CN102742841B - Health food for relieving pulmonary fibrosis - Google Patents
Health food for relieving pulmonary fibrosis Download PDFInfo
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- CN102742841B CN102742841B CN2012102490345A CN201210249034A CN102742841B CN 102742841 B CN102742841 B CN 102742841B CN 2012102490345 A CN2012102490345 A CN 2012102490345A CN 201210249034 A CN201210249034 A CN 201210249034A CN 102742841 B CN102742841 B CN 102742841B
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- pulmonary fibrosis
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Abstract
The invention relates to health food for relieving pulmonary fibrosis. The health food for relieving pulmonary fibrosis is prepared with fig, radix angelicae sinensis, earthworm, rhizoma chuanxiong, radix astragali, stem of noble dendrobium, borneol, and common food accessories. The health food for relieving pulmonary fibrosis has the effect of slowing pulmonary interstitial fibrosis of experimental rats.
Description
Technical field
The present invention relates to field of health care food, a kind of health food of alleviating pulmonary fibrosis and preparation method thereof.
Background technology
Pulmonary fibrosis (pulmonary fibrosis, PF) be the end last pathologic process of multiple PUD D, various disease causes the reason difference of pulmonary fibrosis, its evolution has many common intermediate links and result, but because inflammatory stimulus pulmonary parenchyma cell generation degeneration necrosis, the pathologic process that the cell component of fibrous connective tissue and extracellular matrix increase unusually and excessively precipitate, the consequence of pulmonary fibrosis is that respiratory failure in various degree takes place the patient.The M ﹠ M of pulmonary fibrosis rises just year by year, and the treatment pulmonary fibrosis mainly contains glucocorticoid, immunodepressant and cell toxicity medicament, but prolonged application, side effect is more.Pulmonary fibrosis patient's diet is difficulty relatively also, and therefore, seeking safer, health food effective is the focus of studying at present.
Summary of the invention
The purpose of this invention is to provide: a kind of health food of alleviating pulmonary fibrosis and preparation method thereof, purposes.
A kind of health food of alleviating pulmonary fibrosis that the present invention relates to:
Prepared by fig, Radix Angelicae Sinensis, earthworm, Ligusticum wallichii, the Radix Astragali, the stem of noble dendrobium, borneol, food auxiliary material commonly used.
A kind of preparation method of alleviating the health food of pulmonary fibrosis who the present invention relates to:
By fig
20～50g, Radix Angelicae Sinensis
20～50g, earthworm
3～7g, Ligusticum wallichii
20～50g, the Radix Astragali
10～30g, the stem of noble dendrobium
10～30g, borneol
1～3g, food auxiliary material commonly used is selected from: flour
500～1000g, highland barley
500～1000g,Rice
500～1000g, corn 500～1000g.
With fig
20～50g, Radix Angelicae Sinensis
20～50g, earthworm
3～7g, Ligusticum wallichii
20～50g, the Radix Astragali
10～30g, the stem of noble dendrobium
10～30g, mix in proportion, pulverize and be meal; The concentration of volume percent of doubly measuring with 4-10 is the alcohol immersion 8～12 hours of 50-70%, the ultrasonic extraction of room temperature 2-3 time, and each 20～30min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
Extract is mixed with the food auxiliary material, just obtain health food of the present invention.
Health food general food method for making of the present invention, said regular dosage form during food prepared therefrom is learned is as congee, cake, soup etc.
Through discovering that health food of the present invention has the effect of the experimental rat pulmonary interstitial fibrosis of slowing down.
The specific embodiment
Embodiment 1
With fig
20g, Radix Angelicae Sinensis
20g, earthworm
3g, Ligusticum wallichii
20g, the Radix Astragali
10g, the stem of noble dendrobium
10g, mix in proportion, pulverize and be meal; Be 50% alcohol immersion 8 hours with the concentration of volume percent of 4 times of amounts, the ultrasonic extraction of room temperature 2 times, each 20min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
With extract and flour
500gMix, just obtain health food of the present invention.
