CN102824225A - Micro-dosing system - Google Patents
Micro-dosing system Download PDFInfo
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- CN102824225A CN102824225A CN2012103365304A CN201210336530A CN102824225A CN 102824225 A CN102824225 A CN 102824225A CN 2012103365304 A CN2012103365304 A CN 2012103365304A CN 201210336530 A CN201210336530 A CN 201210336530A CN 102824225 A CN102824225 A CN 102824225A
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Abstract
The invention discloses a micro-dosing system, and relates to dosing equipment in the fields of life science, health care and the like. The micro-dosing system comprises a guide tube, an inner injection tube, a locking screw cap and a guide tube core. During dosing, the guide tube (1), the inner injection tube (2) and the locking screw cap (3) are combined into a whole body; and during sealing, the guide tube (1) and the guide tube core (4) are combined into a whole body. A PE (polyethylene) tube is sleeved onto a small cylinder of the inner injection tube; an injection tube of the inner injection tube is inserted from the front end of the guide tube along an inner hole; a through hole in the locking screw cap penetrates through the PE tube and is connected with an external thread of the guide tube in screwed and locked way; cylindrical sections in tight fit with each other are arranged between the guide tube and the inner injection tube, so that the difficult problem of sealing is solved; and after the inner injection tube, the PE tube and the locking screw cap are dismounted, the guide tube core can also be mounted for sealing an opening of the guide tube so as to guarantee re-injection for dosing. According to the micro dosing system, the purposes that an outer tube is embedded once, dosing is carried out for multiple times, and inner tubes with different thicknesses can also be sealed after being matched with the outer tube are achieved; the sealing property is good; and medicinal liquid can be effectively prevented from overflowing so as to reduce experimental data errors.
Description
Technical field
The present invention relates to test administration device.
Background technology
Present micro-administration system mainly contains three aspects by workflow: at first be that the externally threaded outer tube metal segments of band plastic cement is grown into the animal experiment position and fixed in assigned address; Next is to pass outer pipe orifice and be inserted into after the desired depth and be locked with lock nut having the interior pipe exposed metal pipeline section that connects flexible pipe, the reuse syringe with medicinal liquid through connect flexible pipe and in pipe and then inject animal inner tissue and accomplish administration; The 3rd, administration is extracted interior pipe after accomplishing, and uses nut locking instead and seal outer pipe orifice, makes things convenient for rechallenge.Form of medication is varied at present, but nothing more than minute single administration and multiple dosing.Single administration: simple to operate, only need can accomplish with syringe acupuncture treatment injection, be common in clinical practice.Multiple dosing: need take the mode gradation administration of pre-buried needle tubing, and the micro-administration system realize just multiple dosing indispensable equipment.
The administration process of micro-administration system can be continuously or discontinuity carry out several times, and do not cause the wound once more of laboratory animal.Yet, in the time of need adopting in the different thicknesses pipe administration for same outer tube, can't directly seal between inner and outer pipe, like this, between administration process herb liquid is just easily by pipe, overflow loss in the gap, cause the experimental data error.
Summary of the invention
But the object of the present invention is to provide the micro-administration system of the multiple interior pipe of a kind of adapted, good airproof performance.
The present invention is that the technical scheme that is adopted that achieves the above object is: a kind of micro-administration system comprises pipe, lock nut, catheter core in conduit, the injection; During administration, pipe, lock nut are combined into one in conduit, the injection; When sealing, conduit and catheter core are combined into one;
Conduit is provided with the conduit through hole along the axle center, the pipe shaft outer ring is provided with screw thread, and the front end of conduit screw thread is provided with a frustum, and frustum extends to form a cylinder vertically, and the rear end of conduit through hole is provided with inserts section, and the conduit through hole can be through the syringe of managing in the injection with the insertion section;
Pipe is provided with pipe through-hole in the injection in the injection along the axle center, and the rear end of pipe through-hole is provided with the angle that cooperates with frustum in the injection, and the back segment and the cylinder of pipe through-hole are sealed and matched in the injection; Be provided with syringe, the leading portion of syringe is fixed on the leading portion of pipe through-hole in the injection, and the syringe rear end extends to can pass the length that conduit inserts section; The profile front end of pipe is a cylinder in the injection, but this cylinder socket PE pipe, and the cylindrical diameter of back segment is greater than the cylindrical diameter of leading portion, and is excessive through sloping platform between the section cylinder of front and back;
Lock nut is provided with the endoporus that cooperates with the profile of injecting interior pipe along the axle center, endoporus can hold pipe in the injection, and the front end of endoporus is provided with the female thread that matches with the conduit external screw thread;
Catheter core is provided with the internal thread hole that cooperates with the conduit external screw thread, and the rear end of this internal thread hole is provided with the endoporus of the band frustum that cooperates with the conduit frustum;
During administration, syringe passes conduit and inserts section, and the front end of pipe is installed in the rear end of conduit in injecting, and on lock nut was enclosed within and manages in the injection, lock nut was connected with conduit through screw thread; When sealing, catheter core is connected with conduit through screw thread.
