CN102772517B - Preparation method of guizhi fuling capsules - Google Patents
Preparation method of guizhi fuling capsules Download PDFInfo
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- CN102772517B CN102772517B CN201210260676.5A CN201210260676A CN102772517B CN 102772517 B CN102772517 B CN 102772517B CN 201210260676 A CN201210260676 A CN 201210260676A CN 102772517 B CN102772517 B CN 102772517B
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Abstract
The invention discloses a preparation method of guizhi fuling capsules. The preparation method comprises the following steps of preparing powder of the guizhi fuling capsules, pelleting, conducting first microwave vacuum drying, coating and conducting second microwave vacuum drying, the pelleting is prepared by a one-time molding process, and the pelleting comprises mixing the powder of the guizhi fuling capsules and water to prepare soft materials, refining the soft materials in medicine refining equipment for 2-8 times, pelleting by using refined medicine blocks in pelleting equipment, and placing pills in polishing equipment for reshaping for 10-60min. The one-time molding process is adopted, preparation production of products is controlled by modern technical data to enable production processes to be simple, product quality to be controllable and easy to control, further improve production efficiency, improve product yield, shorten production period, reduce labor intensity, reduce production energy consumption and the like. The preparation method adopts the microwave vacuum drying and has the advantages of being even and rapid in drying, sterilizing, saving energy, being high in efficiency, achieving continuous production and the like.
Description
Technical field
The present invention relates to a kind of preparation method, particularly relate to a kind of preparation method of Ramulus Cinnamomi Poria pill, belong to technical field of Chinese medicines.
Background technology
Ramulus Cinnamomi Poria pill comes from married woman's gestation abnormal pulse in Eastern Han Dynasty's Zhang Zhongjing " Medical Treasures of the Golden Chamber " and demonstrate,proves and the side of controlling, and is blood circulation promoting and blood stasis dispelling, the recipe of the enclosed mass that disappears, and is made up of Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Rubra, Semen Persicae Chinese medicine of the five flavours.At present, the Ramulus Cinnamomi Poria pill of listing all adopts the mode such as traditional technique general processed (the general system of coating pan), heated-air circulation oven dry (cold drying) to produce.
General method for making pill (as shown in Figure 2): a part of medicated powder is first put in and sprays a small amount of water in coating pan, and the lower attaching powder point of brush, then spray water, dusting, coordinate and the general ball action such as rub, rub with the hands, turn over, repeated multiple times, granule increases gradually, and general one-tenth diameter 0.5～1.0mm is spheroidal granule comparatively uniformly, and sieve removes excessive too small powder, obtain ball mould, and the mould having risen is graded, dispar mould is put into respectively different coating pans, continues to increase and approaches finished product.In the process strengthening, constantly add water in right amount, add powder, make medicated powder and water distribution even, ensure pill hardness and roundness, so repeatable operation.General method for making is mainly by manual operation, operation is loaded down with trivial details, pill formability, the big or small uniformity repeatedly strengthen, screen, strengthen and ensure again by workman, it is larger that the part quality index of product is affected by individual operating technology, experience and custom, technological parameter is wayward, and finished product recovery rate is low, and the production cycle is long, labor intensity of operating staff is larger, and workshop Dust Capacity is also larger.Ramulus Cinnamomi Poria pill is formed by Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Rubra, Semen Persicae five kinds of Chinese medicine prescription, because of medicated powder viscosity excessively poor, cannot use and mould method for making and directly carry out pill, and carry out modernization process research and development and need to spend a large amount of human and material resources and financial resources, cause this product to adopt the general technique processed of traditional coating pan to carry out pill since listing always.
The drying mode of Ramulus Cinnamomi Poria pill mainly adopts heated-air circulation oven dry at present---blower fan circulation air supply mode, be that wind regime drives wind wheel to heat via heater by the air supply motor that circulates, the hot blast of sending via air channel to chamber in drying baker, again the air intake air channel after using being become to wind regime circulates once again, heating is used, so repeatedly.The shortcoming of this drying means is: heat from the outside of pill gradually to internal heat transfer to reach dry object, rate of drying is slow, and pill internal/external heating is inhomogeneous, easily causes dry rear pill to split ball, affect the outward appearance of pill, and need operator regularly to turn over medicine, labor intensity is large, and quality index is unstable, in addition this product contains volatile ingredient, need cold drying, arid cycle is long, and production process energy consumption is larger.
Summary of the invention
To the object of the invention is to provide a kind of efficient energy-saving in order addressing the above problem, improve product yield, to realize the preparation method of Ramulus Cinnamomi Poria pill that serialization is produced.
