CN110353855A - A kind of pharmacological experiment intragastric administration on mice device and its application method - Google Patents
A kind of pharmacological experiment intragastric administration on mice device and its application method Download PDFInfo
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- CN110353855A CN110353855A CN201910671505.3A CN201910671505A CN110353855A CN 110353855 A CN110353855 A CN 110353855A CN 201910671505 A CN201910671505 A CN 201910671505A CN 110353855 A CN110353855 A CN 110353855A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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Abstract
The invention discloses a kind of pharmacological experiment intragastric administration on mice devices and its application method, and in particular to Bioexperiment instrument field, including stabilizing mechanism and mechanism for filling liquid；The stabilizing mechanism includes riser, and through jack is equipped on the riser, the jack side is equipped with intubation, inclination cover is equipped at the top of the riser, the bottom of the riser is equipped with transverse slat, and the inclination cover top surface and transverse slat bottom surface are equipped with hook, elastic blanket net hung on the hook.The present invention passes through setting stabilizing mechanism, first rotate screw rod, the position of activity card sets is adjusted, and the position precision in activity card sets is improved through the scale strip on form and the pointer in activity card sets, activity card sets are defined the insertion depth of gastric perfusion needle, prevent insertion position process from injuring mouse, and by intubation so that the mouth of mouse keeps opening, so that insertion process is more stable, integrally make present invention safety with higher.
Description
Technical field
The present invention relates to Bioexperiment equipment technology fields, it is more particularly related to which a kind of pharmacological experiment is used
Intragastric administration on mice device and its application method.
Background technique
Mouse belongs to vertebrate, Mammalia, Rodentia, murine.Mice Body is small, and feeding management is convenient, is easy to
Control；Reproduction is fast；It can wean within 3 weeks after birth.A large amount of inbred strais, mutantion line and envelope with different characteristics is possessed
Closed group, and a variety of internationally recognized standard strains have been formed, it is widely used in various nutrition experimental studies.
It is continuous that the utility model patent of 206080761 U of patent application publication CN discloses a kind of rats and mice experiment use
Experimental drug liquid is perfused to test mouse suitable for medical research in irrigation stomach device.The utility model includes electric pipettor by mouse
Stomach-filling pipe, rat oral gavage pipe, rack are constituted；The Xiang Duan of intragastric administration on mice pipe and rat oral gavage pipe is equipped with medical fluid inlet and medical fluid
Inlet can be exported respectively with the pipettor rubber head on electric pipettor and be connected；The nozzle of rats and mice stomach-filling bottom of the tube is respectively
Round and smooth blunt mouth and round and smooth blunt mouth avoid the alimentary canal of injury rats and mice.Stomach-filling pipe described in the utility model can be disposably continuous
The stomach-filling operation that medical fluid is carried out to 4 to 5 mouse must repeat sucking medical fluid in syringe when reducing each mouse stomach-filling
Lengthy and tedious operation, stomach-filling process is simple and feasible, saves the plenty of time, effectively improves experimental work efficiency.
But still there is more disadvantage in practice in above-mentioned technical proposal, such as the stomach-filling in above-mentioned technical proposal
Device is easy to be influenced to stab murine oral and esophagus by operator itself hand, safety when carrying out stomach-filling to mouse
Property is not ideal enough.
Summary of the invention
In order to overcome the drawbacks described above of the prior art, the embodiment of the present invention provides a kind of pharmacological experiment intragastric administration on mice
Device and its application method first rotate screw rod, are adjusted to the position of activity card sets, and penetrate by the way that stabilizing mechanism is arranged
Pointer on scale strip and activity card sets on form improves the position precision in activity card sets, and activity card sets are to gastric perfusion needle
Insertion depth is defined, and prevents insertion position process from injuring mouse, and by intubation so that the mouth holding opening of mouse, makes
It is more stable to obtain insertion process, integrally makes present invention safety with higher.
