CN102711758A - 用于治疗眼睛的疾病和病症的基于5-(1h-吡唑-5-基)噻唑的化合物 - Google Patents

用于治疗眼睛的疾病和病症的基于5-(1h-吡唑-5-基)噻唑的化合物 Download PDF

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Publication number
CN102711758A
CN102711758A CN201180006709.7A CN201180006709A CN102711758A CN 102711758 A CN102711758 A CN 102711758A CN 201180006709 A CN201180006709 A CN 201180006709A CN 102711758 A CN102711758 A CN 102711758A
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CN
China
Prior art keywords
alkyl
aryl
heteroaryl
halogen
optionally
Prior art date
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Pending
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CN201180006709.7A
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English (en)
Chinese (zh)
Inventor
尼科勒·卡斯利恩·古德温
戴维·布伦特·罗林斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lexicon Pharmaceuticals Inc
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Lexicon Genetics Inc
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Publication date
Application filed by Lexicon Genetics Inc filed Critical Lexicon Genetics Inc
Publication of CN102711758A publication Critical patent/CN102711758A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201180006709.7A 2010-01-22 2011-01-21 用于治疗眼睛的疾病和病症的基于5-(1h-吡唑-5-基)噻唑的化合物 Pending CN102711758A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29739710P 2010-01-22 2010-01-22
US61/297,397 2010-01-22
PCT/US2011/021970 WO2011091204A1 (en) 2010-01-22 2011-01-21 5-(1h-pyrazol-5-yl)thiazole-based compounds for the treatment of diseases and disorders of the eye

Publications (1)

Publication Number Publication Date
CN102711758A true CN102711758A (zh) 2012-10-03

Family

ID=43760212

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180006709.7A Pending CN102711758A (zh) 2010-01-22 2011-01-21 用于治疗眼睛的疾病和病症的基于5-(1h-吡唑-5-基)噻唑的化合物

Country Status (8)

Country Link
US (1) US20130059896A1 (OSRAM)
EP (1) EP2525794A1 (OSRAM)
JP (1) JP2013518048A (OSRAM)
CN (1) CN102711758A (OSRAM)
AU (1) AU2011207280A1 (OSRAM)
CA (1) CA2786730A1 (OSRAM)
IN (1) IN2012DN06061A (OSRAM)
WO (1) WO2011091204A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012170951A2 (en) * 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
US9856240B2 (en) 2011-10-19 2018-01-02 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2018055097A1 (en) 2016-09-23 2018-03-29 Cellipse Lim kinase inhibitors, pharmaceutical composition and method of use in limk-mediated diseases
CN115197166B (zh) * 2022-07-11 2024-07-02 安徽英瑞骐生物科技有限公司 一种4-甲基-2-肼基苯并噻唑的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020447A1 (en) * 1997-09-11 2000-07-19 Nissan Chemical Industries, Ltd. Pyrazole compounds and plant disease control agent
WO2004047868A1 (ja) * 2002-11-27 2004-06-10 Santen Pharmaceutical Co., Ltd. Limキナーゼ阻害作用を有する化合物を有効成分とする緑内障治療剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
CA2449289A1 (en) 2001-06-05 2002-12-12 Exelixis, Inc. Gfats as modifiers of the p53 pathway and methods of use
WO2003003016A1 (en) 2001-06-27 2003-01-09 The Walter And Eliza Hall Institute Of Medical Research Diagnostic methods and agents
TWI336257B (en) 2003-06-13 2011-01-21 Alcon Inc Ophthalmic compositions containing a synergistic combination of three polymers
EP2532239A3 (en) 2007-04-03 2013-03-13 E. I. du Pont de Nemours and Company Substituted benzene fungicides
HUE025788T2 (en) 2007-08-08 2016-04-28 Lexicon Pharmaceuticals Inc (7H-pyrrolo [2,3-D] pyrimidin-4-yl) piperazines as kinase inhibitors for the treatment of cancer and inflammation
MX2010011450A (es) 2008-04-21 2010-11-10 Lexicon Pharmaceuticals Inc Inhibidores del limk2, composiciones que los comprenden y metodos para su uso.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020447A1 (en) * 1997-09-11 2000-07-19 Nissan Chemical Industries, Ltd. Pyrazole compounds and plant disease control agent
WO2004047868A1 (ja) * 2002-11-27 2004-06-10 Santen Pharmaceutical Co., Ltd. Limキナーゼ阻害作用を有する化合物を有効成分とする緑内障治療剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PETRA ROSS-MACDONALD ET AL.: "Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors", 《MOLECULAR CANCER THERAPEUTICS》, vol. 7, no. 11, 30 November 2008 (2008-11-30), pages 3490 - 3498, XP008134900, DOI: 10.1158/1535-7163.MCT-08-0826 *

Also Published As

Publication number Publication date
AU2011207280A1 (en) 2012-07-19
JP2013518048A (ja) 2013-05-20
WO2011091204A1 (en) 2011-07-28
IN2012DN06061A (OSRAM) 2015-09-18
CA2786730A1 (en) 2011-07-28
EP2525794A1 (en) 2012-11-28
US20130059896A1 (en) 2013-03-07

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Application publication date: 20121003