CN102764413A - Di Zhen granule and preparation method thereof - Google Patents
Di Zhen granule and preparation method thereof Download PDFInfo
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- CN102764413A CN102764413A CN2012102943519A CN201210294351A CN102764413A CN 102764413 A CN102764413 A CN 102764413A CN 2012102943519 A CN2012102943519 A CN 2012102943519A CN 201210294351 A CN201210294351 A CN 201210294351A CN 102764413 A CN102764413 A CN 102764413A
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Abstract
The invention provides a Di Zhen granule and a preparation method thereof. Auxiliary materials of the Di Zhen granule include glyceryl monooleate and citric acid monohydrate which have a mole ratio of (1:1)-(2:1), and the mass ratio of the auxiliary materials to the Di Zhen granule is (2-4):5. The auxiliary materials can match with a basic remedy quite well, the prepared Di Zhen granule tastes good and feels cool without bitter and astringent tastes. The basic remedy can perform a curative effect well with few side effects, and people who take the medicine are not increased, especially menopause women who are prone to healthy risks of diseases such as diabetes and high blood pressure.
Description
Technical field:
The invention belongs to field of pharmaceutical preparations, relate to loyal a kind ofly granule and method for preparing.
Background technology:
The loyal granule in ground is made up of this 8 flavor Chinese medicine of Cortex Lycii, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Schisandrae Chinensis, Semen Astragali Complanati, Cortex Albiziae, Radix Glycyrrhizae, Radix Curcumae, for yellowish-brown to brown granular, distinguish the flavor of little salty, little hardship, little acid.Clearind deficient heat, nourish liver and kidney, mind calming is reposed, and is used for the female climacteric syndrome syndrome of endogenous heat due to yin deficiency, and disease opinion is warmed sweating, susceptible to lose temper due to restlessness, feverish sensation in the palms and soles, insomnia and dreamful sleep, soreness of the waist and knees, xerostomia, diseases such as constipation.Owing to have hardship, the unhappy taste of people, patient of letting such as puckery be prone to when taking cause that the sense of taste is uncomfortable, therefore be necessary to add correctives, to improve the loyal particulate mouthfeel in ground.
Mostly the loyal particulate crowd of taking in ground is climacteric women, suffers from diabetes, hypertensive ratio is higher, so can not add sweeting agents such as sucrose, glucose sugar, maltose in the adjuvant.
Summary of the invention:
The invention provides loyal a kind ofly granule, adjuvant has the flavor of rectifying and adherent double effects.
Another object of the present invention is to provide loyal above-mentionedly particulate method for preparing.
First purpose of the present invention is to realize through following scheme:
Loyal a kind ofly granule is characterized in that loyal saidly granule adjuvant comprises glyceryl monooleate, the citric acid monohydrate compound, and the mol ratio of glyceryl monooleate and citric acid monohydrate compound is 1～2: 1, adjuvant is 2～4: 5 with the loyal particulate mass ratio in ground.
Preferably, glyceryl monooleate and citric acid monohydrate compound mol ratio are 1: 1, and adjuvant is 1: 2 with the loyal particulate mass ratio in ground.
In order to make strong flavor and adhesive function all have better effect, above-mentioned glyceryl monooleate and above-mentioned citric acid monohydrate compound are used dissolve with ethanol, and 90～100 ℃ were stirred 1～3 hour, added the loyal granule in ground; Alcoholic acid volume is 15～25 times of citric acid monohydrate compound quality.
Further, above-mentioned glyceryl monooleate and above-mentioned citric acid monohydrate compound are used 95% dissolve with ethanol, and 95 ℃ were stirred 2 hours, add the loyal granule in ground; Consumption of ethanol is 20 times of citric acid monohydrate compound.
For loyal granule in ground and the better coordinated of adjuvant, the raw material of above-mentioned adjuvant also comprises one or both in mannitol and the aspartame, and the mass ratio of loyal granule in ground and mannitol is 1: 2～3; The mass ratio of loyal granule in ground and aspartame is 200～100: 1.Preferably, the mass ratio of the loyal granule in ground, mannitol, aspartame is 200: 400: 1.
