CN102727573A - Water-soluble puffed granules for treating urolithiasis and preparation method thereof - Google Patents
Water-soluble puffed granules for treating urolithiasis and preparation method thereof Download PDFInfo
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- CN102727573A CN102727573A CN2011100887098A CN201110088709A CN102727573A CN 102727573 A CN102727573 A CN 102727573A CN 2011100887098 A CN2011100887098 A CN 2011100887098A CN 201110088709 A CN201110088709 A CN 201110088709A CN 102727573 A CN102727573 A CN 102727573A
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Abstract
The invention belongs to the medical field, and especially to water-soluble puffed granules for treating urolithiasis and a preparation method thereof. The technology problem that the invention solves is to provide water-soluble puffed granules for treating urolithiasis with smooth and compact texture and good fluidity, and the shapes of granules are ball-like. Extraction and decoction of desmodium styracifolium can be performed according to existing methods. A main difference is to prepare the particles of the water-soluble puffed granules for treating urolithiasis into a compressed state. During a process of drying, water content in the particles is controlled at 4-5% at a low temperature, the particles are heated at a high temperature to become puffed and the granules are obtained after drying. The preparation method provided by the invention enables the spheroidic particles to have smooth and compact texture. The interior of a particle has a phenomenon of cavity puffing. The particles have the following advantages: no easy disintegration, attractive appearance, particle angle of repose of 10-25DEG ,high fluidity, no easy moisture absorption, fewer supplementary materials required ,no easy pasty object generation and easy operation when used in infusion. The water-soluble puffed granules for treating urolithiasis provided by the invention can be used as materials for preparing tablets and capsules, and the processes of tabletting and capsulationcan be performed according to regular processes.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to logical swelling granular agent of water solublity stranguria caused by urinary stone and preparation method thereof.
Background technology
At present, for the ease of Application of TCM Chinese medicine, the common mode dosage form that herbal mixture is common is a granule, tablet, and capsules etc. also have processing granule after the single medicinal material extraction.Stranguria caused by urinary stone leads to granule clearing away damp-heat, diuresis and expelling stone.Be used for lithangiuria due to the damp-heat in lower-JIAO, pyelonephritis, cholecystitis.
Obtain extractum after the logical granule of stranguria caused by urinary stone normally adopts organic solvent extraction such as decocte with water or ethanol with crude drug, add then granulate after adjuvant is processed soft material, granulate, obtain granule.Could figurations but need add a large amount of adjuvants usually, and coating of particles is generally indefinite form according to the granule of existing method preparation, granule looses, broken, and profile is poor, and is mobile poor, and the easy moisture absorption is unfavorable for preserving packing and preservation.In order to improve existing method, the inventor desires to provide a kind of brand-new stranguria caused by urinary stone to lead to granule.
Summary of the invention
It is fine and close that the technical problem that the present invention solved provides a kind of smooth-shaped; Good fluidity, the logical swelling granular agent of type spheric stranguria caused by urinary stone, its extraction or decocting process; All can carry out with reference to existing method during granulation, main difference is: the granule of compressive state is processed in (1); (2) during dried particles, adopting first low temperature to be controlled to moisture is 4-5%, and heated particle makes it expanded under hot conditions again, drying.
The logical swelling granular agent of water solublity stranguria caused by urinary stone of the present invention is to be got by following method preparation:
A, with Herba Lysimachiae (preferred Herba Desmodii Styracifolii) decocte with water, concentrate and process extractum;
B, extractum processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
Wherein, the decoction and alcohol sedimentation technique of steps A specifically can be with the Herba Lysimachiae decocte with water, and decoction liquor filters, and is condensed into extractum.
The improvements of the logical swelling granular agent method for preparing of water solublity stranguria caused by urinary stone of the present invention are:
1, step B prepares bulk density greater than 0.78g/cm
3Granule.The inventor will " bulk density be greater than 0.78g/cm
3Granule " be called " granule of compressive state ", the granulation mass density of this compressive state is at least greater than 0.78g/cm
3, with this understanding, just can carry out second committed step of the present invention, realize expanded purpose; The present invention prepares gained " granule of compressive state " bulk density and is generally 0.78-0.90g/cm
3
2, step C dried particles is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5%;
(2) it is expanded under 65-95 ℃ hot conditions, to be heated to granule then;
(3) keep 65-95 ℃ hot conditions again, below the dried particles moisture to 2%, promptly get granule.
