CN102768068B - Biochemical detection system and light source module thereof - Google Patents
Biochemical detection system and light source module thereof Download PDFInfo
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- CN102768068B CN102768068B CN201210099393.7A CN201210099393A CN102768068B CN 102768068 B CN102768068 B CN 102768068B CN 201210099393 A CN201210099393 A CN 201210099393A CN 102768068 B CN102768068 B CN 102768068B
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- 238000001514 detection method Methods 0.000 title claims abstract description 34
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 58
- 150000002367 halogens Chemical class 0.000 claims abstract description 58
- 230000003287 optical effect Effects 0.000 claims description 19
- 238000001914 filtration Methods 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 4
- 235000005811 Viola adunca Nutrition 0.000 abstract 3
- 240000009038 Viola odorata Species 0.000 abstract 3
- 235000013487 Viola odorata Nutrition 0.000 abstract 3
- 235000002254 Viola papilionacea Nutrition 0.000 abstract 3
- 239000006185 dispersion Substances 0.000 description 18
- 238000004458 analytical method Methods 0.000 description 9
- 238000010586 diagram Methods 0.000 description 6
- 229910052724 xenon Inorganic materials 0.000 description 6
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013098 chemical test method Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
A light source module of a biochemical detection system comprises a halogen light source, a first spectroscope, a blue-violet light source, an ultraviolet light source and a second spectroscope. The first beam splitter is used for reflecting the halogen light source. The blue-violet light source penetrates through the first light splitter and is transmitted along the first direction with the halogen light source reflected by the first light splitter. The second beam splitter is used for reflecting the blue-violet light source and the halogen light source to transmit along the second direction. The ultraviolet light source penetrates through the second spectroscope and then is used together with the ultraviolet light source to detect a sample to be detected.
Description
Technical field
The present invention relates to a kind of biochemistry detection system, relate in particular to a kind of optics biochemistry detection system.
Background technology
The light source that optics biochemistry detection system is used is at present mostly xenon lamp, and its main cause, for xenon lamp can provide intensity difference apart from less light source in the scope of visible ray, is conducive to the execution of subsequent analysis.But the price of xenon lamp is higher, be but unfavorable for the universalness of optics biochemistry detection system.
Although, optics biochemistry detection system also has the lower halogen light source of the price of use at present, but when execution analysis, may perform an analysis for the light source of visible ray part wavelength, need to carry out repeatedly just to complete the analysis of the full spectrum of visible ray, and cannot once carry out the analysis of the full spectrum of visible ray.This analysis for the full spectrum of some visible ray is unallowed.Gap between the power of halogen light source in the scope of visible ray may exceed 20 times, and after the full spectrum of sensing visible ray, the execution meeting of subsequent analysis is very difficult maybe cannot be analyzed.
Because above-mentioned problem, optics biochemistry detection system needs a kind of light source module solution of par.
Summary of the invention
Therefore, an object of the present invention is is providing a kind of optics biochemistry detection system of improvement, uses the optics biochemistry detection system replacing with xenon light source.
According to above-mentioned purpose, a kind of light source module of biochemistry detection system is proposed, its comprise a halogen light source, one first spectroscope, a wavelength between the royal purple light source between 380 nanometers and 420 nanometers, a wavelength ultraviolet source between 320 nanometers and 360 nanometers and one second spectroscope.The first spectroscope is in order to reflect halogen light source.Royal purple light source penetrates the first spectroscope, and roughly transmits along first direction with the halogen light source being reflected by the first spectroscope.The second spectroscope is in order to reflect royal purple light source and halogen light source along second direction transmission.Ultraviolet source after penetrating the second spectroscope together with ultraviolet source in order to detect a sample to be detected.
According to one embodiment of the invention, light source module more comprises an optical filtering in order to the light source of halogen light source medium wavelength between 600 nanometers and 800 nanometers of decaying, and this optical filtering is between this halogen light source and this first spectroscope.
According to another embodiment of the present invention, royal purple light source light source is a light emitting diode.
According to another embodiment of the present invention, ultraviolet source is a light emitting diode.