The present invention is achieved by the following technical solutions:
A kind of preparation method of Ramulus Cinnamomi Poria pill, comprise the following steps: prepare Ramulus Cinnamomi Poria pill medicated powder, pill, dry and coating, described pill adopts one-shot forming technique preparation, described one-shot forming technique comprises the following steps: (1) soft material processed: the Ramulus Cinnamomi Poria pill medicated powder preparing is placed in to mixing apparatus, add water by the 60%-110% of medicated powder weight, mix 5-20min, obtain soft material; (2) refining medicine: described soft material is placed in to refining medicine equipment, refines 2-8 time; (3) pill: the medicine piece of refining is placed in to device for producing a granulated material, carries out pill with the break bar that goes out cylindrical void, 6.5-7.2mm of 6.5-7.2mm; (4) shaping: made pill is placed in to the round as a ball 10-60min of polissoir, obtains wet ball.
The a large amount of manual operations that adopt the general technique processed of traditional coating pan to exist for this product, operation is loaded down with trivial details, pill formability and the big or small uniformity are poor, Product Process technical parameter is wayward, finished product recovery rate is low, production cycle is long, labor strength is large, workshop dust is large, the problems such as energy consumption is large, by Imported Modernized preparation equipment, modern pill making craft is set up in innovation, one-shot forming technique pill production technology is simple, automaticity is high, ball shape, ball is heavy can be by mould control, not only good moldability, homogeneous rounding, and one-shot forming rate is high, product quality is also stablized controlled.
Further, the described method of preparing Ramulus Cinnamomi Poria pill medicated powder is as follows: (a) get 10 parts, 10 parts of Ramulus Cinnamomi and Poria and be ground into fine powder, sieve, mix; (b) getting 10 parts, 10 parts of Cortex Moutans, 10 parts of Radix Paeoniae Rubra and Semen Persicae gives as one thinks fit disconnected broken, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.20～1.25 clear paste that filtrate is concentrated into relative density, and the fine powder of preparation in made clear paste and step (a) is mixed, dry, pulverize, sieve.
Further, described step (1) adds water by 77% of medicated powder weight, mixes 10min.
Further, described step (2) is placed in refining medicine equipment by described soft material and refines 4 times.
Further, after described step (3) pill, spread appropriate Ramulus Cinnamomi Poria pill medicated powder on pill surface.
Further, described dry employing vacuum drying.
Further, described vacuum drying adopts microwave vacuum drying.
Further, described microwave vacuum drying comprises microwave vacuum drying and for the second time microwave vacuum drying for the first time, described microwave vacuum drying is for the first time described wet ball to be placed in to micro-wave vacuum equipment be dried 2-6 hour, and 40 DEG C-60 DEG C of baking temperatures per hourly turn over medicine once; Described microwave vacuum drying is for the second time that the pill after coating is placed in to micro-wave vacuum equipment, and be 10-30min drying time, and baking temperature is 40 DEG C-60 DEG C.
Slow for traditional heat-wind circulate drying speed, pill internal/external heating is inhomogeneous, easily causes dry rear pill to split ball, affect the outward appearance of pill, and need operator regularly to turn over medicine, labor intensity is large, the problems such as quality index is unstable, and arid cycle is long, and production process energy consumption is larger, introduce micro-wave vacuum equipment, make that drying process, product quality are more controlled, easily control, further enhance productivity, shorten the production cycle, reduce labor intensity, reduce energy consumption etc.
Further, described microwave vacuum drying is for the first time described wet ball to be placed in to micro-wave vacuum equipment be dried 3.5 hours, and baking temperature is 60 DEG C.
Further, described microwave vacuum drying is for the second time that the pill after coating is placed in to micro-wave vacuum equipment, and be 15min drying time, and baking temperature is 60 DEG C.
The invention has the beneficial effects as follows:
Adopt one-shot forming technique pill, produce with the preparation of modern technology parameter control product, make that production technology is simple, product quality is more controlled, easily control, further enhance productivity, improve product yield, shorten the production cycle, reduce labor intensity, reduce energy consumption etc.Adopt microwave vacuum drying, have uniform drying fast, sterilization, efficient energy-saving, realize the advantages such as serialization production.
Brief description of the drawings
Fig. 1 is process chart of the present invention;
Fig. 2 is the process chart of traditional general method for making pill;
Fig. 3 is the process chart of one-shot forming technique pill in the present invention.
Detailed description of the invention
Below in conjunction with drawings and the specific embodiments, the present invention is described in further detail:
As shown in figures 1 and 3, a preparation method for Ramulus Cinnamomi Poria pill, comprises the following steps: prepare Ramulus Cinnamomi Poria pill medicated powder, pill, dry and coating, the described method of preparing Ramulus Cinnamomi Poria pill medicated powder is as follows: (a) get 10 parts, 10 parts of Ramulus Cinnamomi and Poria and be ground into fine powder, sieve, mix; (b) get 10 parts, 10 parts of Cortex Moutans, 10 parts of Radix Paeoniae Rubra and Semen Persicae disconnected broken, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.20～1.25(80 DEG C that filtrate is concentrated into relative density) clear paste, the fine powder of preparation in made clear paste and step (a) is mixed, dry, pulverize, sieve.
