CN102784415A - Medical degradable magnesium alloy interbody fusion cage - Google Patents
Medical degradable magnesium alloy interbody fusion cage Download PDFInfo
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- CN102784415A CN102784415A CN2012103112885A CN201210311288A CN102784415A CN 102784415 A CN102784415 A CN 102784415A CN 2012103112885 A CN2012103112885 A CN 2012103112885A CN 201210311288 A CN201210311288 A CN 201210311288A CN 102784415 A CN102784415 A CN 102784415A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
The invention discloses a medical degradable magnesium alloy interbody fusion cage, relates to an interbody fusion cage and aims at solving problems that inflammation is caused due to acidic materials which are produced by existing interbody fusion cages during degradation and stress shielding can occur due to inappropriate selection of elasticity modulus. The medical degradable magnesium alloy interbody fusion cage is made of Mg-Sn-Mn series alloy or Mg-Sn-Mn-Zn series alloy; the medical degradable magnesium alloy interbody fusion cage comprises an upper end plate contact surface (1) and a lower end plate contact surface (2), a through hole (3) is opened at the center of the fusion cage, the upper end plate contact surface (1), the lower end plate contact surface (2) and the through hole (3) are polygons which are of the same shape, two protuberant studs (4) are respectively arranged on the upper end plate contact surface (1) and the lower end plate contact surface (2), and the upper end plate contact surface (1) can be an inclined surface to form an angle theta with the lower end plate contact surface (2). The medical degradable magnesium alloy interbody fusion cage can be applied to the field of degradable and absorptive medical instrument manufacturing.
Description
Technical field
The present invention relates to Invasive lumbar fusion device.
Background technology
In recent years; Fusion device has been widely used in the operative treatment of cervical vertebra degenerative disease and wound etc. between cervical vertebra, and its effect mainly is to keep disc height, promotes the bone property fusion of intervertebral; And reduce consumption to a certain extent from the body bone, avoid some complication that cause thus.The material of fusion device is mainly nondegradable metal (NiTi alloy, Ti between cervical vertebra at present
6Al
4V etc.) material and poly carbon fibre material are two kinds.The former has the better tissues compatibility; But the postoperative metal retains in vivo all the life; Increase the puzzlement of permanent retention and the probability of second operation, because elastic modulus difference can produce stress shielding to a certain degree, fused bone intensity and quality have been had certain influence simultaneously; Can produce sedimentation to a certain degree simultaneously, thereby be prone to form the disadvantage that the intervertebral bearing height is lost; The latter is nonmetal macromolecular material, owing to can also do not influenced the intensity after bone merges to a certain extent by the human body degraded and absorbed, the molecule that produces after its wearing and tearing simultaneously causes the local inflammation reaction in can organizing around, is unfavorable for health.
The medical degradable material is meant, material by the implantable bioartificial body after, under the effect of body tissue liquid, various enzyme and cell, according to certain biology or chemical rule degrade, hydrolysis, finally resolve into the micromolecule harmless to body.These micromolecule are perhaps discharged by the organism degraded, are perhaps absorbed by body to be evolved into autologous tissue.The medical degradable material is the ideal material of development body implant, also can be the main flow material of field of medical appliances in future.
Seek a kind of elastic modelling quantity near skeleton, the Res fungibiles that implant into body infectious-related complication incidence rate is low has become the research focus, and at present, polymeric material has caused scholars' extensive concern.The Yang De of Chengdu Dikang Zhongke Biomedical Materials Co., Ltd is beautiful to wait the people to utilize polylactic acid-based macromolecule absorbable material as fusion device material between cervical vertebra; Polylactic acid-based (PLA) macromolecular material has better biocompatibility and degradability; Obtained clinical effectiveness preferably at bone fracture internal fixation material, but the clinical effectiveness of its conduct, to the influence of intervertebral bone-graft fusion and in the alternate situation of intervertebral degraded and absorbed bone, still uncertain at present; Macromolecule polymer material in addition; Its mechanical strength is limited, and in the degradation process, mechanical strength is lower than the requirement of Invasive lumbar fusion device support strength after implantation; And polylactic acid-based degraded back generation acidic materials, can cause the generation of non-bacteria inflammation; The Wu Guang of No.1 Military Medical Univ. Lignum Rhamnellae people's Chinese patent 03236843.7 (open date 2004/04/21) has proposed a kind of Invasive lumbar fusion device; What adopt is PLLA in the macromolecular material (PLLA) and hydroxyapatite (HAP) composite high-molecular material; Its good biocompatibility; Have osteogenic induction and conduction, but the HAP sour environment that degraded produces with PLLA in can only be to a certain extent, the danger that still exists inflammation to take place.
