CN102727834A - Traditional Chinese medicine composition for treating migraine, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating migraine, and preparation method and application thereof Download PDFInfo
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- CN102727834A CN102727834A CN2012102482828A CN201210248282A CN102727834A CN 102727834 A CN102727834 A CN 102727834A CN 2012102482828 A CN2012102482828 A CN 2012102482828A CN 201210248282 A CN201210248282 A CN 201210248282A CN 102727834 A CN102727834 A CN 102727834A
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Abstract
The invention provides a traditional Chinese medicine composition, which treats migraine by promoting blood circulation to remove blood stasis and promoting qi circulation and relieving pain. Through the technical scheme provided by the invention, active ingredients of the raditional Chinese medicine composition for treating the migraine are prepared from the following raw materials in parts by weight: 10-30 parts of curcuma zedoary, 5-15 parts of ardisia crenata sims, 10-20 parts of star-flower lysimachia and 5-15 parts of corydalis tuber; and cataplasma is prepared by a corresponding preparation method. The traditional Chinese medicine composition provided by the invention has the effect of treating the migraine.
Description
Technical field
The present invention relates to the Chinese medicine preparation technical field, be specifically related to the migrainous Chinese medicine composition of a kind of treatment and method for making and application.
Background technology
Migraine is a kind of pulsation headache of showing effect repeatedly, belongs to " rich and influential family " in numerous headache types.Before its outbreak tendencys such as flash of light, blurred vision, numb limbs and tense tendons are often arranged; The pain that one side head one is jumped appearred in approximate number minute to about 1 hour; And aggravation gradually, up to occur to feel sick, after the vomiting, sensation just has improvements in quiet, dark surrounds or headache alleviation after sleeping.Can be before headache takes place or during outbreak with nerve, moral function obstacle.Up to now, Drug therapy is still controlled this sick best method, and doctor trained in Western medicine is with vasoconstrictor, hormone, prostaglandin inhibitor etc., but these medicines all have toxic and side effects in various degree.Chinese medicine preparation such as xiongju shangqing pill, ZHENNAONING, Rhizoma Corydalis tablet for alleviating pain, compound yangjiao granules, CHUANSHAO tea are transferred kinds such as bagged steeping drug, the exceedingly high liquid of Tai Ji, ZHENGTIAN WAN, all belong to oral medicine and onset is slow.Existing market is badly in need of the migrainous medicine for external use of a kind of treatment.
Summary of the invention
Goal of the invention:, the object of the present invention is to provide the migrainous Chinese medicine preparation of a kind of treatment in order to address the above problem.
Another object of the present invention is to provide migrainous Chinese medicine preparation method for preparing of a kind of treatment and application.
Technical scheme: the objective of the invention is to realize through following scheme:
The migrainous Chinese medicine composition of a kind of treatment, its contained active component are extracted following raw materials in part by weight medicine proportioning and are prepared from: Rhizoma Curcumae 10-30 part, Crisped Ardisia Ardisia gigantifolia 5-15 part, Lysimachia trientaloides Hemsl. 10-20 part, Rhizoma Corydalis 5-15 part.
The migrainous Chinese medicine composition of above-mentioned treatment, its contained active component are extracted following raw materials in part by weight medicine proportioning and are prepared from: 20 parts of Rhizoma Curcumae, 10 parts of Crisped Ardisia Ardisia gigantifolias, 15 parts of Lysimachia trientaloides Hemsl.s, 10 parts of Rhizoma Corydalis.
The migrainous Chinese medicine composition of above-mentioned treatment, said crude drug add substrate and process crust cloth cream after extracting.
The migrainous Chinese medicine composition of above-mentioned treatment, said substrate are sodium polyacrylate 3-6 part, polyvinylpyrrolidone 1-3 part, polyvinyl alcohol 1-2 part, gelatin 6-10 part, sodium carboxymethyl cellulose 2-3 part, glycerol 2-3 part, kaolin 3-5 part, calcium carbonate 2-4 part, azone 2-4 part, propylene glycol 2-4 part, water 6-10 part and ethyl hydroxybenzoate 0.02-0.04 part.
The method of the migrainous Chinese medicine composition of above-mentioned treatment, preparation process is:
A. get Rhizoma Curcumae, Crisped Ardisia Ardisia gigantifolia, Lysimachia trientaloides Hemsl., corydalis tuber medicinal material and merge, pulverize, make solvent, carry out percolation after moistening 5-20 hour, collect percolate with ethanol, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be the thick paste of 1.28-1.32;
B. get sodium polyacrylate, kaolin, calcium carbonate and add glycerol and stir, suspension I;
C. get sodium carboxymethyl cellulose and add water, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone, polyvinyl alcohol, and the limit edged stirs, until evenly, mixtures II;
D. gelatin is added water, heating is stirred to and is evenly translucent, merges with mixtures II; Add the thick paste that obtains among the above-mentioned steps a, stir, add suspension I, azone, propylene glycol, ethyl hydroxybenzoate more successively, stir; While hot through coating machine coating, cutting, packing.