Alternatively, said frustum extends to form a cone vertically, and the endoporus of pipe is that taper and cone are sealed and matched in the injection.
Preferably, said catheter core endoporus rear end plant be embedded with metal-cored, metal-cored be provided with along the axle center to stretch out the catheter core rear end face and to extend to can pass the length that conduit inserts section.
The invention solves once pre-buried outer tube, the difficult problem that the pipe adapted still can seal in the different thicknesses.Good airproof performance of the present invention, thus can prevent effectively that medicinal liquid from overflowing loss and causing the experimental data error.
Description of drawings
Fig. 1 is the administration state assembling sketch map of preferred embodiment of the present invention;
Fig. 2 is the state that the seals assembling sketch map of preferred embodiment of the present invention;
Fig. 3 is the guide-tube structure sketch map of preferred embodiment of the present invention;
Fig. 4 is the injection inner tube structure sketch map of preferred embodiment of the present invention;
Fig. 5 is the lock nut structural representation of preferred embodiment of the present invention;
Fig. 6 is the catheter core structural representation of preferred embodiment of the present invention.
The specific embodiment
To combine accompanying drawing and embodiment that the present invention is described further below:
Like Fig. 1, shown in Figure 2, a kind of micro-administration system comprises pipe 2, lock nut 3, catheter core 4 in conduit 1, the injection; During administration, pipe 2, lock nut 3 are combined into one in conduit 1, the injection; When sealing, conduit 1 is combined into one with catheter core 4.
As shown in Figure 3; Conduit 1 is provided with conduit through hole 104 along the axle center; The pipe shaft outer ring is provided with screw thread 103, and the front end of conduit screw thread is provided with a frustum 101, and frustum 101 extends to form a cylinder 102 vertically; The rear end of conduit through hole 104 is provided with inserts section 105, conduit through hole 104 with insert section 105 can be through the syringe 206 of pipe 2 in the injection.
As shown in Figure 4, pipe 2 is provided with pipe through-hole 201 in the injection in the injection along the axle center, and the rear end of pipe through-hole is provided with the angle 202 that cooperates with frustum 101 in the injection, and the back segment and the cylinder 102 of the interior pipe through-hole of injection are sealed and matched; Be provided with syringe 206, the leading portion of syringe 206 is fixed on the leading portion of pipe through-hole 201 in the injection, and the syringe rear end extends to can pass the length that conduit inserts section 105; The profile front end of pipe 2 is a cylinder 204 in the injection, but this cylinder 204 socket PE pipe, and the diameter of back segment cylinder 203 is greater than the cylindrical diameter of leading portion, and is excessive through sloping platform 205 between the section cylinder of front and back.
As shown in Figure 5, lock nut 3 is provided with the endoporus 301 that cooperates with the profile of injecting interior pipe 2 along the axle center, and endoporus 301 can hold pipe 2 in the injection, and the front end of endoporus is provided with the female thread 302 that matches with conduit 1 external screw thread.The rear end of female thread 302 is the inner conical surfaces that match with the interior pipe of injection frustum, and the inner conical surface rear end is a through hole, and through hole can run through the PE flexible pipe.
As shown in Figure 6, catheter core 4 is provided with the internal thread hole 401 that cooperates with the conduit external screw thread, and the rear end of this internal thread hole 401 is provided with the endoporus of the band frustum that cooperates with the conduit frustum.
During administration, syringe 206 passes conduit and inserts section 105, and the front end of pipe 2 is installed in the rear end of conduit 1 in injecting, and lock nut 3 is enclosed within manages in the injection on 2, and lock nut 3 is connected with conduit 1 through screw thread; When sealing, catheter core 4 is connected with conduit 1 through screw thread.
The extension cylinder of conduit 1 cooperates with the interior pipe 2 of injection, can also be, said frustum 101 extends to form a cone 102 vertically, and the endoporus of injecting interior pipe 2 is conical and cone 102 is sealed and matched.Insert in the injection in the pipe 2 the be more convenient for rear end of conduit 1 of cone 102, and sealing effectiveness is better simultaneously.