Embodiment 2
With fig
50g, Radix Angelicae Sinensis
50g, earthworm
7g, Ligusticum wallichii
50g, the Radix Astragali
30g, the stem of noble dendrobium
30g, mix in proportion, pulverize and be meal; Be 70% alcohol immersion 12 hours with the concentration of volume percent of 10 times of amounts, the ultrasonic extraction of room temperature 3 times, each 30min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
With extract and highland barley
1000gMix, just obtain health food of the present invention.
Embodiment 3
With fig
30g, Radix Angelicae Sinensis
30g, earthworm
5g, Ligusticum wallichii
30g, the Radix Astragali
20g, the stem of noble dendrobium
20g, mix in proportion, pulverize and be meal; Be 60% alcohol immersion 10 hours with the concentration of volume percent of 5 times of amounts, the ultrasonic extraction of room temperature 2 times, each 25min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
With extract with
Corn 800gMix, just obtain health food of the present invention.
Embodiment 4
Intervene Pulmonary Fibrosis in Rats pharmacodynamic study result
The extract of the health food of experiment material: embodiment 3 (not containing the food auxiliary material);
Animal subject: the SD rat, male and female half and half, body weight 220～240g,
Modeling and administration: 40 rats are divided into 3 groups of blank groups, model group, prednisone acetate group, embodiment at random.After conventional one week of raising, each rats by intraperitoneal injection 10% chloraldurate, 3mlkg
-1, it is fixing that the position is faced upward in anesthesia.The neck defeathering, the smart sterilization of the tincture of iodine, longitudinal cut exposes tracheae, except the blank group, each rat is all thrust tracheae through two cartilagines tracheales czermak spaces towards heart end with syringe, and about 1.0～1.5cm injects bleomycin behind the pumpback non-resistance in tracheae, 5mg/kg, inject isometric(al) physiological saline in the disposable tracheae of blank group, with the upright rotation of animal 3～5min, medicine is fully distributed in lung immediately, sew up each layer tissue, local alcohol disinfecting.Behind the modeling 24h, embodiment irritates stomach extract 10g crude drug/kg/d for 3 groups; Blank group and model group are irritated the distilled water that stomach waits capacity; The prednisone acetate group is irritated stomach and is given prednisone acetate 5mg/kg/d.Successive administration 28d.
Observation index
In the 14th, 28d puts to death 5 rats for every group.Get full lung and weigh, by formula: lung index=lung weight in wet base/body weight, calculate the lung index; Get right lung 0.1g and place the test tube hydrolysis, press the content that kit specification method detects Hyp in the lung tissue.Get left lung 10% formaldehyde fixed, do HE dyeing and Masson dyeing, carry out qualitative, quantitative and observe.
Evaluation criterion: lung tissue section carries out its pathological change of histological observation through dewaxing, dyeing, dehydration, transparent and mounting, and the pulmonary fibrosis degree is divided into level Four: (-) no pulmonary fibrosis; (+) slight pulmonary fibrosis, the area of getting involved is less than 20%; The pulmonary fibrosis of (++) moderate, the area of getting involved is less than 20%～50%; (+++) the severe pulmonary fibrosis, the area of getting involved is less than greater than 50%.
The microscopically morphologic observation: 28 days rat lung structures of control group are clear, do not occur tangible structural change under the mirror; The model group lung structure destroys, alveolar wall significantly thickens, interstitial lung sees that the fiber scar forms, the change of severe pulmonary fibrosis in mostly being, 3 groups of 28 days alveolar septums of embodiment thicken and the interior fibroblast proliferation of interstitial lung obviously alleviates, lung structure is complete, and the pulmonary fibrosis pathological change obviously alleviates than model group, and this results suggest embodiment 3 prescriptions have the effect that alleviates Pulmonary Fibrosis in Rats due to the bleomycin.
Influence to lung fibrosis in rats lung tissue collagenous fibres area
Influence to lung fibrosis in rats lung index
Influence to lung fibrosis in rats lung tissue Hyp content
Cook congee for 5 pulmonary fibrosis the health food of embodiment 3, took continuously 15 days, every day 3 times, each 50 grams, the pulmonary fibrosis symptom is alleviated to some extent.