Described pill adopts one-shot forming technique preparation, described one-shot forming technique comprises the following steps: (1) soft material processed: the Ramulus Cinnamomi Poria pill medicated powder preparing is placed in to mixing apparatus, add water by the 60%-110% of medicated powder weight, mix 5-20min, obtain soft material; (2) refining medicine: described soft material is placed in to refining medicine equipment, refines 2-8 time; (3) pill: the medicine piece of refining is placed in to device for producing a granulated material, carries out pill with the break bar that goes out cylindrical void, 6.5-7.2mm of 6.5-7.2mm; (4) shaping: made pill is placed in to the round as a ball 10-60min of polissoir, obtains wet ball.
Adopt the general technique processed of traditional coating pan for this product, a large amount of manual operations that heated-air circulation oven drying mode etc. exist in producing, operation is loaded down with trivial details, pill formability and the big or small uniformity are poor, Product Process technical parameter is wayward, finished product recovery rate is low, production cycle is long, labor strength is large, workshop dust is large, the problems such as energy consumption is large, by Imported Modernized preparation equipment, modern pill making craft is set up in innovation, carry out production control technique with modernization process technical parameter, automaticity is high, ball shape, ball is heavy can be by mould control, not only good moldability, homogeneous rounding, and one-shot forming rate is high, product quality is also stablized controlled.
Described dry employing microwave vacuum drying.Described microwave vacuum drying comprises microwave vacuum drying and for the second time microwave vacuum drying for the first time, described microwave vacuum drying is for the first time described wet ball to be placed in to micro-wave vacuum equipment be dried 2-6 hour, 40 DEG C-60 DEG C of baking temperatures, per hourly turn over medicine once; Described microwave vacuum drying is for the second time that the pill after coating is placed in to micro-wave vacuum equipment, and be 10-30min drying time, and baking temperature is 40 DEG C-60 DEG C.
Slow for traditional heat-wind circulate drying speed, pill internal/external heating is inhomogeneous, easily causes dry rear pill to split ball, affect the outward appearance of pill, and need operator regularly to turn over medicine, labor intensity is large, the problems such as quality index is unstable, and arid cycle is long, and production process energy consumption is larger, introduce microwave dryer, make that drying process, product quality are more controlled, easily control, further enhance productivity, shorten the production cycle, reduce labor intensity, reduce energy consumption etc.
Embodiment 1
1. prepare Ramulus Cinnamomi Poria pill medicated powder
Take 10 parts, 10 parts of Ramulus Cinnamomi, 10 parts, Poria, 10 parts of Cortex Moutans, 10 parts of Radix Paeoniae Rubra and Semen Persicae.Ramulus Cinnamomi, Poria powder are broken into fine powder, sieve, mix; Three tastes such as all the other Cortex Moutans are given as one thinks fit disconnected broken, decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, it is 1.20～1.25(80 DEG C that filtrate is concentrated into relative density) clear paste, mix with above-mentioned fine powder, dry, pulverize, sieve, make Ramulus Cinnamomi Poria pill medicated powder.
2. one-shot forming technique pill
As shown in Figure 3, described one-shot forming technique pill comprises (1) soft material processed: get Ramulus Cinnamomi Poria pill medicated powder in mixing apparatus, add water by 77% of medicated powder weight, mix 10min, obtain soft material; (2) refining medicine: described soft material is placed in to refining medicine equipment, refines 4 times.(3) pill: the medicine piece of refining is placed in to device for producing a granulated material, carries out pill with the break bar that goes out cylindrical void, 7.0mm of 6.7mm, and spread appropriate Ramulus Cinnamomi Poria pill medicated powder on pill surface; (4) shaping: made pill is placed in to the round as a ball 10min of polissoir, obtains wet ball.
As can be drawn from Table 1, adopt one-shot forming technique pill, technique is simple, output is high, production efficiency is high, opportunities for contamination is little, the good evenness of pill, weight differential are little.
The technology of table 1 one-shot forming technique pill and general method for making pill is compared
3. microwave vacuum drying for the first time
The ball 120kg that will wet puts in micro-wave vacuum equipment and is dried 3.5 hours, and 60 DEG C of baking temperatures per hourly turn over medicine once.
4. coating
5. microwave vacuum drying for the second time
Pill 120kg after coating is placed in to micro-wave vacuum equipment, and be 15min drying time, and baking temperature is 60 DEG C.