The method for preparing of the migrainous Chinese medicine composition of above-mentioned treatment, concentration of alcohol is 50% among the step a, addition is 5 times of amounts of medical material weight during percolation, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.3 thick paste.
Find that through clinical and experimental study Chinese medicine composition of the present invention has the effect of good treatment migraine.Therefore, the present invention also provides the purposes of aforementioned pharmaceutical compositions, the application of the migrainous Chinese medicine composition of promptly above-mentioned treatment in preparation treatment migraine remedy.
Beneficial effect:
1, sees Rhizoma Curcumae removing blood stasis circulation of qi promoting among the we, removing food stagnancy pain relieving, Crisped Ardisia Ardisia gigantifolia removing stasis to stop bleeding from theory of Chinese medical science; The analgesic therapy of invigorating blood circulation, Rhizoma Curcumae and Crisped Ardisia Ardisia gigantifolia are monarch drug altogether, blood circulation promoting and blood stasis dispelling, Lysimachia trientaloides Hemsl. dispelling wind and removing obstruction in the collateral; Promoting blood circulation and stopping pain, Rhizoma Corydalis are invigorated blood circulation, circulation of qi promoting, pain relieving, and Lysimachia trientaloides Hemsl. and Rhizoma Corydalis are ministerial drug altogether, promoting the circulation of QI to relieve pain; All medicines are harmonious, and play blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain effect altogether, are used to treat migraine.2, the present invention writes out a prescription reasonable in designly, and compatibility is rigorous.3, the present invention consists of Chinese crude drug, has no side effect low price.
The specific embodiment
Below through the embodiment form; Foregoing of the present invention is remake further detailed description; But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following instance, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
1, combine the specific embodiment, the present invention further specified as follows:
Listed weight proportion takes by weighing crude drug required for the present invention in the according to the form below, unit: part
| Rhizoma Curcumae | Crisped Ardisia Ardisia gigantifolia | Lysimachia trientaloides Hemsl. | Rhizoma Corydalis | |
| 1 | 10 | 15 | 10 | 15 |
| 2 | 20 | 10 | 15 | 10 |
| 3 | 30 | 5 | 20 | 5 |
Listed weight proportion takes by weighing base starting material required for the present invention in the according to the form below, unit: part
Among the present invention in the crude drug Lysimachia trientaloides Hemsl. be the herb of Primulaceae Lysimachia plant umbrella leaf Herba lysimachiae capillipedis Lysimachiatrientaloides Hemsl; Perennial herb; Crisped Ardisia Ardisia gigantifolia is used as medicine with root and leaf for for Myrsinacea Ardisa plant Radix Ardisiae Crispae Ardisia crispa (Thunb.) DC..Summer, autumn gather., all the other all select the Chinese Pharmacopoeia kind for use.
2, preparation embodiment
More than proportioning raw materials is an example in the table, may further comprise the steps:
Embodiment 1:
A. get Rhizoma Curcumae 10g, Crisped Ardisia Ardisia gigantifolia 15g, Lysimachia trientaloides Hemsl. 10g, the merging of Rhizoma Corydalis 15g medical material; Pulverize; Make solvent with 50% ethanol, carry out percolation after moistening 5 hours, add 50% ethanol percolation of 5 times of medical material weight; Collect percolate, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.28 thick paste;
B. get sodium polyacrylate 3g, kaolin 3g, calcium carbonate 4g and add glycerol 3g and stir, suspension I;
C. get sodium carboxymethyl cellulose 2g and add water 3g, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone 3g, polyvinyl alcohol 1g, and the limit edged stirs, until evenly, mixtures II;
D. gelatin 10g is added water 3g, heating is stirred to and is evenly translucent; Merge with mixtures II, add the thick paste that obtains among the above-mentioned steps a, stir; Add suspension I, azone 2g, propylene glycol 4g, ethyl hydroxybenzoate 0.04g more successively, stir, be coated with through coating machine while hot; Cutting, packing.
