CN102715399A - Blood sugar and insulin resistance level-controlling organic naked oat with whole germ - Google Patents
Blood sugar and insulin resistance level-controlling organic naked oat with whole germ Download PDFInfo
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- CN102715399A CN102715399A CN2012100089868A CN201210008986A CN102715399A CN 102715399 A CN102715399 A CN 102715399A CN 2012100089868 A CN2012100089868 A CN 2012100089868A CN 201210008986 A CN201210008986 A CN 201210008986A CN 102715399 A CN102715399 A CN 102715399A
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Abstract
The invention discloses a blood sugar and insulin resistance level-controlling organic naked oat with the whole germ. The blood sugar and insulin resistance level-controlling organic naked oat with the whole germ is planted in a semi-arid area of the northwest of China, allows a long duration of sunshine, does not need fertilization and watering, and belongs to an organic food. Through a unique processing technology, the whole germ is retained so that original nutritional values are not lost. 50 to 200g of the blood sugar and insulin resistance level-controlling organic naked oat with the whole germ is taken every day so that blood sugar and an insulin resistance level can be effectively controlled and regulated. Therefore, the blood sugar and insulin resistance level-controlling organic naked oat with the whole germ provides a theoretical basis and an actual value for improving occurrence rates of diabetes mellitus and complications of diabetes mellitus by diet.
Description
Technical field
The present invention relates to the organic full plumule naked oats of a kind of ability regulating and controlling blood sugar and insulin resistance level, belong to health care of food and field of medicaments.
Background technology
Diabetes are chronic diseases of a kind of serious threat public health, and China is one of maximum, fastest-rising country of illness rate of diabetic crowd in the world at present.Diabetology branch of Chinese Medical Association (CDS), International Diabetes Federation (IDF) unite the result who has issued a Chinese diabetes socioeconomic impact research.CDS and IDF estimate that the direct medical expenses that Chinese diabetes cause accounts for 13% of national medical total expenses, reach 1,734 hundred million RMB (25,000,000,000 dollars).Therefore seeking safely and effectively, food comes one of focus that becomes the life science field of early prevention and treatment diabetes and complication thereof.Discover, diet control, particularly edible whole grain food is one of main path of preventing and treating chronic disease.Oat is the full cereal that a kind of vital movement to living organism is useful or have physiological action, has higher nutritive value and health-care effect, and oat is divided into common oat (skin oat) and naked oats.China is the cradle and the main producing region of naked oats.The cereals nutrient composition that produce different regions is different, and different oats are also different to health affected, and the different production processing mode is different to the nutritional labeling influence of oat simultaneously.Organic full plumule naked oats (the organic naked oat with whole germ that this patent is related; ONOG) plant in NORTHWEST CHINA portion semiarid zone; Receive the influence of local geographical environment to have long, the characteristics such as do not water of not applying fertilizer of sunshine-duration; Belong to green organic food, its unique process technology can keep its whole plumules, and this technology has obtained the national inventing patent certificate, and (patent No. is: ZL 2,008 1 0105455.4; Patent name is: oat peeling equipment and peeling method), this has solved for thousands of years oat and can't " remove awns, broken wall, shell " and pained difficult pharynx, stodgy problem, and has kept the naked oats original nutritive value.Research about oat and Chronic Non-Communicable Diseases at present mainly concentrates on common oat (skin oat); And whether organic full plumule naked oats has the improvement effect to the blood sugar of diabetic and does not also have relevant report at present (this conclusion is looked into newly through Ministry of Education science and technology current awareness search work station; Report number is 201136000Z010426, sees Appendix 1).Therefore this research is through recruiting the experimenter, and employing epidemiological method (cohort study) is observed the intervention effect of organic full plumule naked oats to diabetes B patient (50-65 year) perspectively.
