CN102824197B - A kind of stem cell transplantation screw electrode for left ventricle - Google Patents
A kind of stem cell transplantation screw electrode for left ventricle Download PDFInfo
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- CN102824197B CN102824197B CN201210356833.2A CN201210356833A CN102824197B CN 102824197 B CN102824197 B CN 102824197B CN 201210356833 A CN201210356833 A CN 201210356833A CN 102824197 B CN102824197 B CN 102824197B
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- stem cell
- electrode
- polyurethane tube
- left ventricle
- cell transplantation
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Abstract
The invention discloses a kind of stem cell transplantation screw electrode for left ventricle, including box-like housing, polyurethane tube and stem cell injection electrode, retain sheath to be fixedly connected with box-like housing, polyurethane tube is located at retaining in sheath, and stem cell injection electrode is in polyurethane tube；The head end of polyurethane tube is provided with 4 metal joints, and tail end is inlaid with 4 sensing electrodes, and metal joint is connected by wire with sensing electrode；Stem cell injection electrode is hollow structure, and its tail end is provided with spiral electrode and spiral electrode is provided with through hole；2 venting channels are provided with polyurethane tube, the tail end of 2 venting channels is equipped with 1 air bag.The present invention can retain for a long time in vivo, selection implantation point when can repeatedly, multipoint operation.And it can accommodate more liquid（Cell）, it is big with the contact surface of cardiac muscle, make the probability of success of stem cell transplantation higher.It also has the advantages of small to blood vessel injury, massive haemorrhage probability is relatively low in addition.
Description
Technical field
The present invention relates to a kind of screw electrode, particularly a kind of stem cell transplantation screw electrode for left ventricle, belongs to
Medical instruments field.
Background technology
With the arrival of aging society, the incidence of disease of angiocardiopathy increases year by year, acute or chronic angiocardiopathy
Caused cardiac muscle cell, vascular endothelial cell lose cause cardiac insufficiency, thus bring disable, the death rate increases year by year,
Great burden is brought to society, the patient that China has more than 700000 every year dies from coronary heart disease.How to save or substitute and be impaired
Cardiac muscle cell, blood vessel etc. be a task in the urgent need to address.
Previously research is found that stem cell（stem cell）The biological nature of regenerating tissues, possesses treatment human diseases
Tremendous potential.Although stem cell basic research achieves larger progress, under present condition, cardiac stem cells transplanting away from
Also have from clinical extensive practice with a distance from larger.
The preferable transplanting mode of effect is internal membrane of heart injection method at present：Through internal membrane of heart transplanting set in myocardium electromechanical mapping
Under standby guiding, the conduit for carrying injection needle passes through the left chamber of retrograde entrance after aorta petal, in endocardial surface according to current potential
Ishemic part is determined, then by stem cell to be expelled to perpendicular to endocardial direction in cardiac muscle.World wide is using most at present
For generally Noga systems, the system is developed by Johnson Co., and also there are part scientific research institution and clinical portion in the country at present
Separate into the system, the system is divided into two parts：Myocardium electromechanical mapping equipment and injection catheter.
Although Noga systematic comparisons are advanced, also there is the part having much room for improvement in the system：1st, Noga system pass is
Arteries and veins is performed the operation, it is impossible to body is retained in, can only single operation（Can not more time point injections）If more time point transplanting are, it is necessary to multiple hand
Art, expense are larger（Including Noga stem cell injections device and surgery cost）, to patient injure it is also larger（Repeatedly puncture artery）；
2nd, due to being single approach and Noga stem cell injection devices tail end is injection needle sample, therefore the transplanted cells amount comprising liquid
It is restricted, the probability of success of stem cell transplantation is relatively low；3rd, artery approach is not suitable for stem cell transplantation multiple in a short time（Cardiac muscle stalk
After death stem cell transplantation window relative narrower, general transfer operation need to carry out in January after myocardial infarction generation, now infarct
The also incomplete fibrosis in area）, and massive haemorrhage probability be present, endarterium is formed and damaged.
The content of the invention
It is an object of the present invention to provide a kind of stem cell transplantation screw electrode for left ventricle, it can be protected for a long time
Stay in the body, selection implantation point when can repeatedly, multipoint operation.And it can accommodate more liquid（Cell）, with cardiac muscle
Contact surface it is big, make the probability of success of stem cell transplantation higher.It also has small to blood vessel injury in addition, and massive haemorrhage probability is relatively low
The advantages of.
