation of peroxide or peroxy radical.Carry out vacuum packaging, inert atmosphere packaging, hypoxic atmosphere packaging or oxygen-free atmosphere packaging during irradiation and after irradiation by prosthese, greatly can improve the stability of polyethylene prosthese in storage process, significantly reduce or avoid being oxidized.According to air-locked packaging, starvation infiltrates, and the degree be oxidized occurs during can reducing stock further.But, free radical stable existence in polyethylene prosthese that irradiation produces, the polyethylene prosthese that inertia irradiation sterilization and inertia are preserved is after implant into body, although the degree that oxidation occurs significantly reduces, time significant prolongation significantly needed for oxidation occurs, but prosthese long-term (more than 10 years) oxidation stability in vivo still needs clinical research.
Non-irradiation sterilization technology does not change sub polyethylene minor structure, does not produce free radical, the polyethylene oxide problem therefore can free radical being avoided completely to cause.Oxirane is widely used in artificial joint sterilizing.Its cardinal principle oxirane is infiltrated the nearly surface layer of polyethylene prosthese, utilizes the toxicity of oxirane to come kill bacteria, spore etc.After completing sterilizing, thoroughly being volatilized by oxirane, there is not chemical reaction in oxirane and polyethylene, not residual.Oxirane is inflammable and explosive, poisonous gas, therefore must implement in strict accordance with international standard in preservation, sterilizing, disposal process, especially will avoid oxirane remaining in polyethylene prosthese.
The remarkable advantage of irradiation sterilization technology is that efficiency is high, easy to operate, sterilizing thorough, noresidue, and it is crosslinked that polyethylene molecular chain can be made in irradiation process to occur, and obtains outstanding abrasion resistance properties.This abrasion resistance properties for the clinical manifestation of polyethylene prosthese and service life most important.Therefore, irradiation sterilization technology remains very competitive sterilizing methods, is particularly suitable for carrying out sterilization treatment to integral type prosthese, and key is to develop the free radical that a kind of method produces with constant illumination.
On the other hand, irradiation crosslinking technological is widely used in the abrasion resistance properties improving polyethylene prosthese.Similarly, the free radical that irradiation produces causes polyethylene prosthese that the immanent cause be oxidized occurs in vitro and in vivo.Cross-linking radiation melting recrystallization can eliminate free radical, thus the oxidation stability improving polyethylene prosthese, but melting recrystallization causes poly intensity and toughness significantly to decline, and easily fatigue rupture occurs; Melting recrystallization causes polyethylene prosthese to produce internal stress.Therefore, cross-linking radiation and melting recrystallization technology are unsuitable for manufacturing integral type wear resistant polyethylene prosthese.The method of the free radical that a kind of new constant illumination produces need be developed.
US Patent No. 8129440 discloses a kind of ultra-high molecular weight polyethylene containing antioxidant, described antioxidant mainly refers to vitamin E, proton on its phenolic hydroxyl group easily and combined with radical, obtain Phenoxy radical, and Phenoxy radical and phenyl ring form conjugated system, radical reaction activity reduces, and stability improves, reduce free radical and oxygen molecule reacts and causes the ability of material oxidation, therefore can remarkable inhibited oxidation problem.
It is inhibited that Oral etc. (Biomaterials, 2008,29:3557) report the cross-linking radiation of vitamin E to ultra-high molecular weight polyethylene.When the content of vitamin E in ultra-high molecular weight polyethylene is higher (as higher than 0.1 wt ﹪ percentage by weight), vitamin E can react by the free radical rapidly and in polyolefin, thus hinders the compound in polymer between free radical and cross-linking reaction.Like this, vitamin E not only inhibits the generation of cross-linked structure, also promotes molecule chain break simultaneously, reduces molecular weight.Therefore, the vitamin E of high-load not only bad for the raising degree of cross linking and abrasion resistance properties, and can reduce the mechanical property of material.
On the other hand, if during the content of vitamin E lower (as lower than 0.05wt ﹪), vitamin E is subject to high-energy ray bombardment; antioxidant activity can be lost; thus partly losing oxidation resistance, antioxygenic effect significantly declines, and reduces the protective effect of material.
US Patent No. 6448315 B1 discloses a kind of method introducing vitamin E in ultra-high molecular weight polyethylene: vitamin E is dissolved in supercritical CO
2in, rely on supercritical CO
2vitamin E is diffused in ultra-high molecular weight polyethylene, realizes vitamin E and be uniformly distributed in ultra-high molecular weight polyethylene.This method length consuming time, treatment with supercritical fluid also may cause material and prosthese character to decline further, and prosthese is out of shape, and is difficult to realize vitamin E and is really uniformly distributed in prosthese, be unsuitable for preparing ultra-high molecular weight polyethylene-metal-integral acetabular bone.