Summary of the invention
The objective of the invention is; The organic full plumule naked oats of a kind of ability regulating and controlling blood sugar and insulin resistance level is provided; The related organic full plumule naked oats of this product is planted in NORTHWEST CHINA portion semiarid zone, receives the influence of local geographical environment to have long, the characteristics such as do not water of not applying fertilizer of sunshine-duration, belongs to green organic food; Its unique process technology can keep plumule, and this technology has obtained the national inventing patent certificate, and (patent No. is: ZL 2,008 1 0105455.4; Patent name is: oat peeling equipment and peeling method), solve for thousands of years oat and can't " remove awns, broken wall, shell " and pained difficult pharynx, stodgy problem, and kept the naked oats original nutritive value.The present invention proposes the organic full plumule naked oats of edible 50 ~ 200 grams every day effectively regulating and controlling blood sugar and insulin resistance level, and this provides theoretical foundation and real value for the incidence of improving diabetes and complication thereof through diet.
Wherein said organic full plumule naked oats comprises the naked oats seed, naked oats congee, various former powder, rice and naked oats Related product and health food.
?
Specific embodiments
Research approach
1.1 research and design
At random, single blind, many groups of single center parallel tests, between the use group with self two kinds of control design.
Tried thing
(Organic Naked Oat with Whole Germ, ONOG), the natural oat industry of three staple food grains limited company provides organic full plumule naked oats by the Inner Mongol.Concrete nutritional labeling constitutes sees table 1.
The organic full plumule naked oats nutritional labeling of the every 100g of table 1. constitutes
| Nutrient | Content | Nutrient | Content |
| Energy (kJ) | 1623 | Lysine (mg) | ?560 |
| Carbohydrate (g) | 63.5 | Leucine (mg) | 1150 |
| Moisture (g) | ?10.3 | Tyrosine (mg) | ?480 |
| Protein (g) | 13.7 | Cystine (mg) | ?330 |
| Fat (g) | ?7.6 | Alanine (mg) | ?640 |
| Total fiber (g) | ?8.73 | Glutamic acid (mg) | 3300 |
| Beta glucan (g) | ?5.0 | Glycine (mg) | ?670 |
| Vitamin E (T) (mg) | 5.39 | Anthracene acid amides (ug) | ? 12 |
Research object
Recruit the volunteer in China, totally 813 people registration, wherein 567 people think through first trial maybe the Pass Test requirement, by the invite participation primary dcreening operation.The principle of voluntary participation is followed in this research, the design phase through Ethics Committee's audit approval, every patient signs Informed Consent Form with the staff of this research after fully understanding this research related content before the health check-up.
Include standard in:1. select after diet control or drug therapy the state of an illness more stable, do not change types of drugs and dosage, only take the adult diabetes B patient of maintenance dose, Kong Fuxuetang>7.8mmol/L (or) 2h Xue Tang > after the meal; 11.0mmol/L, Hb1Ac＞7.0%; 2. the age is at 50-65 between year; 3. sign Informed Consent Form; 4. can obey regulation according to research approach and tried thing the course of treatment.
Exclusion standard:1. type 1 diabetes patient; 2. gestation or women breast-feeding their children are to the given the test agent allergy sufferers at the right side of fifty or over-65s the age; 3. have the inclination, main organs complication such as liver, kidney, or be associated with other serious disease, the mental patient takes glucocorticoid or other influences blood sugar medicine person; 4. can not cooperate diet control and influence observed result person; 5. in nearly 3 months diabetic ketoacidosis and the infected are arranged; 6. take the article relevant in a short time, have influence on judgement person the result with being tried function; 7. all standards of including in that do not meet are not taken given the test agent by regulation, or data not umbra ring observed result person.
At random with blind method
Random digit sequence according to computer program produces is divided into 4 groups at random with the experimenter: conventional control group, meals control group, 50gONOG with meals control group and 100gONOG with meals control group.Before the experimenter formally got into test, the random digit sequence was packaged in the envelope, by not participating in experimenter special messenger's keeping.This test is a single blind trial owing to can't find the suitable placebo of ONOG, so the experimenter and responsible every day stroke the researcher can't be by blind; Lab assistant and data analyst are not known the grouping situation.
