CN102774801A - Automatic radioactive medicament split charging injector and automatic radioactive medicament split charging method - Google Patents
Automatic radioactive medicament split charging injector and automatic radioactive medicament split charging method Download PDFInfo
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- CN102774801A CN102774801A CN2012102478413A CN201210247841A CN102774801A CN 102774801 A CN102774801 A CN 102774801A CN 2012102478413 A CN2012102478413 A CN 2012102478413A CN 201210247841 A CN201210247841 A CN 201210247841A CN 102774801 A CN102774801 A CN 102774801A
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Abstract
The invention relates to an automatic radioactive medicament split charging injector and an automatic radioactive medicament split charging method, belonging to the technical field of containers dedicated to medicine purpose. The automatic radioactive medicament split charging injector comprises a medicament split charging injection unit and a controller provided with an external data input port. The method is as follows: the external data input port of the controller is utilized for inputting an instruction to the controller, and a radioactive medicament basic solution tank needing to be subjected to split charging is selected; the active value of the medicament in the radioactive medicament basic solution tank can be measured by a radioactive activity instrument, the controller calculates the volume of the needed radioactive medicament according to the active value measured in real time and the instruction, and the automatic split charging of the radioactive medicament can be completed by controlling the opening and closing of a switch valve between the injector and the radioactive medicament basic solution as well as between the switch valve and a solvent tank. According to the automatic radioactive medicament split charging injector and the automatic radioactive medicament split charging method, the automatic split charging and injection can be conducted on the radioactive medicament, and the condition that an injection person is not hurt by radiation can be ensured.
Description
Technical field
The present invention relates to a kind of radiopharmaceutic device and method for filling of being used for, belong to the container technical field that is exclusively used in medical purpose.
Background technology
Under the precondition, the radiopharmaceutic injection of Nuclear Medicine Dept needs the hand-held syringe that hot medicine is housed very much of inoculator to each patient infusion.The patient that the hospital that has need inject every day reaches tens people even up to a hundred people, and the medical exposure intensity that the inoculator suffers is very high, and this has brought great potential health threat to the inoculator.
Further, personnel need omnidistance protection in packing and injection process, but radiopharmaceutic radiation is hard to guard against, and packing and injection process are easy to cause the pollution of protective equipment.Increased the radiation protection cost so virtually.
Further again, Nuclear Medicine Dept's inspection is very strict to patient's drug injection amount and requirement inject time, and there is considerable influence in the inaccurate meeting of ID or inject time to the image quality of inspection.
Understand according to the applicant, when Nuclear Medicine Dept related to the medicine packing, patient's ID often was as the criterion with packing personnel's report dosage, and packing personnel's report dosage can not accurately be confirmed the dosage of syringe, and the dosage of injectable drug is not accurate enough like this.Simultaneously, in practical operation, the packing personnel with the medicine packing after the in time not intact injection process of injection personnel, this has just increased radiopharmaceutic decay greatly, and the dosage of injectable drug is had a greatly reduced quality.Further, the packing personnel measure the medicament after radiopharmaceutical stoste and the solvent for general in order to reduce radiation hazards.
Summary of the invention
The technical matters that the present invention will solve is not enough to prior art, and a kind of radiopharmaceutical automatic subpackaging injection appearance and automatic subpackaging method are provided.