US Patent No. 8038927 discloses a kind ofly permeates and spreads the method for vitamin E in crosslinked ultra-high-molecular-weight polyethylene.After ultra-high molecular weight polyethylene cross-linking radiation, be placed in vitamin E, lower than under melting temperature (as 130 ° of C), vitamin E permeated and diffuses in crosslinked polyethylene, the oxidation stability of crosslinked polyethylene can be improved, and retaining good mechanical property.The method adopts higher temperature process polythene material or blank, easily causes prosthese to be out of shape or produces internal stress, being therefore unsuitable for preparing integrated acetabular bone.
US Patent No. 2008/0293856 A1 discloses many phenolic acids Organic substances and is used as polyolefin antioxidant, but does not relate to the activity of polyolefin cross-linking radiation and antioxidant and suppress problems such as being cross-linked.
In sum, adopt antioxidant (as vitamin E) that the oxidation resistance of ultra-high molecular weight polyethylene can be improved, make ultra-high molecular weight polyethylene prosthese still can keep excellent oxidation stability after irradiation sterilization, but there is the limitation of self.The existing patent of invention all antioxidant do not mentioned beyond vitamin E is applied to ultra-high molecular weight polyethylene-one-body molded prosthese of metal, does not more disclose antioxidant except vitamin E to the static stabilization after artificial joint irradiation sterilization.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of one-body molded prosthese of ultra-high molecular weight polyethylene-metal containing antioxidant is provided, and the method for this prosthese of preparation is provided.
Antioxidation artificial joint prosthesis of the present invention comprises metal acetabulum and polyethylene liner;
Described metal acetabulum is hemispherical shell, and adopt metal material, its inner concave side has the loose structure be interconnected, and the thickness in metal acetabulum with the part of loose structure is 20 ~ 60 ﹪ of gross thickness; Porosity 50 ~ 80 ﹪ of described loose structure, the internal diameter forming the hole of loose structure is 100 ~ 1000 microns; Described porosity is the long-pending ratio of the spatial volume of loose structure mesopore and loose structure sub-population; Described metal material is rustless steel, CoCr alloy, CoCrMo alloy, Ti or Ti alloy;
Described polyethylene liner is the hemispherical shell be embedded in metal acetabulum, and the loose structure of its outer convex surface side and metal acetabulum inner concave matches, and is combined closely by the loose structure inside metal acetabulum and metal acetabulum;
The material of polyethylene liner is mass ratio is the ultra-high molecular weight polyethylene of 1000 ~ 10000:1 and the mixture of antioxidant; Described polyvinyl resin with super-high molecular weight is that molecular weight is more than or equal to 1,000,000 daltonian linear polyethylene resins, and described antioxidant is the one in caffeic acid, gallic acid, dodecyl gallate;
The part ultra-high molecular weight polyethylene of the outer convex surface of polyethylene liner and the mixture of antioxidant infiltrate in the hole of the loose structure of metal acetabulum, and chimeric with the complete physics of metal acetabulum, thus polyethylene liner and metal acetabulum are combined closely.
The loose structure that metal acetabulum in the present invention adopts is ripe prior art, the such as patent No. is 201020142273.7, name is called " material of reticulated porous structures " described in " fastening nail for femoral neck fracture " utility model patent, and inventive point of the present invention is the combination of the antioxidation new material that polyethylene liner adopts and this material and metal acetabulum.