To achieve the above object, the invention provides the following technical scheme: a kind of pharmacological experiment intragastric administration on mice device, packet
Include stabilizing mechanism and mechanism for filling liquid；
The stabilizing mechanism includes riser, and through jack is equipped on the riser, the jack side is equipped with intubation, described
Inclination cover is equipped at the top of riser, the bottom of the riser is equipped with transverse slat, and the inclination cover top surface and transverse slat bottom surface are equal
Equipped with hook, elastic blanket net is hung on the hook, described elasticity blanket net one end is equipped with rubber ring, and the intubation front side surface is set
There is form, the form is equipped with scale strip, and the cannula interior is equipped with activity card sets, and the activity card sets front side surface is equipped with
Pointer, the activity card sets top are equipped with first connecting rod, sliding slot are equipped at the top of the first connecting rod, the sliding slot inside is equipped with spiral shell
Line casing, the threaded sleeve inside are equipped with screw rod, and the threaded sleeve is fixedly connected with first connecting rod top.
In a preferred embodiment, the mechanism for filling liquid includes injection tube, and described injection tube one end is equipped with connection
Mouthful.
In a preferred embodiment, set is equipped with connector sleeve, connector sleeve one end connection on the connector
Equipped with gastric perfusion needle, the end shape of the gastric perfusion needle is set as arc.
In a preferred embodiment, the first active rubber block, first activity are equipped with inside the injection tube
Rubber block one end is equipped with the first push rod, and the first active rubber block surface is equipped with multiple sealing strips.
In a preferred embodiment, first push rod one end is equipped with the first push plate, first active rubber
Block internal run-through is equipped with through slot, and one end is equipped with check valve inside the through slot.
In a preferred embodiment, the second active rubber block, the described second movable rubber are equipped with inside the through slot
Blob of viscose one end is equipped with the second push rod, and second push rod one end is equipped with the second push plate.
In a preferred embodiment, described intubation one end is equipped with rubber sleeve, and described rubber sleeve one end is equipped with opening,
The activity card sets bottom is equipped with second connecting rod, and the second connecting rod bottom end is equipped with movable balls, is equipped with and lives on the outside of the movable balls
Dynamic slot.
A kind of application method of pharmacological experiment intragastric administration on mice device, comprising the following steps:
Step 1: the position of activity card sets is adjusted according to the size of mouse, the screw rod in intubation, screw rod are turned
Rotation drives threaded sleeve to slide in sliding slot, and threaded sleeve is mobile to drive first connecting rod mobile, and mobile drive of first connecting rod is lived
Dynamic cutting ferrule is mobile, and the mobile pointer for driving its surface of activity card sets is mobile, through the form in intubation to the finger in activity card sets
The position of needle is observed, and improves degree of regulation by the scale strip on form while adjusting；
Step 2: hanging over one end of elastic blanket net on hook after the completion of adjusting, rubber ring is then pulled out, then will
Rubber ring sleeve will so that elastic blanket net covers the head of mouse, then with the position being intubated on hand adjustment section riser in the neck of mouse
The end of intubation is inserted into the mouth of mouse, guarantees that the mouth of mouse is in the state opened；
Step 3: first covering the connector sleeve of gastric perfusion needle one end on the connector of injection tube, the first push plate is then pulled, the
One push plate is mobile to drive the first push rod mobile, and the first push rod is mobile to drive the first active rubber block mobile, will be required for stomach-filling
Liquid is drawn into injection tube；
Step 4: the injection tube equipped with gastric perfusion needle is inserted into cannula interior by jack, injection tube passes through activity card sets
And be stuck in activity card sets, gastric perfusion needle passes through the opening on rubber sleeve, and is inserted into the stomach of mouse；
Step 5: when needing to pour into other liquid during stomach-filling, to through slot inside be passed through liquid, then again by second
Active rubber block is inserted into through slot, pushes the second push plate, and the second push plate is mobile to drive the second push rod mobile, and the second push rod is mobile
The second active rubber block is driven, liquid is pushed into injection tube；
Step 6: slowly pulling injection tube outward after the completion of stomach-filling, injection tube being extracted from intubation, thus by stomach-filling
Needle is extracted out of Mice Body, then rubber ring is removed from the neck of mouse, carries out cleaning and sterilizing to device.