The present invention solves the problems of the technologies described above one of technical scheme of proposition to be: a kind of radiopharmaceutical automatic subpackaging injection appearance; Comprise medicine packing injecting unit and the controller that is provided with the external data input port; Said medicine packing injecting unit comprises solvent tank, place the radiopharmaceutical original fluid container in the cage and have the injecting propeller of syringe; Be provided with switch valve in the said cage and be arranged at the activity appearance on the radiopharmaceutical original fluid container; The import of said syringe is connected with solvent tank, radiopharmaceutical original fluid container respectively through switch valve; The outlet of said syringe connects outside injection port through switch valve, and the control output end of said controller is connected with switch valve, injecting propeller and the control input end of activity appearance respectively, said activity
Further, in one of technique scheme,
Said activity appearance is used for measuring in real time the activity value of the medicine in the said radiopharmaceutical original fluid container, and the activity value that will measure in real time sends to controller;
Said controller is used to receive the instruction of outside input; Receive the real-time measured real-time activity of activity appearance value again; Patient body weight value according to comprising in real-time activity value and the instruction calculates the radiopharmaceutic volume that needs, and calculates first distance measurements that the injecting propeller needs move according to calculating radiopharmaceutic stereometer again; The master cock valve is opened, and the control syringe extracts radiopharmaceutical and solvent respectively according to first distance measurements and second distance amount;
Said switch valve is used to receive the on-off signal that controller sends, respectively conducting syringe and radiopharmaceutical original fluid container and solvent tank;
Said syringe is used under the drive of injecting propeller, forming vacuum drawn radiopharmaceutical stoste and solvent and mixing;
Said injecting propeller is used to receive first distance measurements and the second distance amount that controller sends, and drives syringe and moves.
The present invention solves the problems of the technologies described above two of the technical scheme of proposition to be: a kind of radiopharmaceutical automatic subpackaging method, adopt radiopharmaceutical automatic subpackaging injection appearance according to claim 1, and may further comprise the steps:
1) the external data input port that passes through controller is to the controller input instruction, and selection needs the radiopharmaceutical original fluid container of packing;
2) the activity appearance is measured the activity value of the medicine in the said radiopharmaceutical original fluid container in real time, and the activity value that will measure in real time sends to controller;
3) controller is according to the patient body weight value that comprises in real-time activity value of measuring of activity appearance and the said instruction; Calculate the radiopharmaceutic volume that needs, calculate first distance measurements that the injecting propeller needs move according to calculating radiopharmaceutic stereometer simultaneously;
4) open switch valve between syringe and the said radiopharmaceutical original fluid container; Controller control injecting propeller moves according to first distance measurements, and syringe forms in the vacuum drawn radiopharmaceutical original fluid container and the identical radiopharmaceutical of radiopharmaceutical volume that calculates needs;
5) close switch valve between syringe and the radiopharmaceutical original fluid container;
6) open switch valve between syringe and the solvent tank, controller control injecting propeller moves according to the second distance amount of setting, and syringe extracts behind the solvent in the solvent tank that syringe is interior to be mixed with the radiopharmaceutical in syringe;
7) close switch valve between syringe and the solvent tank, accomplish radiopharmaceutic packing.
One of variation of one of technique scheme is: said switch valve comprises three electromagnetic valves; Be respectively first, second and the 3rd electromagnetic valve; Said solvent tank is connected with the input port of first electromagnetic valve; Said radiopharmaceutical original fluid container is connected with the input port of second electromagnetic valve; The import of said syringe is connected with the output port of first electromagnetic valve and the output port of second electromagnetic valve respectively, and the outlet of said syringe is communicated with the input port of the 3rd electromagnetic valve, and the output port of the 3rd electromagnetic valve connects said outside injection port.
Two of the variation of one of technique scheme is: said switch valve comprises two electromagnetic valves and a check valve; Said solvent tank is connected with the input port of first electromagnetic valve; Said radiopharmaceutical original fluid container is connected with the input port of second electromagnetic valve; The import of said syringe is connected with the output port of first electromagnetic valve and the output port of second electromagnetic valve respectively, and the outlet of said syringe connects the import of check valve, and the outlet of said check valve connects said outside injection port.
Three of the variation of one of technique scheme is: said switch valve is to select valve, said selection valve contain one first opening and a plurality of can be respectively and second opening of the first opening conducting; The import and export of said syringe is connected with first opening, and one of said second opening is connected with solvent tank, and two of said second opening is connected with the radiopharmaceutical original fluid container, and three of said second opening connects said outside injection port.
The improvement of one of technique scheme is: said injecting propeller is a target control syringe pump, and said outside injection port is an injection needle.
The improvement of one of technique scheme is: said syringe is fixed on the box; Said injecting propeller comprises miniature motor and is fixed in syringe and pushes away the push pedal on the handle; Be fixed with tooth bar in the said push pedal; The mouth of said miniature motor is fixed with gear, and said wheel and rack is meshed, and said outside injection port is an injection needle.