The concrete steps preparing the method for this antioxidation artificial joint prosthesis are:
Step (1). antioxidant is added mix homogeneously in organic solvent, form antioxidant solution, again polyvinyl resin with super-high molecular weight powder is added in antioxidant solution, after abundant mixing under 40 ~ 80 ° of C dry 5 ~ 14 days, obtain antioxidant and ultra-high molecular weight polyethylene mix powder;
Described organic solvent is the one in acetone, ethanol, petroleum ether, and often liter of organic solvent adds 50 ~ 200 grams of antioxidants, and the quality of the polyvinyl resin with super-high molecular weight powder added is 1000 ~ 10000 times of the quality of the antioxidant added;
Described antioxidant is the one in caffeic acid, gallic acid, dodecyl gallate;
Described polyvinyl resin with super-high molecular weight is that molecular weight is more than or equal to 1,000,000 daltonian linear polyethylene resins;
Step (2). antioxidant and ultra-high molecular weight polyethylene mix powder are placed in the metal acetabulum of hemisphere hull shape, are heated to 180 ~ 240 ° of C, antioxidant and ultra-high molecular weight polyethylene mix powder become mixture melt; With pestle type formpiston, 5 ~ 25 MPa are forced into mixture melt, force mixture melt to penetrate in the hole of the loose structure of metal acetabulum; Then be cooled to 110 ~ 130 ° of C, constant 1 ~ 72 hour of 5 ~ 25 MPa pressure keeping pestle type formpiston to apply, then be down to room temperature, after the demoulding, obtain prosthese blank;
Described metal acetabulum is hemispherical shell, and adopt metal material, its inner concave side has the loose structure be interconnected, and the thickness in metal acetabulum with the part of loose structure is 20 ~ 60 ﹪ of gross thickness; Porosity 50 ~ 80 ﹪ of described loose structure, the internal diameter forming the hole of loose structure is 100 ~ 1000 microns; Described metal material is rustless steel, CoCr alloy, CoCrMo alloy, Ti or Ti alloy;
Step (3). under room temperature, prosthese blank precision cutting sanding and polishing is become goods.
Patent system of the present invention standby ultra-high molecular weight polyethylene-metal integral type prosthese and metal acetabulum is adopted to become a complete entirety, avoid the back of the body fretting wear that relative movement occurs, prosthesis wear can be reduced, because polyethylene embeds loose structure, there is good stability and reliability, the structure that polyethylene-metal is fitted together to is that polyethylene rubbing surface provides best mechanical support, reduces the prosthese yield stress because excessive shear, stretching, compression cause and fatigue rupture.
Prosthese prepared by the inventive method contains potent antioxidant, stronger than the oxidation resistance of vitamin E, gamma ray or electron beam sterilization can be adopted, also can by the gamma ray of high dose or electron beam to irradiate crosslinked, obtain the higher degree of cross linking, improve the antiwear property of prosthese, possess excellent oxidation stability simultaneously.
Accompanying drawing explanation
Fig. 1 is the structural representation of antioxidation artificial joint prosthesis of the present invention;
Fig. 2 is the loose structure schematic diagram in Fig. 1 inside metal acetabulum.
Detailed description of the invention
As shown in Figure 1, a kind of antioxidation artificial joint prosthesis comprises metal acetabulum 1 and polyethylene liner 2.Metal acetabulum 1 is hemispherical shell, adopts rustless steel, CoCr alloy, CoCrMo alloy, Ti or Ti alloy material.Polyethylene liner 2 is hemispherical shell, material is mass ratio is the ultra-high molecular weight polyethylene of 1000 ~ 10000:1 and the mixture of antioxidant, wherein polyvinyl resin with super-high molecular weight is that molecular weight is more than or equal to 1,000,000 daltonian linear polyethylene resins, and antioxidant is the one in caffeic acid, gallic acid, dodecyl gallate.The outer convex surface of polyethylene liner 2 is together with the inner concave compact siro spinning technology of metal acetabulum 1.
As shown in Figure 2, the inner concave side of metal acetabulum 1 has the solid netted loose structure be interconnected, the thickness in metal acetabulum 1 with the part of loose structure is 20 ~ 60 ﹪ of gross thickness, porosity 50 ~ 80 ﹪ of loose structure, the internal diameter forming the hole 1-1 of loose structure is 100 ~ 1000 microns.
The loose structure of the outer convex surface side of polyethylene liner and metal acetabulum inner concave matches, and is combined closely by the loose structure inside metal acetabulum and metal acetabulum.
The part ultra-high molecular weight polyethylene of the outer convex surface of polyethylene liner and the mixture of antioxidant infiltrate in the hole of the loose structure of metal acetabulum, and chimeric with the complete physics of metal acetabulum, thus polyethylene liner and metal acetabulum are combined closely.
The method preparing this antioxidation artificial joint prosthesis is as follows:
Embodiment 1.