According to another embodiment of the present invention, ultraviolet source comprises another halogen light source and the interference filters of a wavelength between 320 nanometers and 360 nanometers, and interference filters is between another halogen light source and the second spectroscope.
According to another embodiment of the present invention, the first spectroscope is an all band spectroscope.
According to another embodiment of the present invention, the second spectroscope be one for ultraviolet source 85% penetrate and 15% reflection spectroscope.
According to above-mentioned purpose, a kind of light source module of biochemistry detection system is proposed, it comprises a halogen light source, an optical filtering, wavelength ultraviolet source and one second spectroscope between 320 nanometers and 360 nanometers.Halogen light source is along first direction transmission.Optical filtering in order to the halogen light source medium wavelength of decaying lower than 300 meters and higher than the light source of 600 nanometers.The second spectroscope is in order to reflect halogen light source along second direction transmission.Ultraviolet source after penetrating spectroscope together with halogen light source in order to detect a sample to be detected.
According to one embodiment of the invention, ultraviolet source is a light emitting diode.
According to another embodiment of the present invention, ultraviolet source comprises another halogen light source and the interference filters of a wavelength between 320 nanometers and 360 nanometers, and interference filters is between another halogen light source and the second spectroscope.
According to another embodiment of the present invention, the second spectroscope be one for ultraviolet source 85% penetrate and 15% reflection spectroscope.
According to above-mentioned purpose, a kind of biochemistry detection system is proposed, it comprises a kind of light source module described above and a spectroanalysis instrument.Spectroanalysis instrument is in order to analyze the light passing through after sample to be detected.
According to one embodiment of the invention, spectroanalysis instrument comprises an entrance slit, and focuses on dispersion element and a light sensitive diode array.Entrance slit is in order to receive the light passing through after sample to be detected.Focus on dispersion element and launch the light through entrance slit in order to spatial dispersion.Light after light sensitive diode array launches in order to sensing line focus dispersion element.
According to another embodiment of the present invention, spectroanalysis instrument comprises an entrance slit, a collimating mirror, a dispersion element, a condenser and a light sensitive diode array.Entrance slit is in order to receive the light passing through after sample to be detected.Collimating mirror passes through the light of entrance slit in order to reflection.Dispersion element is in order to launch the light after collimating mirror reflection.Light sensitive diode array is the light after dispersion element launches in order to sensing.Condenser in order to by the light focusing after this dispersion element launches in light sensitive diode array.
From the above, apply biochemistry detection system of the present invention, utilize its optics module to improve the characteristic of halogen light source, make halogen light source more can meet the demand of making full spectral detection in the scope of visible ray, use the xenon light source that substitutes high price, and make the element of biochemistry detection system become instinct further to reduce.
Brief description of the drawings
For above and other object of the present invention, feature, advantage and embodiment can be become apparent, the description of the drawings is as follows:
Figure 1A is a kind of biochemistry detection system illustrating according to an embodiment of the present invention;
Figure 1B is a kind of biochemistry detection system illustrating according to another embodiment of the present invention;
Fig. 2, Fig. 3 illustrate respectively according to the light source module of biochemistry detection system of the present invention to process forward and backward measured data plot through optics module;
Fig. 4 is the schematic diagram illustrating according to a kind of optics module of one embodiment of the invention;
Fig. 5 is the schematic diagram illustrating according to a kind of optics module of another embodiment of the present invention; And
Fig. 6 is the schematic diagram illustrating according to a kind of optics module of further embodiment of this invention.