Two improvement of technique scheme is: if the 7th) the step branch install radiopharmaceutical after the residence time long; Controller is according to the activity value in the said radiopharmaceutical original fluid container of activity appearance measurement in real time; Poor according to the front and back activity value of residence time section again; Calculating needs additional radiopharmaceutic volume, repeats the 3rd) to the 5th) step.
Two further improvement of technique scheme is: said switch valve is to select valve, said selection valve contain one first opening and a plurality of can be respectively and second opening of the first opening conducting; The import and export of said syringe is connected with first opening, and one of said second opening is connected with solvent tank, and two of said second opening is connected with the radiopharmaceutical original fluid container, and three of said second opening connects said outside injection port.
The beneficial effect that the present invention has is: the external data input port that 1) passes through controller is to the controller input instruction, and selection needs the radiopharmaceutical original fluid container of packing; Measure in real time the activity value of the medicine in the said medicine original fluid container through the activity appearance, the patient's who comprises in the activity value that controller is measured according to the activity appearance in real time and the instruction body weight value calculates the radiopharmaceutic volume that needs; Through controlling the switch valve opening and closing between injector inlet and radiopharmaceutical original fluid container and solvent tank and the injection port respectively; Accomplished radiopharmaceutic automatic subpackaging; Switch valve opening and closing through the control syringe outlet; Accomplished radiopharmaceutic automatic injection, realized the injection of radiopharmaceutical automatic subpackaging has been guaranteed the harm of not raying of inoculator; 2) because through measuring the activity value of the medicine in the radiopharmaceutical original fluid container in real time; Controller is according to the patient body weight value that comprises in activity value of measuring in real time and the instruction; Calculate the radiopharmaceutic volume that needs; Drug injection amount accurately control and the accuracy control of inject time have been realized, the function of had real-time packing, injecting in real time.
Description of drawings
Be described further of the present invention below in conjunction with accompanying drawing.
Fig. 1 is the system architecture diagram of the radiopharmaceutical automatic subpackaging injection appearance of the embodiment of the invention one.
Fig. 2 is the system architecture diagram of the radiopharmaceutical automatic subpackaging injection appearance of the embodiment of the invention two.
The specific embodiment
Embodiment one
The radiopharmaceutical automatic subpackaging injection appearance of present embodiment, as shown in Figure 1, comprise medicine packing injecting unit 1 and the controller 2 that is provided with external data input port 2-1.
The external data input port 2-1 that the operator can pass through controller 2 is to controller 2 input instructions, and selection needs the radiopharmaceutical original fluid container 3 of packing.Instruction contains patient's weight data and the radiopharmaceutical kind that will select etc.
Medicine packing injecting unit 1 can be one, also can be a plurality of.
Medicine packing injecting unit 1 comprises solvent tank 4, place the radiopharmaceutical original fluid container 3 in the cage 5 and have the injecting propeller 6 of syringe 6-1.
Be provided with switch valve in the cage 5 and be arranged at the activity appearance 3-1 on the radiopharmaceutical original fluid container 3.The import of syringe 6-1 is connected with solvent tank 4, radiopharmaceutical original fluid container 3 respectively through switch valve.The outlet of syringe 6-1 connects outside injection port 6-2 through switch valve.
The control output end of controller 2 is connected with switch valve, injecting propeller 6 and the control input end of activity appearance 3-1 respectively, and the signal output part of activity appearance 3-1 is connected with the signal input part of controller 2.
The activity appearance 3-1 of present embodiment is used for measuring in real time the activity value of the medicine in the radiopharmaceutical original fluid container 3, and the activity value that will measure in real time sends to controller 2;
Switch valve is used to receive the on-off signal that controller 2 sends, respectively conducting syringe 6-1 and radiopharmaceutical original fluid container 3 and solvent tank 4.
Syringe 6-1 is used under the drive of injecting propeller 6, forming vacuum drawn radiopharmaceutical stoste and solvent and mixing.
Injecting propeller 6 is used to receive first distance measurements and the second distance amount that controller 2 sends, and drives syringe 6-1 and moves.
