CN102743423A - Traditional Chinese medicine preparation for treating liver diseases and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating liver diseases and preparation method thereof Download PDFInfo
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- CN102743423A CN102743423A CN2012102775320A CN201210277532A CN102743423A CN 102743423 A CN102743423 A CN 102743423A CN 2012102775320 A CN2012102775320 A CN 2012102775320A CN 201210277532 A CN201210277532 A CN 201210277532A CN 102743423 A CN102743423 A CN 102743423A
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- chinese medicine
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- calculus bovis
- liver disease
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating liver diseases and a preparation method thereof. The traditional Chinese medicine preparation is prepared by the following traditional Chinese medicinal materials by part of weight: 10-30 parts of calculus bovis and 100-300 parts of araliaceae panax medicines, wherein the calculus bovis is natural calculus bovis or externally-cultured calculus bovis, and the araliaceae panax medicines are ginseng or American ginseng. The traditional Chinese medicine preparation for treating liver diseases can promote apopososis of liver cancer cell HepG2, has good inhibiting effect on hepatitis B virus, has good protecting effect on liver cells, and can be used for treating diseases like liver cancer and hepatitis B. The traditional Chinese medicine preparation for treating liver diseases is scientific in production technology, stable in product quality, safe and reliable, small in taking amount, convenient to take, small in side effect and good in curing effect and greatly improves living quality of patients.
Description
Technical field:
The invention belongs to pharmaceutical chemistry technical field, particularly a kind of Chinese medicine preparation that is used to treat liver disease and preparation method thereof.
Background technology:
Liver disease is varied, and hepatopathys such as viral hepatitis, fatty liver, medicamentous liver lesion and liver cirrhosis, hepatocarcinoma are that current society threatens one of principal disease of human health.
Liver disease hazardness maximum is hepatitis B (abbreviation hepatitis B) the most widely, and China is a hepatopathy big country, and there are nearly 9,300 ten thousand hepatitis B virus carrierss in China.For the hepatopath, to emotional affection, marriage, entrance, obtain employment, go abroad, socially all receive restriction in various degree, even discriminate against, life has been coverd with grieved color unavoidablely.Hepatitis B does not have the efficacious therapy medicine at present.
Primary hepatocarcinoma is meant hepatocyte or the cytogenetic cancerous protuberance of stones in intrahepatic bile duct; It is one of clinical common cancerous protuberance; Mortality rate is high, in alimentary system malignant tumour, is only second to gastric cancer, the esophageal carcinoma according to the 3rd, is one of modal ten kinds of malignant tumor of serious harm human health in the world.Over nearly 20 years, case fatality rate is on the rise again, has become the 2nd malignant tumor cause of death of China.At present, excision is still first-selected Therapeutic Method, but the method is suitable for subclinical carcinoma of liver and small liver cancer, and its cure rate also is merely 15-30%, and relapse rate reached 40-80% in 5 years.And, since the concealment of hepatocarcinoma onset, the lack of specific symptom, majority has been middle and advanced stage during discovery, quite a few patient has lost the chance of excision.Rely on serum alpha-fetoprotein to detect and combine ultrasonoscopy that the high-risk group is monitored, hepatocarcinoma is diagnosable in the subclinical stage, but early diagnosis is comparatively difficult, and treatment is very thorny.Methods such as appeasing property intervene operation or chemotherapy have obvious toxic and side effects again, and many patients are difficult to stand, and owing to reasons such as sickness rate height, can not solve patient's misery.
Summary of the invention
The object of the invention is exactly to above-mentioned deficiency of the prior art, provide a kind of with Calculus Bovis be used as medicine and technology simple, Chinese medicine preparation of the treatment hepatopathy of better efficacy and preparation method thereof.
Technical solution of the present invention is:
One, a kind of Chinese medicine preparation of treating liver disease, it is characterized in that: the Chinese crude drug by comprising following weight parts is formulated: Calculus Bovis 10-30 part, Araliaceae Panax medical material 100-300 part.
