CN102755615B - Plaster for preventing chilblain - Google Patents
Plaster for preventing chilblain Download PDFInfo
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- CN102755615B CN102755615B CN201210261129.9A CN201210261129A CN102755615B CN 102755615 B CN102755615 B CN 102755615B CN 201210261129 A CN201210261129 A CN 201210261129A CN 102755615 B CN102755615 B CN 102755615B
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- chilblain
- frostbite
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Abstract
The invention relates to a plaster for preventing chilblain. The plaster is prepared from ginger and can achieve a good effect for preventing chilblain. The plaster has a curative effect on chilblain of cheek, auricle, lobes, tip of nose, fingers, insteps and heel, and causes no any toxic or side effects.
Description
Technical field
The present invention relates to Chinese medicine composition, particularly a kind of plaster of anti-frostbite.
Background technology
Chilblain refers to the comparison limitations scytitis infringement due to cold.Chilblain is multiple is born in centrifugal dirty far away, blood flow is slow, blood supply is less, subcutaneous fat is thinner position, with the tips such as finger, the back of the hand, toes, heel, auricle, nose, buccal and exposure portion, the most easily show effect, chilblain is commonly encountered diseases, the frequently-occurring disease in winter clinically, though the medicine of existing treatment chilblain has certain curative effect, but onset is slower, therapeutic effect is poor, and local excitation is larger.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of plaster of pre-anti-frostbite.
Solving the scheme that technical problem of the present invention adopts is:
A plaster for pre-anti-frostbite, is prepared from by Rhizoma Zingiberis Recens.
A pre-anti-frostbite plaster, the ratio of weight grams is: 10～40 grams, Rhizoma Zingiberis Recens, 5～10 grams of Radix Angelicae Sinensis, 20～40 grams of Herba Cistanches, 5～10 grams of Herba Epimedii, 5～10 grams of Radix Morindae Officinaliss, 20～40 grams of Scolopendras.
A kind of pre-anti-frostbite plaster, by 1～4 gram of Semen Raphani and 6～10 grams of pulverizing of Radix Trichosanthis, add the decocting 5-10 hour of 40-60 gram, filter, obtain filtrate, concentrated as for paste, add 15～40 grams of the Fructus Cannabiss of pulverizing, 2～4 grams of 15～40 grams of the Semen Armeniacae Amarums of pulverizing, 2～4 grams of the Radix Scrophulariaes of pulverizing, the root of phragmites communis of pulverizing, vacuum drying, obtains product of the present invention.
A kind of preparation of pre-anti-frostbite plaster: by 10～40 grams, Rhizoma Zingiberis Recens, 5～10 grams of Radix Angelicae Sinensis, 20～40 grams of Herba Cistanches, 5～10 grams of Herba Epimedii, 5～10 grams of Radix Morindae Officinaliss, 20～40 grams of ethanol of putting into 50-75% of Scolopendra soak after 48-96h, filter, obtain filtrate, filtrate is condensed into paste under vacuum.
The present invention can reach good prevention effects to chilblain.All effective in cure to buccal, auricle, ear-lobe, nose, finger, instep, heel chilblain, use this medicine, without any side effects.
The specific embodiment
Embodiment 1:
A kind of preparation of pre-anti-frostbite plaster: by 10 grams, Rhizoma Zingiberis Recens, 5 grams of Radix Angelicae Sinensis, 20 grams of Herba Cistanches, 5 grams of Herba Epimedii, 5 grams of Radix Morindae Officinaliss, 20 grams of Scolopendras are put into 50% ethanol and soak after 48h, filter, and obtain filtrate, and filtrate is condensed into paste under vacuum.
Embodiment 2:
A kind of preparation of pre-anti-frostbite plaster: by 40 grams, Rhizoma Zingiberis Recens, 10 grams of Radix Angelicae Sinensis, 40 grams of Herba Cistanches, 10 grams of Herba Epimedii, 10 grams of Radix Morindae Officinaliss, 40 grams of Scolopendras are put into 75% ethanol and soak after 96h, filter, and obtain filtrate, and filtrate is condensed into paste under vacuum.