Main element symbol description
100: biochemistry detection system
100 ': biochemistry detection system
101: first direction
101 ': second direction
102: halogen light source
104: optics module
104 ': optics module
104 ": optics module
104a: royal purple light source
104b: spectroscope
104c: spectroscope
104d: ultraviolet source
104e: optical filtering
104f: halogen light source
104g: optical filtering
104h: optical filtering
106: sample carrier
106a: sample to be detected
108: spectroanalysis instrument
108a: light sensitive diode array
108b: entrance slit
108c: collimating mirror
108d: dispersion element
108e: condenser
108f: focus on dispersion element
Embodiment
Please refer to Figure 1A, it illustrates a kind of biochemistry detection system according to an embodiment of the present invention.Biochemistry detection system 100 comprises a halogen light source 102, an optics module 104 and a spectroanalysis instrument 108, uses for a sample 106a to be detected who is loaded in sample carrier 106 and carries out optical analysis.The function of optics module 104 is to adjust the optical characteristics of halogen light source 102, makes the demand of the optical analysis that halogen light source 102 can more meet.In the present embodiment, spectroanalysis instrument 108 comprises an entrance slit 108b, a collimating mirror 108c, a dispersion element 108d, a condenser 108e and a light sensitive diode array 108a.Entrance slit 108b is in order to receive and to sample the light passing through after sample 106a to be detected.Collimating mirror 108c passes through the light of entrance slit 108b in order to reflection, and what make light ray parallel is passed to dispersion element 108d.Dispersion element 108d, in order to launch the light after collimating mirror 108c reflection, is convenient to light sensitive diode array 108a sensing.Condenser 108e in order to be beneficial to sensing by the light focusing after dispersion element 108d launches on light sensitive diode array 108a.
Please refer to Figure 1B, it illustrates a kind of biochemistry detection system according to another embodiment of the present invention.Biochemistry detection system 100 ' is that with the Main Differences of biochemistry detection system 100 collimating mirror 108c and dispersion element 108d are integrated into single focusing dispersion element 108f, and has omitted non-essential condenser 108e.Focus on dispersion element 108f and launch the light through entrance slit 108b in order to spatial dispersion, and by the light guiding light sensitive diode array 108a after launching.Just for example, the applicable spectroanalysis instrument of the present invention is not limited to above-mentioned example to the structure of above-mentioned spectroanalysis instrument.
Please refer to Fig. 2, Fig. 3, it illustrates respectively according to the halogen light source of biochemistry detection system of the present invention and processes forward and backward measured data plot (longitudinal axis is relative intensity numerical value, therefore there is no absolute unit) through optics module.Fig. 2 is halogen light source measured data plot before optics module is processed, and Fig. 3 is halogen light source measured data plot after optics module is processed.With reference to Fig. 2, the light that halogen light source sends before unprocessed in the scope of visible ray the strong and weak gap of (wavelength approximately between 400 nanometers between 750 nanometers) can exceed more than 20 times (for example 60000/2946>20), if all spectrum in sensing visible-range of use sense light diode array, will make follow-up data assorted compared high factor and be difficult to analyze because interrogating.Therefore, biochemistry detection system of the present invention adds an optics module (for example optics module 104 "), uses processing halogen light source, and after processing, measured data plot as shown in Figure 3.As shown in Figure 3, in the scope of visible ray, the light intensity difference of (wavelength approximately between 400 nanometers between 750 nanometers) is less than 5 times (for example 60000/12000<5) apart from meeting, will make follow-up data analysis easily many.The possible structure of the various optics modules of graphic explanation will be coordinated below.In addition, optics module 104 is because increasing the required royal purple light source of biochemistry detection, and therefore near light intensity wavelength 400 nanometers can increase severely.
Please refer to Fig. 4, it illustrates the schematic diagram according to a kind of optics module of one embodiment of the invention.Optics module 104 comprises a royal purple light source 104a, one first spectroscope 104b, a ultraviolet source 104d and one second spectroscope 104c.The light that the first spectroscope 104b sends halogen light source 102 reflects towards the second spectroscope 104c(along first direction 101).The light that royal purple light source 104a sends penetrates the first spectroscope 104b, and roughly transmits along equidirectional (first direction 101) with the halogen light source being reflected by the first spectroscope 104b, and reflects towards corpse or other object for laboratory examination and chemical testing sample to be measured in the second spectroscope 104c.The second spectroscope 104c is in order to allow ultraviolet source penetrate towards sample to be detected (along second direction 101 ').In the present embodiment, the substantially vertical first direction 101 of second direction 101 ', but be not limited to this.In the present embodiment, royal purple light source 104a is the light source of a wavelength between 380 nanometers and 420 nanometers, for example the light emitting diode of a wavelength between 380 nanometers and 420 nanometers.Ultraviolet source 104d is the light source of a wavelength between 320 nanometers and 360 nanometers, for example, be the light emitting diode of wavelength between 320 nanometers and 360 nanometers.In the present embodiment, the first spectroscope 104b is an all band spectroscope, uses the function of incident light approximately 50% reflection (remaining approximately 50% incident light penetrates).In addition, the second spectroscope 104c, for ultraviolet source, has the function that allows incident light approximately 85% penetrate (remaining approximately 15% reflection).In other words, the second spectroscope 104c be one for ultraviolet source 85% penetrate and 15% reflection spectroscope.The second spectroscope 104c also has the function of visible ray reflection.The object that optics module 104 increases ultraviolet source and royal purple light source is to supply halogen light source in the problem of the light intensity deficiency of this wavelength.