Technical scheme：A kind of stem cell transplantation screw electrode for left ventricle, including box-like housing, reservation
Sheath, polyurethane tube and stem cell injection electrode, retain sheath and be fixedly connected with box-like housing, polyurethane tube is located at reservation sheath
Interior, stem cell injection electrode is in polyurethane tube；The head end of polyurethane tube is provided with 4 metal joints, and tail end is inlaid with 4 senses
Know electrode, 4 metal joints are connected by wire with 4 sensing electrodes；Stem cell injection electrode is hollow structure, its tail end
Provided with spiral electrode, spiral electrode is hollow structure, and spiral electrode is provided with through hole；2 are provided with polyurethane tube
Venting channels, 2 venting channels are symmetricly set on the both sides of stem cell injection electrode, and the tail end of 2 venting channels is equipped with 1
Air bag.Polyurethane tube plays a supportive role, and the compatibility of polyurethane is good；Retain sheath during operation as operation path, polyurethane tube
It is operated by retaining sheath；3 are used for perceiving intracavitary current potential in 4 sensing electrodes, and 1 is used to perceive current potential.Sense
Know that electrode is positioned according to current potential and changes of magnetic field, the tail end of whole stem cell transplantation screw electrode is flexible angle of transformation
Degree design.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
Because air bag is exposed in left room, it is necessary to prevent thrombosis using heparin, therefore heparin coating is set outside air bag.Move every time
Plant terminates, air bag expansion, for fixed electrode head end.Sensing electrode is positioned according to current potential and changes of magnetic field.For a left side
The tail end of the stem cell transplantation screw electrode of ventricle designs for flexible translation-angle.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The head end of stem cell injection electrode is higher than the head end of polyurethane tube.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The height of the box-like housing is 8CM, and width 8CM, top is provided with the with matching first capping, box-like housing and first
Capping is connected through a screw thread；The head end of polyurethane tube is provided with the second matched capping, and the second capping passes through with polyurethane tube
Threaded connection.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The wall thickness of polyurethane tube is 1.5F；The internal diameter of stem cell injection electrode is 1F, wall thickness 1F.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
Polyurethane tube and stem cell injection electrode are made of 316L shaped steel.In addition to using 316L shaped steel, other can also be used
The alloy of electric signal conduction and stem cell injection channeling can be played.Because 316 L-type steels have price advantage, therefore this case
It is preferred that 316L shaped steel.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
A diameter of 0.5F of venting channels.Medically 1F=0.33mm, F are conventional unit.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The aperture of the through hole is 30 μm~50 μm, and the distance between 2 through holes of arbitrary neighborhood are 50 μm.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The total length of stem cell injection electrode is 65 cm~75cm.
In the foregoing this stem cell transplantation screw electrode for left ventricle, the outer wall of air bag is provided with heparin coating.
The head end of the stem cell injection electrode covers provided with four fence gate plastic cement.
Compared with prior art, the present invention can retain in vivo for a long time, realize multiple injection, surgery cost is relatively
It is low, and patient is injured small.
The stem cell injection electrode tail end of the present invention is helical design, can accommodate more liquid（Cell）, due to
There is provided through hole on spiral electrode can effectively increase the contact surface with cardiac muscle, is advantageous to stem cell and permeates into cardiac muscular tissue
In, effectively increase the probability of success of stem cell transplantation.
Because the present invention can be retained in body for a long time, body January can be typically retained in, blood vessel is injured small, is effectively reduced
The probability of massive haemorrhage.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Mark in accompanying drawing for：The box-like housings of 1-, 2- retain sheath, 3- polyurethane tubes, 4- stem cell injection electrodes, 5- gold
Category joint, 6- sensing electrodes, 7- spiral electrodes, 8- through holes, 9- first are covered, the capping of the fence gate plastic cement of 10- tetra-, the envelopes of 11- second
Lid, 12- venting channels, 13- air bags, 14- heparin coatings.
Embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples, but is not intended as appointing the present invention
The foundation of what limitation.
Embodiments of the invention 1：As shown in figure 1, a kind of stem cell transplantation screw electrode for left ventricle, including it is box-like
Housing 1, retain sheath 2, polyurethane tube 3 and stem cell injection electrode 4, retain sheath 2 and be fixedly connected with box-like housing 1, poly- ammonia
Ester pipe 3 retains sheath 2 during operation and be used as operation path, polyurethane tube 3 is by retaining the progress hand of sheath 2 located at retaining in sheath 2
Art operates, and stem cell injection electrode 4 is in polyurethane tube 3；The head end of polyurethane tube 3 is provided with 4 metal joints 5, tail end edge
Be connected embedded with 4 sensing electrodes, 6,4 metal joints 5 by wire with 4 sensing electrodes 6, sensing electrode 6 according to current potential and
Changes of magnetic field is positioned；Stem cell injection electrode 4 is hollow structure, and its tail end is provided with spiral electrode 7, spiral electrode
7 be hollow structure, and spiral electrode 7 is provided with through hole 8；2 venting channels, 12,2 venting channels are provided with polyurethane tube 3
12 are symmetricly set on the both sides of stem cell injection electrode 4, and the tail end of 2 venting channels 12 is equipped with 1 air bag 13.Air bag 13
Outer wall is provided with heparin coating 14.The head end of stem cell injection electrode 4 is provided with four fence gate plastic cement capping 10.