Cooperate above-mentioned technology, need were processed soft material after extractum is processed dry extract again when extractum was processed soft material, and so processing can reduce supplementary product consumption, reduced and took in unnecessary adjuvant, reduced production costs.
Committed step of the present invention is at first to adopt the compressing grains machine to process the granule of compressive state; In low temperature-pyritous processing mode, make granule at drying stage again, especially expansible phenomenon (expanded) appears in granule during high-temperature process; Make and form smooth in appearance fine and close sphere or spherical particle; Granule interior has the expanded phenomenon of cavity, and granule is not fragmentary, and profile is good; Granule scope angle of repose is 10-25 °, and good fluidity is difficult for the moisture absorption; Supplementary product consumption is few; Be not prone to pasty masses when brewing at the bottom of the cup, be prone to brew.The logical granule of stranguria caused by urinary stone of the present invention can also be pressed common process tabletting or encapsulated getting final product as the raw material of preparation tablet or capsule.
Description of drawings
Fig. 1 is the sketch map of compressing grains machine of the present invention.
Fig. 2 is the front view that the present invention gathers charging tray.
Fig. 3 is the left view of Fig. 2.
Fig. 4 is the front view of splitter section of the present invention.
Fig. 5 is the rearview of Fig. 4.
Fig. 6 is the A-A profile of Fig. 5.
Fig. 7 is the B-B profile of Fig. 5.
Fig. 8 is the front view of extrusion die of the present invention.
Fig. 9 is the left view of Fig. 8.
Figure 10 is the structure chart that existing screw rod is extruded the pay-off screw rod.
Figure 11 is the sketch map of screw rod cooling structure of the present invention.
Figure 12 is the front view of rotary-cut cutter of the present invention.
Figure 13 is the vertical view of Figure 12.
Be labeled as among the figure, the 1-head, the 2-discharge barrel, the 3-extrusion die, 4-gathers charging tray, 5-by-passing parts, 6-rotary-cut cutter; The 7-screw rod, 8-dynamical system, 9-rotary-cut system, 10-water collar, 30-discharge opening, 31-macropore, 32-aperture; The 40-centre bore, the 51-splitter box, 52-shunts ridge, and 53-blow tank, 54-gather the charging tray bayonet socket, 55-central boss, 56-back-up block; The 60-elastic, 61-sword limit, the 70-blind hole, the 71-inner cool tube, 72-cools off lid, the 73-nut, 74-cools off inlet; The 75-coolant outlet, 76-front end fixed disk, 77-gear shaft part, the 78-thread segment, the 700-cooling duct, 720-cools off cover cavity.
The specific embodiment
Below through to the description of specific embodiment of the invention explanation but do not limit the present invention.
The logical swelling granular of water solublity stranguria caused by urinary stone of the present invention adopts following method preparation:
A, with Herba Lysimachiae (preferred Herba Desmodii Styracifolii) decocte with water, concentrate and process dry extract;
B, dry extract processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
It is characterized in that:
Step B processes bulk density greater than 0.78g/cm
3Granule;
Step C dried particles is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5% (w/w);
(2) it is expanded under the hot conditions of 65-95 ℃ (preferred 75-95 ℃), to be heated to granule then;
(3) keep the hot conditions of 65-95 ℃ (preferred 75-95 ℃) again, below the dried particles moisture to 2% (w/w), promptly get granule.
In the past according to the granulation mass density of existing method preparation usually at 0.55-0.7g/cm
3Even adopt first low temperature-pyritous again drying mode also can't realize expanded purpose.And granule of the present invention prepares bulk density greater than 0.78g/cm in step B
3" granule of compressive state ", should " granule of compressive state " bulk density be generally 0.78-0.90g/cm
3, be to realize one of expanded key parameter.
Further, the conventional method that steps A prepares extractum has, the Herba Lysimachiae decocte with water, and collecting decoction filters, and concentrated filtrate is processed extractum.Also find during preparation, use method for preparing of the present invention extractum is processed refabrication soft material behind the extract powder, can obviously reduce supplementary product consumption, reduce the absorption of unnecessary adjuvant, reduce production costs.