The switch valve of present embodiment comprises three electromagnetic valves, is respectively the first electromagnetic valve 7-1, the second electromagnetic valve 7-2 and the 3rd electromagnetic valve 7-3.Solvent tank 4 is connected with the input port of the first electromagnetic valve 7-1; Radiopharmaceutical original fluid container 3 is connected with the input port of the second electromagnetic valve 7-2; The import of syringe 6-1 is connected with the output port of the first electromagnetic valve 7-1 and the output port of the second electromagnetic valve 7-2 respectively; The outlet of syringe 6-1 is communicated with the input port of the 3rd electromagnetic valve 7-3, and the output port of the 3rd electromagnetic valve 7-3 connects outside injection port 6-2.
The injecting propeller 6 of present embodiment is a target control syringe pump, and outside injection port 6-2 can be an injection needle.
A kind of variation that can expect of present embodiment is: the 3rd electromagnetic valve 7-3 can replace with check valve, and the outlet of syringe 6-1 connects the import of check valve, and the outlet of check valve connects outside injection port 6-2.
The radiopharmaceutical automatic subpackaging method of present embodiment may further comprise the steps:
1) the external data input port 2-1 that passes through controller 2 is to controller 2 input instructions, and selection needs the radiopharmaceutical original fluid container 3 of packing;
2) activity appearance 3-1 measures the activity value of the medicine in the radiopharmaceutical original fluid container 3 in real time, and the activity value that will measure in real time sends to controller 2;
3) controller 2 is according to the patient body weight value that comprises in real-time activity value of measuring of activity appearance 3-1 and the instruction; Calculate the radiopharmaceutic volume that needs, calculate first distance measurements that injecting propeller 6 needs move according to calculating radiopharmaceutic stereometer simultaneously;
The inoculator is in practical operation, and the body weight value that for example records patient is 60kg, and the activity value that records the medicine in the radiopharmaceutical original fluid container 3 in real time is 105mci, and the cumulative volume of radiopharmaceutical original fluid container 3 is 15ml, and selecting coefficient η is 0.12.
Radiopharmaceutic like this volume
4) open switch valve between syringe 6-1 and the radiopharmaceutical original fluid container 3; Controller 2 control injecting propellers 6 move according to first distance measurements, and syringe 6-1 forms in the vacuum drawn radiopharmaceutical original fluid container 3 and the identical radiopharmaceutical of radiopharmaceutical volume that calculates needs;
5) close switch valve between syringe 6-1 and the radiopharmaceutical original fluid container 3;
6) open switch valve between syringe 6-1 and the solvent tank 4; Controller control injecting propeller 6 moves according to the second distance amount of setting, and syringe 6-1 extracts behind the solvent in the solvent tank 4 that syringe 6-1 is interior to be mixed with the radiopharmaceutical in syringe 6-1;
Solvent in the solvent tank 4, general selective chlorination sodium injection extracts the general 1ml～1.5ml of volume at every turn.Because each volume that extracts solvent is more fixing generally at 1ml～1.5ml, can configure the second distance amount with this.
7) close switch valve between syringe 6-1 and the solvent tank 4, accomplish radiopharmaceutic packing.
In use, when needs are injected, open the switch valve of syringe 6-1 outlet, controller 2 controllers control injecting propeller 6 moves, and the radiopharmaceutical after packing finishes in the syringe 6-1 is pushed out through outside injection port 6-2.
The radiopharmaceutical automatic subpackaging method of present embodiment is further further comprising the steps of:
If the residence time was long after the 7th) the step branch installed radiopharmaceutical; Controller 2 is according to the activity value in the radiopharmaceutical original fluid container 3 of activity appearance 3-1 measurement in real time; Poor according to the front and back activity value of residence time section again; Calculating needs additional radiopharmaceutic volume, repeats the 3rd) to the 5th) step.
Embodiment two
The radiopharmaceutical automatic subpackaging injection appearance of present embodiment is the improvement on embodiment one basis, and as shown in Figure 2, improvements are:
Switch valve is to select valve 8, and selecting valve 8 to contain one first opening a and eight can be respectively and the second opening b of the first opening conducting, c; D, e, f; G; H, k, the concrete structure of selection valve 8 can be referring to the specification sheets 5-6 page or leaf of patent No. CN200720043444.9 Chinese patent " automatic chemical analyzer ".