Research method
The experimenter all moves in the hotel, unified board and lodging.The experimenter divides to 4 groups at random, the suggestion of wherein conventional control group aspect before on-test, reaching the diabetes that give routine 1 the end of month, does not give other any interventions; All the other 3 groups give diet and life style education and structuring diet control, on this basis, 2 ONOG group also be asked to respectively with contain 50g or >=sowens (boiling 1.5h by ONOG processes) of 100gONOG substitutes the part staple food of breakfast and dinner.Duration of test, the experimenter is asked to keep physical exertion situation and medication constant.Before on-test and after intervening end in 1 month, the experimenter has respectively carried out a health check-up.
Observation index
1. ordinary circumstance investigation: use standardized questionnaire investigation experimenter's physical data, comprise sex, age, nationality, schooling, marital status, medicining condition, smoking history of drinking history, family history, personal illness history etc.;
2. physical examination: respectively at 0d and 30d the experimenter is carried out height, body weight, waistline, hip circumference and blood pressure determination, calculate BMI and waist-to-hipratio;
3. laboratory examination: gather venous blood, measure fasting blood-glucose, postprandial blood sugar, FPI, insulin, glycosylated hemoglobin (HbA1c), blood fat (T-CHOL, total triglycerides, HDL-C, LDL-C) hepatic and renal function and other safety indexes after the meal;
1.7 statistical method
All datas are all set up database with the EXCEL program, use SPSS 17.0 softwares the gained data is analyzed.Each is organized the difference of self and uses pairing T check carrying out statistical analysis.Be the comparative group differences, measurement data adopts one-way analysis of variance (One-Way ANOVE) or non-parametric test, and enumeration data adopts R * C contingency table frequency Chi-square Test, and α gets 0.05.
The result
2.1 organic full plumule naked oats is to the influence of healthy population blood sugar
Before carrying out the Study on effect of intervention of organic full plumule naked oats to diabetes B; For observing of the influence of organic full plumule naked oats to the non-diabetic people blood sugar level; 35 healthy volunteers have been carried out 1 month by a definite date meals intervention, intervening measure with 100gONOG with meals control group.Healthy volunteer's mean age is 33.6 ± 9.0 years old, and average BMI is 22.13 ± 3.13 kg/m
2, average HbA
1cBe 5.60 ± 0.91%, it is the male sex that 13 (37.1%) volunteers are wherein arranged.The demonstration of pairing T assay, the equal not statistically significant of the variation of the blood sugar of this healthy population of patients before and after intervention, blood fat, BMI (P>0.05).
The baseline data
Test is carried out in Baotou, Inner Mongolia Autonomous Region; Totally 445 experimenters are by in Random assignment to 4 group, wherein conventional control group 112 people, and 109 people are organized in meals control; 112 people are organized in the control of the organic full plumule naked oats of 50g (ONOG) meals, and 112 people are organized in the control of >=100gONOG meals.In the process of the test, 25 people lose visit rate group difference not statistically significant because of dropping by the wayside with the irrelevant individual reason of this test.Experimenter's physical data situation is seen table 2, and the baseline case of part final result index is seen table 3, table 4.Sex between 4 groups, age, schooling, BMI, WHR, the course of disease, medicining condition, FBG, PG, TG, TC, LDL-c etc. are carried out the harmony check, find group difference not statistically significant (P>0.05), guaranteed comparativity between group.
The variation (table 3) of patients before and after intervention blood sugar index of correlation
(1) compare with conventional control group, the fasting blood-glucose of its excess-three group and level of postprandial blood sugar have all had more significantly and to have descended (P<0.05); And the fasting blood-glucose decline situation more obvious (P=0.005) of the simple meals control group of>=100gONOG meals control group.
(2) through 1 month intervention, the glycosylated hemoglobin of conventional control group rose 0.03%, and its excess-three group all descends to some extent, is respectively 0.36%, 0.72% and 0.87%.Relatively find in twos between group, the difference not statistically significant (P=0.074) between meals control group and conventional control group, and ONOG meals control group than conventional control group descending water on average clearly (P=0.001, P=0.000); And the simple meals control group of >=100gONOG meals control group is to the improvement effect of Hb1Ac more obviously (P=0.016).
(3) patients before and after intervention, the insulin resistance situation of 3 groups of intervening has all obtained improvement in various degree, and wherein the insulin resistance of ONOG two groups of intervening improves situation difference has statistical significance (P<0.05);>=100gONOG meals control group is superior to conventional control group (P=0.000) and simple meals control group (P=0.015) to the improvement effect of insulin resistance.
