CN102805096A - Fungicide composition for effectively preventing wheat fungi - Google Patents
Fungicide composition for effectively preventing wheat fungi Download PDFInfo
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- CN102805096A CN102805096A CN2012103221238A CN201210322123A CN102805096A CN 102805096 A CN102805096 A CN 102805096A CN 2012103221238 A CN2012103221238 A CN 2012103221238A CN 201210322123 A CN201210322123 A CN 201210322123A CN 102805096 A CN102805096 A CN 102805096A
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- prochloraz
- ring azoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
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Abstract
The invention relates to application of fungicide composition for effectively preventing wheat fungi. The fungicide composition comprises two active components and pesticide auxiliary acceptable in agriculture, wherein the component a is epoxiconazole and the component b is prochloraz (or metal salt type compound acceptable on agriculture). In the active components, the weight ratio of the epoxiconazole and the prochloraz is 0.03-65, and preferentially 0.05-55. The fungicide composition is capable of effectively preventing wheat rust, gibberellic disease, powdery mildew, banded sclerotial blight and full rot, has positive advantages in the aspects of postponing fungal resistance and improving prevention effect by complexing the component a and the component b, and shows quite strong fungicidal activity.
Description
Technical field
The present invention relates to a kind of purposes with microbicide compositions control wheat fungal disease of synergistic function.The invention belongs to the agriculture plant protection field.
Technical background
The fungal disease of wheat such as rust, powdery mildew, head blight, banded sclerotial blight, full rot etc. are the common disease of wheat; These diseases have become the main disease of restriction wheat growth and good harvest at present; The normally used medicament of these diseases is conventional dose such as thiophanate methyl, jinggangmeisu, triazolone, carbendazim; Because just beginning large tracts of land the seventies from eighties of last century, promote these medicaments; Long-term use kind of high dose ground continuously or the single chemical bactericide of the mode of action influence residual, the environmental pollution and the pesticide resistance fungi developing problems of medicament easily.Fluorine ring azoles and Prochloraz all are very effective bactericide in the agricultural production.Fluorine ring azoles is a kind of novel fluorine-containing bactericide of important triazole type, not only has good protection, treats and roots out activity, and have preferable systemic activity, can be is rapidly absorbed and conducts to susceptible position by plant, disease is infected immediately stop.Because this compound imports fluorine ion, thus extra high bactericidal activity had for the wheat fungal disease, but because fluorine ring azoles cost is higher, is difficult to large tracts of land and promotes.Prochloraz is a broad-spectrum germicide, is the strongest active kind in the amino formyl imidazole class, has good conductive performance; The multiple diseases that Ascomycetes, Basidiomycetes, deuteromycetes etc. are caused has reasonable effect; For the wheat fungal disease reasonable preventive effect is arranged also, and moderate, be easy to promote; But chronic administration, the fungus resistant problem also becomes increasingly conspicuous.For this type of problem, present normally used method is that the mixture that filters out the compound of different activities is prevented and treated harmful fungoid.But produce through the method delaying drug resistance, reduce amount of application, improve control efficiency, reduce the control cost.
Summary of the invention
The object of the invention: to above-mentioned weak point; Through fluorine ring azoles, Prochloraz (or its agricultural goes up acceptable metal salt compound) effective active composition are made up; And be aided with insecticides adjuvant, a kind of microbicide compositions that has synergistic function for control wheat fungoid germ is provided.Result of the test shows that composition of the present invention is obvious to the synergistic effect of wheat fungal disease, has reduced formulation rate simultaneously, has reduced spraying times, and does not have cross resistance between fluorine ring azoles and the Prochloraz.
Prochloraz (english common name Prochloraz), chemical name (formula I): N-propyl group-N-[2-(2,4, the 6-Trichlorophenoxy) ethyl]-imidazoles-1-formamide
The metal ion that is suitable for Prochloraz metal salt compound of the present invention can be selected in the periodic table of elements first to second excessive family element, the especially manganese, iron, zinc, copper; The ion that also has second major element, especially calcium and magnesium; And third and fourth major element, especially aluminium ion.If suitable, metal ion can exist with the various chemical valences that they possibly appear.For example, select the salt compounds (suc as formula II) of metal ion manganese, that is, and N-propyl group-N-[2-(2,4, the 6-Trichlorophenoxy) ethyl]-1-H-imidazoles-1-formamide-manganese chloride.