Embodiment 2:
A. get Rhizoma Curcumae 20g, Crisped Ardisia Ardisia gigantifolia 10g, Lysimachia trientaloides Hemsl. 15g, the merging of Rhizoma Corydalis 10g medical material; Pulverize; Make solvent with 50% ethanol, carry out percolation after moistening 15 hours, add 50% ethanol percolation of 5 times of medical material weight; Collect percolate, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.30 thick paste;
B. get sodium polyacrylate 5g, kaolin 4g, calcium carbonate 3g and add glycerol 2.5g and stir, suspension I;
C. get sodium carboxymethyl cellulose 2.5g and add water 4g, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone 2g, polyvinyl alcohol 1.5g, and the limit edged stirs, until evenly, mixtures II;
D. gelatin 8g is added water 4g, heating is stirred to and is evenly translucent; Merge with mixtures II, add the thick paste that obtains among the above-mentioned steps a, stir; Add suspension I, azone 3g, propylene glycol 3g, ethyl hydroxybenzoate 0.03g more successively, stir, be coated with through coating machine while hot; Cutting, packing.
Embodiment 3:
A. get Rhizoma Curcumae 30g, Crisped Ardisia Ardisia gigantifolia 5g, Lysimachia trientaloides Hemsl. 20g, the merging of Rhizoma Corydalis 5g medical material; Pulverize; Make solvent with 50% ethanol, carry out percolation after moistening 15 hours, add 50% ethanol percolation of 5 times of medical material weight; Collect percolate, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.30 thick paste;
B. get sodium polyacrylate 6g, kaolin 5g, calcium carbonate 2g and add glycerol 2g and stir, suspension I;
C. get sodium carboxymethyl cellulose 3g and add water 5g, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone 1g, polyvinyl alcohol 2g, and the limit edged stirs, until evenly, mixtures II;
D. gelatin 6g is added water 5g, heating is stirred to and is evenly translucent; Merge with mixtures II, add the thick paste that obtains among the above-mentioned steps a, stir; Add suspension I, azone 4g, propylene glycol 2g, ethyl hydroxybenzoate 0.02g more successively, stir, be coated with through coating machine while hot; Cutting, packing.
3. clinical observation and model case: traditional Chinese medicine composition for treating migraineur's of the present invention clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 30 examples altogether, male's 18 examples wherein, women's 12 examples; The oldest person 52 years old, age reckling 35 years old, the mean age was at 44.5 years old; The course of disease between 5 months-10 years, average out to 2 years half, attack times was at 2-4 time in every month; Each outbreak persistent period 1-4 days, average attack times is 3 times/month, the persistent period is 3 days.All migraineurs are all the out-patient; All case is all through cranium brain CT examination no abnormality seen; And due to medical history, physical examination and other causes of disease of coherence check eliminating, have a headache, diseases such as no hypertension, epilepsy, all patients go to a doctor and did not take the medicine of other treatment headache in preceding 1 month.
Two, Therapeutic Method: usage and dosage: adopt the prepared crust cloth cream of the embodiment of the invention 2; Step is that a. gets Rhizoma Curcumae 20g, Crisped Ardisia Ardisia gigantifolia 10g, Lysimachia trientaloides Hemsl. 15g, the merging of Rhizoma Corydalis 10g medical material, pulverizes, and makes solvent with 50% ethanol; Carry out percolation after moistening 15 hours; 50% ethanol percolation that adds 5 times of medical material weight is collected percolate, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.30 thick paste; B. get sodium polyacrylate 5g, kaolin 4g, calcium carbonate 3g and add glycerol 2.5g and stir, suspension I; C. get sodium carboxymethyl cellulose 2.5g and add water 4g, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone 2g, polyvinyl alcohol 1.5g, and the limit edged stirs, until evenly, mixtures II; D. gelatin 8g is added water 4g, heating is stirred to and is evenly translucent, merges with mixtures II, adds the thick paste that obtains among the above-mentioned steps a; Stir, add suspension I, azone 3g, propylene glycol 3g, ethyl hydroxybenzoate 0.03g more successively, stir, be coated with through coating machine while hot; Cutting, packing gets 10 cataplasmas, and its usage and consumption are each 1 subsides; Every day 3 times, apply ointment or plaster in the temple place, and one month is a course of treatment, treats 3 courses of treatment altogether.
Three, therapeutic evaluation standard
Recovery from illness: headache disappears, and simultaneous phenomenon is turned out cloudy, and physico-chemical examination is normal, not outbreak in 6 months.Effectively: headache alleviates, and duration of seizure shortens or cycle stretch-out, simultaneous phenomenon is arranged or recurrence is arranged, and physico-chemical examination is normal.Invalid: no significant changes such as headache and simultaneous phenomenon.
In the 30 routine cases of being accepted for medical treatment,, wherein cure 21 examples through treatment in 3 months, effective 6 examples, invalid 3 examples, total effective rate reaches 90%.The result shows that Chinese medicine composition of the present invention has extremely significant effect to the treatment migraineur.