Step (1). just 50 grams add in 1 liter of acetone solvent, then add 500 kilograms of polyvinyl resin with super-high molecular weight powder, fully after mixing under 80 ° of C dry 5 days, obtain antioxidant/ultra-high molecular weight polyethylene mix powder;
Step (2). be placed in the metal acetabulum of hemisphere hull shape by antioxidant/ultra-high molecular weight polyethylene mix powder, be heated to 240 ° of C, antioxidant/ultra-high molecular weight polyethylene mix powder becomes mixture melt; With pestle type formpiston, 5MPa is forced into mixture melt, forces mixture melt to penetrate in the hole of the loose structure of metal acetabulum; Then be cooled to 110 ° of C, constant 72 hours of the 5MPa pressure keeping pestle type formpiston to apply, then be down to room temperature, after the demoulding, obtain prosthese blank;
Step (3). under room temperature, prosthese blank precision cutting sanding and polishing is become goods.
Embodiment 2.
Step (1). 100 grams of gallic acids are added in 1 liter of alcohol solvent, then adds 500 kilograms of polyvinyl resin with super-high molecular weight powder, fully after mixing under 60 ° of C dry 10 days, obtain antioxidant/ultra-high molecular weight polyethylene mix powder;
Step (2). be placed in the metal acetabulum of hemisphere hull shape by antioxidant/ultra-high molecular weight polyethylene mix powder, be heated to 200 ° of C, antioxidant/ultra-high molecular weight polyethylene mix powder becomes mixture melt; With pestle type formpiston, 15MPa is forced into mixture melt, forces mixture melt to penetrate in the hole of the loose structure of metal acetabulum; Then be cooled to 120 ° of C, constant 24 hours of the 15MPa pressure keeping pestle type formpiston to apply, then be down to room temperature, after the demoulding, obtain prosthese blank;
Step (3). under room temperature, prosthese blank precision cutting sanding and polishing is become goods.
Embodiment 3.
Step (1). 200 grams of dodecyl gallates are added in 1 liter of petroleum ether solvent, add 200 kilograms of polyvinyl resin with super-high molecular weight powder again, after abundant mixing under 40 ° of C dry 14 days, obtain antioxidant/ultra-high molecular weight polyethylene mix powder;
Step (2). be placed in the metal acetabulum of hemisphere hull shape by antioxidant/ultra-high molecular weight polyethylene mix powder, be heated to 180 ° of C, antioxidant/ultra-high molecular weight polyethylene mix powder becomes mixture melt; With pestle type formpiston, 25MPa is forced into mixture melt, forces mixture melt to penetrate in the hole of the loose structure of metal acetabulum; Then be cooled to 130 ° of C, constant 1 hour of the 25MPa pressure keeping pestle type formpiston to apply, then be down to room temperature, after the demoulding, obtain prosthese blank;
Step (3). under room temperature, prosthese blank precision cutting sanding and polishing is become goods.
Polyvinyl resin with super-high molecular weight above in each embodiment is that molecular weight is greater than 1,000,000 daltonian linear polyethylene resins.
Claims (10)
1. an antioxidation artificial joint prosthesis, comprises metal acetabulum and polyethylene liner, it is characterized in that:
Described metal acetabulum is hemispherical shell, and adopt metal material, its inner concave side has the loose structure be interconnected, and the thickness in metal acetabulum with the part of loose structure is 20 ~ 60 ﹪ of gross thickness;
Described polyethylene liner is the hemispherical shell be embedded in metal acetabulum, and the loose structure of its outer convex surface side and metal acetabulum inner concave matches, and is combined closely by the loose structure inside metal acetabulum and metal acetabulum;
The material of polyethylene liner is mass ratio is the ultra-high molecular weight polyethylene of 1000 ~ 10000:1 and the mixture of antioxidant;
The part ultra-high molecular weight polyethylene of the outer convex surface of polyethylene liner and the mixture of antioxidant infiltrate in the hole of the loose structure of metal acetabulum, and chimeric with the complete physics of metal acetabulum.
2. a kind of antioxidation artificial joint prosthesis as claimed in claim 1, is characterized in that: porosity 50 ~ 80 ﹪ of described loose structure, and the internal diameter forming the hole of loose structure is 100 ~ 1000 microns.
3. a kind of antioxidation artificial joint prosthesis as claimed in claim 1, is characterized in that: described metal material is rustless steel.
4. a kind of antioxidation artificial joint prosthesis as claimed in claim 1, is characterized in that: described metal material is CoCr alloy, CoCrMo alloy, Ti or Ti alloy.
5. a kind of antioxidation artificial joint prosthesis as claimed in claim 1, it is characterized in that: described polyvinyl resin with super-high molecular weight is that molecular weight is more than or equal to 1,000,000 daltonian linear polyethylene resins, and described antioxidant is the one in caffeic acid, gallic acid, dodecyl gallate.