Fluorine ring azoles (english common name epoxiconazole), chemical name (formula III): (2RS, 3RS)-1-[3-(2-chlorphenyl)-2,3-epoxy-2-(4-fluorophenyl) propyl group]-1 hydrogen-1,2, the 4-triazole.
Concrete scheme of the present invention is: a kind of microbicide compositions of preventing and treating the wheat fungal disease comprises following component: the conventional auxiliary agent of fluorine ring azoles and Prochloraz (or agricultural goes up acceptable its metal salt compound) and agricultural chemicals is formed.
Be suitable for wherein a kind of such as the preferred prochloraz-manganese chloride complex of Prochloraz metal salt compound of the present invention, prochloraz zinc salt, prochloraz nantokite.
Bactericidal composition of the present invention is made up of the active component of 8～88% weight portions and the insecticides adjuvant of 92～12% weight portions.
In the composition of the present invention, Prochloraz and fluorine ring azoles weight ratio are 1:50～50:1, are preferably 1:30～30:1.
Mixture of the present invention uses with the form of composition, uses with usual auxiliaries such as other carriers, surfactants usually during use.
Suitable additive and carrier can be solid or liquid, and they are material commonly used in the formulation process normally, mineral matter for example natural or regeneration, solvent, dispersant, wetting agent, adhesive, thickener, adhesive or fertilizer.
The method for optimizing of using the present composition comprises the acrial part that composition of the present invention is used for plant growing, particularly leaf portion (foliage applying).Frequency of utilization and amount of application depend on the biology and the weather life condition of pathogene.
Composition of the present invention can use with constant form, perhaps preferably in configuration technology normally used additive use, so these compounds can be configured in known manner, for example process wetting powder, suspending agent, water dispersible granules.According to the character that these compositions had, can according to the purpose that will reach and ambient conditions select like spraying, atomizing, broadcast sowing, bold and vigorous application process of watering etc. and so on.
Composition as solid form; That can mention has following several kinds: (content of its active component is generally than higher for water dispersible granules; Usually between 50%-90%), normally prepare through the agglomeration of wettable powder type composition in suitable granular system, make this formulation.
Wetting powder is general to be prepared with such method, and promptly so that its active component that contains is as the criterion, except that solid carrier, they generally contain the wetting agent of 0-7%, and the dispersant of 3-10% in case of necessity, contains one or more other the additive of 0-10% again.Like dyestuff, colouring agent, bleeding agent, adhesive or anti-caking agent etc.
Suspending agent is to prepare with following method; Promptly be as the criterion not form sedimental stable fluid; They generally contain the active component of 10-85%; The surfactant of 0.5-45%, the additive such as dyestuff, colouring agent, foam reducing composition, corrosion inhibitor, stabilizing agent and bleeding agent and adhesive etc. that 0-10% is suitable, carrier can be water or organic liquid; Active component indissoluble or water fast can be dissolved in the liquid some solid organic matter or mineral salt so that help sediments to form or as the antifreezing agent of water.
Available known method prepares various formulations: for example with active ingredient and filler, like solvent, solid carrier, can evenly mix, grind with surfactant when needing.
The solvent that is suitable for inventing is alternative to be had: aromatic hydrocarbon preferably contains 8-12 carbon atom, like xylene mixture or substituted benzene; Phthalate, sad like Dibutyl phthalate or phthalandione two, fat hydrocarbon; Like thiacyclohexane or paraffin, pure and mild ethylene glycol and their ether and ester are like ethanol; Ethylene glycol, the glycol monomethyl methyl; Ketone, like cyclohexanone, the solvent of strong polarity, like the N-N-methyl-2-2-pyrrolidone N-, dimethyl sulfoxide (DMSO) or dimethyl formamide and vegetable oil or vegetable oil are like soybean oil.