The head end of stem cell injection electrode 4 is higher than the head end of polyurethane tube 3.Polyurethane tube 3 and stem cell injection electrode 4 are equal
It is made of 316L shaped steel.The height of box-like housing 1 is 8CM, and width 8CM, top is provided with the with matching first capping
9, box-like housing 1 is connected through a screw thread with the first capping 9；The head end of polyurethane tube 3 is provided with the second matched capping 11, the
Two cappings 11 are connected through a screw thread with polyurethane tube 3.
The wall thickness of polyurethane tube 3 is 1.5F；The internal diameter of stem cell injection electrode 4 is 1F, wall thickness 1F.Venting channels 12
A diameter of 0.5F.
The aperture of through hole 8 is 30 μm, and the distance between 2 through holes 8 of arbitrary neighborhood are 50 μm.Stem cell injection electrode 4
Total length is 65 cm.
Embodiments of the invention 2：As shown in figure 1, a kind of stem cell transplantation screw electrode for left ventricle, including it is box-like
Housing 1, retain sheath 2, polyurethane tube 3 and stem cell injection electrode 4, retain sheath 2 and be fixedly connected with box-like housing 1, poly- ammonia
Ester pipe 3 retains sheath 2 during operation and be used as operation path, polyurethane tube 3 is by retaining the progress hand of sheath 2 located at retaining in sheath 2
Art operates, and stem cell injection electrode 4 is in polyurethane tube 3；The head end of polyurethane tube 3 is provided with 4 metal joints 5, tail end edge
Be connected embedded with 4 sensing electrodes, 6,4 metal joints 5 by wire with 4 sensing electrodes 6, sensing electrode 6 according to current potential and
Changes of magnetic field is positioned；Stem cell injection electrode 4 is hollow structure, and its tail end is provided with spiral electrode 7, spiral electrode
7 be hollow structure, and spiral electrode 7 is provided with through hole 8；2 venting channels, 12,2 venting channels are provided with polyurethane tube 3
12 are symmetricly set on the both sides of stem cell injection electrode 4, and the tail end of 2 venting channels 12 is equipped with 1 air bag 13.Air bag 13
Outer wall is provided with heparin coating 14.The head end of stem cell injection electrode 4 is provided with four fence gate plastic cement capping 10.
The head end of stem cell injection electrode 4 is higher than the head end of polyurethane tube 3.Polyurethane tube 3 and stem cell injection electrode 4 are equal
It is made of 316L shaped steel.The height of box-like housing 1 is 8CM, and width 8CM, top is provided with the with matching first capping
9, box-like housing 1 is connected through a screw thread with the first capping 9；The head end of polyurethane tube 3 is provided with the second matched capping 11, the
Two cappings 11 are connected through a screw thread with polyurethane tube 3.
The wall thickness of polyurethane tube 3 is 1.5F；The internal diameter of stem cell injection electrode 4 is 1F, wall thickness 1F.Venting channels 12
A diameter of 0.5F.
The aperture of through hole 8 is 40 μm, and the distance between 2 through holes 8 of arbitrary neighborhood are 50 μm.Stem cell injection electrode 4
Total length is 70cm.
Embodiments of the invention 3：As shown in figure 1, a kind of stem cell transplantation screw electrode for left ventricle, including it is box-like
Housing 1, retain sheath 2, polyurethane tube 3 and stem cell injection electrode 4, retain sheath 2 and be fixedly connected with box-like housing 1, poly- ammonia
Ester pipe 3 retains sheath 2 during operation and be used as operation path, polyurethane tube 3 is by retaining the progress hand of sheath 2 located at retaining in sheath 2
Art operates, and stem cell injection electrode 4 is in polyurethane tube 3；The head end of polyurethane tube 3 is provided with 4 metal joints 5, tail end edge
Be connected embedded with 4 sensing electrodes, 6,4 metal joints 5 by wire with 4 sensing electrodes 6, sensing electrode 6 according to current potential with
And changes of magnetic field is positioned；Stem cell injection electrode 4 is hollow structure, and its tail end is provided with spiral electrode 7, helical form electricity
Pole 7 is hollow structure, and spiral electrode 7 is provided with through hole 8；It is logical that 2 venting channels, 12,2 ventilations are provided with polyurethane tube 3
Road 12 is symmetricly set on the both sides of stem cell injection electrode 4, and the tail end of 2 venting channels 12 is equipped with 1 air bag 13.Air bag 13
Outer wall be provided with heparin coating 14.The head end of stem cell injection electrode 4 is provided with four fence gate plastic cement capping 10.
