CN102763671A - Quickly disintegrated imidacloprid and emamectin benzoate water dispersible granules and preparation method thereof - Google Patents
Quickly disintegrated imidacloprid and emamectin benzoate water dispersible granules and preparation method thereof Download PDFInfo
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- CN102763671A CN102763671A CN2012102454118A CN201210245411A CN102763671A CN 102763671 A CN102763671 A CN 102763671A CN 2012102454118 A CN2012102454118 A CN 2012102454118A CN 201210245411 A CN201210245411 A CN 201210245411A CN 102763671 A CN102763671 A CN 102763671A
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Abstract
The invention belongs to the technical field of pesticides, and relates to quickly disintegrated imidacloprid and emamectin benzoate water dispersible granules and a preparation method thereof. A formula comprises the following components: imidacloprid and emamectin benzoate in a mass ratio of 9:1, 3.0 to 20.0 percent of dispersant, 1.0 to 5.0 percent of wetting agent, 0 to 20.0 percent of disintegrating agent and the balance of filler. The preparation method comprises the following steps of: changing a part of components in the formula into water, grinding to obtain a suspending agent, adding the changed components into the suspension, stirring uniformly, granulating with a 'dry method', and drying, thus obtaining the water dispersible granules. According to the technology, the conventional equipment is integrated, and production can be carried out without adding expensive equipment; and due to small granule diameter and low requirement for the dispersion wetting agent, the prepared water dispersible granules have the characteristics of small granule diameter, quick dispersion and disintegration in water and good dispersion and suspension properties.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to a kind of quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule and preparation method thereof.
Background technology
Water dispersible granules is the novel form that grows up nearest decades, and it mainly contains compositions such as former medicine, dispersant, wetting agent, disintegrant, pH regulator agent, stabilizing agent, binding agent, filler.The disintegrative of water dispersible granules can have influence on the dispersiveness and the service efficiency of preparation.Generally there is the problem of disintegrative difference in the water dispersible granules of traditional prilling process preparation.The disintegrative of water dispersible granules is general relevant with the own size of employed filler, dispersant, wetting agent and preparation.When filler, dispersant, wetting agent one regularly, preparation 90% material particular diameter is easy to disintegration after the entry of preparation particle during less than 5 μ m; Dispersiveness and suspension are good; Soup can guarantee the longer lasting period preferably attached to the target surface, has the good advantage of drug effect and safety.Imidacloprid and first dimension salt all are the insecticides of high-efficiency low-toxicity, have and tag and stomach poison function, and both combine according to a certain percentage, and integrated control is good.
Summary of the invention
It is very fast to the purpose of this invention is to provide a kind of disintegration rate, Imidacloprid emamectin benzoate water dispersible granule that dispersiveness and suspensibility are high and preparation method thereof.
The object of the invention is realized through following technical scheme:
Each component is in the quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule: the mass ratio of Imidacloprid and first dimension salt is 9:1, and all the other are 3.0% ~ 20.0% dispersant, 1.0% ~ 5.0% wetting agent, and 0 ~ 20.0% disintegrant, filler complements to 100%.
The component that component in the described Imidacloprid emamectin benzoate water dispersible granule prescription is known by those skilled in that art: dispersant is non-ionic dispersing agent and combinations thereof such as anionic dispersing agents such as polycarboxylate, naphthalene sulfonate, lignosulfonates and NPE; Wetting agent is nonionic wetting agent and combinations thereof such as anionic dispersing agents such as neopelex, lauryl sodium sulfate, sodium olefin sulfonate and aliphatic alcohol polyether; Disintegrant is mineral salt, urea, sodium carboxymethyl starch, Ac-Di-Sol, polyvinylpyrrolidone etc. and combination thereof; Filler is atlapulgite, attapulgite, kaolin, bentonite, white carbon black, precipitated calcium carbonate, diatomite, potter's clay, talcum powder etc. and combination thereof.
Quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule preparation method is:
Change 25.0% ~ 90.0% part component in the pre-designed Imidacloprid emamectin benzoate water dispersible granule prescription into water; Sand milling becomes 10.0% ~ 75.0% material particular diameter to be not more than the suspending agent of 5 μ m; The component of wherein being changed is disintegrant, filler, can add a small amount of antifoaming agent according to circumstances in the sand grinding process; The component that to be changed then joins in the suspension and stirs, and carries out granulation with " dry method ", the oven dry water dispersible granules.
Described antifoaming agent is for the component that those skilled in the art knew, such as silicone defoaming agent, polyether antifoam agent etc.
The described component of being changed is crushed to below the 10 μ m.
Described " dry method " granulation is rotary table granulation, extruder grain, mixed at high speed granulation, thermopnore granulation and compression granulation etc.