Be suitable for solid carrier of the present invention, but as be used for the normally natural minerals filler of pulvis and dispersant, for example talcum, kaolin, montmorillonite or atlapulgite.For the managing physical performance also can add polymolecularity silicic acid or polymolecularity adsorpting polymerization thing.Suitable granular absorption carrier is a porous type, like float stone, bentonite or bentonite; Suitable non-absorption carrier is for example calcite or sand.In addition, can use being prefabricated into of a large amount of inorganic in nature or organic character granular material, particularly dolomite.
The chemical property of two components according to the present invention, suitable surfactant are alkali metal salt, alkali salt and the amine salt of lignin sulfonic acid, naphthalene sulfonic acids, phenolsulfonic acid, dibutyl naphthalene sulfonic acids, alkylaryl sulfonates, alkyl sulfate; Alkylsulfonate, alkylsulfonate, aliphatic alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether; The condensation product that also has sulfonated naphthalene and naphthalene derivatives and formaldehyde, the condensation product of naphthalene or naphthalene sulfonic acids and phenol and formaldehyde, NONIN HS 240, ethoxylation isooctylphenol; Octyl phenol, nonyl phenol, alkylaryl polyglycol ether; Tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol; Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation product, ethoxylation polyoxypropylene; Lauric acid polyglycol ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
Can use in the composition of the present invention, when using two components jointly, the effect of stack (equaling synergy) occur.The specific activity of this composition is used the activity expection summation of single compound, and the independent activity of single compound is more remarkable.Synergistic effect allow to show as amount of application minimizing, action effect instant effect, more lasting control efficiency, through only once or minority use several times can better the controlling plant harmful fungoid.
Other characteristics that show of bactericidal composition of the present invention mainly show as: 1, because two single thinner architectural differences of this composition are very big, do not have cross resistance, can delay two single agent and use the resistance problem that is produced separately; 2, composition of the present invention is good to crop safety, preventive effect.Through evidence, microbicide compositions chemical property of the present invention is stable, and synergy is remarkable, and controlling object is shown tangible synergy and complementation; 3, reduced dosage, thereby reduced cost and alleviated pollution environment.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer,, the present invention is further elaborated below in conjunction with embodiment.Should be appreciated that specific embodiment described herein only in order to explaining the present invention, and be not used in qualification the present invention, all any modifications of within spirit of the present invention and principle, being made, be equal to and replace and improvement etc., all should be included within protection scope of the present invention.
Percentage all is weight percentage in all prescriptions of following examples.The processing technology of the various preparations of the present composition is prior art, can change to some extent according to different situations.
One, formulation prepares embodiment
(4) processing of aqueous emulsion and embodiment
Active component a and b, solvent, auxiliary agent are mixed under mechanical agitation, drop into emulsifier then and stabilizing agent stirs, add entry at last, under 100-12000 rev/min rotating speed, stirred 10-30 minute, make it to become the product of even emulsus.
Embodiment 1:30% Prochloraz epoxiconazole aqueous emulsion
Prochloraz 5%, fluorine ring azoles 25%, polyoxyethylene block copolymer 4%, propane diols 2%, xanthans 3% gathers isosuccinic acid acid anhydride-ethylene glycol copolymer 4%, silicone defoaming agent 2%, water complements to 100%.
In the foregoing description 1, also available prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt substitute Prochloraz and prepare this embodiment.
Embodiment 2:30% Prochloraz epoxiconazole aqueous emulsion
Prochloraz 25%, fluorine ring azoles 5%, N-dodecyl pyrrolidone 3%, castor oil polyoxyethylene ether 2%, glycerine 2%, polyvinyl alcohol 3%, Sodium Benzoate 3%, isooctanol 2%, water complements to 100%.
In the foregoing description 2, also available prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt substitute Prochloraz and prepare this embodiment.
(2) processing of suspending agent and embodiment
Each component such as active component a and b, dispersant, wetting agent, thickener and water is even by the mixed of prescription, after sand milling and/or high speed shear, obtain semi-finished product, add water after the analysis and mix to filter and get product.