Summary of the invention
The present invention will solve existing Invasive lumbar fusion device and in degradation process, produce acidic materials, can cause the generation of inflammation and elastic modelling quantity selection improper, the problem of stress shielding can occur, and propose the medical degradable magnesium alloy Invasive lumbar fusion device.
Medical degradable magnesium alloy Invasive lumbar fusion device among the present invention; It is the polygon prism that has through hole (3) along its axis direction; All there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that each bossed embedding post (4) of surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, and it is that alloy is processed by Mg-Sn-Mn; Wherein the mass percentage content of Sn is 1% ~ 3%; The mass percentage content of Mn is 0.15% ~ 1%, and the mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg;
The medical degradable magnesium alloy Invasive lumbar fusion device; It is the polygon prism that has through hole (3) along its axis direction, and all there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that respectively there is the embedding post (4) of two projections on the surface of soleplate contact surface (1) and following soleplate contact surface (2) on it; It is that alloy is processed by Mg-Sn-Mn-Zn; Wherein the mass percentage content of Sn is 1% ~ 5%, and the mass percentage content of Mn is 0.15% ~ 1.5%, and the mass percentage content of Zn is 0.5% ~ 3%; The mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg.
Material of the present invention is selected according to being: magnesium is one of metallic element that reserves enrich the most on the earth; It also is one of the abundantest cation of people's in-vivo content; It is the indispensable important nutrient of human body; Magnesium alloy has good medical science foundation for security as a kind of novel bio-medical material; Have following medical advantage simultaneously: 1) elastic modelling quantity and the yield strength of the elastic modelling quantity of Mg and yield strength and people's bone are more approaching, and density is also also very close with people's bone, can avoid stress-shielding effect effectively; 2) magnesium alloy is the basic element in human body metabolism and the osseous tissue, has better biocompatibility; 3) magnesium has low-down equilibrium electrod potential, particularly in containing the solution of Cl, is prone to be corroded and degrades, if as embedded material, can avoid second operation.Magnesium alloy is in degradation process in addition, and the reduction gradually of its mechanical performance can form good cooperating with new osteogenesis.
Zinc can be participated in the formation of the zymophore of multiple human important enzymes such as alkali phosphatase, carbonic anhydrase, in metalloenzyme, has the function of catalysis, structure and adjusting; Zinc can enhances human body immunologic function, keep the g and D of body; Zinc can be kept the barrier function of endothelial cellular membrane.The solid solubility of zinc in magnesium alloy is 6.2%, magnesium alloy had the effect of solution strengthening.It is the another kind of very effective alloy element except that aluminum.In addition, zinc content can make when following the local corrosion tendency of magnesium alloy diminish 2%, thereby effectively improves the decay resistance of magnesium alloy.
The toxicity of stannum is minimum, and the animal per os is taken in heavy dose of metallic tin, does not find specific toxicity.The adult of a 70kg body weight needs the stannum of 7.0mg every day approximately; From the mechanical property angle of magnesium alloy, stannum is typical precipitation strength element, can improve the temperature-room type plasticity and the intensity of magnesium alloy.The compacting factor of metallic tin is 1.31, helps alloy surface to form passivating film, improves the corrosion resistance of magnesium alloy.
