CN110353855A - A kind of pharmacological experiment intragastric administration on mice device and its application method - Google Patents

Abstract

The invention discloses a mouse gavage device for pharmacological experiments and its use method, and specifically relates to the field of biological experiment equipment, including a stabilizing mechanism and a liquid injection mechanism; the stabilizing mechanism includes a vertical plate, and the vertical plate runs through a There is a jack, the side of the jack is provided with an intubation tube, the top of the vertical plate is provided with an inclined cover, the bottom of the vertical plate is provided with a horizontal plate, and the top surface of the inclined cover and the bottom surface of the horizontal plate are provided with hooks , an elastic net is hung on the hook. The present invention adjusts the position of the movable ferrule by arranging a stabilizing mechanism, rotating the screw rod first, and improves the position accuracy of the movable ferrule through the scale bar on the window and the pointer on the movable ferrule, so that the movable ferrule has a good effect on gastric administration. The insertion depth of the needle is limited to prevent the mouse from being injured during the insertion position process, and the mouth of the mouse is kept open through the intubation, so that the insertion process is more stable, and the present invention has higher safety as a whole.

Description

A mouse gavage device for pharmacological experiments and its application method

technical field

The invention relates to the technical field of biological experiment equipment, and more specifically, the invention relates to a mouse gavage device for pharmacological experiments and a use method thereof.

Background technique

Mice belong to the phylum Vertebrate, the class Mammalia, the order Rodentia, and the family Muridae. The mice are small in size, convenient in feeding and management, and easy to control; they produce and reproduce quickly; they can be weaned 3 weeks after birth. It has a large number of inbred lines, mutant lines and closed groups with different characteristics, and has formed a variety of internationally recognized standard strains, which are widely used in various nutritional experimental studies.

The utility model patent of the patent application publication number CN 206080761 U discloses a kind of rats and mice experimental continuous gastrofusion device, which is suitable for perfusing experimental medicinal liquid to experimental rats in medical research. The utility model includes that the electric pipette is composed of a mouse gastric feeding tube, a rat gastric feeding tube, and a placement frame; the tip ends of the mouse gastric feeding tube and the rat gastric feeding tube are provided with a drug liquid injection port and a drug liquid injection port , which can be connected to the outlet of the pipette rubber head on the electric pipette respectively; the nozzles at the bottom of the gastric irrigation tube for rats and mice are respectively round and blunt and smooth and blunt to avoid damage to the digestive tract of rats and mice. The gavage tube described in the utility model can continuously gavage 4 to 5 rats with medicinal liquid at one time, which reduces the cumbersome operation of repeatedly inhaling the medicinal liquid in the syringe when each rat is gavaged. The process is simple and feasible, saves a lot of time, and effectively improves the efficiency of experimental work.

However, when the above-mentioned technical solution is used in practice, there are still many shortcomings. When the gavage device in the above-mentioned technical solution is used to gavage mice, it is easy to be affected by the operator's own hands and stab the mouse mouth and esophagus. Security is less than ideal.

Contents of the invention

In order to overcome the above-mentioned defects of the prior art, an embodiment of the present invention provides a mouse gavage device for pharmacological experiments and its use method. By setting a stabilizing mechanism, the screw rod is first rotated to adjust the position of the movable ferrule, and The position accuracy on the movable ferrule is improved through the scale bar on the window and the pointer on the movable ferrule. The movable ferrule limits the insertion depth of the gavage needle to prevent the mouse from being injured during the insertion position, and makes the small The mouth of the mouse is kept open, so that the insertion process is more stable, and the overall safety of the present invention is higher.