Embodiment 3:42% prochloraz nantokite epoxiconazole suspension concentrate
Prochloraz nantokite 40%, fluorine ring azoles 2%, sodium lignin sulfonate 8%, white carbon 2%, ethylene glycol 5%, xanthans 2%, water complements to 100%.
In the foregoing description 3, also available Prochloraz, prochloraz-manganese chloride complex, prochloraz zinc salt substitute prochloraz nantokite and prepare this embodiment.
Embodiment 4:42% prochloraz nantokite epoxiconazole suspension concentrate (2:40)
Prochloraz nantokite 2%, fluorine ring azoles 40%, white carbon 2%, aliphatic alcohol polyoxyvinethene phosphate 6%, Sodium Benzoate 3%, glycerine 7%, water complements to 100%.
In the foregoing description 4, also available Prochloraz, prochloraz-manganese chloride complex, prochloraz zinc salt substitute prochloraz nantokite and prepare this embodiment.
(1) processing of water dispersible granules and embodiment
Active component a and b, auxiliary agent and filler is even by the mixed of prescription, become wetting powder through comminution by gas stream, add the granulation of a certain amount of water extrusion again, after dry screened, make the water dispersible granules product.
Embodiment 5:75% prochloraz-manganese chloride complex epoxiconazole water dispersant
Prochloraz-manganese chloride complex 2%, fluorine ring azoles 73%, sodium alginate 4%, methyl naphthalene sulfonate formaldehyde condensate 2%, ammonium sulfate 2%, organic silicone 2%, bentonite complements to 100%.
In the foregoing description 5, also available prochloraz nantokite, prochloraz zinc salt or Prochloraz substitute prochloraz-manganese chloride complex and prepare this embodiment.
Embodiment 6:80% prochloraz zinc salt epoxiconazole water dispersant
Prochloraz zinc salt 78%, fluorine ring azoles 2%, sodium lignin sulfonate 4%, sodium carboxymethyl starch 1%, dodecyl sodium sulfate 2%, xanthans 4%, attapulgite complements to 100%.
In the foregoing description 6, also available prochloraz nantokite, prochloraz-manganese chloride complex or Prochloraz substitute prochloraz zinc salt and prepare this embodiment.
(3) processing of wetting powder and embodiment
Active component a is fully mixed with b, various auxiliary agent and filler etc. in proportion, after ultrafine crusher is pulverized, make wetting powder.
Embodiment 7:85% prochloraz nantokite fluorine ring azoles wetting powder
Prochloraz nantokite 78%, fluorine ring azoles 7%, calcium lignosulfonate 6%, bentonite 3%, NONIN HS 240 4%, attapulgite complements to 100%.
In the foregoing description 7, also available prochloraz-manganese chloride complex, Prochloraz or prochloraz zinc salt substitute prochloraz nantokite and prepare this embodiment.
Embodiment 8:50% prochloraz nantokite fluorine ring azoles wetting powder
Prochloraz nantokite 25%, fluorine ring azoles 25%, calcium lignosulfonate 4%, white carbon 8%, neopelex 3%, attapulgite complements to 100%.
In the foregoing description 8, also available prochloraz-manganese chloride complex, Prochloraz or prochloraz zinc salt substitute prochloraz nantokite and prepare this embodiment.
Embodiment 9:55% prochloraz-manganese chloride complex fluorine ring azoles wetting powder
Prochloraz-manganese chloride complex 5%, fluorine ring azoles 50%, NONIN HS 240 6%, sodium lignin sulfonate 7%, white carbon 15%, diatomite complements to 100%.
In the foregoing description 9, also available prochloraz nantokite, Prochloraz or Prochloraz substitute prochloraz-manganese chloride complex and prepare this embodiment.
Two, application implementation example
(1) indoor biological activity determination co-toxicity coefficient of the present invention
Control efficiency is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value (x) to, and concentration EC50 in calculating the virulence equation and suppress with method of least squares is according to the toxicity index level co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.Toxicity test result sees table 1.
Actual measurement toxicity index (ATI)=(standard medicament EC50/ supplies reagent agent EC50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100CTC≤80; The composition performance is antagonism, 80＜CTC＜120, and the composition performance is summation action; CTC>=120, the composition performance is synergistic effect.