Technical characterstic of the present invention is: after material was carried out sand milling, dispersion moisture agent fully was adsorbed on around the material particle, and most material particular diameters are not more than 5 μ m, so preparation entry disintegration is fast, the dispersion suspension rate is high.Compare with " wet method " granulating technique, the present invention can not use expensive spray drying device, only uses " dry method " granulation to get final product, and the general factory of this equipment can buy use.Compare with " dry method " granulating technique, the particle diameter of most components is not more than 5 μ m in the water dispersible granules of the present invention's preparation, has overcome " dry method " granulation material particular diameter and has been difficult to reach the difficult problem below the 5 μ m.Generally speaking, present technique gets up to use existing equipment complex, need not add expensive new equipment and just can produce; Because particle diameter is less, less demanding to dispersion moisture agent, it is less that prepared water dispersible granules has particle diameter, and the entry disintegration disperses fast, the characteristics that dispersion suspension property is good.
Description of drawings
Fig. 1 is the quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule of a present invention preparation method flow chart.
Embodiment
In order to understand the present invention better, the present invention is described further below in conjunction with embodiment.But the scope that the present invention requires to protect is not limited to the scope that embodiment indicates.
" % " representative " quality percentage composition " among the following embodiment.
Embodiment 1 4.5% Imidacloprid+0.5% emamectin benzoate water dispersible granule and preparation method thereof
Each component of filling a prescription and quality percentage composition thereof are: the former medicine 0.7% of former medicine 4.7%, the 72.0% first dimension salt of 96.5% Imidacloprid, dispersant 8.0%, wetting agent 2.0%, kaolin 20.0%, corn starch 20.0%, silica 9.0%, white carbon 35.6%.
The preparation method of this water dispersible granules is:
With the former medicine 4.7g of 96.5% Imidacloprid, the former medicine 0.7g of 72.0% first dimension salt, dispersant 8.0g, wetting agent 2.0g; Kaolin 20.0g, white carbon 23.0g, water 41.6g puts into the sand mill sand milling; Below sand milling to the particle diameter 5 μ m, add the silica 9.0g that comminution by gas stream is crossed then, corn starch 20.0g, white carbon 12.6g; Stir, on extrusion equipment, carry out extruder grain, be 4.5% Imidacloprid+0.5% emamectin benzoate water dispersible granule after the oven dry.
Through detecting, the disintegration number of times of water dispersible granules is 2 times, and disintegration time is 4s, and suspensibility is 93.2%.
Embodiment 2 9.0% Imidacloprids+1.0% emamectin benzoate water dispersible granule and preparation method thereof
Each component of filling a prescription and quality percentage composition thereof are: the former medicine 1.4% of former medicine 9.4%, the 72.0% first dimension salt of 96.5% Imidacloprid, dispersant 8.0%, wetting agent 2.0%, kaolin 10.0%, corn starch 20%, white carbon 49.2%.
The preparation method of this water dispersible granules is:
The former medicine 9.4g of 96.5% Imidacloprid, the former medicine 1.4g of 72.0% first dimension salt, dispersant 8.0g, wetting agent 2.0g; Kaolin 10.0g, corn starch 20g, water 49.2g; Put into the sand mill sand milling, below sand milling to the particle diameter 5 μ m, add white carbon 49.2g then; Stir, on extrusion equipment, carry out extruder grain, be 9.0% Imidacloprid+1.0% emamectin benzoate water dispersible granule after the oven dry.
Through detecting, the disintegration number of times of water dispersible granules is 2 times, and disintegration time is 4s, and suspensibility is 95.7%.
Embodiment 3 18.0% Imidacloprids+2.0% emamectin benzoate water dispersible granule and preparation method thereof
Each component of filling a prescription and quality percentage composition thereof are: the former medicine 2.8% of former medicine 18.8%, the 72.0% first dimension salt of 96.5% Imidacloprid, dispersant 10.0%, wetting agent 2.0%, kaolin 10.0%, corn starch 20%, sodium sulphate 15.0%, white carbon 21.4%.
The preparation method of this water dispersible granules is:
The former medicine 18.8g of 96.5% Imidacloprid, the former medicine 2.8g of 72.0% first dimension salt, dispersant 10.0g, wetting agent 2.0g; Kaolin 10.0g, water 56.4g puts into the sand mill sand milling, below sand milling to the particle diameter 5 μ m; Add corn starch 20.0g then, sodium sulphate 15.0g, white carbon 21.4g; Stir, on extrusion equipment, carry out extruder grain, be 18.0% Imidacloprid+2.0% emamectin benzoate water dispersible granule after the oven dry.
Through detecting, the disintegration number of times of water dispersible granules is 2 times, and disintegration time is 4s, and suspensibility is 94.8%.