Technical effect and advantage of the invention:
1, the present invention is first rotated screw rod, is adjusted to the position of activity card sets by setting stabilizing mechanism, and through view
Pointer on scale strip and activity card sets on window improves the position precision in activity card sets, and activity card sets insert gastric perfusion needle
Enter depth to be defined, prevents insertion position process from injuring mouse, and by being intubated the mouth holding opening so that mouse, so that
Insertion process is more stable, integrally makes present invention safety with higher；
2, the present invention pushes the second push plate to drive the second active rubber block in through slot by opening up through slot in the first push rod
Middle movement to pour into other liquid during stomach-filling, and avoids repeatedly carrying out insertion to gastric perfusion needle and extracts behaviour out
Make, reduces the pain of mouse, further increase stomach-filling efficiency；
3, the present invention passes through activity card sets in the process of moving, and activity card sets drive the second connecting rod of its bottom mobile,
The mobile convenience of activity card sets is improved, and provides support to activity card sets, further improves the stability of activity card sets.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention.
Fig. 2 is intubation external structure front view of the invention.
Fig. 3 is mechanism for filling liquid internal structure front view of the invention.
Fig. 4 is schematic enlarged-scale view at A in Fig. 2 of the invention.
Fig. 5 is schematic enlarged-scale view at B in Fig. 1 of the invention.
Fig. 6 is schematic enlarged-scale view at C in Fig. 1 of the invention.
Fig. 7 is rubber ring three-dimensional structure diagram of the invention.
Appended drawing reference are as follows: 1 stabilizing mechanism, 2 mechanism for filling liquid, 3 risers, 4 jacks, 5 intubation, 6 inclination covers, 7 transverse slats, 8 link up with,
9 elastic blanket nets, 10 rubber rings, 11 forms, 12 scale strips, 13 intubations, 14 pointers, 15 first connecting rods, 16 sliding slots, 17 thread bush
Pipe, 18 injection tubes, 19 connectors, 20 connector sleeves, 21 gastric perfusion needles, 22 first active rubber blocks, 23 first push rods, 24 sealing strips,
25 first push plates, 26 through slots, 27 check valves, 28 second active rubber blocks, 29 second push rods, 30 second push plates, 31 rubber sleeves, 32
Opening, 33 openings, 34 movable balls, 35 loose slots.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
According to Fig. 1, Fig. 2, Fig. 4, Fig. 5 and a kind of pharmacological experiment intragastric administration on mice device shown in Fig. 7, including stablize machine
Structure 1；
The stabilizing mechanism 1 includes riser 3, runs through on the riser 3 and is equipped with jack 4, and 4 side of jack is equipped with intubation
5, inclination cover 6 is equipped at the top of the riser 3,3 bottom of riser is equipped with transverse slat 7, inclination 6 top surfaces of cover and transverse slat
7 bottom surfaces are equipped with hook 8, and elastic blanket net 9 is hung on the hook 8, and described elasticity 9 one end of blanket net is equipped with rubber ring 10,
5 front side surfaces of the intubation are equipped with form 11, and the form 11 is equipped with scale strip 12, and 13 inside of intubation is equipped with active card
Set 13,13 front side surface of activity card sets are equipped with pointer 14, are equipped with first connecting rod 15 at the top of the activity card sets 13, and described the
Sliding slot 16 is equipped at the top of one connecting rod 15, the sliding slot 16 is internally threaded casing 17, is equipped with spiral shell inside the threaded sleeve 17
Bar, the threaded sleeve 17 are fixedly connected with 15 top of first connecting rod；
5 one end of the intubation are equipped with rubber sleeve 31, and described 31 one end of rubber sleeve is equipped with opening 32；
A kind of application method of pharmacological experiment intragastric administration on mice device, comprising the following steps:
Step 1: the position of activity card sets 13 is adjusted according to the size of mouse, the screw rod in intubation 5, spiral shell are turned
Bar rotation drives threaded sleeve 17 to slide in sliding slot 16, and threaded sleeve 17 is mobile to drive first connecting rod 15 mobile, first connecting rod
15 mobile drive activity card sets 13 are mobile, and the mobile pointer 14 for driving its surface of activity card sets 13 is mobile, through the view being intubated on 5
Window 11 observes the position of the pointer 14 in activity card sets 13, and passes through the scale strip 12 on form 11 while adjusting
Improve degree of regulation；
Step 2: one end of elastic blanket net 9 is hung on hook 8, rubber ring 10 is then pulled out after the completion of adjusting,
Again by 10 sets of the rubber ring necks in mouse, so that elastic blanket net 9 covers the head of mouse, then 5 are intubated on hand adjustment section riser 3
Position, the end for being intubated 5 is inserted into the mouth of mouse, guarantee mouse mouth be in open state.