1, indoor biological activity determination composition of the present invention is measured the co-toxicity coefficient of wheat powdery mildew
Subjects: wheat powdery mildew germ
Table 1 Prochloraz is composite to the interpretation of result of wheat powdery mildew toxicity test with fluorine ring azoles and different proportioning thereof
| The medicament title | ?EC 50（μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Fluorine ring azoles | 4.25 | 100.0 | / | / |
| Prochloraz | 5.41 | 78.6 | / | / |
| Proportioning Prochloraz: fluorine ring azoles=50:1 | 3.23 | 131.6 | 99.580 | 132.134 |
| Proportioning Prochloraz: fluorine ring azoles=30:1 | 2.79 | 152.3 | 99.310 | 153.388 |
| Proportioning Prochloraz: fluorine ring azoles=10:1 | 2.04 | 208.3 | 98.055 | 212.466 |
| Proportioning Prochloraz: fluorine ring azoles=1:1 | 1.96 | 216.8 | 89.300 | 242.818 |
| Proportioning Prochloraz: fluorine ring azoles=1:10 | 2.51 | 169.3 | 80.545 | 210.221 |
| Proportioning Prochloraz: fluorine ring azoles=1:30 | 3.76 | 113.0 | 79.290 | 142.555 |
| Proportioning Prochloraz: fluorine ring azoles=1:50 | 4.28 | 99.3 | 79.020 | 125.663 |
Measuring result's (table 1) shows; Prochloraz and fluorine ring azoles have synergistic effect to the control of paddy rice powdery mildew between proportioning 50:1～1:50; Especially between 30:1～1:30; Synergistic effect is remarkable, and co-toxicity coefficient explains that all more than 140 the composite synergistic effect to wheat powdery mildew of Prochloraz and fluorine ring azoles is obvious.
2, indoor biological activity determination composition of the present invention is measured the co-toxicity coefficient of wheat scab
Subjects: wheat scab
Table 2 Prochloraz is composite to the interpretation of result of wheat scab toxicity test with fluorine ring azoles and different proportioning thereof
| The medicament title | ?EC 50（μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Prochloraz | 4.82 | 100.000 | / | / |
| Fluorine ring azoles | 3.96 | 121.717 | / | / |
| Proportioning Prochloraz: fluorine ring azoles=50:1 | 3.69 | 130.463 | 100.426 | 129.91 |
| Proportioning Prochloraz: fluorine ring azoles=30:1 | 2.56 | 188.129 | 100.701 | 186.82 |
| Proportioning Prochloraz: fluorine ring azoles=10:1 | 1.85 | 260.779 | 101.974 | 255.73 |
| Proportioning Prochloraz: fluorine ring azoles=1:1 | 1.98 | 243.257 | 110.859 | 219.43 |
| Proportioning Prochloraz: fluorine ring azoles=1:10 | 1.94 | 247.879 | 119.743 | 207.01 |
| Proportioning Prochloraz: fluorine ring azoles=1:30 | 2.24 | 215.046 | 121.016 | 177.70 |
| Proportioning Prochloraz: fluorine ring azoles=1:50 | 3.17 | 152.051 | 121.291 | 125.36 |
Measure result's (table 2) and show, Prochloraz and fluorine ring azoles have synergistic effect to the control of wheat scab between proportioning 50:1～1:50, and especially between 30:1～1:30, synergistic effect is particularly remarkable, and co-toxicity coefficient is all more than 170.