The import of syringe 6-1 and outlet are outlets, all are connected with the first opening a, and one of second opening f is connected with solvent tank 4, and two e of second opening are connected with radiopharmaceutical original fluid container 3, and three g of second opening connect outside injection port 6-2.
The syringe 6-1 of present embodiment is fixed on the box 6-2; Injecting propeller 6 comprises miniature motor 6-3 and is fixed in syringe and pushes away the push pedal 6-4 on the handle; Be fixed with tooth bar 6-5 on the push pedal 6-4; The mouth of miniature motor 6-3 is fixed with gear 6-6, and gear 6-6 is meshed with tooth bar 6-5, and outside injection port 6-2 is an injection needle.
The present invention is not limited to the foregoing description.All employings are equal to the technical scheme that replacement forms, and all are included in the protection domain of requirement of the present invention.
Claims (10)
1. a radiopharmaceutical automatic subpackaging is injected appearance; Comprise medicine packing injecting unit and the controller that is provided with the external data input port; Said medicine packing injecting unit comprises solvent tank, place the radiopharmaceutical original fluid container in the cage and have the injecting propeller of syringe; It is characterized in that: be provided with switch valve in the said cage and be arranged at the activity appearance on the radiopharmaceutical original fluid container; The import of said syringe is connected with solvent tank, radiopharmaceutical original fluid container respectively through switch valve; The outlet of said syringe connects outside injection port through switch valve, and the control output end of said controller is connected with switch valve, injecting propeller and the control input end of activity appearance respectively, and the signal output part of said activity appearance is connected with the signal input part of controller.
2. the radiopharmaceutical automatic subpackaging is injected appearance according to claim 1, it is characterized in that: said activity appearance is used for measuring in real time the activity value of the medicine in the said radiopharmaceutical original fluid container, and the activity value that will measure in real time sends to controller;
Said controller is used to receive the instruction of outside input; Receive the real-time measured real-time activity of activity appearance value again; Patient body weight value according to comprising in real-time activity value and the instruction calculates the radiopharmaceutic volume that needs, and calculates first distance measurements that the injecting propeller needs move according to calculating radiopharmaceutic stereometer again; The master cock valve is opened, and the control syringe extracts radiopharmaceutical and solvent respectively according to first distance measurements and second distance amount;
Said switch valve is used to receive the on-off signal that controller sends, respectively conducting syringe and radiopharmaceutical original fluid container and solvent tank;
Said syringe is used under the drive of injecting propeller, forming vacuum drawn radiopharmaceutical stoste and solvent and mixing;
Said injecting propeller is used to receive first distance measurements and the second distance amount that controller sends, and drives syringe and moves.
3. the radiopharmaceutical automatic subpackaging is injected appearance according to claim 1 or claim 2; It is characterized in that: said switch valve comprises three electromagnetic valves; Be respectively first, second and the 3rd electromagnetic valve; Said solvent tank is connected with the input port of first electromagnetic valve, and said radiopharmaceutical original fluid container is connected with the input port of second electromagnetic valve, and the import of said syringe is connected with the output port of first electromagnetic valve and the output port of second electromagnetic valve respectively; The outlet of said syringe is communicated with the input port of the 3rd electromagnetic valve, and the output port of the 3rd electromagnetic valve connects said outside injection port.
4. the radiopharmaceutical automatic subpackaging is injected appearance according to claim 1 or claim 2; It is characterized in that: said switch valve comprises two electromagnetic valves and a check valve; Said solvent tank is connected with the input port of first electromagnetic valve; Said radiopharmaceutical original fluid container is connected with the input port of second electromagnetic valve; The import of said syringe is connected with the output port of first electromagnetic valve and the output port of second electromagnetic valve respectively, and the outlet of said syringe connects the import of check valve, and the outlet of said check valve connects said outside injection port.