Water solublity stranguria caused by urinary stone of the present invention leads to the granule of swelling granular agent in profile, flowability, and moisture absorption brews the stranguria caused by urinary stone that all is superior on the complexity preparing than existing methods and leads to granule
To prepare bulk density at least greater than 0.78g/cm in the method for preparing of the present invention
3Granule; When step B granulates, need use following compressing grains mechanism and be equipped with granule; This compressing grains machine such as Fig. 1～Fig. 9, Figure 11～shown in Figure 13 comprise that the double-screw type in the head 1 is extruded pay-off and extruded the discharge barrel 2 that pay-off cooperates with this, and the exit of discharge barrel 2 is provided with the extrusion die 3 that has discharge opening 30; In the discharge barrel 2; Extrude between pay-off and the extrusion die 3 at twin screw and to be provided with by-passing parts 5, twin screw extrude be provided with between pay-off and the by-passing parts 5 with by-passing parts 5 each other by touch have a centre bore 40 gather charging tray 4, the supplied materials side of by-passing parts 5 is evenly equipped with splitter box 51; Splitter box 51 converges at the blow tank 53 of by-passing parts exit side, and blow tank 53 is corresponding with the discharge opening 30 of extrusion die 3.The hollow charging tray 4 that gathers of the present invention can be extruded Double Circle stock column that pay-off sees off with twin screw and assembles and change over mono-cylindrical and water conservancy diversion before by-passing parts 5; Supplied materials side at by-passing parts 5 is evenly equipped with splitter box 51 as material channel; Guarantee to assemble the mono-cylindrical material bar that forms and evenly to be branched to extrusion die 3; Make material evenly to extrude,, be generally 0.78-0.90g/cm thereby obtain bulk density through its powerful extrusion capability
3Granule, and even particle size, good looking appearance obviously improves the particle appearance quality.The squeeze pressure scope of compressing grains machine can be floated at 45000N～150000N; When feeding at first; The feeding amount adopts less relatively squeeze pressure 45000N-6000N more at least; After feeding gets into normality, then adopt relatively large pressure 70000N～120000N extruding,, also can suitably increase squeeze pressure if the feeding amount is big.
Like Fig. 4, Fig. 5, Fig. 6 and shown in Figure 7, for further improving granular mass, said splitter box 51 is the sector diffuence groove, is shunting ridge 52 between the adjacent two sector diffuence grooves; Shunting ridge 52 is as separation between the sector diffuence groove and by-passing parts and gather the contacted part of charging tray, plays the effect of transmitting extruding force, and the sector diffuence groove is more shallow near the degree of depth of the part groove at middle part; Area is less, and extruding force is bigger, and corresponding material flow is less; And darker near the degree of depth of the part groove of circumference, area is bigger, and extruding force is less; Help giving full play to the homogenization of by-passing parts, make that the material bar linear velocity of extruding is more consistent, granule is more even.
For taking into account uniformity and easy to process, the number of sector diffuence groove is generally 4-7.
Like Fig. 5 and shown in Figure 6,, avoid template 3 local pressures excessive and damage for extruding force is delivered to extrusion die 3 uniformly; Should be provided with central boss 55 at the center of the exit side of said by-passing parts 5, be provided with back-up block 56 around the exit side, central boss 55 and back-up block 56 respectively with the center of extrusion die 3 with contact all around; Blow tank 53 is between central boss 55 and back-up block 56; Like this, the suffered pressure ratio of template is more even, also makes material to extrude more equably.
Like Fig. 4 and shown in Figure 6, for making things convenient for the location of by-passing parts 5, can be provided with in the supplied materials side of said by-passing parts 5 with centre bore 40 adaptive gather charging tray bayonet socket 54.
Shown in figure 11; Among the present invention; The screw rod 7 that double-screw type is extruded pay-off is provided with cooling structure; Said cooling structure be included in offer on the screw rod 7 with concentric blind hole of screw axis 70 and the inner cool tube 71 that is provided with cooling inlet 74; The cooling lid 72 that inner cool tube 71 passes this blind hole 70 of sealing stretch in the said blind hole 70 and its built-in length less than blind hole 70 degree of depth, cooling cover 72 and is had the cooling cover cavity 720 that is provided with coolant outlet 75, the cooling duct 700 that forms between inner cool tube 71 and the blind pore wall with cool off cover cavity 720 and be communicated with.This structure can feed cooling medium screw rod 7 is cooled off in running; Cooling medium is got into by cooling inlet 74, and the inner cool tube 71 of flowing through is flowed out by coolant outlet 75 with cooling duct 700, cooling cover cavity 720 backs, temperature arrising caused by friction in the time of can avoiding the equipment operation and the material viscosity that causes increases; Be prone to problems such as bonding; Guarantee normal discharging, for mechanical pelletizing provides precondition, the equipment that also makes can be applicable to the material extrusion granulator that viscosity is big.