In order to achieve the above object, the present invention provides the following technical solutions: a mouse gavage device for pharmacological experiments, including a stabilizing mechanism and a liquid injection mechanism;

The stabilizing mechanism includes a vertical plate, a socket is formed on the vertical plate, an intubation tube is provided on one side of the socket, an inclined cover is provided on the top of the vertical plate, and a horizontal plate is provided at the bottom of the vertical plate. The top surface of the inclined cover and the bottom surface of the horizontal plate are all provided with a hook, and an elastic net is hung on the hook, and a rubber ring is provided at one end of the elastic net, and a window is provided on the front side surface of the intubation tube. The window is provided with a scale bar, the inside of the intubation tube is provided with a movable ferrule, the front surface of the movable ferrule is provided with a pointer, the top of the movable ferrule is provided with a first connecting rod, and the top of the first connecting rod A chute is provided, and a threaded sleeve is provided inside the chute, and a screw rod is provided inside the threaded sleeve, and the threaded sleeve is fixedly connected with the top end of the first connecting rod.

In a preferred embodiment, the liquid injection mechanism includes a syringe, and one end of the syringe is provided with a connection port.

In a preferred embodiment, a connecting sleeve is sleeved on the connecting port, and a gastric feeding needle is communicated with one end of the connecting sleeve, and the shape of the end of the gastric feeding needle is set as an arc.

In a preferred embodiment, a first movable rubber block is provided inside the injection barrel, a first push rod is provided at one end of the first movable rubber block, and a plurality of sealing strips are provided on the surface of the first movable rubber block .

In a preferred embodiment, a first push plate is provided at one end of the first push rod, a through groove is formed inside the first movable rubber block, and a one-way valve is arranged at one end inside the through groove.

In a preferred embodiment, a second movable rubber block is provided inside the through groove, a second push rod is provided at one end of the second movable rubber block, and a second push plate is provided at one end of the second push rod.

In a preferred embodiment, a rubber sleeve is provided at one end of the cannula, an opening is provided at one end of the rubber sleeve, a second connecting rod is provided at the bottom of the movable ferrule, and a second connecting rod is provided at the bottom end of the second connecting rod. The movable ball is provided with a movable groove on the outside of the movable ball.

A method for using a mouse gavage device for pharmacological experiments, comprising the following steps:

Step 1. Adjust the position of the movable ferrule according to the size of the mouse, and turn the screw in the intubation tube. The rotation of the screw drives the threaded sleeve to slide in the chute, and the movement of the threaded sleeve drives the movement of the first connecting rod. The movement of a connecting rod drives the movable ferrule to move, and the movement of the movable ferrule drives the pointer on its surface to move. Observe the position of the pointer on the movable ferrule through the window on the intubation tube, and pass the scale on the window while adjusting. improve the adjustment accuracy;

Step 2. After the adjustment is completed, hang one end of the elastic net on the hook, then pull the rubber ring outward, and then wrap the rubber ring around the mouse's neck so that the elastic net covers the mouse's head, and then use Adjust the position of the intubation tube on the vertical plate by hand, and insert the end of the intubation tube into the mouth of the mouse to ensure that the mouth of the mouse is in an open state;

Step 3: Put the connecting sleeve on one end of the gavage needle on the connecting port of the injection barrel, and then pull the first push plate, the movement of the first push plate will drive the movement of the first push rod, and the movement of the first push rod will drive the movement of the first movable rubber block , inhale the liquid required for gavage into the syringe;

Step 4. Insert the syringe equipped with the gavage needle into the cannula through the socket, the syringe passes through the movable ferrule and is stuck in the movable ferrule, the gavage needle passes through the opening on the rubber sleeve, and inserts it into the in the stomach of mice;

Step 5. When other liquids need to be poured into the gavage process, the liquid is passed into the through groove, and then the second movable rubber block is inserted into the through groove, and the second push plate is pushed, and the second push plate moves to drive the first push plate. The second push rod moves, and the second push rod moves to drive the second movable rubber block to push the liquid into the injection barrel;

Step 6. After the gavage is completed, pull the injection barrel outward slowly, pull out the injection barrel from the intubation tube, thereby pull out the gavage needle from the mouse body, and then remove the rubber ring from the neck of the mouse, and replace the device. Clean and disinfect.