Embodiment specifically: first according to the size of mouse, the position of activity card sets 13 is adjusted, intubation 5 is turned
In screw rod, screw rod rotation drives threaded sleeve 17 to slide in sliding slot 16, and threaded sleeve 17 is mobile to drive first connecting rod 15 to move
Dynamic, first connecting rod 15 is mobile to drive activity card sets 13 mobile, and the mobile pointer 14 for driving its surface of activity card sets 13 is mobile, penetrates
Form 11 in intubation 5 observes the position of the pointer 14 in activity card sets 13, and passes through form 11 while adjusting
On scale strip 12 improve degree of regulation, the insertion depth of gastric perfusion needle 21 can be adjusted in activity card sets 13, so as to
Effectively prevent insertion process to damage mouse, after the completion of adjusting, by one end of elastic blanket net 9 hang over hook 8 on, then to
Outer pulling rubber ring 10, then by 10 sets of the rubber ring necks in mouse, rubber ring 10 has preferable elasticity, can adapt to difference
The mouse of size, so that elastic blanket net 9 can cover the head of mouse, then with the position of intubation 5 on hand adjustment section riser 3,
The end for being intubated 5 is inserted into the mouth of mouse, guarantee mouse mouth be in open state, riser 3 top and
Bottom is respectively fixed with an inclination cover 6 and transverse slat 7, and the head of mouse is fixed by inclination cover 6 and transverse slat 7, improves and stablizes
Property, by the way that stabilizing mechanism 1 is arranged, screw rod is first rotated, the position of activity card sets 13 is adjusted, and through the quarter on form 11
The position precision in the raising activity card sets 13 of pointer 14 in item 12 and activity card sets 13 is spent, activity card sets 13 are to gastric perfusion needle 21
Insertion depth be defined, prevent insertion position process injure mouse, and by intubation 5 make mouse mouth keep
It opens, so that insertion process is more stable, integrally makes present invention safety with higher.
A kind of pharmacological experiment intragastric administration on mice device according to FIG. 1 and FIG. 3 further includes mechanism for filling liquid 2, the note
Liquid mechanism 2 includes injection tube 18, and described 18 one end of injection tube is equipped with connector 19, and set is equipped with connector sleeve on the connector 19
20,20 one end of connector sleeve connection is equipped with gastric perfusion needle 21, and the end shape of the gastric perfusion needle 21 is set as arc, the injection
Cylinder 18 inside be equipped with the first active rubber block 22, described first active rubber block, 22 one end be equipped with the first push rod 23, described first
22 surface of active rubber block is equipped with multiple sealing strips 24, and described first push rod, 23 one end is equipped with the first push plate 25, and described first is living
Dynamic 22 internal run-through of rubber block is equipped with through slot 26, and described 26 inside one end of through slot is equipped with check valve 27, first push rod 23 1
End is equipped with the first push plate 25, and 22 internal run-through of the first active rubber block is equipped with through slot 26, and described 26 inside one end of through slot is set
There is check valve 27；
A kind of application method of pharmacological experiment intragastric administration on mice device, further comprising the steps of:
Step 3: then pulling first by 20 sets of connector sleeve of 21 one end of gastric perfusion needle on the connector 19 of injection tube 18
One push plate 25, the first push plate 25 is mobile to drive the first push rod 23 mobile, and the first push rod 23 is mobile to drive the first active rubber block 22
It is mobile, liquid required for stomach-filling is drawn into injection tube 18；
Step 4: the injection tube 18 equipped with gastric perfusion needle 21 is inserted into inside intubation 5 by jack 4, injection tube 18 is passed through
Activity card sets 13 are simultaneously stuck in activity card sets 13, and gastric perfusion needle 21 passes through the opening 32 on rubber sleeve 31, and is inserted into the stomach of mouse
In；
Step 5: when needing to pour into other liquid during stomach-filling, to through slot 26 inside be passed through liquid, then again by
Two active rubber blocks 28 are inserted into through slot 26, push the second push plate 30, and the second push plate 30 is mobile to drive the second push rod 29 mobile,
Second push rod 29 is mobile to drive the second active rubber block 28, and liquid is pushed into injection tube 18；
Step 6: slowly pulling injection tube 18 outward after the completion of stomach-filling, injection tube 18 is extracted from intubation 5, thus will
Gastric perfusion needle 21 is extracted out of Mice Body, then rubber ring 10 is removed from the neck of mouse, carries out cleaning and sterilizing to device.