For same purpose, as shown in Figure 1, can be on the such scheme basis, the barrel of extruding pay-off at double-screw type adds water collar 10 etc., and barrel is also lowered the temperature, and reaches better effect.
Shown in figure 11; Said inner cool tube 71 can be fixed on cooling through nut 73 and cover on 72, and said cooling lid 72 is fixedly connected with head 1, nut 73 and cooling off cover 72 can the while as the axial limiting structure of screw rod 7; Be limited to the axial displacement of extruding force screw rod 7 when excessive; Avoid two screw rods 7 to hang each other, improve the equipment reliability of operation, the equipment that also makes can be applicable to the material extrusion granulator that viscosity is big.
Be same purpose, on the such scheme basis, also can increase front end fixed disk 76 at the bearing side of screw rod 7, front end fixed disk 76 is fixedly connected with barrel, guarantees that screw rod 7 do not hang each other.
Like Fig. 8 and shown in Figure 9; For improving granular mass, said extrusion die 3 does not adopt common cylindrical hole, but at the supplied materials sidetracking macropore 31 of said extrusion die 3; The discharging sidetracking aperture 32 of extrusion die; Macropore 31 correspondences are communicated with one or two apertures 32 and form discharge opening 30, and material by further compression, obtains granule more closely through extrusion die 3 time like this.Consider the discharging uniformity; The aperture 32 of the exit side of extrusion die generally should be uniformly distributed with; Can be communicated with two apertures 32 with a macropore 31 more ground correspondences in the periphery of extrusion die 3, extrusion die 3 is communicated with an aperture 32 near the position at center with a macropore 31 more ground correspondences.
Usually, can bear bigger extruding force, guarantee that equipment also can normally move when the very big material of extruding viscosity for guaranteeing template; Give full play to the squeezing action in discharging hole 30 simultaneously; Said extrusion die 3 should have suitable thickness, and its thickness should reach more than the 30mm usually, considers the processing in hole; Thickness also should not be too thick, and its thickness generally is not more than 40mm.
Like Fig. 1, Figure 12 and shown in Figure 13; Since adopted extruding granulation mode, tightr from the material bar quality that extrusion die comes out, the rotary-cut cutter 6 cutting granulating that the exit side of available extrusion die 3 is provided with; Injure extrusion die 3 when avoiding rotary-cut cutter 6 operation and produce metal fillings; Its cutter hub is the elastic 60 that is convexly curved near the part on sword limit 61, then when feed is adjusted, make 61 two ends, sword limit can both with extrusion die 3 cutting of fitting well.
Be to increase extrusion pressure, said combination bore of gathering the centre bore 40 of charging tray 4 for taper hole and circular hole is promptly also pushed material gathering charging tray 4 places, and the equipment that makes can be applicable to the material extrusion granulator that viscosity is bigger.
Compressing grains facility of the present invention have powerful extrusion force (45000N～150000N); Reach 40～90% material for the dry extract amount; Also can mandatoryly extrude, cutting; Also can not influence the equipment operation too much, can't granulate owing to material contains extractum, the granulation mass density that obtains be at least greater than 0.78g/cm
3, scope is 0.78-0.9g/cm
3
Step B adopts compressing grains mechanism to be equipped with granule, and the granule that obtains through cold drying-high temperature puffing, dried then is in profile, flowability, and moisture absorption brews and all is superior to the granule for preparing than existing methods on the complexity; And preparation the time also finds, uses method for preparing of the present invention, can obviously reduce supplementary product consumption, and the minimizing patient takes in unnecessary adjuvant, reduces production costs.
Below prove beneficial effect of the present invention through the preparation instance, all adopt compressing grains of the present invention mechanism grain during granulation.
Get Herba Desmodii Styracifolii 1500g, the decocte with water secondary, each 1 hour, collecting decoction filtered, and filtrating is concentrated into relative density for degree 1.35 (50 ℃) thick paste, is dried to dry extract.The dry extract of following embodiment all adopts method for preparing.
Comparative Examples 1
(1) get extractum, it is an amount of to add cane sugar powder, processes granule, and bulk density is about 0.65g/cm
3, drying gets granule 1000g, is distributed into 100 bags and promptly gets.