The head end of stem cell injection electrode 4 is higher than the head end of polyurethane tube 3.Polyurethane tube 3 and stem cell injection electrode 4 are equal
It is made of 316L shaped steel.The height of box-like housing 1 is 8CM, and width 8CM, top is provided with the with matching first capping
9, box-like housing 1 is connected through a screw thread with the first capping 9；The head end of polyurethane tube 3 is provided with the second matched capping 11, the
Two cappings 11 are connected through a screw thread with polyurethane tube 3.
The wall thickness of polyurethane tube 3 is 1.5F；The internal diameter of stem cell injection electrode 4 is 1F, wall thickness 1F.Venting channels 12
A diameter of 0.5F.
The aperture of through hole 8 is 50 μm, and the distance between 2 through holes 8 of arbitrary neighborhood are 50 μm.Stem cell injection electrode 4
Total length is 75cm.
In addition, the tail end of the present invention designs for flexible translation-angle.
The application method of the present invention：Femoral vein having sexual intercourse interval oval foramen is first passed around to puncture（7F-8F）, success.Puncture again
Jugular vein, the stem cell transplantation screw electrode for left ventricle reach left room by oval foramen puncture portion from left room（During operation
Need the auxiliary of similar pacing electrode guide wire）, intercoil connection external first to metal joint 5, then metal joint 5 one terminate
Positioned on to magnetic navigation or current potential navigation system（It will not so pollute）.After positioning terminates, it is implanted at corresponding position
Spiral electrode 7, four fence gate plastic cement capping 10 is then opened, stem cell suspension is injected into from the head end of stem cell injection electrode 4,
After end, change position and continue to transplant, transplanted around infarct border area（Typically can be 10-20 injection site）.Move
After plant terminates, polyurethane tube 3 is retracted and is retained in atrial septal puncture portion（In left room）, to the gas injection of air bag 13, expansion, for fixing
The tail end of stem cell injection electrode 4（Blood flow direction is left to right shunt, therefore is retracted into without having to worry about electrode in right room）.Pull out gap bridge
Line, with the closing metal joint 5 of the second capping 11, the head end of closing stem cell injection electrode 4 is covered using four fence gate plastic cement, is filled
Heparin, antibiotic liquid are closed in box-like housing 1, and with the first capping 9.After transplanting terminates every time, the ventilative sterilization application of external application
Close wound.
Claims (10)
- A kind of 1. stem cell transplantation screw electrode for left ventricle, it is characterised in that：Including box-like housing (1), retain sheath (2), polyurethane tube (3) and stem cell injection electrode (4), retain sheath (2) and be fixedly connected with box-like housing (1), polyurethane tube (3) located at retaining in sheath (2), stem cell injection electrode (4) is in polyurethane tube (3)；The head end of polyurethane tube (3) is provided with 4 metal joints (5), tail end are inlaid with 4 sensing electrodes (6), and 4 metal joints (5) pass through wire and 4 sensing electrodes (6) connect；Stem cell injection electrode (4) is hollow structure, and its tail end is provided with spiral electrode (7), and spiral electrode (7) is Hollow structure, and spiral electrode (7) is provided with through hole (8)；2 venting channels (12) are provided with polyurethane tube (3), 2 logical Gas passage (12) is symmetricly set on the both sides of stem cell injection electrode (4), and the tail end of 2 venting channels (12) is equipped with 1 gas Capsule (13)；After transplanting terminates, polyurethane tube (3) is retracted and is retained in atrial septal puncture portion, to air bag (13) gas injection, expansion, used To fix stem cell injection electrode (4) tail end.
- A kind of 2. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：Air bag (13) outer wall is provided with heparin coating (14).
- A kind of 3. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：Stem cell The head end of injection electrodes (4) is higher than the head end of polyurethane tube (3).
- A kind of 4. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：The box The height of shape housing (1) is 8CM, width 8CM, and top is provided with the with matching first capping (9), box-like housing (1) with First capping (9) is connected through a screw thread；The head end of polyurethane tube (3) is provided with the second matched capping (11), the second capping (11) it is connected through a screw thread with polyurethane tube (3).