Technical effect and advantage of the present invention:

1. The present invention adjusts the position of the movable ferrule by first turning the screw rod by setting a stabilizing mechanism, and improves the positional accuracy of the movable ferrule through the scale bar on the window and the pointer on the movable ferrule. The insertion depth of the gavage needle is limited to prevent the mouse from being injured during the insertion position, and the mouth of the mouse is kept open through the intubation, so that the insertion process is more stable, and the present invention has higher safety as a whole;

2. In the present invention, a through groove is opened in the first push rod, and the second push plate is pushed to drive the second movable rubber block to move in the through groove, so that other liquids are poured in during the stomach filling process, and multiple injections are avoided. Stomach needles are inserted and withdrawn to reduce the pain of mice and further improve the efficiency of gavage;

3. During the moving process of the movable ferrule, the present invention drives the second connecting rod at the bottom to move, which improves the convenience of moving the movable ferrule and provides support for the movable ferrule, further improving the movement of the movable ferrule. set of stability.

Description of drawings

Figure 1 is a schematic diagram of the overall structure of the present invention.

Fig. 2 is a front view of the external structure of the cannula of the present invention.

Fig. 3 is a front view of the internal structure of the liquid injection mechanism of the present invention.

Fig. 4 is an enlarged view of the structure at A in Fig. 2 of the present invention.

Fig. 5 is an enlarged view of the structure at B in Fig. 1 of the present invention.

FIG. 6 is an enlarged view of the structure at C in FIG. 1 of the present invention.

Fig. 7 is a three-dimensional structure diagram of the rubber ring of the present invention.

The reference signs are: 1 stabilizing mechanism, 2 liquid injection mechanism, 3 vertical plate, 4 jack, 5 intubation tube, 6 inclined cover, 7 horizontal plate, 8 hook, 9 elastic pocket net, 10 rubber ring, 11 window, 12 Scale bar, 13 intubation tube, 14 pointer, 15 first connecting rod, 16 chute, 17 threaded casing, 18 injection barrel, 19 connection port, 20 connection sleeve, 21 gastric feeding needle, 22 first movable rubber block, 23 The first push rod, 24 sealing strip, 25 the first push plate, 26 through groove, 27 one-way valve, 28 the second movable rubber block, 29 the second push rod, 30 the second push plate, 31 rubber sleeve, 32 opening, 33 openings, 34 movable balls, 35 movable slots.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

According to a mouse gavage device for pharmacological experiments shown in Fig. 1, Fig. 2, Fig. 4, Fig. 5 and Fig. 7, including a stabilizing mechanism 1;

The stabilizing mechanism 1 includes a riser 3, a jack 4 is formed through the riser 3, an intubation tube 5 is arranged on one side of the jack 4, a tilting cover 6 is arranged on the top of the riser 3, the Vertical plate 3 bottom is provided with horizontal plate 7, and described inclined cover 6 top surfaces and horizontal plate 7 bottom surfaces are all provided with hook 8, and elastic net 9 is hung on described hook 8, and described elastic pocket net 9 one ends are provided with Rubber ring 10, the front surface of the intubation tube 5 is provided with a window 11, the window 11 is provided with a scale bar 12, the inside of the intubation tube 13 is provided with a movable ferrule 13, and the front surface of the movable ferrule 13 is A pointer 14 is provided, a first connecting rod 15 is provided on the top of the movable ferrule 13, a chute 16 is provided on the top of the first connecting rod 15, and a threaded sleeve 17 is provided inside the chute 16, and the thread A threaded rod is provided inside the casing 17, and the threaded casing 17 is fixedly connected with the top end of the first connecting rod 15;

One end of the cannula 5 is provided with a rubber sleeve 31, and one end of the rubber sleeve 31 is provided with an opening 32;

A method for using a mouse gavage device for pharmacological experiments, comprising the following steps:

Step 1. Adjust the position of the movable ferrule 13 according to the size of the mouse, turn the screw in the intubation tube 5, the screw rotates to drive the threaded sleeve 17 to slide in the chute 16, and the movement of the threaded sleeve 17 drives the first The connecting rod 15 moves, the first connecting rod 15 moves to drive the movable ferrule 13 to move, and the movable ferrule 13 moves to drive the pointer 14 on its surface to move. Observe the position, and improve the adjustment accuracy through the scale bar 12 on the window 11 while adjusting;

Step 2: After the adjustment is completed, hang one end of the elastic net 9 on the hook 8, then pull the rubber ring 10 outward, and then put the rubber ring 10 on the neck of the mouse, so that the elastic net 9 covers the mouse Then adjust the position of the intubation tube 5 on the vertical board 3 by hand, and insert the end of the intubation tube 5 into the mouth of the mouse to ensure that the mouth of the mouse is in an open state.