Have as optimal technical scheme of the present invention:
1, a kind of Chinese medicine preparation of treating liver disease, it is characterized in that: the Chinese crude drug by comprising following weight parts is formulated: 25 parts of Calculus Boviss, 150 parts of Araliaceae Panax medical materials.
2, described Calculus Bovis is natural Calculus Bovis or In vitro cultured Calculus Bovis.
3, described Araliaceae Panax medical material is Radix Ginseng or Radix Panacis Quinquefolii.
4, described Chinese medicine preparation is granule, tablet or capsule.
Two, the method for preparing of Chinese medicine preparation of the present invention has following two kinds:
1, a kind of method for preparing of treating the Chinese medicine preparation of liver disease, it is characterized in that: it includes following production process:
The first step: get Araliaceae Panax medical material, process fine powder, promptly get medicated powder 1, subsequent use;
Second step: get Calculus Bovis, pulverize and obtain bovine calculus powder, subsequent use;
The 3rd step: medicated powder 1, bovine calculus powder and acceptable accessories or complementary composition is evenly mixed, and preparation is shaped, and promptly gets.
2, a kind of method for preparing of Chinese medicine preparation of said treatment liver disease is characterized in that it includes following production process:
The first step: get Araliaceae Panax medical material, extractum is extracted, concentrates, obtained to 25%～100% of its weight, subsequent use; The remainder pulverizing medicinal materials is obtained fine powder, promptly get medicated powder 1, subsequent use;
Second step: get Calculus Bovis, pulverize and obtain bovine calculus powder, subsequent use;
The 3rd step:, obtain mixed powder with medicated powder 1, bovine calculus powder mixing;
The 4th step: extractum, mixed powder and acceptable accessories or complementary composition is evenly mixed, and preparation is shaped, and promptly gets.
In the above-mentioned method for preparing, its total preferred version has:
1, described Calculus Bovis is natural Calculus Bovis or In vitro cultured Calculus Bovis;
2, described Araliaceae Panax medical material is Radix Ginseng or Radix Panacis Quinquefolii;
3, described Chinese medicine preparation is granule, tablet or capsule.
The present invention not only has good inhibitory effect to hepatitis B virus, can be used for the treatment of hepatitis B.And the present invention also has remarkable inhibitory action to the growth of human liver cancer cell, and in vitro tests shows that the present invention is inhibited to the human liver cancer cell HepG2 of In vitro culture, can promote the apoptosis of HCC HepG2, can be used for the treatment of hepatocarcinoma.
The present invention is used as medicine with national Chinese medicine one kind new medicine In vitro cultured Calculus Bovis of the high-quality succedaneum of natural Calculus Bovis or high-quality natural Calculus Bovis; These article of making have good heat clearing away, Detoxication; Also play cancer cell specific induction of apoptosis; The effect of antioxidation and elimination activity oxygen and free radical, relieve clinical symptoms and the generation that reduces complication; The effect of Radix Panacis Quinquefolii (or Radix Ginseng) tool benefiting QI and nourishing blood, and ability human body immunity improving power can suppress the growth of tumor cell.
The present invention be advantageous in that: 1, little, the taking convenience of taking dose of the present invention, side effect is little, and good effect has improved patients ' life quality greatly; 2) the present invention its can alleviate BCG and add LPS immunity damage destruction the mouse liver pathologic structure, protect its liver function; 3) the present invention has good inhibitory effect to hepatitis B virus, can obviously reduce the level of ALT, AST, Tbil, improves hepatic fibrosis indexs such as IV one C, PV one III, LN, HA; 4) the present invention has remarkable inhibitory action to the growth of human liver cancer cell, and in vitro tests shows that the present invention is inhibited to the human liver cancer cell HepG2 of In vitro culture, can promote the apoptosis of HCC HepG2, can be used for the treatment of hepatocarcinoma.