Manganese is the element favourable to cardiovascular, and is especially very important to safeguarding the cell mitochondrial function.And can promote bone growth and development, and keep normal brain function, can also keep normal sugar, lipid metabolism, improve the hemopoietic function of body.Manganese can also strengthen endocrine function, keeps thyroid normal function, promotes the synthetic of gonadal hormone, regulates the nerves reaction ability; Though manganese is little to the influence of the mechanical property of magnesium alloy, even may reduce the plasticity of magnesium alloy a little, and manganese itself do not have benefit to the corrosion resistance of raising magnesium, and excessive manganese is to the corrosion of magnesium alloy even also harmful.But manganese can suppress the adverse effect of some impurity elements such as Fe, Cu and Ni widely, thereby effectively improves the decay resistance of magnesium alloy.
The present invention includes following beneficial effect:
1, medical degradable magnesium alloy Invasive lumbar fusion device degraded afterproduct provided by the invention is the alkalescence material, has avoided the generation of embedded material nonspecific inflammation in human body to a great extent;
2, the magnesium alloy selected for use of medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention possesses good stable property, because elastic modelling quantity and bone photo are near, can avoid stress shielding, helps recovering the physiology curvature;
3, medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention has good fusion rate of bone graft; Bone-graft fusion is not had tangible negative effect, can progressively degrade, absorb, substituted by osseous tissue; Balance bone resorption and new bone formation; Realized the intervertebral bony union, and its biomechanical strength enough keeps bone and merge omnidistancely, can improve spinal function preferably.
4, medical degradable magnesium alloy Invasive lumbar fusion device form provided by the invention is hollow solid, and cavity shape is consistent with whole fusion device outermost layer shape, and fusion device is horizontal by existing certain angle of inclination; Be convenient to adapt to the physiology curvature of implant site; The soleplate contact surface all has tooth engaged up and down simultaneously, is convenient to and the adjacent vertebral bodies interlock, can increase the contact area with adjacent vertebral bodies; Reduce interface pressure; Strut intervertebral space, recover disc height, help keeping the normal physiological radian of cervical vertebra.One side of fusion device respectively has the embedding post of two projections up and down, is equipped with the adjacent vertebral body of implant site and beats the hole of identical size, embeds; Can prevent effectively that Invasive lumbar fusion device is absorbed in vertebral body; Fusion device reduces the range of activity of fixed-segment through the shearing resistance effect of the tooth engaged of embedding vertebral body and the anti-turning effort of profile between cervical vertebra, reduces the fine motion between fusion device and the upper and lower interface; Make the fusion sections reach instant stable, increase the stability of fusion device in intervertebral space.
5, medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention can carry out surperficial high molecular polymer modification; Be used for magnesium alloy degradation speed in matrix is regulated and control; Described high molecular polymer comprises chitosan and derivant; Polylactic acid-glycolic guanidine-acetic acid copolymer, polylactic acid, one or more blends in the Biodegradable high-moleculars such as polyglycolic acid ester; Adopt excusing from death ripple atomizing spraying technology to form uniform controlled degradation polymer coating, can recover needs design controllable degradation polymer coating layer thickness according to the patient on the fusion device surface.
Description of drawings
Fig. 1 is a degradable magnesium alloy Invasive lumbar fusion device side cut away view;
Fig. 2 is a degradable magnesium alloy Invasive lumbar fusion device vertical view.
The specific embodiment
Technical scheme of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the medical degradable magnesium alloy Invasive lumbar fusion device in this embodiment; It is the polygon prism that has through hole (3) along its axis direction; All there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that each bossed embedding post (4) of surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, and it is that alloy is processed by Mg-Sn-Mn; Wherein the mass percentage content of Sn is 1% ~ 3%; The mass percentage content of Mn is 0.15% ~ 1%, and the mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg.
Material of the present invention is selected according to being: magnesium is one of metallic element that reserves enrich the most on the earth; It also is one of the abundantest cation of people's in-vivo content; It is the indispensable important nutrient of human body; Magnesium alloy has good medical science foundation for security as a kind of novel bio-medical material; Have following medical advantage simultaneously: 1) elastic modelling quantity and the yield strength of the elastic modelling quantity of Mg and yield strength and people's bone are more approaching, and density is also also very close with people's bone, can avoid stress-shielding effect effectively; 2) magnesium alloy is the basic element in human body metabolism and the osseous tissue, has better biocompatibility; 3) magnesium has low-down equilibrium electrod potential, particularly in containing the solution of Cl, is prone to be corroded and degrades, if as embedded material, can avoid second operation.Magnesium alloy is in degradation process in addition, and the reduction gradually of its mechanical performance can form good cooperating with new osteogenesis.