3, indoor biological activity determination composition of the present invention is to the co-toxicity coefficient of wheat rust
Controlling object: wheat rust (leaf rust)
Table 3 Prochloraz and fluorine ring azoles and the composite toxicity test interpretation of result of different proportioning thereof to wheat rust
| The medicament title | ?EC 50（μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Prochloraz | 5.51 | 100 | / | / |
| Fluorine ring azoles | 3.42 | 161.11 | / | / |
| Proportioning Prochloraz: fluorine ring azoles=50:1 | 4.24 | 130.069 | 101.198 | 128.529 |
| Proportioning Prochloraz: fluorine ring azoles=30:1 | 3.35 | 164.535 | 101.971 | 161.354 |
| Proportioning Prochloraz: fluorine ring azoles=10:1 | 2.31 | 239.043 | 105.555 | 226.462 |
| Proportioning Prochloraz: fluorine ring azoles=1:1 | 2.31 | 238.343 | 130.555 | 182.561 |
| Proportioning Prochloraz: fluorine ring azoles=1:10 | 2.01 | 274.481 | 155.555 | 176.453 |
| Proportioning Prochloraz: fluorine ring azoles=1:30 | 2.09 | 263.185 | 159.139 | 165.381 |
| Proportioning Prochloraz: fluorine ring azoles=1:50 | 2.58 | 213.677 | 159.912 | 133.622 |
Measure result's (table 3) and show, Prochloraz and fluorine ring azoles have synergistic effect to the control of wheat rust between proportioning 50:1～1:50, and especially between 30:1～1:30, synergistic effect is particularly remarkable, and co-toxicity coefficient is all more than 160.
4, indoor biological activity determination composition of the present invention is to the co-toxicity coefficient of wheat sharp eyespot
Controlling object: wheat sharp eyespot
Table 4 Prochloraz and fluorine ring azoles and the composite toxicity test interpretation of result of different proportioning thereof to wheat sharp eyespot
| The medicament title | EC 50（μg/ml） | ATI | TTI | Co-toxicity coefficient (CTC) |
[0090]
| Prochloraz | 5.82 | 100.000 | / | / |
| Fluorine ring azoles | 4.71 | 123.567 | / | / |
| Proportioning Prochloraz: fluorine ring azoles=50:1 | 4.61 | 126.238 | 100.462 | 125.657 |
| Proportioning Prochloraz: fluorine ring azoles=30:1 | 3.74 | 155.781 | 101.971 | 152.769 |
| Proportioning Prochloraz: fluorine ring azoles=10:1 | 2.87 | 202.817 | 102.142 | 198.563 |
| Proportioning Prochloraz: fluorine ring azoles=1:1 | 2.85 | 204.252 | 111.784 | 182.721 |
| Proportioning Prochloraz: fluorine ring azoles=1:10 | 2.69 | 216.555 | 121.425 | 178.345 |
| Proportioning Prochloraz: fluorine ring azoles=1:30 | 2.95 | 197.488 | 122.807 | 160.812 |
| Proportioning Prochloraz: fluorine ring azoles=1:50 | 3.63 | 160.296 | 123.105 | 130.211 |
Measure result's (table 4) and show, Prochloraz and fluorine ring azoles have synergistic effect to the control of wheat sharp eyespot between proportioning 50:1～1:50, and especially between 30:1～1:30, synergistic effect is particularly remarkable, and co-toxicity coefficient is all more than 150.
5, indoor biological activity determination composition of the present invention is to the co-toxicity coefficient of take-all
Controlling object: take-all
Table 5 Prochloraz and fluorine ring azoles and the composite toxicity test interpretation of result of different proportioning thereof to take-all
| The medicament title | ?EC 50（μg/ml) | ATI | TTI | Co-toxicity coefficient (CTC) |
| Prochloraz | 4.72 | 100.000 | / | / |
| Fluorine ring azoles | 3.21 | 147.040 | / | / |
| Proportioning Prochloraz: fluorine ring azoles=50:1 | 3.61 | 130.854 | 100.922 | 129.658 |
| Proportioning Prochloraz: fluorine ring azoles=30:1 | 2.80 | 168.298 | 101.517 | 165.782 |
| Proportioning Prochloraz: fluorine ring azoles=10:1 | 1.91 | 247.704 | 104.276 | 237.546 |
| Proportioning Prochloraz: fluorine ring azoles=1:1 | 2.00 | 235.705 | 123.520 | 190.823 |
| Proportioning Prochloraz: fluorine ring azoles=1:10 | 1.84 | 256.719 | 142.764 | 179.821 |
| Proportioning Prochloraz: fluorine ring azoles=1:30 | 1.93 | 244.079 | 145.523 | 167.726 |
| Proportioning Prochloraz: fluorine ring azoles=1:50 | 2.46 | 191.606 | 146.118 | 131.131 |
Measure result's (table 5) and show, Prochloraz and fluorine ring azoles have synergistic effect to the control of take-all between proportioning 50:1～1:50, and especially between 30:1～1:30, synergistic effect is particularly remarkable, and co-toxicity coefficient is all more than 160.