Embodiment specifically: first by 20 sets of connector sleeve of 21 one end of gastric perfusion needle on the connector 19 of injection tube 18, so
After pull the first push plate 25, the first push plate 25 is mobile to drive the first push rod 23 mobile, and the first push rod 23 is mobile to drive the first activity
Rubber block 22 is mobile, and liquid required for stomach-filling is drawn into injection tube 18；Injection tube 18 equipped with gastric perfusion needle 21 is passed through
Jack 4 is inserted into inside intubation 5, and injection tube 18 passes through activity card sets 13 and is stuck in activity card sets 13, and gastric perfusion needle 21 passes through rubber
Opening 32 on gum cover 31, and be inserted into the stomach of mouse；When needing to pour into other liquid during stomach-filling, into through slot 26
Portion is passed through liquid, and then the second active rubber block 28 is inserted into through slot 26 again, pushes the second push plate 30, and the second push plate 30 moves
Dynamic to drive the second push rod 29 mobile, the second push rod 29 is mobile to drive the second active rubber block 28, and liquid is pushed into injection tube 18；
Other liquid can be poured into during stomach-filling, and avoid repeatedly carrying out insertion and draw out operation to gastric perfusion needle 21, subtracted
The pain of mouse further increases stomach-filling efficiency, after the completion of stomach-filling, outward slowly pull injection tube 18, by injection tube 18 from
It extracts, so that gastric perfusion needle 21 be extracted out of Mice Body, then rubber ring 10 is removed from the neck of mouse, to device in intubation 5
Carry out cleaning and sterilizing.
It further include second connecting rod 33 according to Fig. 1 and a kind of pharmacological experiment intragastric administration on mice device shown in fig. 6, it is described
13 bottom of activity card sets is arranged in second connecting rod 33, and 33 bottom end of second connecting rod is equipped with movable balls 34,34 outside of movable balls
Equipped with loose slot 35.
Embodiment specifically: in using the present invention, in the process of moving, activity card sets 13 drive activity card sets 13
The second connecting rod 33 of its bottom is mobile, and the mobile movable balls 34 for driving its bottom end of second connecting rod 33 slide in loose slot 35, mentions
The high mobile convenience of activity card sets 13, and support is provided to activity card sets 13, further improve the steady of activity card sets 13
It is qualitative.
Working principle of the present invention:
Referring to Figure of description 1, attached drawing 2, attached drawing 4, attached drawing 5 and attached drawing 7, the screw rod in intubation 5 is turned, screw rod rotates band
Dynamic activity card sets 13 are mobile, and the mobile pointer 14 for driving its surface of activity card sets 13 is mobile, through 11 pairs of work of form in intubation 5
The position of pointer 14 on dynamic cutting ferrule 13 is observed, and is improved and adjusted by the scale strip 12 on form 11 while adjusting
Precision, the insertion depth of gastric perfusion needle 21 can be adjusted in activity card sets 13, so as to effectively prevent insertion process to small
Mouse damages, after the completion of adjusting, by 10 sets of the rubber ring necks in mouse, so that elastic blanket net 9 can cover mouse
Head, then on hand adjustment section riser 3 intubation 5 position, the end for being intubated 5 is inserted into the mouth of mouse, guarantees mouse
Mouth is in the state opened, and by setting stabilizing mechanism 1, first rotates screw rod, is adjusted to the position of activity card sets 13, and
Pointer 14 through the scale strip 12 on form 11 and in activity card sets 13 improves the position precision in activity card sets 13, activity
Cutting ferrule 13 is defined the insertion depth of gastric perfusion needle 21, prevent insertion position process injure mouse, and by intubation 5 make it is small
The mouth of mouse keeps opening, so that insertion process is more stable, integrally makes present invention safety with higher；
Referring to Figure of description 1 and attached drawing 3, first by 20 sets of the connector sleeve connectors in injection tube 18 of 21 one end of gastric perfusion needle
On 19, the first push plate 25 is then pulled, the first push plate 25 is mobile to drive the first active rubber block 22 mobile, will be required for stomach-filling
Liquid is drawn into injection tube 18；Injection tube 18 equipped with gastric perfusion needle 21 is inserted into inside intubation 5 by jack 4, gastric perfusion needle
21 openings 32 passed through on rubber sleeve 31 are inserted into the stomach of mouse；When needing to pour into other liquid during stomach-filling, Xiang Tong