Another object of the present invention realizes through following measure:
Loyal a kind ofly particulate method for preparing; With mol ratio is that 1: 1～2: 1 glyceryl monooleate, citric acid monohydrate compound is dissolved in ethanol and makes alcoholic solution; Alcoholic acid volume is 15～25 times of citric acid monohydrate compound quality; The summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 2～4: 5 with the loyal particulate mass ratio in ground, and esterification is 1～3 hour under 90～100 ℃ of stirrings; Get the loyal granule in ground, add mannitol and aspartame, the mass ratio of loyal granule in ground and mannitol is 1: 2～1: 3; The mass ratio of loyal granule in ground and aspartame is 200: 1～100: 1, and mixing adds said alcoholic solution again; The kneading soft material is granulated, and dry back granulate makes.
More specifically; Loyal above-mentionedly particulate method for preparing; With mol ratio is that 1: 1 glyceryl monooleate, citric acid monohydrate compound is dissolved in 95% ethanol and makes alcoholic solution; Alcoholic acid volume is 20 times of citric acid monohydrate compound quality, and the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 1: 2 with the loyal particulate mass ratio in ground, and esterification is 2 hours under 95 ℃ of stirrings; Get the loyal granule in ground, add mannitol and aspartame, the mass ratio of loyal granule in ground and mannitol is 1: 2～1: 3; The mass ratio of loyal granule in ground and aspartame is 200: 1～100: 1, and mixing adds said alcoholic solution again; The kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.
Beneficial effect
1. loyal provided by the inventionly granule adjuvant, glyceryl monooleate and citric acid monohydrate compound carry out esterification, and the carboxylate of formation can be used as binding agent again both as the debitterize agent.Can cover the loyal particulate unhappy taste in ground, the sense of taste of avoiding causing is uncomfortable, possesses the binding agent effect again, need not to add extra binding agent, can make qualified preparation.
2. adjuvant of the present invention and principal agent be coordinated well, and the loyal granule mouthfeel in the ground of preparation is good, and has refrigerant sense; No bitterness and astringent taste; Its curative effect of the fine performance of principal agent ability does not contain sugar sweetener, and side effect is little; Can not increase especially climacteric women of the crowd of taking medicine, the healthy hidden danger of diseases such as diabetes, hypertension.
The specific embodiment:
Through instance the present invention is specifically described below.Be necessary to be pointed out that at this; Following instance only is used for the present invention is further specified; Can not be interpreted as the restriction to protection domain of the present invention, the person skilled in the art in this field can make some nonessential improvement and adjustment to the present invention according to the foregoing invention content.
It is following to rectify flavor evaluation of result method:
The loyal particulate bitterness in ground is divided into 7 ranks, and standards of grading are following:
7 minutes: very undesirable bitter taste
6 minutes: undesirable bitter taste
5 minutes: strong bitter taste
4 minutes: feel bitter taste
3 minutes: feel a little bitter taste
2 minutes: feel faint bitter taste
1 minute: do not feel bitter taste fully
Loyal granule of the present inventionly is made as experimental group, and the loyal granule in the ground before handling is made as matched group, all is dissolved into 2.5% solution with 50 ℃ of warm water, gives a mark after the trial test respectively.
It is 1: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 1 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 15 times of citric acid monohydrate compound quality, and esterification is 2 hours under 95 ℃ of stirrings.Add the loyal granule in ground, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 1: 2 with the loyal particulate mass ratio in ground, the kneading soft material, and 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
It is 2: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 2 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 25 times of citric acid monohydrate compound quality, and esterification is 1 hour under 100 ℃ of stirrings.
Take by weighing the loyal granule in ground, mannitol and aspartame, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 2: 5 with the loyal particulate mass ratio in ground, and the mass ratio of loyal granule in ground and mannitol is 1: 2, and the mass ratio of loyal granule in ground and aspartame is 200: 1, mixing.Add above-mentioned esterification products, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
It is 1: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 3 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 15 times of citric acid monohydrate compound quality, and esterification is 3 hours under 90 ℃ of stirrings.
Take by weighing the loyal granule in ground, mannitol and aspartame, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 4: 5 with the loyal particulate mass ratio in ground, and the mass ratio of loyal granule in ground and mannitol is 1: 3, and the mass ratio of loyal granule in ground and aspartame is 100: 1, mixing.Add above-mentioned esterification products, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
It is 1.5: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 4 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 18 times of citric acid monohydrate compound quality, and esterification is 2.3 hours under 92 ℃ of stirrings.