(2) field control effectiveness test (adopting the method for parallel test to verify the field trial control efficiency of composition of the present invention) to wheat rust, head blight, powdery mildew, banded sclerotial blight, full rot
Test method: at the initial stage of a disease, carry out the spraying first time immediately, carry out the dispenser second time after 7 days, each handles 4 sub-districts, each sub-district 20 square meter.Before medicine with medicine for the second time after 10 days investigation statistics incidences; 5 random sampling in each sub-district; Every some investigation 5 strain wheats, disease index and control efficiency are calculated in the lesion area of every blade or leaf sheath accounts for blade area on the whole strain wheat of investigation percentage and classification.
Expection preventive effect (%)=X+Y-XY/100 (wherein, X, Y are single agent preventive effect)
Grade scale:
0 grade: no scab;
1 grade: leaf spot lesion is less than 5, and length is less than 1cm;
3 grades: leaf spot lesion 6-10, part scab length is greater than 1cm;
5 grades: leaf spot lesion 11-25, the part scab is linked to be sheet, and lesion area accounts for the 10-25% of leaf area;
7 grades: leaf spot lesion is more than 26, and scab is linked to be sheet, and lesion area accounts for the 26-50% of leaf area;
9 grades: scab is linked to be sheet, lesion area account for leaf area more than 50% or full leaf withered.
(1) composition of the present invention is to the field control effectiveness test analysis of wheat powdery mildew
The composite field efficiency test result of table 6 Prochloraz and fluorine ring azoles to wheat powdery mildew
Measure result's (table 6) and show, Prochloraz or prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt and fluorine ring azoles are composite to the preventive effect of preventing and treating wheat powdery mildew is obviously improved, and explain that the two compositely has significant synergistic effect to powdery mildew.
(2) composition of the present invention is to the field control effectiveness test analysis of wheat scab
The composite field efficiency test result of table 7 Prochloraz and fluorine ring azoles to wheat scab
Measure result's (table 7) and show that Prochloraz or prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt and fluorine ring azoles are composite to the preventive effect of preventing and treating wheat scab is obviously improved, explain that the two compositely has significant synergistic effect to wheat scab.
(3) composition of the present invention is to the field control effectiveness test analysis of wheat rust
The composite field efficiency test result of table 8 Prochloraz and fluorine ring azoles to wheat rust
Measure result's (table 8) and show that Prochloraz or prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt and fluorine ring azoles are composite to the preventive effect of preventing and treating wheat rust is obviously improved, explain that the two compositely has significant synergistic effect to wheat rust.
(4) composition of the present invention is to the field control effectiveness test analysis of wheat sharp eyespot
The composite field efficiency test result of table 9 Prochloraz and fluorine ring azoles to wheat sharp eyespot
Measure result's (table 9) and show, Prochloraz or prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt and fluorine ring azoles are composite to the preventive effect of preventing and treating wheat sharp eyespot is obviously improved, and explain that the two compositely has significant synergistic effect to wheat sharp eyespot.
(4) composition of the present invention is to the field control effectiveness test analysis of take-all
The composite field efficiency test result of table 10 Prochloraz and fluorine ring azoles to take-all
Measure result's (table 10) and show that Prochloraz or prochloraz-manganese chloride complex, prochloraz nantokite, prochloraz zinc salt and fluorine ring azoles are composite to the preventive effect of preventing and treating take-all is obviously improved, explain that the two compositely has significant synergistic effect to take-all.
Claims (10)
1. the microbicide compositions of a synergistic effect is prevented and treated the purposes of wheat fungal disease; Described composition comprises active component a and b; Wherein active component a is Prochloraz or its acceptable metal salt compound on agricultural; Active component b is a fluorine ring azoles, and the weight ratio between two components is 1:50～50:1.