Embodiment 3:
A kind of preparation of pre-anti-frostbite plaster: by 30 grams, Rhizoma Zingiberis Recens, 8 grams of Radix Angelicae Sinensis, 30 grams of Herba Cistanches, 8 grams of Herba Epimedii, 8 grams of Radix Morindae Officinaliss, 30 grams of Scolopendras are put into 65% ethanol and soak after 60h, filter, and obtain filtrate, and filtrate is condensed into paste under vacuum.
Embodiment 4:
The right effect of embodiment 3 products prepared by the present invention,
First by hair-dryer preheating, by observation thermometer, regulating the distance of hair-dryer and thermometer to control temperature makes it in (45 ± 5) ℃, again white mice ear is used to the ice cube cold compress 60s of-20 ℃, immediately the white mice ear of processing through cold injury is placed on to rewarming 20s under the hair-dryer of preheating, white mice ear is placed on thermometer side to guarantee rewarming temperature.
Treatment will cause 30 of the white mice of II degree the cold-injury models to be divided at random 3 groups, and the 1st group is blank group, the 2nd group of embodiment 3 products.After cold injury 1h, start to smear medicine, matched group is smeared with 0.9% sodium chloride solution, and experimental group is evenly applied in corresponding white mice ear surface according to grouping by embodiment 3 products (1g/Kg), adds medicine to every day afterwards by early, middle and late minute 3 times.
Observation index matched group and matched group, get respectively mouse ear for 1,3,5 day and make pathological section and dyeed and examined under a microscope by HE after cold injury treatment.3 pathological sections of each preparation of specimen.
Edema degree: every section is got at random 3 points and be take middle cartilaginous tissue and measure mouse ear back side thickness as boundary.
Thrombosis degree standards of grading, 5 minutes: hemagglutination is agglomerating, account for lumen of vessels area and are greater than 5/6; 4 minutes: hemagglutination is agglomerating, account for the 5/6-3/6 of lumen of vessels area; 3 minutes: hemagglutination is agglomerating, account for lumen of vessels area and be less than 3/6 and be greater than 2/6; 2 minutes: hemagglutination is agglomerating, account for lumen of vessels area and be less than 2/6; 1 minute: hemocyte is noncondensing agglomerating.Getting at random a visual field starts to get continuously 10 blood vessels and marks.
Edema is alleviated situation
It is not obvious that As time goes on model group edema degree alleviates degree after causing injury, and embodiment 3 product groups prepared by the present invention alleviate relatively obvious.
Edema degree (μ m, x ± s) after treatment
Group treatment was treated after 3 days and is treated after 5 days after 1 day
Model group 231.2 ± 67.1 246.9 ± 16.7 151.2 ± 10.7
Embodiment 3 group 127.4 ± 15.7 201.8 ± 9.6 101.2 ± 7.6
Thrombosis is alleviated situation
It is not obvious that As time goes on model group thrombosis degree alleviates degree after causing injury, and embodiment 3 product groups prepared by the present invention alleviate relatively obvious.
Thrombosis degree (μ m, x ± s) after treatment
Group treatment was treated after 3 days and is treated after 5 days after 1 day
Model group 5.7 ± 2.1 4.8 ± 1.4 3.4 ± 0.6
Rhizoma Zingiberis Recens group 3.1 ± 1.5 2.7 ± 0.5 2.4 ± 0.7
Embodiment 5:
Case inclusion criteria: it is buccal, auricle, ear-lobe, nose, finger, instep, heel that chilblain is damaged typical predilection site.
MethodsThe cases enrolled, according to above case inclusion criteria, is selected case 40 examples.Man's 30 examples, female's 10 examples; Age is at 18～65 years old, average 28.5 years old;
Red and swollen scope is less than 2cm person's 10 examples, and 2～8cm person, 20 examples, are greater than 8cm person's 10 examples;
1～15 of red and swollen number, average 8.5, person's 20 examples that have skin lesion.
Therapeutic Method: treatment group is applied the kibe ointment described in the embodiment of the present invention 3,1 day 3 times, each 2-5 gram.
Observational technique: observe the curative effect after two weeks, redness is eliminated completely as curing; Red and swollen decreased number or scope are reduced to effectively.The case of curing of take is radix, and Second Year is added up relapse rate winter.