The variation (table 4) of other indexs of patients before and after intervention
(1) research is also found, three groups that meals are intervened descend more obvious than conventional control group TG, but only>=and the difference of 100gONOG meals control group and conventional control group has statistical significance (P=0.000); ONOG meals control group also is superior to conventional control group and simple meals control group to the improvement effect of TC, LDL-C, and difference has statistical significance (P<0.05).
(2) before and after the test, the BMI of each group and weight average level all descend to some extent.Simple meals control group and 100gONOG meals control group are more obvious than the decline degree of conventional control group, and difference has statistical significance.
Table 2
Each is organized the physical data situation and gathers
1
1. descriptive statistic is: mean value (standard deviation) or median (range interquartile) or n (percentage);
2. waist-to-hipratio=waistline/hip circumference;
3. the P value (а=0.05) of each variable average between four groups being carried out variance analysis or non-parametric test.
Table 3 is respectively organized the variation of patients before and after intervention blood sugar index of correlation
1
1. descriptive statistic is: mean value (standard deviation) or median (range interquartile);
HOMA-IR, insulin resistance index=fasting blood-glucose * FPI/22.5;
HbA1c, glycosylated hemoglobin;
2. physical examination result and baseline result's difference for the second time;
3. the P value (ANOVA analyzes or Mann-Whitney non-parametric test) that compares in twos between intervention group (simple meals control group, 50g-ONOG meals control group, 100gONOG meals control group) and conventional control group;
4. the P value that compares in twos between ONOG intervention group (50g-ONOG meals control group, 100gONOG meals control group) and simple and meals control group (ANOVA analyzes or Mann-Whitney non-parametric test);
*. through paired t-test or Wilcoxon non-parametric test, self cross-reference P value < 0.05.
Table 4 is respectively organized blood fat (TG, TC, LDL-c, HLD-c), body weight and the BMI of patients before and after intervention
1
1. descriptive statistic is: mean value (standard deviation) or median (range interquartile);
TG, total triglycerides; TC, T-CHOL; LDL-c, LDL-C;
HDL-c, HDL-C; BMI, constitutional index=body weight (kg)/height (m)
2
2. physical examination result and baseline result's difference for the second time;
3. the P value (ANOVA analysis or Mann-Whitney non-parametric test) that compares in twos between intervention group (simple meals control group, 50g-ONOG meals control group, >=100gONOG meals control group) and conventional control group;
4. the P value that compares in twos between ONOG intervention group (50g-ONOG meals control group, >=100gONOG meals control group) and simple and meals control group (ANOVA analysis or Mann-Whitney non-parametric test);
*. through paired t-test or Wilcoxon non-parametric test,
self cross-reference P value; 0.05.
Research conclusion
The organic full plumule naked oats of edible 50 ~ 200 grams is after 30 days, and the blood sugar level of diabetic and insulin resistance level have had obvious improvement, and this shows that organic full plumule naked oats improves significantly to diabetic.
Claims (4)
1. can regulating and controlling blood sugar and the organic full plumule naked oats of insulin resistance level.
2. said by claim 1, wherein can regulating and controlling blood sugar and the organic full plumule naked oats of insulin resistance level, it is characterized in that not applying fertilizer and do not water, belong to organic food.
3. said by claim 1, wherein can regulating and controlling blood sugar and the organic full plumule naked oats of insulin resistance level, it is characterized in that keeping whole plumules, kept the naked oats original nutritive value.
4. by claim 1, organic full plumule naked oats comprises naked oats seed, naked oats congee, naked oats rice, the former powder of various naked oats, naked oats Related product (beverage) and health food.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110810694A (en) * | 2019-11-14 | 2020-02-21 | 王艳辉 | Special blood sugar reducing solid beverage for diabetic patients and preparation and use methods thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110810694A (en) * | 2019-11-14 | 2020-02-21 | 王艳辉 | Special blood sugar reducing solid beverage for diabetic patients and preparation and use methods thereof |
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Application publication date: 20121010 |