Through relatively, before coating, when microwave vacuum drying is equivalent to heated-air circulation oven back tender 25% of number, microwave vacuum drying energy consumption is equivalent to 56% of heated-air circulation oven energy consumption for drying; After coating, when microwave vacuum drying is equivalent to heated-air circulation oven back tender 20% of number, microwave vacuum drying energy consumption is equivalent to 45% of heated-air circulation oven energy consumption for drying, so microwave vacuum drying has improved production efficiency greatly, shorten the production cycle, reduced the energy consumption of production process.
Claims (10)
1. the preparation method of a Ramulus Cinnamomi Poria pill, comprise the following steps: prepare Ramulus Cinnamomi Poria pill medicated powder, pill, dry and coating, it is characterized in that: described pill adopts one-shot forming technique preparation, described one-shot forming technique comprises the following steps: (1) soft material processed: the Ramulus Cinnamomi Poria pill medicated powder preparing is placed in to mixing apparatus, add water by the 60%-110% of medicated powder weight, mix 5-20min, obtain soft material; (2) refining medicine: described soft material is placed in to refining medicine equipment, refines 2-8 time; (3) pill: the medicine piece of refining is placed in to device for producing a granulated material, carries out pill with the break bar that goes out cylindrical void, 6.5-7.2mm of 6.5-7.2mm; (4) shaping: made pill is placed in to the round as a ball 10-60min of polissoir, obtains wet ball.
2. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 1, is characterized in that: the described method of preparing Ramulus Cinnamomi Poria pill medicated powder is as follows: (a) get 10 parts, 10 parts of Ramulus Cinnamomi and Poria and be ground into fine powder, sieve, mix; (b) getting 10 parts, 10 parts of Cortex Moutans, 10 parts of Radix Paeoniae Rubra and Semen Persicae gives as one thinks fit disconnected broken, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.20-1.25, and the fine powder of preparation in made clear paste and step (a) is mixed, dry, pulverize, sieve.
3. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 1, is characterized in that: described step (1) adds water by 77% of medicated powder weight, mixes 10min.
4. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 1, is characterized in that: described step (2) is placed in refining medicine equipment by described soft material and refines 4 times.
5. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 1, is characterized in that: after described step (3) pill, spread appropriate Ramulus Cinnamomi Poria pill medicated powder on pill surface.
6. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 1, is characterized in that: described dry employing vacuum drying.
7. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 6, is characterized in that: described vacuum drying is microwave vacuum drying.
8. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 7, it is characterized in that: described microwave vacuum drying comprises microwave vacuum drying and for the second time microwave vacuum drying for the first time, described microwave vacuum drying is for the first time described wet ball to be placed in to micro-wave vacuum equipment be dried 2-6 hour, 40 DEG C-60 DEG C of baking temperatures, per hourly turn over medicine once; Described microwave vacuum drying is for the second time that the pill after coating is placed in to micro-wave vacuum equipment, and be 10-30min drying time, and baking temperature is 40 DEG C-60 DEG C.
9. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 8, is characterized in that: described microwave vacuum drying is for the first time described wet ball to be placed in to micro-wave vacuum equipment be dried 3.5 hours, and baking temperature is 60 DEG C.
10. the preparation method of a kind of Ramulus Cinnamomi Poria pill according to claim 8, is characterized in that: described microwave vacuum drying is for the second time that the pill after coating is placed in to micro-wave vacuum equipment, and be 15min drying time, and baking temperature is 60 DEG C.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103750689B (en) * | 2013-12-21 | 2015-07-29 | 江西省喜果绿化有限公司 | A kind of Chinese yew traditional Chinese medicine health care and preparation method thereof |
| CN103654044B (en) * | 2013-12-24 | 2015-05-27 | 福建喜果红豆杉科技发展有限公司 | Production process for camptotheca acuminata fruit Chinese yew health pillow |
| JP6626093B2 (en) | 2014-05-12 | 2019-12-25 | 北京慧宝源企▲業▼管理有限公司 | Pharmaceutical composition and preparation method thereof |
| CN107137475A (en) * | 2017-07-11 | 2017-09-08 | 山西华康药业股份有限公司 | A kind of production technology of guizhi fuling pill |
| CN107308234A (en) * | 2017-08-04 | 2017-11-03 | 山西正元盛邦制药有限公司 | A kind of preparation method of guizhi fuling pill |
| CN115590834A (en) * | 2022-10-28 | 2023-01-13 | 北京亚东生物制药有限公司（Cn） | Cassia twig and poria cocos pills and preparation method thereof |
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| CN101653491A (en) * | 2009-07-16 | 2010-02-24 | 陈世忠 | Preparation technology and quality control method of preparation containing cassia twig and tuckahoe |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653491A (en) * | 2009-07-16 | 2010-02-24 | 陈世忠 | Preparation technology and quality control method of preparation containing cassia twig and tuckahoe |
Non-Patent Citations (1)
| Title |
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| 刘凯南，刘纪青.滋肾降糖丸制备工艺研究.《河北中医药学报》.2010,第25卷(第1期),37－38. * |
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