CN102712690A - 长效Exendin 4的类似物 - Google Patents

长效Exendin 4的类似物 Download PDF

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Publication number
CN102712690A
CN102712690A CN200980162062XA CN200980162062A CN102712690A CN 102712690 A CN102712690 A CN 102712690A CN 200980162062X A CN200980162062X A CN 200980162062XA CN 200980162062 A CN200980162062 A CN 200980162062A CN 102712690 A CN102712690 A CN 102712690A
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China
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glu
leu
exendin
gly
diabetes
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CN200980162062XA
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CN102712690B (zh
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吴晓琰
龚铁军
孙玉琨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

提供了Exendin 4类似物多肽。本发明的多肽与野生Exendin 4相比在C-端短7个氨基酸。肽链长度与人源GLP-1相近，所述肽的结构中仅含有一个Lys20残基，从而脂肪酸酰化专一地在Lys20的-NH2上发生，形成脂肪酸酰化衍生物。还提供了含有这样的多肽的药物组合物以及通过化学合成或重组DNA技术来生产所述多肽的方法。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN200980162062.XA 2009-11-26 2009-11-26 长效Exendin 4的类似物 Active CN102712690B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/001321 WO2011063549A1 (zh) 2009-11-26 2009-11-26 长效exendin4的类似物

Publications (2)

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CN102712690A true CN102712690A (zh) 2012-10-03
CN102712690B CN102712690B (zh) 2016-04-13

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ID=44065807

Family Applications (1)

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CN200980162062.XA Active CN102712690B (zh) 2009-11-26 2009-11-26 长效Exendin 4的类似物

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CN (1) CN102712690B (zh)
WO (1) WO2011063549A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193881A (zh) * 2013-04-22 2013-07-10 中国药科大学 一种可口服给药的降糖多肽衍生物及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101768446B1 (ko) * 2014-03-21 2017-08-17 애니젠 주식회사 신규한 엑세나타이드 유사체 및 그의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1746185A (zh) * 2004-09-06 2006-03-15 上海华谊生物技术有限公司 Exendin 4的类似物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1162446C (zh) * 2001-05-10 2004-08-18 上海华谊生物技术有限公司 促胰岛素分泌肽衍生物
CN100429227C (zh) * 2005-06-29 2008-10-29 常州制药厂有限公司 Exendin4多肽片段
US20090318353A1 (en) * 2006-08-25 2009-12-24 Novo Nordisk A/S Acylated Exendin-4 Compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1746185A (zh) * 2004-09-06 2006-03-15 上海华谊生物技术有限公司 Exendin 4的类似物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEN,Y.E. AND DRUCKER,D.J.: "P26349.2", 《UNIPROTKB/SWISS-PROT》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103193881A (zh) * 2013-04-22 2013-07-10 中国药科大学 一种可口服给药的降糖多肽衍生物及其用途

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Publication number Publication date
WO2011063549A1 (zh) 2011-06-03
CN102712690B (zh) 2016-04-13

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