Through demonstrations such as pharmacodynamics test, stability tests, steady quality of the present invention, safe and reliable:
1, pharmacodynamics test:
1. the present invention has remarkable inhibitory action to the growth of human liver cancer cell, and in vitro tests shows that its human liver cancer cell HepG2 to In vitro culture is inhibited, can promote the apoptosis of HCC HepG2.
2. the present invention has protective effect to liver, and in vitro tests shows that it can alleviate BCG and add the destruction of LPS immunity damage to the mouse liver pathologic structure, protects its liver function.
3. the present invention has good inhibitory effect to hepatitis B virus; Can obviously reduce the level of ALT, AST, Tbil, improve hepatic fibrosis indexs such as IV one C, PV one III, LN, HA, general curative effect is superior to Entecavir; Prompting the present invention has the patients with hepatic of improvement function, suppresses the effect of hepatic fibrosis.
2, stability test:
The present invention carries out observing the investigation of room temperature quality stability in 0～24 month to 3 lot sample article of trial production, investigates the result and shows that indexs such as its character, discriminating, inspection, assay and limit test of microbe have no significant change, and show steady quality of the present invention.
The specific embodiment:
Below in conjunction with specific embodiment the present invention is done further introduction:
Instance 1:
In vitro cultured Calculus Bovis 30g, Radix Panacis Quinquefolii 100g.Get Radix Panacis Quinquefolii and pulverize, cross 80 mesh sieves, obtain fine powder, subsequent use; In vitro cultured Calculus Bovis is pulverized, and crosses 80 mesh sieves, obtains fine powder, and is subsequent use; With the In vitro cultured Calculus Bovis fine powder, the Radix Panacis Quinquefolii fine powder, starch, magnesium stearate mixing incapsulate, and process 1000, promptly get.
Instance 2:
In vitro cultured Calculus Bovis 25g, Radix Ginseng 150g; Get Radix Ginseng 38g, water extraction, extracting solution concentrates, and gets extractum, and is subsequent use; The Radix Ginseng of remainder is pulverized, obtained fine powder, subsequent use; In vitro cultured Calculus Bovis is pulverized, obtained fine powder, subsequent use; With the In vitro cultured Calculus Bovis fine powder, Radix Ginseng fine powder mixing obtains mixed powder; With extractum, mixed powder, starch mixing, process granule, promptly get.
Instance 3:
Natural Calculus Bovis 10g, Radix Panacis Quinquefolii 300g; Get Radix Panacis Quinquefolii, 80% ethanol extraction, extracting solution concentrates, and gets extractum, and is subsequent use; The Radix Panacis Quinquefolii of remainder is pulverized, obtained fine powder, subsequent use; In vitro cultured Calculus Bovis is pulverized, obtained fine powder, subsequent use; With the In vitro cultured Calculus Bovis fine powder, Radix Panacis Quinquefolii fine powder mixing obtains mixed powder; With extractum, mixed powder, starch mixing, process granule, add magnesium stearate, mixing, tabletting is processed 1000, promptly gets.
Claims (10)
1. Chinese medicine preparation of treating liver disease, it is characterized in that: the Chinese crude drug by comprising following weight parts is formulated: Calculus Bovis 10-30 part, Araliaceae Panax medical material 100-300 part.
2. a kind of Chinese medicine preparation of treating liver disease as claimed in claim 1 is characterized in that: described Calculus Bovis is natural Calculus Bovis or In vitro cultured Calculus Bovis.
3. a kind of Chinese medicine preparation of treating liver disease as claimed in claim 1 is characterized in that: described Araliaceae Panax medical material is Radix Ginseng or Radix Panacis Quinquefolii.
4. like the Chinese medicine preparation of the arbitrary described treatment liver disease of claim 1-3, it is characterized in that: the Chinese crude drug by comprising following weight parts is formulated: 25 parts of Calculus Boviss, 150 parts of Araliaceae Panax medical materials.
5. a kind of Chinese medicine preparation of treating liver disease as claimed in claim 1 is characterized in that: described Chinese medicine preparation is granule, tablet or capsule.