The implementation method is as follows: firstly adjust the position of the movable ferrule 13 according to the size of the mouse, turn the screw rod in the intubation tube 5, the rotation of the screw rod drives the threaded sleeve 17 to slide in the chute 16, and the threaded sleeve 17 moves Drive the first connecting rod 15 to move, the first connecting rod 15 moves to drive the movable ferrule 13 to move, the movable ferrule 13 moves to drive the pointer 14 on its surface to move, through the window 11 on the intubation tube 5 to the movable ferrule 13 Observe the position of the pointer 14, and improve the adjustment accuracy through the scale bar 12 on the window 11 while adjusting. The movable ferrule 13 can adjust the insertion depth of the gavage needle 21, thereby effectively preventing the insertion process from causing damage to the mice. Injury, after the adjustment is completed, one end of the elastic pocket net 9 is hung on the hook 8, then the rubber ring 10 is pulled outwards, and then the rubber ring 10 is enclosed in the neck of the mouse. The rubber ring 10 has good elasticity and can Adapt to mice of different sizes, so that the elastic net 9 can cover the head of the mouse, and then adjust the position of the cannula 5 on the vertical plate 3 by hand, and insert the end of the cannula 5 into the mouth of the mouse To ensure that the mouth of the mouse is in an open state, a tilting cover 6 and a horizontal plate 7 are respectively fixed on the top and bottom of the vertical plate 3, and the head of the mouse is fixed by the tilting cover 6 and the horizontal plate 7 to improve stability. The position of the movable ferrule 13 is adjusted by setting the stabilizing mechanism 1, first turning the screw, and improving the position accuracy of the movable ferrule 13 through the scale bar 12 on the window 11 and the pointer 14 on the movable ferrule 13 , the movable ferrule 13 limits the insertion depth of the gavage needle 21, prevents the insertion position process from injuring the mouse, and keeps the mouse's mouth open through the intubation tube 5, so that the insertion process is more stable. High security.

According to a kind of mouse gavage device for pharmacological experiment shown in Fig. 1 and Fig. 3, also comprise injection mechanism 2, described injection mechanism 2 comprises syringe 18, and described syringe 18 one end is provided with connecting port 19 , the connecting port 19 is sleeved with a connecting sleeve 20, and one end of the connecting sleeve 20 is connected with a gastric feeding needle 21, the shape of the end of the gastric feeding needle 21 is set as an arc, and the inside of the syringe 18 A first movable rubber block 22 is provided, and one end of the first movable rubber block 22 is provided with a first push rod 23. The surface of the first movable rubber block 22 is provided with a plurality of sealing strips 24, and the first push rod 23 One end is provided with a first push plate 25, and the inside of the first movable rubber block 22 is provided with a through groove 26, and one end of the inside of the through groove 26 is provided with a check valve 27, and one end of the first push rod 23 is provided with a second A push plate 25, the inside of the first movable rubber block 22 is provided with a through groove 26, and one end of the inside of the through groove 26 is provided with a check valve 27;

A method for using a mouse gavage device for pharmacological experiments, further comprising the following steps:

Step 3, first put the connecting sleeve 20 at one end of the gavage needle 21 on the connecting port 19 of the syringe 18, then pull the first push plate 25, the movement of the first push plate 25 drives the first push rod 23 to move, and the first push The movement of the rod 23 drives the movement of the first movable rubber block 22, sucking the liquid required for gavage into the syringe 18;

Step 4: Insert the syringe 18 equipped with the gavage needle 21 into the cannula 5 through the socket 4, the syringe 18 passes through the movable ferrule 13 and is stuck in the movable ferrule 13, and the gavage needle 21 passes through the rubber Opening 32 on the sleeve 31, and inserted into the stomach of the mouse;