Please refer to Fig. 5, it illustrates the schematic diagram according to a kind of optics module of another embodiment of the present invention.The place that optics module 104 ' is different from optics module 104 is mainly to increase optical filtering 104e.Optical filtering 104e is between halogen light source 102 and the first spectroscope 104b.Optical filtering 104e, in order to the light source of halogen light source 102 medium wavelengths between approximately 600 nanometers and 800 nanometers of decaying, makes the overall efficiency of optics module 104 ' can more approach the data of above-mentioned Fig. 3.In addition, by a halogen light source 104f and a wavelength, the interference filters 104g between 320 nanometers and 360 nanometers replaces the ultraviolet source light emitting diode in optics module 104 '.Interference filters 104g, between halogen light source 104f and spectroscope 104c, uses the other light sources of decay except wavelength is between 320 nanometers and 360 nanometers.Halogen light source 104f adds that interference filters 104g has with ultraviolet source light emitting diode and has identical function, but the cost of element is lower.In addition, royal purple light source 104a also can add that interference filters mode realizes (not being illustrated in drawing) with halogen light source.
Please refer to Fig. 6, it illustrates the schematic diagram according to a kind of optics module of further embodiment of this invention.Optics module 104 " comprise an optical filtering 104h, a ultraviolet source 104d and one second spectroscope 104c.Optical filtering 104h in order to halogen light source 102 medium wavelengths of decaying lower than approximately 300 nanometers and higher than the light source of approximately 600 nanometers.The second spectroscope 104c is in order to reflect halogen light source towards sample to be detected (along second direction 101 ').The second spectroscope 104c, for ultraviolet source, has the function that allows incident light approximately 85% penetrate (remaining approximately 15% reflection).In other words, the second spectroscope be one for ultraviolet source 85% penetrate and 15% reflection spectroscope.The second spectroscope 104c also has the function of infrared light and ultraviolet light reflection loss.Therefore, halogen light source 102 after optical filtering 104h processes along first direction 101, then by after the second spectroscope 104c reflection with ultraviolet source in order to detect a sample to be detected together with second direction 101 '.In the present embodiment, the substantially vertical first direction 101 of second direction 101 ', but be not limited to this.Compared to optics module 104 and 104 ', optics module 104 " there is the advantage of less optical element, but can make equally light that halogen light source 102 sends through optics module 104 " can be similar to the data of above-mentioned Fig. 3 after processing or the light intensity difference in the scope of visible ray is less than in 5 times apart from meeting.In addition, ultraviolet source 104d also can add that interference filters mode realizes (not being illustrated in drawing) with halogen light source.
From the invention described above embodiment, apply biochemistry detection system of the present invention, utilize its optics module to improve the characteristic of halogen light source, make halogen light source more can meet the demand of making full spectral detection in the scope of visible ray, use the xenon light source that substitutes high price, and make the element of biochemistry detection system become instinct further to reduce.
Although the present invention discloses as above with embodiment; so it is not in order to limit the present invention; without departing from the spirit and scope of the present invention, when doing various changes and retouching, therefore protection scope of the present invention is when being as the criterion with the scope that accompanying claims were defined for those skilled in the art.