Four. model case
1, Lee XX, the woman, 46 years old, the migraine course of disease was 1 year, every monthly average attack times is shown effect 2 days persistent period at 2 times at every turn.Look into: dimly red tongue, white and thin fur, stringy and tense pulse.Use cataplasma of the present invention, used continuously 1 month, all disease disappearances are fully recovered, and follow up a case by regular visits to the half a year of recurrence again.
2, king XX, man 42 years old, the migraine course of disease is 3 years, every monthly average attack times is shown effect 3 days persistent period at 3 times at every turn.Look into: dimly red tongue, white and thin fur, deep-slow pulse.Use cataplasma of the present invention, used continuously 2 months, all disease disappearances are fully recovered, and follow up a case by regular visits to the half a year of recurrence again.
Claims (7)
1. the migrainous Chinese medicine composition of treatment is characterized in that, its contained active component is extracted following raw materials in part by weight medicine proportioning and is prepared from: Rhizoma Curcumae 10-30 part, Crisped Ardisia Ardisia gigantifolia 5-15 part, Lysimachia trientaloides Hemsl. 10-20 part, Rhizoma Corydalis 5-15 part.
2. treat migrainous Chinese medicine composition according to claim 1, it is characterized in that, its contained active component is extracted following raw materials in part by weight medicine proportioning and is prepared from: 20 parts of Rhizoma Curcumae, 10 parts of Crisped Ardisia Ardisia gigantifolias, 15 parts of Lysimachia trientaloides Hemsl.s, 10 parts of Rhizoma Corydalis.
3. treat migrainous Chinese medicine composition according to claim 1, it is characterized in that, said crude drug adds substrate and processes crust cloth cream after extracting.
4. like the migrainous Chinese medicine composition of the said treatment of claim 3; It is characterized in that said substrate is sodium polyacrylate 3-6 part, polyvinylpyrrolidone 1-3 part, polyvinyl alcohol 1-2 part, gelatin 6-10 part, sodium carboxymethyl cellulose 2-3 part, glycerol 2-3 part, kaolin 3-5 part, calcium carbonate 2-4 part, azone 2-4 part, propylene glycol 2-4 part, water 6-10 part and ethyl hydroxybenzoate 0.02-0.04 part.
5. one kind prepares the method for treating migrainous Chinese medicine composition according to claim 1, it is characterized in that, preparation process is:
A. get Rhizoma Curcumae, Crisped Ardisia Ardisia gigantifolia, Lysimachia trientaloides Hemsl., corydalis tuber medicinal material and merge, pulverize, make solvent, carry out percolation after moistening 5-20 hour, collect percolate with ethanol, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be the thick paste of 1.28-1.32;
B. get sodium polyacrylate, kaolin, calcium carbonate and add glycerol and stir, suspension I;
C. get sodium carboxymethyl cellulose and add water, heating is stirred to constantly and is evenly, slowly adds polyvinylpyrrolidone, polyvinyl alcohol, and the limit edged stirs, until evenly, mixtures II;
D. gelatin is added water, heating is stirred to and is evenly translucent, merges with mixtures II; Add the thick paste that obtains among the above-mentioned steps a, stir, add suspension I, azone, propylene glycol, ethyl hydroxybenzoate more successively, stir; While hot through coating machine coating, cutting, packing.
6. according to the method for preparing of the migrainous Chinese medicine composition of the said treatment of claim 5; It is characterized in that concentration of alcohol is 50% among the step a; Addition is 5 times of amounts of medical material weight during percolation, decompression recycling ethanol and when being concentrated into 50 ℃ relative density be 1.3 thick paste.
7. treat the application of migrainous Chinese medicine composition in preparation treatment migraine remedy according to claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104906329A (en) * | 2015-07-09 | 2015-09-16 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine combination for oral ulcer treatment and production method thereof |
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2012
- 2012-07-18 CN CN 201210248282 patent/CN102727834B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1169292A (en) * | 1996-06-21 | 1998-01-07 | 刘庆海 | Preparation of traditional Chinese herbs for treatment of cephalagra |
| CN1270043A (en) * | 2000-01-27 | 2000-10-18 | 冀承环 | Medicine for treating hemicrania |
| CN101049367A (en) * | 2006-04-07 | 2007-10-10 | 广东宏远集团药业有限公司 | Preparation of Chinese medicament for treating hemicrania |
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| 王胜春邓: "莪术当归延胡索及配伍后的活血行气作用", 《解放军药学学报》 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104906329A (en) * | 2015-07-09 | 2015-09-16 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine combination for oral ulcer treatment and production method thereof |
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