Take by weighing the loyal granule in ground; Mannitol and aspartame, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 3: 5 with the loyal particulate mass ratio in ground, the mass ratio of loyal granule in ground and mannitol is 1: 2.6; The mass ratio of loyal granule in ground and aspartame is 160: 1, mixing.Add above-mentioned esterification products, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
It is 1.5: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 5 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 18 times of citric acid monohydrate compound quality, and esterification is 2.3 hours under 92 ℃ of stirrings.
Take by weighing the loyal granule in ground; Mannitol and aspartame, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 3.5: 5 with the loyal particulate mass ratio in ground, the mass ratio of loyal granule in ground and mannitol is 1: 2.6; The mass ratio of loyal granule in ground and aspartame is 160: 1, mixing.Add above-mentioned esterification products, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
It is 1.8: 1 glyceryl monooleate and citric acid monohydrate compound that embodiment 6 takes by weighing mol ratio, adds dissolve with ethanol, and alcoholic acid volume is 13 times of citric acid monohydrate compound quality, and esterification is 1.6 hours under 98 ℃ of stirrings.
Take by weighing the loyal granule in ground, mannitol and aspartame, the summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 2.8: 5 with the loyal particulate mass ratio in ground, the mass ratio of the loyal granule in ground, mannitol, aspartame is 200: 400: 1, mixing.Add above-mentioned esterification products, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate make.It is following to rectify the flavor appraisal result:
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
Embodiment 7
Loyal granule flavoring agent in ground and preparation method thereof: take by weighing glyceryl monooleate 3.58g, citric acid monohydrate compound 2.1g, add the 20ml95% dissolve with ethanol, esterification is 2 hours under 95 ℃ of stirrings.Take by weighing the loyal particulate extract 10g in ground, mannitol 20g and aspartame 0.05g, mixing.Add esterification products 5ml, the kneading soft material, 16 orders are granulated, and 60 ℃ of dry back granulate promptly get the loyal granule of rectifying behind the flavor in ground.
Through statistical test, two groups of comparing differences have statistical significance (P＜0.01), and experimental group is superior to matched group.
Claims (8)
1. loyal granule in ground; It is characterized in that loyal saidly particulate adjuvant comprises glyceryl monooleate; The citric acid monohydrate compound; The mol ratio of glyceryl monooleate and citric acid monohydrate compound is 1:1～2:1, and the summation of said glyceryl monooleate and said Fructus Citri Limoniae monohydrate is 2～4:5 with the loyal particulate mass ratio in ground.
2. according to the loyal saidly granule of claim 1, it is characterized in that glyceryl monooleate and citric acid monohydrate compound mol ratio are 1:1, the summation of said glyceryl monooleate and said Fructus Citri Limoniae monohydrate is 1:2 with the loyal particulate mass ratio in ground.
3. according to the loyal saidly granule of claim 1; It is characterized in that said glyceryl monooleate and said citric acid monohydrate compound use dissolve with ethanol; 90～100 ℃ were stirred 1～3 hour, added the loyal granule in ground, and alcoholic acid volume is 15～25 times of citric acid monohydrate compound quality.
4. according to the loyal saidly granule of claim 3, it is characterized in that said glyceryl monooleate and said citric acid monohydrate compound use dissolve with ethanol, 95 ℃ were stirred 2 hours, added the loyal granule in ground, and consumption of ethanol is 20 times of citric acid monohydrate compound.
5. according to the loyal saidly granule of claim 1 or 3, it is characterized in that said adjuvant also comprises one or both in mannitol and the aspartame, the mass ratio of loyal granule in ground and mannitol is 1:2～3, and the mass ratio of loyal granule in ground and aspartame is 200～100:1.
6. according to the loyal saidly granule of claim 5, it is characterized in that the mass ratio of the loyal granule in ground, mannitol, aspartame is 200:400:1.