Step 5. When other liquids need to be poured in during the gavage process, the liquid is passed into the inside of the through groove 26, and then the second movable rubber block 28 is inserted into the through groove 26, and the second push plate 30 is pushed. The movement of the plate 30 drives the second push rod 29 to move, and the movement of the second push rod 29 drives the second movable rubber block 28 to push the liquid into the injection cylinder 18;

Step 6. After the gavage is completed, slowly pull the syringe 18 outward, pull out the syringe 18 from the intubation tube 5, thereby pull out the gavage needle 21 from the mouse, and then pull the rubber ring 10 from the neck of the mouse. Remove and clean and disinfect the device.

The specific implementation method is as follows: firstly put the connecting sleeve 20 at one end of the gavage needle 21 on the connecting port 19 of the syringe 18, and then pull the first push plate 25, the movement of the first push plate 25 drives the first push rod 23 to move, the second The movement of a push rod 23 drives the first movable rubber block 22 to move, sucking the liquid required for gastric gavage into the syringe 18; inserting the syringe 18 equipped with a gastric gavage needle 21 into the inside of the intubation tube 5 through the jack 4, The syringe 18 passes through the movable ferrule 13 and is stuck in the movable ferrule 13, and the gavage needle 21 passes through the opening 32 on the rubber sheath 31, and is inserted into the stomach of the mouse; When the liquid is used, the liquid is passed into the inside of the channel 26, and then the second movable rubber block 28 is inserted into the channel 26 to push the second push plate 30, and the second push plate 30 moves to drive the second push rod 29 to move, and the second push plate 30 moves to drive the second push rod 29 to move. The second push rod 29 moves to drive the second movable rubber block 28, and the liquid is pushed into the syringe 18; other liquids can be poured in during the gavage process, and the insertion and extraction of the gavage needle 21 can be avoided multiple times. Reduce the pain of the mice and further improve the efficiency of gavage. After the gavage is completed, slowly pull the syringe 18 outward to pull the syringe 18 out of the cannula 5, thereby pulling the gavage needle 21 out of the mouse. Then the rubber ring 10 is removed from the mouse's neck, and the device is cleaned and disinfected.

According to a kind of mouse gavage device for pharmacological experiment shown in Fig. 1 and Fig. 6, also comprise the second connecting rod 33, described second connecting rod 33 is provided with the movable ferrule 13 bottom, described second connecting rod 33 A movable ball 34 is arranged at the bottom end, and a movable groove 35 is arranged on the outer side of the movable ball 34 .

The embodiment is specifically: when using the present invention, during the moving process of the movable ferrule 13, the movable ferrule 13 drives the second connecting rod 33 at the bottom to move, and the second connecting rod 33 moves to drive the movable ball 34 at the bottom end to move. Sliding in the movable groove 35 improves the convenience of moving the movable ferrule 13 and provides support for the movable ferrule 13 to further improve the stability of the movable ferrule 13 .

The working principle of the present invention:

Referring to accompanying drawings 1, 2, 4, 5 and 7 of the instruction manual, turn the screw in the intubation tube 5, the rotation of the screw drives the movement of the movable ferrule 13, and the movement of the movable ferrule 13 drives the pointer on its surface 14 to move, observe the position of the pointer 14 on the movable ferrule 13 through the window 11 on the intubation tube 5, and improve the adjustment accuracy through the scale bar 12 on the window 11 while adjusting, the movable ferrule 13 can control the irrigation The insertion depth of the gastric needle 21 is adjusted, thereby effectively preventing the mouse from being injured during the insertion process. After the adjustment is completed, the rubber ring 10 is placed on the neck of the mouse, so that the elastic net 9 can cover the head of the mouse. Then adjust the position of the intubation tube 5 on the vertical plate 3 by hand, insert the end of the intubation tube 5 into the mouth of the mouse, and ensure that the mouth of the mouse is in an open state. The screw rod adjusts the position of the movable ferrule 13, and improves the position accuracy of the movable ferrule 13 through the scale bar 12 on the window 11 and the pointer 14 on the movable ferrule 13, and the movable ferrule 13 is paired with the gavage needle 21 The insertion depth is limited to prevent the mouse from being injured during the insertion position process, and the mouth of the mouse is kept open through the intubation tube 5, so that the insertion process is more stable, and the present invention has higher safety as a whole;