Therapeutic effect: cure 35 examples, effective 5 examples, Second Year recurs 7 examples.
Claims (1)
1. the preparation method of an anti-frostbite plaster: it is characterized in that: by 10～40 grams, Rhizoma Zingiberis Recens, 5～10 grams of Radix Angelicae Sinensis, 20～40 grams of Herba Cistanches, 5～10 grams of Herba Epimedii, 5～10 grams of Radix Morindae Officinaliss, 20～40 grams of ethanol of putting into 50-75% of Scolopendra soak after 48-96h, filter, obtain filtrate, filtrate is condensed into paste under vacuum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210261129.9A CN102755615B (en) | 2012-07-26 | 2012-07-26 | Plaster for preventing chilblain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210261129.9A CN102755615B (en) | 2012-07-26 | 2012-07-26 | Plaster for preventing chilblain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102755615A CN102755615A (en) | 2012-10-31 |
| CN102755615B true CN102755615B (en) | 2014-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210261129.9A Expired - Fee Related CN102755615B (en) | 2012-07-26 | 2012-07-26 | Plaster for preventing chilblain |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
| CN101062395A (en) * | 2007-05-21 | 2007-10-31 | 王军 | Eggplant and lilac daphne herb chilblain liquid medicine |
| CN101134097A (en) * | 2006-08-30 | 2008-03-05 | 刘永斌 | Tincture for treating frostbite and chilblain |
| CN101822810A (en) * | 2010-05-07 | 2010-09-08 | 成都海旺科技有限责任公司 | Method for preparing red medicated wine |
-
2012
- 2012-07-26 CN CN201210261129.9A patent/CN102755615B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101134097A (en) * | 2006-08-30 | 2008-03-05 | 刘永斌 | Tincture for treating frostbite and chilblain |
| CN1966057A (en) * | 2006-11-02 | 2007-05-23 | 张新成 | Externally applied Chinese medicinal liquid for preventing and treating chilblain |
| CN101062395A (en) * | 2007-05-21 | 2007-10-31 | 王军 | Eggplant and lilac daphne herb chilblain liquid medicine |
| CN101822810A (en) * | 2010-05-07 | 2010-09-08 | 成都海旺科技有限责任公司 | Method for preparing red medicated wine |
Non-Patent Citations (7)
| Title |
|---|
| 不同药物对冻疮治疗的疗效;盛景怡等;《辽宁中医药大学学报》;20110105;第13卷(第1期);第199页右栏第1.2.2节 * |
| 中药治疗非冻结性冻伤的研究进展;刘锁兰等;《解放军医学学报》;20011030;第17卷(第5期);270-271 * |
| 刘锁兰等.中药治疗非冻结性冻伤的研究进展.《解放军医学学报》.2001,第17卷(第5期),270-271. |
| 吴恒亚.运用补肾法治疗皮肤顽疾.《吉林中医药》.1987,(第3期),13-14. |
| 曾冲等.治疗冻疮验方.《开卷有益（求医问药）》.2003,(第1期),23. * |
| 盛景怡等.不同药物对冻疮治疗的疗效.《辽宁中医药大学学报》.2011,第13卷(第1期),199-200. |
| 运用补肾法治疗皮肤顽疾;吴恒亚;《吉林中医药》;19870630(第3期);13-14 * |
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| CN102755615A (en) | 2012-10-31 |
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Owner name: NINGBO YINZHOU FURUIDA BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: NINGBO YINZHOU HAOSI RUIPU BIOTECHNOLOGY CO., LTD. Effective date: 20140219 |
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Effective date of registration: 20140219 Address after: 315199 Zhejiang city of Ningbo province Yinzhou District Zhonggongmiao Street Tiantong Road No. 1388 room 3624 Applicant after: Ningbo Yinzhou Furuida Biotechnology Co., Ltd. Address before: 315100 Zhejiang city of Ningbo province Yinzhou District River Street 4 No. 11 Kaixuan tomorrow Applicant before: Ningbo Yinzhou Haosi Ruipu Biological Technology Co., Ltd. |
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