5. radiopharmaceutical automatic subpackaging injection appearance according to claim 1 or claim 2, it is characterized in that: said switch valve is to select valve, said selection valve contain one first opening and a plurality of can be respectively and second opening of the first opening conducting; The import and export of said syringe is connected with first opening, and one of said second opening is connected with solvent tank, and two of said second opening is connected with the radiopharmaceutical original fluid container, and three of said second opening connects said outside injection port.
6. the radiopharmaceutical automatic subpackaging is injected appearance according to claim 1 or claim 2, and it is characterized in that: said injecting propeller is a target control syringe pump, and said outside injection port is an injection needle.
7. the radiopharmaceutical automatic subpackaging is injected appearance according to claim 1 or claim 2; It is characterized in that: said syringe is fixed on the box; Said injecting propeller comprises miniature motor and is fixed in syringe and pushes away the push pedal on the handle, is fixed with tooth bar in the said push pedal, and the mouth of said miniature motor is fixed with gear; Said wheel and rack is meshed, and said outside injection port is an injection needle.
8. a radiopharmaceutical automatic subpackaging method adopts radiopharmaceutical automatic subpackaging injection appearance according to claim 1, it is characterized in that may further comprise the steps:
1) the external data input port that passes through controller is to the controller input instruction, and selection needs the radiopharmaceutical original fluid container of packing;
2) the activity appearance is measured the activity value of the medicine in the said radiopharmaceutical original fluid container in real time, and the activity value that will measure in real time sends to controller;
3) controller is according to the patient body weight value that comprises in real-time activity value of measuring of activity appearance and the said instruction; Calculate the radiopharmaceutic volume that needs, calculate first distance measurements that the injecting propeller needs move according to calculating radiopharmaceutic stereometer simultaneously;
4) open switch valve between syringe and the said radiopharmaceutical original fluid container; Controller control injecting propeller moves according to first distance measurements, and syringe forms in the vacuum drawn radiopharmaceutical original fluid container and the identical radiopharmaceutical of radiopharmaceutical volume that calculates needs;
5) close switch valve between syringe and the radiopharmaceutical original fluid container;
6) open switch valve between syringe and the solvent tank, controller control injecting propeller moves according to the second distance amount of setting, and syringe extracts behind the solvent in the solvent tank that syringe is interior to be mixed with the radiopharmaceutical in syringe;
7) close switch valve between syringe and the solvent tank, accomplish radiopharmaceutic packing.
9. like the said radiopharmaceutical automatic subpackaging of claim 8 method, it is characterized in that:
If the residence time was long after the 7th) the step branch installed radiopharmaceutical; Controller is according to the activity value in the said radiopharmaceutical original fluid container of activity appearance measurement in real time; Poor according to the front and back activity value of residence time section again; Calculating needs additional radiopharmaceutic volume, repeats the 3rd) to the 5th) step.
10. like claim 8 or 9 said radiopharmaceutical automatic subpackaging methods, it is characterized in that: said switch valve is to select valve, said selection valve contain one first opening and a plurality of can be respectively and second opening of the first opening conducting; The import and export of said syringe is connected with first opening, and one of said second opening is connected with solvent tank, and two of said second opening is connected with the radiopharmaceutical original fluid container, and three of said second opening connects said outside injection port.
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| CN105311737A (en) * | 2015-11-27 | 2016-02-10 | 程木华 | Radioactive automatic injection system based on wireless control technology and use method thereof |
| CN105833422A (en) * | 2016-03-18 | 2016-08-10 | 程大彦 | Semi-automatic preparing and injecting system of radioactive medicine |
| CN107462915A (en) * | 2017-04-07 | 2017-12-12 | 中国人民解放军北京军区疾病预防控制中心 | A kind of real-time measuring method of radiopharmaceutical activity and system |
| CN108686296A (en) * | 2017-04-07 | 2018-10-23 | 华克医疗科技（北京）股份公司 | Radiopharmaceutical automated injection device |
| CN107462915B (en) * | 2017-04-07 | 2023-12-05 | 中国人民解放军北京军区疾病预防控制中心 | Method and system for measuring activity of radioactive drug in real time |
| CN108095769A (en) * | 2017-11-27 | 2018-06-01 | 成都菲斯普科技有限公司 | Integration apparatus is analyzed for the living body sampling of GI Medicine |
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