Referring to the attached drawings 1 and 3 of the description, first put the connecting sleeve 20 at one end of the gavage needle 21 on the connecting port 19 of the syringe 18, and then pull the first push plate 25, and the first push plate 25 moves to drive the first movable The rubber block 22 moves to inhale the liquid required for gavage into the syringe 18; insert the syringe 18 equipped with the gavage needle 21 into the cannula 5 through the socket 4, and the gavage needle 21 passes through the rubber sleeve 31 The upper opening 32 is inserted into the mouse's stomach; when other liquids need to be poured into the stomach during gavage, the liquid is passed into the inside of the through groove 26, and then the second movable rubber block 28 is inserted into the through groove 26 to push The second push plate 30 pushes the liquid into the syringe 18; it can pour other liquids in the process of gavage, and avoid repeatedly inserting and extracting the gavage needle 21, reducing the pain of the mice. To further improve the gavage efficiency, after the gavage is completed, slowly pull the syringe 18 outwards, pull the syringe 18 out of the intubation tube 5, thereby pull out the gavage needle 21 from the mouse, and then pull the rubber ring 10 out of the mouse. Remove the neck of the device and clean and disinfect the device;

With reference to accompanying drawing 1 and accompanying drawing 6 of specification sheet, when using the present invention, movable ferrule 13 is in the process of moving, and movable ferrule 13 drives the second connecting rod 33 of its bottom to move, and the second connecting rod 33 moves to drive its bottom. The movable ball 34 at the end slides in the movable groove 35, which improves the convenience of moving the movable ferrule 13, provides support for the movable ferrule 13, and further improves the stability of the movable ferrule 13.

The last few points should be explained: First, in the description of this application, it should be explained that, unless otherwise specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, which can be mechanical connection Or electrical connection, it can also be the internal communication of two components, it can be directly connected, "up", "down", "left", "right", etc. are only used to indicate the relative positional relationship, when the absolute position of the object being described Change, the relative positional relationship may change;

Secondly: in the drawings of the disclosed embodiments of the present invention, only the structures related to the disclosed embodiments are involved, and other structures can refer to the usual design. In the case of no conflict, the same embodiment and different embodiments of the present invention can be combined with each other;

Finally: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the present invention within the scope of protection.

Claims (8)

1. a kind of pharmacological experiment intragastric administration on mice device, it is characterised in that: including stabilizing mechanism (1) and mechanism for filling liquid (2)；

The stabilizing mechanism (1) includes riser (3), and through jack (4) are equipped on the riser (3), jack (4) side is set Have intubation (5), inclination cover (6) is equipped at the top of the riser (3), riser (3) bottom is equipped with transverse slat (7), the inclination cover (6) top surface and transverse slat (7) bottom surface are equipped with hook (8), are hung with elastic blanket net (9) on the hook (8), described Elastic blanket net (9) one end is equipped with rubber ring (10), and intubation (5) front side surface is equipped with form (11), on the form (11) Equipped with scale strip (12), activity card sets (13) are equipped with inside the intubation (13), activity card sets (13) front side surface is equipped with Pointer (14), activity card sets (13) top are equipped with first connecting rod (15), sliding slot are equipped at the top of the first connecting rod (15) (16), the sliding slot (16) is internally threaded casing (17), and screw rod, the thread bush are equipped with inside the threaded sleeve (17) Pipe (17) is fixedly connected with first connecting rod (15) top.

2. a kind of pharmacological experiment intragastric administration on mice device according to claim 1, it is characterised in that: the mechanism for filling liquid It (2) include injection tube (18), described injection tube (18) one end is equipped with connector (19).