As shown in Figure 2, catheter core 4 is provided with endoporus 401, and this endoporus 401 matches with the back segment of conduit 1, and catheter core 4 is connected with conduit 1 through screw thread.The endoporus 401 of said catheter core cooperates with the rear end pipe of pipe 2 in the injection, is provided with and injects the interior taper hole 402 that 2 frustums match of managing in the hole, and the hole wall of taper hole below is provided with the female thread 403 that matches with the conduit external screw thread.
Like Fig. 2, shown in Figure 5, said catheter core 4 endoporus rear ends are planted and are embedded with metal-cored 404, metal-cored 404 and are provided with to stretch out the catheter core rear end face and to extend to along the axle center and can pass the length that conduit inserts section.Metal-cored 404 insert conduit inserts section 105, can catheter opening be covered, and prevents that medicinal liquid from leaking; Prevent also that simultaneously conduit from inserting in the section 105 body fluid of injection experiments body and condensing and result in blockage.
The outer wall of said catheter core 4 is provided with anti-skidding stricture of vagina 405.The setting of anti-skidding stricture of vagina 405 makes things convenient for the user catheter core 4. of screwing
Operating process: in advance laboratory animal is anaesthetized and fixing the processing; And insert section 105 at its test position according to conduit and expose length and the size aperture that spuds in; Conduit is inserted section 105 insert in the boring, and with bonding agent that conduit 1 and animal experiment position is bonding firmly; The good elongated PE pipe of cylindrical section 204 covers before the pipe in the injection; Pipe 2 was adjacent to conduit 1 in the syringe 206 of pipe inserted and also will inject on earth in the guide hole in will injecting again; And then manage 2 with lock nut 3 through the PE pipe and in injecting, make its interior pitch thread be connected locking with conduit 1 external screw thread.So far, just can medicinal liquid be injected the animal experiment position via pipe 2 in PE pipe, the injection through syringe or other pressure injection apparatus; Drug administration by injection unclamps lock nut 3 after accomplishing; Take out pipe 2 in the injection, again the intermetallic metal core 404 of catheter core 4 is inserted the conduit endoporus and be locked on the conduit 1, like this; Just covered guide hole; Simultaneously owing to metal-cored 404 be to see through the conduit endoporus to insert and the same degree of depth of interior pipe, when continuing administration, can pull out catheter core 4, carry out administration after inserting in the injection pipe and locking again.
On the conduit in small column 102 and the injection 201 of pipe orifices closely cooperate with conical surface form, like this, though the part medicinal liquid that injection arranged in conduit endoporus and injection, manage between the gap overflow, can not leak out yet.
Good airproof performance of the present invention, thus can prevent effectively that medicinal liquid from overflowing loss and causing the experimental data error.Wound site sealing simultaneously can repeatedly repeat to launch, and realizes continuously or the discontinuity multiple dosing, and exempts experimental animal and injure once more.
Claims (4)
1. a micro-administration system is characterized in that: comprise pipe (2), lock nut (3), catheter core (4) in conduit (1), the injection; During administration, pipe (2), lock nut (3) are combined into one in conduit (1), the injection; When sealing, conduit (1) and catheter core (4) are combined into one;
Conduit (1) is provided with conduit through hole (104) along the axle center; The pipe shaft outer ring is provided with screw thread (103); The front end of conduit screw thread is provided with a frustum (101); Frustum (101) extends to form a cylinder (102) vertically, and the rear end of conduit through hole (104) is provided with inserts section (105), and conduit through hole (104) can be through managing the syringe (206) of (2) with insertion section (105) in the injection;
Pipe (2) is provided with pipe through-hole (201) in the injection in the injection along the axle center, and the rear end of pipe through-hole is provided with the angle (202) that cooperates with frustum (101) in the injection, and the back segment and the cylinder (102) of pipe through-hole are sealed and matched in the injection; Be provided with syringe (206), the leading portion of syringe (206) is fixed on the leading portion of pipe through-hole (201) in the injection, and the syringe rear end extends to can pass the length that conduit inserts section (105); The profile front end of pipe (2) is cylinder (204) in the injection, this cylinder (204) but socket PE pipe, the diameter of back segment cylinder (203) is greater than the cylindrical diameter of leading portion, and is excessive through sloping platform (205) between the section cylinder of front and back;
Lock nut (3) is provided with the endoporus (301) that cooperates with the profile of injecting interior pipe (2) along the axle center, endoporus (301) can hold pipe (2) in the injection, and the front end of endoporus is provided with the female thread (302) that matches with conduit (1) external screw thread;
Catheter core (4) is provided with the internal thread hole (401) that cooperates with the conduit external screw thread, and the rear end of this internal thread hole (401) is provided with the endoporus of the band frustum that cooperates with the conduit frustum;
During administration, syringe (206) passes conduit and inserts section (105), and the front end of pipe (2) is installed in the rear end of conduit (1) in injecting, and lock nut (3) is enclosed within manages in the injection on (2), and lock nut (3) is connected with conduit (1) through screw thread; When sealing, catheter core (4) is connected with conduit (1) through screw thread.