Claims (2)
1. quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule; It is characterized in that each constituent and percentage by weight are: the mass ratio of Imidacloprid and first dimension salt is 9:1, and all the other are 3.0% ~ 20.0% dispersant, 1.0% ~ 5.0% wetting agent; 0 ~ 20.0% disintegrant, filler complements to 100%; Wherein said dispersant is non-ionic dispersing agent and combinations thereof such as anionic dispersing agents such as polycarboxylate, naphthalene sulfonate, lignosulfonates and NPE; Wetting agent is nonionic wetting agent and combinations thereof such as anionic dispersing agents such as neopelex, lauryl sodium sulfate, sodium olefin sulfonate and aliphatic alcohol polyether; Disintegrant is mineral salt, urea, sodium carboxymethyl starch, Ac-Di-Sol, polyvinylpyrrolidone etc. and combination thereof; Filler is atlapulgite, attapulgite, kaolin, bentonite, white carbon black, precipitated calcium carbonate, diatomite, potter's clay, talcum powder etc. and combination thereof.
2. quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule preparation method according to claim 1; It is characterized in that: change 25.0% ~ 90.0% part component in the pre-designed Imidacloprid emamectin benzoate water dispersible granule prescription into water; Sand milling becomes 10.0% ~ 75.0% material particular diameter to be not more than the suspending agent of 5 μ m; The component of wherein being changed is disintegrant, filler, can add a small amount of antifoaming agent according to circumstances in the sand grinding process; The component that to be changed then joins in the suspension and stirs, and carries out granulation with " dry method ", the oven dry water dispersible granules; Described antifoaming agent is for the component that those skilled in the art knew, such as silicone defoaming agent, polyether antifoam agent etc.; The described component of being changed is crushed to below the 10 μ m; Described " dry method " granulation is rotary table granulation, extruder grain, mixed at high speed granulation, thermopnore granulation and compression granulation etc.
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| CN201210245411.8A CN102763671B (en) | 2012-07-17 | 2012-07-17 | Quickly disintegrated Imidacloprid emamectin benzoate water dispersible granule and preparation method thereof |
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| CN102763671B CN102763671B (en) | 2016-04-13 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105248446A (en) * | 2015-11-18 | 2016-01-20 | 中国农业科学院棉花研究所 | Complex synergism insecticide and application thereof |
| CN106259412A (en) * | 2016-08-16 | 2017-01-04 | 仇颖莹 | A kind of preparation method of imidacloprid water dispersible granule |
| GB2541374A (en) * | 2015-08-11 | 2017-02-22 | Rotam Agrochem Int Co Ltd | Synergistic insecticidal composition |
| CN106962371A (en) * | 2017-03-16 | 2017-07-21 | 中化化工科学技术研究总院 | For flying anti-emamectin benzoate dry suspending agent and preparation method thereof |
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| CN101199279A (en) * | 2006-12-11 | 2008-06-18 | 潘贞德 | A set of soluble liquid pesticide using imidacloprid as raw material |
| CN101336636A (en) * | 2007-07-05 | 2009-01-07 | 青岛海利尔药业有限公司 | Insecticidal composition containing imidacloprid and emamectin-benzoate |
| JP2009057320A (en) * | 2007-08-31 | 2009-03-19 | Nissan Chem Ind Ltd | Pest controlling composition |
| CN101518236A (en) * | 2008-02-28 | 2009-09-02 | 北京绿色农华植保科技有限责任公司 | Imidacloprid water dispersible granule |
| CN101578989A (en) * | 2008-05-16 | 2009-11-18 | 上海禾本药业有限公司 | Preparation method of emamectin benzoate 2-5 percent water granules |
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- 2012-07-17 CN CN201210245411.8A patent/CN102763671B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101199279A (en) * | 2006-12-11 | 2008-06-18 | 潘贞德 | A set of soluble liquid pesticide using imidacloprid as raw material |
| CN101336636A (en) * | 2007-07-05 | 2009-01-07 | 青岛海利尔药业有限公司 | Insecticidal composition containing imidacloprid and emamectin-benzoate |
| JP2009057320A (en) * | 2007-08-31 | 2009-03-19 | Nissan Chem Ind Ltd | Pest controlling composition |
| CN101518236A (en) * | 2008-02-28 | 2009-09-02 | 北京绿色农华植保科技有限责任公司 | Imidacloprid water dispersible granule |
| CN101578989A (en) * | 2008-05-16 | 2009-11-18 | 上海禾本药业有限公司 | Preparation method of emamectin benzoate 2-5 percent water granules |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2541374A (en) * | 2015-08-11 | 2017-02-22 | Rotam Agrochem Int Co Ltd | Synergistic insecticidal composition |
| GB2541374B (en) * | 2015-08-11 | 2020-04-22 | Rotam Agrochem Int Co Ltd | Synergistic insecticidal composition |
| CN105248446A (en) * | 2015-11-18 | 2016-01-20 | 中国农业科学院棉花研究所 | Complex synergism insecticide and application thereof |
| CN106259412A (en) * | 2016-08-16 | 2017-01-04 | 仇颖莹 | A kind of preparation method of imidacloprid water dispersible granule |
| CN106962371A (en) * | 2017-03-16 | 2017-07-21 | 中化化工科学技术研究总院 | For flying anti-emamectin benzoate dry suspending agent and preparation method thereof |
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| CN102763671B (en) | 2016-04-13 |
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