7. according to the loyal saidly particulate method for preparing of claim 1～6; It is characterized in that: with mol ratio is that glyceryl monooleate, the citric acid monohydrate compound of 1:1～2:1 is dissolved in 95% ethanol and makes alcoholic solution; Alcoholic acid volume is 15～25 times of citric acid monohydrate compound quality; The summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 2～4:5 with the loyal particulate mass ratio in ground, and esterification is 1～3 hour under 90～100 ℃ of stirrings; Get the loyal granule in ground, add mannitol and aspartame, the mass ratio of loyal granule in ground and mannitol is 1:2～1:3; The mass ratio of loyal granule in ground and aspartame is 200:1～100:1, and mixing adds said alcoholic solution again, and the kneading soft material is granulated, and dry back granulate makes.
8. according to the loyal saidly particulate method for preparing of claim 7; It is characterized in that: with mol ratio is that glyceryl monooleate, the citric acid monohydrate compound of 1:1 is dissolved in 95% ethanol and makes alcoholic solution; Alcoholic acid volume is 20 times of citric acid monohydrate compound quality; The summation of glyceryl monooleate and Fructus Citri Limoniae monohydrate is 1:2 with the loyal particulate mass ratio in ground, and esterification is 2 hours under 95 ℃ of stirrings; Get the loyal granule in ground, add mannitol and aspartame, the mass ratio of loyal granule in ground and mannitol is 1:2～1:3; The mass ratio of loyal granule in ground and aspartame is 200:1～100:1, and mixing adds said alcoholic solution again, the kneading soft material, and 16 orders are granulated, and 60 ℃ of dry back granulate make.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210294351.9A CN102764413B (en) | 2012-08-16 | 2012-08-16 | Di Zhen granule and preparation method thereof |
| CN201410735532.XA CN104474474B (en) | 2012-08-16 | 2012-08-16 | A kind of Chinese patent medicine particles and preparation method |
| CN201410735516.0A CN104383545B (en) | 2012-08-16 | 2012-08-16 | Good-palatability Chinese wolfberry root bark-glossy privet fruit granules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210294351.9A CN102764413B (en) | 2012-08-16 | 2012-08-16 | Di Zhen granule and preparation method thereof |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410735516.0A Division CN104383545B (en) | 2012-08-16 | 2012-08-16 | Good-palatability Chinese wolfberry root bark-glossy privet fruit granules and preparation method thereof |
| CN201410735532.XA Division CN104474474B (en) | 2012-08-16 | 2012-08-16 | A kind of Chinese patent medicine particles and preparation method |
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| Publication Number | Publication Date |
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| CN102764413A true CN102764413A (en) | 2012-11-07 |
| CN102764413B CN102764413B (en) | 2014-12-10 |
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| CN201210294351.9A Active CN102764413B (en) | 2012-08-16 | 2012-08-16 | Di Zhen granule and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1468614A (en) * | 2002-07-15 | 2004-01-21 | 深圳清华现代中医药科技有限公司 | Chinese medicine composition for treatnig female's climacteric syndrome and its prepn process |
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2012
- 2012-08-16 CN CN201210294351.9A patent/CN102764413B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1468614A (en) * | 2002-07-15 | 2004-01-21 | 深圳清华现代中医药科技有限公司 | Chinese medicine composition for treatnig female's climacteric syndrome and its prepn process |
Non-Patent Citations (4)
| Title |
|---|
| 凌关庭等: "《食品添加剂手册》", 28 February 1997, article "柠檬酸单甘酯", pages: 765-766 * |
| 寸冬梅等: "儿科药物制剂设计及新剂型开发", 《中国药学杂志》, vol. 47, no. 10, 31 May 2012 (2012-05-31), pages 760 - 765 * |
| 胡连栋等: "口服药物掩味方法的研究进展", 《中国药房》, vol. 18, no. 7, 31 March 2007 (2007-03-31), pages 552 - 554 * |
| 艾伦等: "《安塞尔药物剂型给药系统：原书第9版》", 29 February 2012, article "制剂的矫味", pages: 124 * |
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Owner name: TIANSHENG PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER OWNER: HUBEI TIANSHENG KANGDI PHARMACEUTICAL CO., LTD. Effective date: 20141218 |
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Effective date of registration: 20141218 Address after: Chaoyang Industrial Park, 408300 Chongqing County of Dianjiang city (Dianjiang Guixi) Patentee after: Tiansheng Pharmaceutical Group Co., Ltd. Address before: 442500, 171, East Ling Ling Street, meteorite County, Hubei, Shiyan Patentee before: Sky, Hubei Sheng Kangdi pharmaceutical Co. Ltd |