(2) or get extractum, add an amount of dextrin and sweeting agent, process granule, bulk density is about 0.67g/cm
3, drying is processed 600g (Sugarless type) granule, is distributed into 100 bags, promptly gets.
Embodiment 1
Get dry extract, pulverize, adding sucrose is an amount of, processes granule, and bulk density is about 0.80g/cm
3, dried particles was kept 5 minutes under 65-95 ℃ hot conditions to water content 4-5% then at least under 50-60 ℃ cryogenic conditions earlier, and is expanded to granule; Keep the high-temperature condition again, below the dried particles moisture to 2%, the dry granule 250g that gets is distributed into 250 bags, promptly gets.
Embodiment 2
Get dry extract, pulverize, add an amount of dextrin and sweeting agent, process granule, bulk density is about 0.82g/cm
3, dried particles was kept 5 minutes under 75-95 ℃ hot conditions to water content 4-5% then at least under 40-60 ℃ cryogenic conditions earlier, and is expanded to granule; Keep this hot conditions again, below the dried particles moisture to 2%, the dry granule 250g that gets is distributed into 250 bags, promptly gets.[this granule is a Sugarless type]
Get dry extract, pulverize, add an amount of dextrin, process granule, bulk density is about 0.86g/cm
3, dried particles was kept 5 minutes under 65-95 ℃ hot conditions to water content 4-5% then at least under 40-60 ℃ cryogenic conditions earlier, and is expanded to granule; Keep this hot conditions again, below the dried particles moisture to 2%, the dry granule 250g that gets is distributed into 250 bags, promptly gets.[this granule is a Sugarless type]
Get dry extract, pulverize, mix suitable amount of sucrose, process granule, bulk density is about 0.80g/cm
3, first dried particles to water content 6% under 40-60 ℃ cryogenic conditions, then keep under 65-75 ℃ the hot conditions more than 15 minutes to below the pellet moisture to 2% yet for expanded situation occurring, granule 250g, be distributed into 250 bags.Particulate amorphous is prone to diffusing, broken, mobile relatively poor.
Embodiment 5
Get dry extract, pulverize, add an amount of dextrin, process granule, bulk density is about 0.82g/cm
3, first dried particles to water content 3% under 40-60 ℃ cryogenic conditions, then keep under 65-75 ℃ the hot conditions more than 15 minutes to below the pellet moisture to 2% yet for expanded situation occurring, granule 250g, be distributed into 250 bags, promptly get.Particulate amorphous is prone to diffusing, broken, mobile relatively poor.[this granule is a Sugarless type]
To sum up visible, the granule of existing prepared is an amorphous granular, is prone to diffusing, broken; Mobile relatively poor; And when adopting technology of the present invention if the cold drying water content exceeds the scope of 4-5%, under hot conditions, also can't reach expanded effect, like embodiment 4 and embodiment 5.And the obviously existing process shape of the profile of the logical swelling granular agent (embodiment 1-3) of the water solublity stranguria caused by urinary stone of prepared of the present invention is more attractive in appearance, and its smooth in appearance is fine and close, spherical particle, in the expanded phenomenon of cavity is arranged; Granule scope angle of repose is 10-25 °, and good fluidity is difficult for the moisture absorption; Supplementary product consumption is few; It is also easier to brew.
Claims (10)
1. the method for preparing of the logical swelling granular agent of water solublity stranguria caused by urinary stone, by following method preparation and get:
A, with the Herba Lysimachiae decocte with water, concentrate and to process extractum;
B, extractum processed soft material after, granulate, granulate is to crossing the 14-24 mesh sieve;
C, dried particles;
It is characterized in that:
The said granulation of step B is for processing bulk density greater than 0.78g/cm
3Granule;
The described dried particles of step C is to adopt following method:
(1) earlier under 40-60 ℃ cryogenic conditions dried particles to water content 4-5%;
(2) it is expanded under 65-95 ℃ hot conditions, to be heated to granule then;
(3) keep 65-95 ℃ of hot conditions again, below the dried particles moisture to 2%, promptly get granule.
2. the method for preparing of the logical swelling granular agent of water solublity stranguria caused by urinary stone according to claim 1 is characterized in that: step B processes refabrication soft material behind the dry extract with extractum.