6. prepare the method for antioxidation artificial joint prosthesis according to claim 1, it is characterized in that the concrete steps of the method are:
Step (1). antioxidant is added mix homogeneously in organic solvent, form antioxidant solution, again polyvinyl resin with super-high molecular weight powder is added in antioxidant solution, after abundant mixing at 40 ~ 80 DEG C dry 5 ~ 14 days, obtain antioxidant and ultra-high molecular weight polyethylene mix powder;
Described organic solvent is the one in acetone, ethanol, petroleum ether, and often liter of organic solvent adds 50 ~ 200 grams of antioxidants, and the quality of the polyvinyl resin with super-high molecular weight powder added is 1000 ~ 10000 times of the quality of the antioxidant added;
Step (2). antioxidant and ultra-high molecular weight polyethylene mix powder are placed in the metal acetabulum of hemisphere hull shape, are heated to 180 ~ 240 DEG C, antioxidant and ultra-high molecular weight polyethylene mix powder become mixture melt; With pestle type formpiston, 5 ~ 25MPa is forced into mixture melt, forces mixture melt to penetrate in the hole of the loose structure of metal acetabulum; Then be cooled to 110 ~ 130 DEG C, constant 1 ~ 72 hour of the 5 ~ 25MPa pressure keeping pestle type formpiston to apply, then be down to room temperature, after the demoulding, obtain prosthese blank; Described metal acetabulum is hemispherical shell, and adopt metal material, its inner concave side has the loose structure be interconnected, and the thickness in metal acetabulum with the part of loose structure is 20 ~ 60 ﹪ of gross thickness;
Step (3). under room temperature, prosthese blank precision cutting sanding and polishing is become goods.
7. the preparation method of a kind of antioxidation artificial joint prosthesis as claimed in claim 6, it is characterized in that: described polyvinyl resin with super-high molecular weight is that molecular weight is more than or equal to 1,000,000 daltonian linear polyethylene resins, and described antioxidant is the one in caffeic acid, gallic acid, dodecyl gallate.
8. the preparation method of a kind of antioxidation artificial joint prosthesis as claimed in claim 6, is characterized in that: porosity 50 ~ 80 ﹪ of described loose structure, and the internal diameter forming the hole of loose structure is 100 ~ 1000 microns.
9. the preparation method of a kind of antioxidation artificial joint prosthesis as claimed in claim 6, is characterized in that: described metal material is rustless steel.
10. the preparation method of a kind of antioxidation artificial joint prosthesis as claimed in claim 6, is characterized in that: described metal material is CoCr alloy, CoCrMo alloy, Ti or Ti alloy.
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| CN103222904B (en) * | 2013-04-27 | 2015-10-14 | 上海交通大学 | Distributed acetabular component |
| CN103495201B (en) * | 2013-09-05 | 2015-04-29 | 苏州博恩瑞科生物材料有限公司 | Novel acetabulum assembly, and preparation method and application thereof |
| CN106580521B (en) * | 2017-01-10 | 2018-04-13 | 李国安 | A kind of composite head artificial hip joint |
| CN110123491B (en) * | 2019-04-28 | 2021-06-25 | 深圳大学 | Artificial acetabulum liner based on titanium alloy porous framework and manufacturing method thereof |
| CN115957384A (en) * | 2022-12-28 | 2023-04-14 | 中国科学院宁波材料技术与工程研究所 | Bionic joint super-lubricant and preparation method and application thereof |
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| CN1135321A (en) * | 1995-02-14 | 1996-11-13 | 布里斯托尔-迈尔斯斯奎布公司 | Acetabulum seat |
| CN1177468A (en) * | 1996-02-02 | 1998-04-01 | 布里斯托尔-迈尔斯斯奎布公司 | Restraining ring for hip-joint cup contacting to artificial pone |
| US8038927B2 (en) * | 2003-01-16 | 2011-10-18 | The General Hosital Corporation | Methods for making oxidation resistant polymeric material |
| CN102630197A (en) * | 2009-11-13 | 2012-08-08 | 欧洲涂料有限公司 | Process for coupling a polymeric component to a metal component forming part of or a biomedical joint prosthesis |
| CN102604188A (en) * | 2012-03-02 | 2012-07-25 | 中国科学院宁波材料技术与工程研究所 | Antioxidant cross-linked polymer and preparation method thereof |
| CN202843852U (en) * | 2012-08-28 | 2013-04-03 | 中国科学院宁波材料技术与工程研究所 | Oxidation resisting artificial joint prosthesis |
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|---|---|
| CN102824232A (en) | 2012-12-19 |
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