It is passed through liquid inside slot 26, then the second active rubber block 28 is inserted into through slot 26 again, the second push plate 30 is pushed, by liquid
It is pushed into injection tube 18；Other liquid can be poured into during stomach-filling, and avoid repeatedly carrying out gastric perfusion needle 21 slotting
Enter and draw out operation, reduce the pain of mouse, further increase stomach-filling efficiency, after the completion of stomach-filling, slowly pulls injection tube outward
18, injection tube 18 is extracted from intubation 5, so that gastric perfusion needle 21 be extracted out of Mice Body, then by rubber ring 10 from mouse
Neck is removed, and carries out cleaning and sterilizing to device；
Referring to Figure of description 1 and attached drawing 6, in using the present invention, activity card sets 13 in the process of moving, active card
Set 13 drives the second connecting rod 33 of its bottom mobile, and the mobile movable balls 34 for driving its bottom end of second connecting rod 33 are in loose slot 35
Sliding improves the mobile convenience of activity card sets 13, and provides support to activity card sets 13, further improves activity card sets
13 stability.
The several points that should finally illustrate are: firstly, in the description of the present application, it should be noted that unless otherwise prescribed and
It limits, term " installation ", " connected ", " connection " shall be understood in a broad sense, can be mechanical connection or electrical connection, be also possible to two
Connection inside element, can be directly connected, and "upper", "lower", "left", "right" etc. are only used for indicating relative positional relationship, when
The absolute position for being described object changes, then relative positional relationship may change；
Secondly: the present invention discloses in embodiment attached drawing, relates only to the structure being related to the embodiment of the present disclosure, other knots
Structure, which can refer to, to be commonly designed, and under not conflict situations, the same embodiment of the present invention and different embodiments be can be combined with each other；
Last: the foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, all in the present invention
Spirit and principle within, any modification, equivalent replacement, improvement and so on, should be included in protection scope of the present invention it
It is interior.
Claims (8)
1. a kind of pharmacological experiment intragastric administration on mice device, it is characterised in that: including stabilizing mechanism (1) and mechanism for filling liquid (2)；
The stabilizing mechanism (1) includes riser (3), and through jack (4) are equipped on the riser (3), jack (4) side is set
Have intubation (5), inclination cover (6) is equipped at the top of the riser (3), riser (3) bottom is equipped with transverse slat (7), the inclination cover
(6) top surface and transverse slat (7) bottom surface are equipped with hook (8), are hung with elastic blanket net (9) on the hook (8), described
Elastic blanket net (9) one end is equipped with rubber ring (10), and intubation (5) front side surface is equipped with form (11), on the form (11)
Equipped with scale strip (12), activity card sets (13) are equipped with inside the intubation (13), activity card sets (13) front side surface is equipped with
Pointer (14), activity card sets (13) top are equipped with first connecting rod (15), sliding slot are equipped at the top of the first connecting rod (15)
(16), the sliding slot (16) is internally threaded casing (17), and screw rod, the thread bush are equipped with inside the threaded sleeve (17)
Pipe (17) is fixedly connected with first connecting rod (15) top.
2. a kind of pharmacological experiment intragastric administration on mice device according to claim 1, it is characterised in that: the mechanism for filling liquid
It (2) include injection tube (18), described injection tube (18) one end is equipped with connector (19).
3. a kind of pharmacological experiment intragastric administration on mice device according to claim 2, it is characterised in that: the connector
(19) set is equipped with connector sleeve (20) on, and connector sleeve (20) one end connection is equipped with gastric perfusion needle (21), the gastric perfusion needle (21)
End shape be set as arc.
4. a kind of pharmacological experiment intragastric administration on mice device according to claim 2, it is characterised in that: the injection tube
(18) internal to be equipped with the first active rubber block (22), the first active rubber block (22) one end is equipped with the first push rod (23), institute
The first active rubber block (22) surface is stated equipped with multiple sealing strips (24).