6. method for preparing of treating the Chinese medicine preparation of liver disease according to claim 1, it is characterized in that: it includes following production process:
The first step: get Araliaceae Panax medical material, process fine powder, promptly get medicated powder 1, subsequent use;
Second step: get Calculus Bovis, pulverize and obtain bovine calculus powder, subsequent use;
The 3rd step: medicated powder 1, bovine calculus powder and acceptable accessories or complementary composition is evenly mixed, and preparation is shaped, and promptly gets.
7. method for preparing of treating the Chinese medicine preparation of liver disease according to claim 1, it is characterized in that: it includes following production process:
The first step: get Araliaceae Panax medical material, extractum is extracted, concentrates, obtained to 25%～100% of its weight, subsequent use; Its residue pulverizing medicinal materials is obtained fine powder, promptly get medicated powder 1, subsequent use;
Second step: get Calculus Bovis, pulverize and obtain bovine calculus powder, subsequent use;
The 3rd step:, obtain mixed powder with medicated powder 1, bovine calculus powder mixing;
The 4th step: extractum, mixed powder and acceptable accessories or complementary composition is evenly mixed, and preparation is shaped, and promptly gets.
8. like claim 6 or the 7 described method for preparinies that are used to treat the Chinese medicine preparation of liver disease, it is characterized in that: described Calculus Bovis is natural Calculus Bovis or In vitro cultured Calculus Bovis.
9. like claim 6 or the 7 described method for preparinies that are used to treat the Chinese medicine preparation of liver disease, it is characterized in that: described Araliaceae Panax medical material is Radix Ginseng or Radix Panacis Quinquefolii.
10. like claim 6 or the 7 described method for preparinies that are used to treat the Chinese medicine preparation of liver disease, it is characterized in that: described Chinese medicine preparation is granule, tablet or capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102775320A CN102743423A (en) | 2012-08-07 | 2012-08-07 | Traditional Chinese medicine preparation for treating liver diseases and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102775320A CN102743423A (en) | 2012-08-07 | 2012-08-07 | Traditional Chinese medicine preparation for treating liver diseases and preparation method thereof |
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| CN102743423A true CN102743423A (en) | 2012-10-24 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949022A (en) * | 2022-06-06 | 2022-08-30 | 尚药局(宁夏)制药有限公司 | A Chinese medicinal composition for treating tumor |
Citations (3)
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| CN1167637A (en) * | 1997-04-15 | 1997-12-17 | 胡安黎 | Medicine for removing hepatitis B virus and preparing method thereof |
| CN1242203A (en) * | 1998-07-21 | 2000-01-26 | 邢炳荣 | Pure traditional Chinese medicine concentrated capsule for treating hepatitis B |
| CN1167637C (en) * | 2002-04-26 | 2004-09-22 | 上海高雅玻璃有限公司 | Production process and equipment for multiple-cavity glass bottle and jar |
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2012
- 2012-08-07 CN CN2012102775320A patent/CN102743423A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167637A (en) * | 1997-04-15 | 1997-12-17 | 胡安黎 | Medicine for removing hepatitis B virus and preparing method thereof |
| CN1242203A (en) * | 1998-07-21 | 2000-01-26 | 邢炳荣 | Pure traditional Chinese medicine concentrated capsule for treating hepatitis B |
| CN1167637C (en) * | 2002-04-26 | 2004-09-22 | 上海高雅玻璃有限公司 | Production process and equipment for multiple-cavity glass bottle and jar |
Non-Patent Citations (2)
| Title |
|---|
| 李羚青等: "MTT法检测牛黄参胶囊对HepG2细胞增殖影响的实验研究", 《湖北中医杂志》 * |
| 陈利锋等: "牛黄与西洋参并用治疗慢性乙型病毒性肝炎的临床研究", 《湖北中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114949022A (en) * | 2022-06-06 | 2022-08-30 | 尚药局(宁夏)制药有限公司 | A Chinese medicinal composition for treating tumor |
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Application publication date: 20121024 |