Claims (3)
1. preparation method of alleviating the health food of the pulmonary fibrosis that non-lung cancer causes:
With fig 20g, Radix Angelicae Sinensis 20g, earthworm 3g, Ligusticum wallichii 20g, Radix Astragali 10g, stem of noble dendrobium 10g, mix in proportion, pulverize and be meal; Be 50% alcohol immersion 8 hours with the concentration of volume percent of 4 times of amounts, the ultrasonic extraction of room temperature 2 times, each 20min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
Extract is mixed with flour 500g, just obtain health food.
2. preparation method of alleviating the health food of the pulmonary fibrosis that non-lung cancer causes:
With fig 50g, Radix Angelicae Sinensis 50g, earthworm 7g, Ligusticum wallichii 50g, Radix Astragali 30g, stem of noble dendrobium 30g, mix in proportion, pulverize and be meal; Be 70% alcohol immersion 12 hours with the concentration of volume percent of 10 times of amounts, the ultrasonic extraction of room temperature 3 times, each 30min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
Extract is mixed with highland barley 1000g, just obtain health food.
3. preparation method of alleviating the health food of the pulmonary fibrosis that non-lung cancer causes:
With fig 30g, Radix Angelicae Sinensis 30g, earthworm 5g, Ligusticum wallichii 30g, Radix Astragali 20g, stem of noble dendrobium 20g, mix in proportion, pulverize and be meal; Be 60% alcohol immersion 10 hours with the concentration of volume percent of 5 times of amounts, the ultrasonic extraction of room temperature 2 times, each 25min, merging filtrate, ethanol is reclaimed in decompression, obtains extract,
Extract is mixed with corn 800g, just obtain health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102490345A CN102742841B (en) | 2012-07-18 | 2012-07-18 | Health food for relieving pulmonary fibrosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102490345A CN102742841B (en) | 2012-07-18 | 2012-07-18 | Health food for relieving pulmonary fibrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102742841A CN102742841A (en) | 2012-10-24 |
| CN102742841B true CN102742841B (en) | 2013-09-11 |
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|---|---|---|---|
| CN2012102490345A Expired - Fee Related CN102742841B (en) | 2012-07-18 | 2012-07-18 | Health food for relieving pulmonary fibrosis |
Country Status (1)
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105211848A (en) * | 2014-06-26 | 2016-01-06 | 天津市康信医药科技有限公司 | The health caring product prescription of anti-fibrosis |
| CN110679957A (en) * | 2019-11-04 | 2020-01-14 | 江西沐恩堂生物科技有限公司 | Earthworm protein health-care product and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559459A (en) * | 2004-03-11 | 2005-01-05 | 宋美池 | Traditional Chinese medicine capsule for treating tuberculosis and neo-last-cough |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742939B (en) * | 2005-09-29 | 2011-09-28 | 济南宏济堂制药有限责任公司 | Medicine for treating pulmonary fibrosis and preparing method |
| CN101849987B (en) * | 2010-05-29 | 2012-07-25 | 甘肃中医学院 | Preparation of Chinese angelica and astragalus root mixture ethanol extract and aqueous extract and application in intervening in pulmonary fibrosis |
| CN102091110B (en) * | 2011-01-06 | 2012-07-04 | 申作洵 | Chinese patent medicine capsule for treating lung cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1559459A (en) * | 2004-03-11 | 2005-01-05 | 宋美池 | Traditional Chinese medicine capsule for treating tuberculosis and neo-last-cough |
Non-Patent Citations (2)
| Title |
|---|
| 晏媛等.脉络宁的临床应用.《中国医院药学杂志》.1998,第18卷(第1期),全文. |
| 脉络宁的临床应用;晏媛等;《中国医院药学杂志》;19980131;第18卷(第1期);全文 * |
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| CN102742841A (en) | 2012-10-24 |
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