3. a kind of pharmacological experiment intragastric administration on mice device according to claim 2, it is characterised in that: the connector (19) set is equipped with connector sleeve (20) on, and connector sleeve (20) one end connection is equipped with gastric perfusion needle (21), the gastric perfusion needle (21) End shape be set as arc.

4. a kind of pharmacological experiment intragastric administration on mice device according to claim 2, it is characterised in that: the injection tube (18) internal to be equipped with the first active rubber block (22), the first active rubber block (22) one end is equipped with the first push rod (23), institute The first active rubber block (22) surface is stated equipped with multiple sealing strips (24).

5. a kind of pharmacological experiment intragastric administration on mice device according to claim 4, it is characterised in that: first push rod (23) one end is equipped with the first push plate (25), and the first active rubber block (22) internal run-through is equipped with through slot (26), the through slot (26) internal one end is equipped with check valve (27).

6. a kind of pharmacological experiment intragastric administration on mice device according to claim 5, it is characterised in that: the through slot (26) Inside is equipped with the second active rubber block (28), and the second active rubber block (28) one end is equipped with the second push rod (29), and described the Two push rods (29) one end is equipped with the second push plate (30).

7. a kind of pharmacological experiment intragastric administration on mice device according to claim 1, it is characterised in that: the intubation (5) One end is equipped with rubber sleeve (31), and described rubber sleeve (31) one end is equipped with opening (32), and activity card sets (13) bottom is equipped with the Two connecting rods (33), second connecting rod (33) bottom end are equipped with movable balls (34), and loose slot is equipped on the outside of the movable balls (34) (35)。

8. a kind of user using pharmacological experiment intragastric administration on mice device described in -7 any one according to claim 1 Method, it is characterised in that: the following steps are included:

Step 1: the position of activity card sets (13) is adjusted according to the size of mouse, the screw rod in intubation (5), spiral shell are turned Bar rotation drives threaded sleeve (17) sliding in sliding slot (16), and threaded sleeve (17) is mobile to drive first connecting rod (15) mobile, First connecting rod (15) is mobile to drive activity card sets (13) mobile, and the mobile pointer (14) for driving its surface of activity card sets (13) moves It is dynamic, it is observed through position of the form (11) on intubation (5) to the pointer (14) on activity card sets (13), and in adjusting Degree of regulation is improved by the scale strip (12) on form (11) simultaneously；

Step 2: one end of elastic blanket net (9) is hung on hook (8), rubber ring is then pulled out after the completion of adjusting (10), the neck in mouse then by rubber ring (10) is covered, so that elastic blanket net (9) covers the head of mouse, then perpendicular with hand adjustment section It is intubated the position of (5) on plate (3), the end of intubation (5) is inserted into the mouth of mouse, guarantees that the mouth of mouse is in opening State；

Step 3: first covering the connector sleeve (20) of gastric perfusion needle (21) one end on the connector (19) of injection tube (18), then draw Dynamic first push plate (25), the first push plate (25) is mobile to drive the first push rod (23) mobile, and the first push rod (23) is mobile to drive first Active rubber block (22) is mobile, and liquid required for stomach-filling is drawn into injection tube (18)；

Step 4: the injection tube (18) equipped with gastric perfusion needle (21) is inserted into intubation (5) inside, injection tube by jack (4) (18) activity card sets (13) are passed through and are stuck in activity card sets (13), gastric perfusion needle (21) passes through the opening on rubber sleeve (31) (32), it and is inserted into the stomach of mouse；

Step 5: liquid is passed through to through slot (26) is internal, then again by second when needing to pour into other liquid during stomach-filling Active rubber block (28) is inserted into through slot (26), is pushed the second push plate (30), and the second push plate (30) is mobile to drive the second push rod (29) mobile, the second push rod (29) is mobile to drive the second active rubber block (28), and liquid is pushed into injection tube (18)；

Step 6: slowly pulling injection tube (18) outward after the completion of stomach-filling, injection tube (18) is extracted from intubation (5), thus Gastric perfusion needle (21) is extracted out of Mice Body, then rubber ring (10) is removed from the neck of mouse, cleaning and sterilizing is carried out to device.