Zinc can be participated in the formation of the zymophore of multiple human important enzymes such as alkali phosphatase, carbonic anhydrase, in metalloenzyme, has the function of catalysis, structure and adjusting; Zinc can enhances human body immunologic function, keep the g and D of body; Zinc can be kept the barrier function of endothelial cellular membrane.The solid solubility of zinc in magnesium alloy is 6.2%, magnesium alloy had the effect of solution strengthening.It is the another kind of very effective alloy element except that aluminum.In addition, zinc content can make when following the local corrosion tendency of magnesium alloy diminish 2%, thereby effectively improves the decay resistance of magnesium alloy.
The toxicity of stannum is minimum, and the animal per os is taken in heavy dose of metallic tin, does not find specific toxicity.The adult of a 70kg body weight needs the stannum of 7.0mg every day approximately; From the mechanical property angle of magnesium alloy, stannum is typical precipitation strength element, can improve the temperature-room type plasticity and the intensity of magnesium alloy.The compacting factor of metallic tin is 1.31, helps alloy surface to form passivating film, improves the corrosion resistance of magnesium alloy.
Manganese is the element favourable to cardiovascular, and is especially very important to safeguarding the cell mitochondrial function.And can promote bone growth and development, and keep normal brain function, can also keep normal sugar, lipid metabolism, improve the hemopoietic function of body.Manganese can also strengthen endocrine function, keeps thyroid normal function, promotes the synthetic of gonadal hormone, regulates the nerves reaction ability; Though manganese is little to the influence of the mechanical property of magnesium alloy, even may reduce the plasticity of magnesium alloy a little, and manganese itself do not have benefit to the corrosion resistance of raising magnesium, and excessive manganese is to the corrosion of magnesium alloy even also harmful.But manganese can suppress the adverse effect of some impurity elements such as Fe, Cu and Ni widely, thereby effectively improves the decay resistance of magnesium alloy.
The present invention includes following beneficial effect:
1, medical degradable magnesium alloy Invasive lumbar fusion device degraded afterproduct provided by the invention is the alkalescence material, has avoided the generation of embedded material nonspecific inflammation in human body to a great extent;
2, the magnesium alloy selected for use of medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention possesses good stable property, because elastic modelling quantity and bone photo are near, can avoid stress shielding, helps recovering the physiology curvature;
3, medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention has good fusion rate of bone graft; Bone-graft fusion is not had tangible negative effect, can progressively degrade, absorb, substituted by osseous tissue; Balance bone resorption and new bone formation; Realized the intervertebral bony union, and its biomechanical strength enough keeps bone and merge omnidistancely, can improve spinal function preferably.
4, medical degradable magnesium alloy Invasive lumbar fusion device form provided by the invention is hollow solid, and cavity shape is consistent with whole fusion device outermost layer shape, and fusion device is horizontal by existing certain angle of inclination; Be convenient to adapt to the physiology curvature of implant site; The soleplate contact surface all has tooth engaged up and down simultaneously, is convenient to and the adjacent vertebral bodies interlock, can increase the contact area with adjacent vertebral bodies; Reduce interface pressure; Strut intervertebral space, recover disc height, help keeping the normal physiological radian of cervical vertebra.One side of fusion device respectively has the embedding post of two projections up and down, is equipped with the adjacent vertebral body of implant site and beats the hole of identical size, embeds; Can prevent effectively that Invasive lumbar fusion device is absorbed in vertebral body; Fusion device reduces the range of activity of fixed-segment through the shearing resistance effect of the tooth engaged of embedding vertebral body and the anti-turning effort of profile between cervical vertebra, reduces the fine motion between fusion device and the upper and lower interface; Make the fusion sections reach instant stable, increase the stability of fusion device in intervertebral space.