3. the method for preparing of the logical swelling granular agent of water solublity stranguria caused by urinary stone according to claim 3 is characterized in that: described granulation is to adopt compressing grains machine compressed granulate;
Said compressing grains machine; Comprise that the double-screw type in the head (1) extrudes pay-off and extrude the discharge barrel (2) that pay-off cooperates with this; The exit of discharge barrel (2) is provided with the extrusion die (3) that has discharge opening (30); In the discharge barrel (2), extrude between pay-off and the extrusion die (3) at twin screw and to be provided with by-passing parts (5);
Wherein, Twin screw extrude be provided with between pay-off and the by-passing parts (5) with by-passing parts (5) each other by touch have a centre bore (40) gather charging tray (4); The supplied materials side of by-passing parts (5) is evenly equipped with splitter box (51); Splitter box (51) converges at the blow tank (53) of by-passing parts exit side, and blow tank (53) is corresponding with the discharge opening (30) of extrusion die (3).
4. the method for preparing of the logical swelling granular agent of water solublity stranguria caused by urinary stone according to claim 3, it is characterized in that: said splitter box (51) is the sector diffuence groove, is shunting ridge (52) between the adjacent two sector diffuence grooves.
5. according to the method for preparing of the logical swelling granular decoction pieces of claim 3 or 4 described water solublity stranguria caused by urinary stones; It is characterized in that: the center of the exit side of said by-passing parts (5) is provided with central boss (55); Be provided with back-up block (56) around the exit side; Central boss (55) and back-up block (56) respectively with the center of extrusion die (3) with contact all around, blow tank (53) is positioned between central boss (55) and the back-up block (56); Further preferably the supplied materials side of said by-passing parts (5) be provided with centre bore (40) adaptive gather charging tray bayonet socket (54).
6. according to the method for preparing of the logical swelling granular agent of claim 3 or 4 described water solublity stranguria caused by urinary stones; It is characterized in that: the screw rod (7) that said double-screw type is extruded pay-off is provided with cooling structure; Said cooling structure be included in offer on the screw rod (7) with the concentric blind hole of screw axis (70) and be provided with the inner cool tube (71) of cooling inlet (74); The cooling lid (72) that inner cool tube (71) passes this blind hole of sealing (70) stretch in the said blind hole (70) and its built-in length less than blind hole (70) degree of depth; Cooling lid (72) has the cooling cover cavity (720) that is provided with coolant outlet (75), the cooling duct (700) that forms between inner cool tube (71) and the blind pore wall with cool off cover cavity (720) and be communicated with; Further preferred said inner cool tube (71) is fixed on the cooling lid (72) through nut (73), and said cooling lid (72) is fixedly connected with head (1).
7. according to the method for preparing of the logical swelling granular agent of claim 3 or 4 described water solublity stranguria caused by urinary stones; It is characterized in that: the supplied materials side of said extrusion die (3) is macropore (31); The exit side of extrusion die is aperture (32), and a macropore (31) is corresponding to be communicated with one or two aperture (32) and formation discharge opening (30).
8. according to the method for preparing of the logical swelling granular agent of claim 3 or 4 described water solublity stranguria caused by urinary stones; It is characterized in that: the exit side of said extrusion die (3) is provided with rotary-cut cutter (6), and its cutter hub is the elastic (60) that is convexly curved near the part of sword limit (61).
9. according to the method for preparing of claim 3 or the logical swelling granular agent of 4 described water solublity stranguria caused by urinary stones, it is characterized in that: said combination bore of gathering the centre bore (40) of charging tray (4) for taper hole and circular hole.
Each described method for preparing preparation of claim 1-9 and the logical swelling granular agent of water solublity stranguria caused by urinary stone.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110088709.8A CN102727573B (en) | 2011-04-08 | 2011-04-08 | Water-soluble puffed granules for treating urolithiasis and preparation method thereof |
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| CN201110088709.8A CN102727573B (en) | 2011-04-08 | 2011-04-08 | Water-soluble puffed granules for treating urolithiasis and preparation method thereof |
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|---|---|---|---|---|
| CN101953883A (en) * | 2010-10-22 | 2011-01-26 | 重庆科瑞制药有限责任公司 | Chinese medicinal granules for treating calculosis and preparation method thereof |
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| CN101953883A (en) * | 2010-10-22 | 2011-01-26 | 重庆科瑞制药有限责任公司 | Chinese medicinal granules for treating calculosis and preparation method thereof |
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