2. purposes according to claim 1 is characterized in that described Prochloraz metal salt compound is selected from prochloraz-manganese chloride complex, prochloraz zinc salt or prochloraz nantokite a kind of compound wherein.
3. purposes according to claim 1 is characterized in that the weight ratio of active component a and active component b is 1:30～30:1 in the described composition.
4. purposes according to claim 3 is characterized in that described Prochloraz metal salt compound is a prochloraz nantokite.
5. purposes according to claim 3 is characterized in that described Prochloraz metal salt compound is a prochloraz-manganese chloride complex.
6. purposes according to claim 3 is characterized in that described Prochloraz metal salt compound is a prochloraz zinc salt.
7. purposes according to claim 3 is characterized in that the weight ratio of active component prochloraz nantokite and active component fluorine ring azoles is 1:30～30:1.
8. purposes according to claim 3 is characterized in that the weight ratio of active component prochloraz-manganese chloride complex salt and active component fluorine ring azoles is 1:30～30:1.
9. purposes according to claim 3 is characterized in that the weight ratio of active component prochloraz zinc salt salt and active component fluorine ring azoles is 1:30～30:1.
10. according to the purposes of claim 1-9, it is characterized in that the wheat fungal disease is wheat rust, powdery mildew, head blight, banded sclerotial blight, full rot.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103221238A CN102805096A (en) | 2012-09-03 | 2012-09-03 | Fungicide composition for effectively preventing wheat fungi |
| PCT/CN2012/084388 WO2014032364A1 (en) | 2012-09-03 | 2012-11-09 | Fungicide composition for effectively preventing wheat fungal diseases |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103221238A CN102805096A (en) | 2012-09-03 | 2012-09-03 | Fungicide composition for effectively preventing wheat fungi |
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| CN102805096A true CN102805096A (en) | 2012-12-05 |
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| CN2012103221238A Pending CN102805096A (en) | 2012-09-03 | 2012-09-03 | Fungicide composition for effectively preventing wheat fungi |
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| CN (1) | CN102805096A (en) |
| WO (1) | WO2014032364A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105875627A (en) * | 2014-10-17 | 2016-08-24 | 中国农科院植保所廊坊农药中试厂 | Preparation method of prochloraz-epoxiconazole micro-emulsion |
| CN115624032A (en) * | 2022-07-12 | 2023-01-20 | 江苏剑牌农化股份有限公司 | Preparation method of prochloraz-epoxiconazole water emulsion |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019544A (en) * | 2007-03-15 | 2007-08-22 | 江苏辉丰农化股份有限公司 | Bactericide composition for effectively preventing and treating false smut of rice |
| CN102150678A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing prochloraz |
| CN102273442A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Ultralow volume liquid containing epoxiconazole |
-
2012
- 2012-09-03 CN CN2012103221238A patent/CN102805096A/en active Pending
- 2012-11-09 WO PCT/CN2012/084388 patent/WO2014032364A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101019544A (en) * | 2007-03-15 | 2007-08-22 | 江苏辉丰农化股份有限公司 | Bactericide composition for effectively preventing and treating false smut of rice |
| CN102150678A (en) * | 2010-12-16 | 2011-08-17 | 陕西韦尔奇作物保护有限公司 | Sterilization composition containing prochloraz |
| CN102273442A (en) * | 2011-09-13 | 2011-12-14 | 广西田园生化股份有限公司 | Ultralow volume liquid containing epoxiconazole |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105875627A (en) * | 2014-10-17 | 2016-08-24 | 中国农科院植保所廊坊农药中试厂 | Preparation method of prochloraz-epoxiconazole micro-emulsion |
| CN115624032A (en) * | 2022-07-12 | 2023-01-20 | 江苏剑牌农化股份有限公司 | Preparation method of prochloraz-epoxiconazole water emulsion |
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| Publication number | Publication date |
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| WO2014032364A1 (en) | 2014-03-06 |
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Application publication date: 20121205 |