5, medical degradable magnesium alloy Invasive lumbar fusion device provided by the invention can carry out surperficial high molecular polymer modification; Be used for magnesium alloy degradation speed in matrix is regulated and control; Described high molecular polymer comprises chitosan and derivant; Polylactic acid-glycolic guanidine-acetic acid copolymer, polylactic acid, one or more blends in the Biodegradable high-moleculars such as polyglycolic acid ester; Adopt excusing from death ripple atomizing spraying technology to form uniform controlled degradation polymer coating, can recover needs design controllable degradation polymer coating layer thickness according to the patient on the fusion device surface.
The specific embodiment two: what this embodiment and the specific embodiment one were different is: the mass percentage content of described Sn is 2%; The mass percentage content of Mn is 0.5%; The mass percentage content of impurity element Fe, Cu and Ni is 0.005%, and the mass percentage content of Mg is 97.495%.Other structure is identical with the specific embodiment one with annexation.
The specific embodiment three: the medical degradable magnesium alloy Invasive lumbar fusion device in this embodiment; It is the polygon prism that has through hole (3) along its axis direction, and all there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that each bossed embedding post (4) of surface of soleplate contact surface (1) and following soleplate contact surface (2) on it; It is that alloy is processed by Mg-Sn-Mn-Zn; Wherein the mass percentage content of Sn is 1% ~ 5%, and the mass percentage content of Mn is 0.15% ~ 1.5%, and the mass percentage content of Zn is 0.5% ~ 3%; The mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg.
The specific embodiment four: what this embodiment and the specific embodiment three were different is: the mass percentage content of described Sn is 4%; The mass percentage content of Mn is 0.25%; The mass percentage content of Zn is 1.5%; The mass percentage content of impurity element Fe, Cu and Ni is 0.005%, and the mass percentage content of Mg is 94.275%.Other structure is identical with the specific embodiment three with annexation.
The specific embodiment five: what this embodiment was different with one of specific embodiment one to four is: the cross section of the tooth engaged on the described medical degradable magnesium alloy Invasive lumbar fusion device on soleplate contact surface 1 and the following soleplate contact surface 2 is that the length of side is the isosceles triangle of 0.5mm.Other structure is identical with one of specific embodiment one to four with annexation.
The specific embodiment six: what this embodiment was different with one of specific embodiment one to five is: soleplate contact surface 1, following soleplate contact surface 2 and center through hole 3 are tetragon, pentagon, hexagon, heptagon or octagon on the described medical degradable magnesium alloy Invasive lumbar fusion device.Other structure is identical with one of specific embodiment one to five with annexation.
The specific embodiment seven: what this embodiment was different with one of specific embodiment one to six is: slick transition shape circular arc all is processed at described tetragon, pentagon, hexagon, heptagon or octagonal each angle.Other structure is identical with one of specific embodiment one to six with annexation.
The specific embodiment eight: what this embodiment was different with one of specific embodiment one to seven is: the last soleplate contact surface 1 of described medical degradable magnesium alloy Invasive lumbar fusion device is the inclined-plane; With the angle of following soleplate contact surface 2 be θ, the scope at θ angle is 0 ° ~ 15 °.Other structure is identical with one of specific embodiment one to seven with annexation.
The specific embodiment nine: what this embodiment was different with one of specific embodiment one to eight is: the embedding post 4 of the projection on the described medical degradable magnesium alloy Invasive lumbar fusion device on soleplate contact surface 1 and the following soleplate contact surface 2 is respectively done for oneself two, and material is identical with the material of said degradable magnesium alloy Invasive lumbar fusion device.Other structure is identical with one of specific embodiment one to eight with annexation.
The specific embodiment ten: what this embodiment was different with one of specific embodiment one to nine is: the surface of described medical degradable magnesium alloy Invasive lumbar fusion device is carried out high molecular polymer and is modified; Wherein high molecular polymer is chitosan, chitosan derivatives, polylactic acid-glycolic guanidine-acetic acid copolymer, polylactic acid or polyglycolic acid ester, and the thickness of described high molecular polymer is 0 ~ 100 μ m.Other structure is identical with one of specific embodiment one to nine with annexation.