2. according to the said micro-administration of claim 1 system, it is characterized in that: said frustum (101) extends to form a cone (102) vertically, and the endoporus of pipe (2) is that taper and cone (102) are sealed and matched in the injection.
3. according to the said micro-administration of claim 1 system; It is characterized in that: said catheter core (4) endoporus rear end is planted and is embedded with metal-cored (404), and metal-cored (404) are provided with along the axle center to stretch out the catheter core rear end face and extend to and can pass the length that conduit inserts section (105).
4. according to the said micro-administration of claim 3 system, it is characterized in that: the outer wall of said catheter core (4) is provided with anti-skidding stricture of vagina (405).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103365304A CN102824225A (en) | 2012-06-29 | 2012-09-13 | Micro-dosing system |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220310475.7 | 2012-06-29 | ||
| CN201220310475 | 2012-06-29 | ||
| CN2012103365304A CN102824225A (en) | 2012-06-29 | 2012-09-13 | Micro-dosing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102824225A true CN102824225A (en) | 2012-12-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012103365304A Pending CN102824225A (en) | 2012-06-29 | 2012-09-13 | Micro-dosing system |
Country Status (1)
| Country | Link |
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| CN (1) | CN102824225A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353855A (en) * | 2019-07-24 | 2019-10-22 | 兰州大学 | A kind of pharmacological experiment intragastric administration on mice device and its application method |
| CN113198029A (en) * | 2021-04-12 | 2021-08-03 | 杭州优尼克消毒设备有限公司 | Vehicle-mounted type ethylene oxide sterilizer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2055291A1 (en) * | 2007-11-02 | 2009-05-06 | Policare S.r.l. | Device designed to aid drawing of liquid medicaments from containers |
| US20110214777A1 (en) * | 2010-03-08 | 2011-09-08 | Rudolf Matusch | Method and device for filling a disposable injector |
| US20120083739A1 (en) * | 2010-10-05 | 2012-04-05 | Nelson Brian D | Retainer for immobilizing an implanted catheter during stylet retraction, and stylet holder for use with same |
-
2012
- 2012-09-13 CN CN2012103365304A patent/CN102824225A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2055291A1 (en) * | 2007-11-02 | 2009-05-06 | Policare S.r.l. | Device designed to aid drawing of liquid medicaments from containers |
| US20110214777A1 (en) * | 2010-03-08 | 2011-09-08 | Rudolf Matusch | Method and device for filling a disposable injector |
| US20120083739A1 (en) * | 2010-10-05 | 2012-04-05 | Nelson Brian D | Retainer for immobilizing an implanted catheter during stylet retraction, and stylet holder for use with same |
Non-Patent Citations (4)
| Title |
|---|
| DADASAHEB M.KOKARE等: "《a simple and inexpensive method to fabricate a cannula system for intracranial injections in rats and mice》", 《JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS》, vol. 64, 31 December 2011 (2011-12-31), pages 246 - 250, XP028117531, DOI: doi:10.1016/j.vascn.2011.08.002 * |
| DMITRY V. ZARETSKY等: "《stress-free microinjection in conscious rats》", 《JOURNAL OF NEUROSCIENCE METHOD》, vol. 199, 31 December 2011 (2011-12-31), pages 199 - 207 * |
| Y.XIA等: "《differential neuronal activation in the hypothalamic paraventricular nucleus and autonomic/neuroendocrine responses to I.C.V. endotoxin》", 《NEUROSCIENCE》, vol. 121, 31 December 2003 (2003-12-31), pages 219 - 231 * |
| 于海明等: "《大脑侧脑室置管方法的改良》", 《大脑侧脑室置管方法的改良》, vol. 21, no. 2, 31 March 2005 (2005-03-31), pages 207 - 211 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353855A (en) * | 2019-07-24 | 2019-10-22 | 兰州大学 | A kind of pharmacological experiment intragastric administration on mice device and its application method |
| CN113198029A (en) * | 2021-04-12 | 2021-08-03 | 杭州优尼克消毒设备有限公司 | Vehicle-mounted type ethylene oxide sterilizer |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20121219 |