Claims (7)
1. a light source module for biochemistry detection system, is characterized in that, at least comprises:
One halogen light source;
One first spectroscope, in order to reflect this halogen light source;
The royal purple light source of one wavelength between 380 nanometers and 420 nanometers, penetrates this first spectroscope, and roughly transmits along a first direction with this halogen light source being reflected by this first spectroscope;
The ultraviolet source of one wavelength between 320 nanometers and 360 nanometers; And
One second spectroscope, in order to reflect this royal purple light source and this halogen light source along a second direction transmission, wherein this ultraviolet source penetrate after this second spectroscope with this royal purple light source together with this halogen light source in order to detect a sample to be detected.
2. light source module as claimed in claim 1, is characterized in that, also comprises an optical filtering in order to the light source of this halogen light source medium wavelength between 600 nanometers and 800 nanometers of decaying, and this optical filtering is between this halogen light source and this first spectroscope.
3. light source module as claimed in claim 1, is characterized in that, this royal purple light source is a light emitting diode.
4. light source module as claimed in claim 1, is characterized in that, this ultraviolet source is a light emitting diode.
5. light source module as claimed in claim 1, it is characterized in that, this ultraviolet source comprises another halogen light source and the interference filters of a wavelength between 320 nanometers and 360 nanometers, and this interference filters is between this another halogen light source and this second spectroscope.
6. light source module as claimed in claim 1, is characterized in that, this first spectroscope is an all band spectroscope.
7. light source module as claimed in claim 1, is characterized in that, this second spectroscope be one for this ultraviolet source 85% penetrate and 15% reflection spectroscope.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW100115368A TWI454684B (en) | 2011-05-02 | 2011-05-02 | Biochemical measurement system and lamp module thereof |
| TW100115368 | 2011-05-02 |
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| Publication Number | Publication Date |
|---|---|
| CN102768068A CN102768068A (en) | 2012-11-07 |
| CN102768068B true CN102768068B (en) | 2014-10-01 |
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| CN103728018A (en) * | 2014-01-15 | 2014-04-16 | 武汉科晟华科技有限公司 | Waveband-selectable deuterium-halide combined light source |
Citations (4)
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|---|---|---|---|---|
| US6582363B2 (en) * | 2000-08-25 | 2003-06-24 | Pentax Corporation | Video endoscope system and illumination optical system |
| US7149033B2 (en) * | 2004-10-28 | 2006-12-12 | Ocean Optics, Inc. | UV visual light beam combiner |
| CN101055245A (en) * | 2007-05-24 | 2007-10-17 | 吉林大学 | Portable near infrared spectrometer for soybean quality detection |
| CN101339198A (en) * | 2007-07-06 | 2009-01-07 | 株式会社东芝 | Automatic analysis apparatus and automatic analysis method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100798486B1 (en) * | 2006-03-29 | 2008-01-28 | 한국전기연구원 | Light source for Fluorescence Diagnosis and Photodynamic Therapy |
| CN101275908B (en) * | 2008-03-10 | 2010-07-28 | 重庆大学 | Food safe monitoring instrument based on space light modulator |
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2011
- 2011-05-02 TW TW100115368A patent/TWI454684B/en active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582363B2 (en) * | 2000-08-25 | 2003-06-24 | Pentax Corporation | Video endoscope system and illumination optical system |
| US7149033B2 (en) * | 2004-10-28 | 2006-12-12 | Ocean Optics, Inc. | UV visual light beam combiner |
| CN101055245A (en) * | 2007-05-24 | 2007-10-17 | 吉林大学 | Portable near infrared spectrometer for soybean quality detection |
| CN101339198A (en) * | 2007-07-06 | 2009-01-07 | 株式会社东芝 | Automatic analysis apparatus and automatic analysis method |
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| Publication number | Publication date |
|---|---|
| TWI454684B (en) | 2014-10-01 |
| TW201245689A (en) | 2012-11-16 |
| CN102768068A (en) | 2012-11-07 |
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Application publication date: 20121107 Assignee: Meikang, Ningbo Bao Sheng biomedical engineering company limited Assignor: Protectlife International Biomedical Lnc. Contract record no.: 2016990000127 Denomination of invention: Biochemical detection system and light source module thereof Granted publication date: 20141001 License type: Common License Record date: 20160401 |
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