Claims (10)
1. medical degradable magnesium alloy Invasive lumbar fusion device; It is the polygon prism that has through hole (3) along its axis direction; All there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that each bossed embedding post (4) of surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, and it is that alloy is processed by Mg-Sn-Mn; Wherein the mass percentage content of Sn is 1% ~ 3%; The mass percentage content of Mn is 0.15% ~ 1%, and the mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg.
2. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 1; The mass percentage content that it is characterized in that Sn is 2%; The mass percentage content of Mn is 0.5%, and the mass percentage content of impurity element Fe, Cu and Ni is 0.005%, and the mass percentage content of Mg is 97.495%.
3. medical degradable magnesium alloy Invasive lumbar fusion device; It is the polygon prism that has through hole (3) along its axis direction, and all there is tooth engaged (5) on surface of soleplate contact surface (1) and following soleplate contact surface (2) on it, it is characterized in that respectively there is the embedding post (4) of two projections on the surface of soleplate contact surface (1) and following soleplate contact surface (2) on it; It is that alloy is processed by Mg-Sn-Mn-Zn; Wherein the mass percentage content of Sn is 1% ~ 5%, and the mass percentage content of Mn is 0.15% ~ 1.5%, and the mass percentage content of Zn is 0.5% ~ 3%; The mass percentage content of impurity element Fe, Cu and Ni is 0 ~ 0.006%, and surplus is Mg.
4. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 3; The mass percentage content that it is characterized in that Sn is 4%; The mass percentage content of Mn is 0.25%; The mass percentage content of Zn is 1.5%, and the mass percentage content of impurity element Fe, Cu and Ni is 0.005%, and the mass percentage content of Mg is 94.275%.
5. like each described medical degradable magnesium alloy Invasive lumbar fusion device in the claim 1 to 4; The cross section that it is characterized in that the tooth engaged on soleplate contact surface on the described medical degradable magnesium alloy Invasive lumbar fusion device 1 and the following soleplate contact surface 2 is an equilateral triangle, and the tooth engaged height is 0.5mm.
6. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 5 is characterized in that soleplate contact surface 1 on the described medical degradable magnesium alloy Invasive lumbar fusion device, following soleplate contact surface 2 and center through hole 3 are tetragon, pentagon, hexagon, heptagon or octagon.
7. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 6 is characterized in that soleplate contact surface 1 all is processed into slick transition shape circular arc with tetragon, pentagon, hexagon, heptagon or octagonal each angle that following soleplate contact surface 2 constitutes on the described medical degradable magnesium alloy Invasive lumbar fusion device.
8. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 7 is characterized in that the last soleplate contact surface 1 of described medical degradable magnesium alloy Invasive lumbar fusion device is the inclined-plane, with the angle of following soleplate contact surface 2 be θ, the scope at θ angle is 0 ° ~ 15 °.
9. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 8; The embedding post 4 that it is characterized in that the projection on soleplate contact surface on the described medical degradable magnesium alloy Invasive lumbar fusion device 1 and the following soleplate contact surface 2 is respectively done for oneself two, and material is identical with the material of said degradable magnesium alloy Invasive lumbar fusion device.
10. medical degradable magnesium alloy Invasive lumbar fusion device as claimed in claim 9; The high molecular polymer modification is carried out on the surface that it is characterized in that described medical degradable magnesium alloy Invasive lumbar fusion device; Wherein high molecular polymer is chitosan, chitosan derivatives, polylactic acid-glycolic guanidine-acetic acid copolymer, Polyethylene Glycol, polylactic acid or polyglycolic acid ester, and the thickness of described high molecular polymer is 0 ~ 100 μ m.
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| CN108056847A (en) * | 2017-12-15 | 2018-05-22 | 深圳清华大学研究院 | For the preceding road lumbar intervertebral fusion device of intervertebral fusion |
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