- A kind of 5. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：Polyurethane The wall thickness for managing (3) is 1.5F, and medically 1F=0.33mm, F are conventional unit；The internal diameter of stem cell injection electrode (4) is 1F, Wall thickness is 1F.
- A kind of 6. stem cell transplantation screw electrode for left ventricle according to claim 1 or 5, it is characterised in that：It is poly- Wire and stem cell injection electrode (4) in urethane pipe (3) are made of 316L shaped steel.
- A kind of 7. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：Ventilation is logical A diameter of 0.5F in road (12).
- A kind of 8. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：It is described logical The aperture in hole (8) is 30 μm~50 μm, and the distance between 2 through holes (8) of arbitrary neighborhood are 50 μm.
- A kind of 9. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：Stem cell The total length of injection electrodes (4) is 65cm~75cm.
- A kind of 10. stem cell transplantation screw electrode for left ventricle according to claim 1, it is characterised in that：It is described The head end of stem cell injection electrode (4) is provided with four fence gate plastic cement capping (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210356833.2A CN102824197B (en) | 2012-09-21 | 2012-09-21 | A kind of stem cell transplantation screw electrode for left ventricle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210356833.2A CN102824197B (en) | 2012-09-21 | 2012-09-21 | A kind of stem cell transplantation screw electrode for left ventricle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102824197A CN102824197A (en) | 2012-12-19 |
| CN102824197B true CN102824197B (en) | 2017-11-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210356833.2A Expired - Fee Related CN102824197B (en) | 2012-09-21 | 2012-09-21 | A kind of stem cell transplantation screw electrode for left ventricle |
Country Status (1)
| Country | Link |
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| CN (1) | CN102824197B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8948883B2 (en) * | 2013-04-24 | 2015-02-03 | Medtronic, Inc. | Electrode assemblies and associated fixation members for implantable medical devices |
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| US5522874A (en) * | 1994-07-28 | 1996-06-04 | Gates; James T. | Medical lead having segmented electrode |
| CA2168860C (en) * | 1993-08-27 | 2000-02-08 | Peter M. J. Mulier | Method and apparatus for r-f ablation |
| CN1652839A (en) * | 2002-05-08 | 2005-08-10 | 加利福尼亚大学董事会 | System and method for treating cardiac arrhythmias with fibroblast cells |
| CN101076369A (en) * | 2004-05-28 | 2007-11-21 | 莫顿·M·莫厄尔 | System and method for managing detrimental cardiac remodeling |
| CN102198305A (en) * | 2010-03-23 | 2011-09-28 | 微创医疗器械(上海)有限公司 | Device and system for locally delivering therapeutic agents |
| CN202761830U (en) * | 2012-09-21 | 2013-03-06 | 复旦大学附属华山医院 | Spiral electrode for left ventricular stem cells transplantation (SCT) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7103418B2 (en) * | 2002-10-02 | 2006-09-05 | Medtronic, Inc. | Active fluid delivery catheter |
| WO2010011930A2 (en) * | 2008-07-24 | 2010-01-28 | Boston Scientific Scimed, Inc. | Various catheter devices for myocardial injections or other uses |
| EP2327366B1 (en) * | 2009-11-30 | 2012-03-14 | Sorin CRM SAS | Kit for piercing the cardiac septum and implanting a transseptal probe, in particular a probe for detection/stimulation of a left cavity of the heart |
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|---|---|---|---|---|
| US5374287A (en) * | 1991-04-10 | 1994-12-20 | British Technology Group Usa Inc. | Defibrillator and demand pacer catheters and methods for using same |
| US5447533A (en) * | 1992-09-03 | 1995-09-05 | Pacesetter, Inc. | Implantable stimulation lead having an advanceable therapeutic drug delivery system |
| CA2168860C (en) * | 1993-08-27 | 2000-02-08 | Peter M. J. Mulier | Method and apparatus for r-f ablation |
| US5522874A (en) * | 1994-07-28 | 1996-06-04 | Gates; James T. | Medical lead having segmented electrode |
| CN1652839A (en) * | 2002-05-08 | 2005-08-10 | 加利福尼亚大学董事会 | System and method for treating cardiac arrhythmias with fibroblast cells |
| CN101076369A (en) * | 2004-05-28 | 2007-11-21 | 莫顿·M·莫厄尔 | System and method for managing detrimental cardiac remodeling |
| CN102198305A (en) * | 2010-03-23 | 2011-09-28 | 微创医疗器械(上海)有限公司 | Device and system for locally delivering therapeutic agents |
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| CN102824197A (en) | 2012-12-19 |
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