5. a kind of pharmacological experiment intragastric administration on mice device according to claim 4, it is characterised in that: first push rod
(23) one end is equipped with the first push plate (25), and the first active rubber block (22) internal run-through is equipped with through slot (26), the through slot
(26) internal one end is equipped with check valve (27).
6. a kind of pharmacological experiment intragastric administration on mice device according to claim 5, it is characterised in that: the through slot (26)
Inside is equipped with the second active rubber block (28), and the second active rubber block (28) one end is equipped with the second push rod (29), and described the
Two push rods (29) one end is equipped with the second push plate (30).
7. a kind of pharmacological experiment intragastric administration on mice device according to claim 1, it is characterised in that: the intubation (5)
One end is equipped with rubber sleeve (31), and described rubber sleeve (31) one end is equipped with opening (32), and activity card sets (13) bottom is equipped with the
Two connecting rods (33), second connecting rod (33) bottom end are equipped with movable balls (34), and loose slot is equipped on the outside of the movable balls (34)
(35)。
8. a kind of user using pharmacological experiment intragastric administration on mice device described in -7 any one according to claim 1
Method, it is characterised in that: the following steps are included:
Step 1: the position of activity card sets (13) is adjusted according to the size of mouse, the screw rod in intubation (5), spiral shell are turned
Bar rotation drives threaded sleeve (17) sliding in sliding slot (16), and threaded sleeve (17) is mobile to drive first connecting rod (15) mobile,
First connecting rod (15) is mobile to drive activity card sets (13) mobile, and the mobile pointer (14) for driving its surface of activity card sets (13) moves
It is dynamic, it is observed through position of the form (11) on intubation (5) to the pointer (14) on activity card sets (13), and in adjusting
Degree of regulation is improved by the scale strip (12) on form (11) simultaneously；
Step 2: one end of elastic blanket net (9) is hung on hook (8), rubber ring is then pulled out after the completion of adjusting
(10), the neck in mouse then by rubber ring (10) is covered, so that elastic blanket net (9) covers the head of mouse, then perpendicular with hand adjustment section
It is intubated the position of (5) on plate (3), the end of intubation (5) is inserted into the mouth of mouse, guarantees that the mouth of mouse is in opening
State；
Step 3: first covering the connector sleeve (20) of gastric perfusion needle (21) one end on the connector (19) of injection tube (18), then draw
Dynamic first push plate (25), the first push plate (25) is mobile to drive the first push rod (23) mobile, and the first push rod (23) is mobile to drive first
Active rubber block (22) is mobile, and liquid required for stomach-filling is drawn into injection tube (18)；
Step 4: the injection tube (18) equipped with gastric perfusion needle (21) is inserted into intubation (5) inside, injection tube by jack (4)
(18) activity card sets (13) are passed through and are stuck in activity card sets (13), gastric perfusion needle (21) passes through the opening on rubber sleeve (31)
(32), it and is inserted into the stomach of mouse；
Step 5: liquid is passed through to through slot (26) is internal, then again by second when needing to pour into other liquid during stomach-filling
Active rubber block (28) is inserted into through slot (26), is pushed the second push plate (30), and the second push plate (30) is mobile to drive the second push rod
(29) mobile, the second push rod (29) is mobile to drive the second active rubber block (28), and liquid is pushed into injection tube (18)；
Step 6: slowly pulling injection tube (18) outward after the completion of stomach-filling, injection tube (18) is extracted from intubation (5), thus
Gastric perfusion needle (21) is extracted out of Mice Body, then rubber ring (10) is removed from the neck of mouse, cleaning and sterilizing is carried out to device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910671505.3A CN110353855B (en) | 2019-07-24 | 2019-07-24 | Mouse gastric perfusion device for pharmacology experiments and use method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910671505.3A CN110353855B (en) | 2019-07-24 | 2019-07-24 | Mouse gastric perfusion device for pharmacology experiments and use method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110353855A true CN110353855A (en) | 2019-10-22 |
| CN110353855B CN110353855B (en) | 2021-11-19 |
Family
ID=68220677
Family Applications (1)
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| CN201910671505.3A Active CN110353855B (en) | 2019-07-24 | 2019-07-24 | Mouse gastric perfusion device for pharmacology experiments and use method thereof |
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