CN102703547B - Method for producing glucose bulk drug for injection by using rice - Google Patents
Method for producing glucose bulk drug for injection by using rice Download PDFInfo
- Publication number
- CN102703547B CN102703547B CN 201210195837 CN201210195837A CN102703547B CN 102703547 B CN102703547 B CN 102703547B CN 201210195837 CN201210195837 CN 201210195837 CN 201210195837 A CN201210195837 A CN 201210195837A CN 102703547 B CN102703547 B CN 102703547B
- Authority
- CN
- China
- Prior art keywords
- sugar
- rice
- temperature
- glucose
- crystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 43
- 235000007164 Oryza sativa Nutrition 0.000 title claims abstract description 36
- 235000009566 rice Nutrition 0.000 title claims abstract description 36
- 239000008103 glucose Substances 0.000 title claims abstract description 26
- 238000002347 injection Methods 0.000 title claims abstract description 16
- 239000007924 injection Substances 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 title claims abstract description 10
- 229940079593 drug Drugs 0.000 title claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 title abstract description 12
- 240000007594 Oryza sativa Species 0.000 title 1
- 241000209094 Oryza Species 0.000 claims abstract description 35
- 238000002425 crystallisation Methods 0.000 claims abstract description 29
- 230000008025 crystallization Effects 0.000 claims abstract description 29
- 238000005342 ion exchange Methods 0.000 claims abstract description 19
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 16
- 239000002893 slag Substances 0.000 claims abstract description 10
- 238000009835 boiling Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 5
- 238000010924 continuous production Methods 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 238000004806 packaging method and process Methods 0.000 claims abstract description 4
- 238000007670 refining Methods 0.000 claims abstract description 4
- 239000013078 crystal Substances 0.000 claims description 28
- 239000007788 liquid Substances 0.000 claims description 26
- 238000007599 discharging Methods 0.000 claims description 19
- 238000004042 decolorization Methods 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 238000012546 transfer Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 235000020265 peanut milk Nutrition 0.000 claims description 15
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- 229920001353 Dextrin Polymers 0.000 claims description 10
- 239000004375 Dextrin Substances 0.000 claims description 10
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 235000019425 dextrin Nutrition 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 7
- 229910052740 iodine Inorganic materials 0.000 claims description 7
- 239000011630 iodine Substances 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- 235000017550 sodium carbonate Nutrition 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- 235000013339 cereals Nutrition 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 4
- 229960004793 sucrose Drugs 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 238000004061 bleaching Methods 0.000 claims description 3
- 230000002950 deficient Effects 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000009826 distribution Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 229910001651 emery Inorganic materials 0.000 claims description 3
- 239000011552 falling film Substances 0.000 claims description 3
- 239000010408 film Substances 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 230000035807 sensation Effects 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 abstract description 6
- 238000000855 fermentation Methods 0.000 abstract description 3
- 230000004151 fermentation Effects 0.000 abstract description 3
- 238000009395 breeding Methods 0.000 abstract description 2
- 230000001488 breeding effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 abstract description 2
- 238000005119 centrifugation Methods 0.000 abstract 2
- 206010022998 Irritability Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000002791 soaking Methods 0.000 abstract 1
- 229960001031 glucose Drugs 0.000 description 19
- 229920002472 Starch Polymers 0.000 description 10
- 235000019698 starch Nutrition 0.000 description 10
- 239000008107 starch Substances 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 229960000673 dextrose monohydrate Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000011169 microbiological contamination Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
Description
Test item | 2010 editions " Chinese Pharmacopoeia standard " | Detected result |
Proterties | It is sweet that colourless or white crystalline powder does not have stink | Qualified |
Differentiate | Should be up to specification | Qualified |
Specific optical rotation | +52.6°- +53.2° | Qualified (+53.1 °) |
Acidity | Should be up to specification | Qualified |
The clarity of solution and color | Should be up to specification | Qualified (<1#) |
The clarity of ethanolic soln | Should be up to specification | Qualified |
Muriate | ≤100ppm | Qualified (≤30ppm) |
Vitriol | ≤0.01% | Qualified |
Sulphite and Zulkovsky starch | Should be up to specification | Qualified |
Weight loss on drying | ≤1.0% | Qualified (0.5%) |
Residue on ignition | ≤0.1% | Qualified (<0.02%) |
Protein | Should be up to specification | Qualified |
Barium salt | Should be up to specification | Qualified |
Calcium salt | ≤0.01% | Qualified |
Molysite | ≤0.001% | Qualified |
Heavy metal | ≤5ppm | Qualified (1ppm) |
Arsenic salt | ≤0.0001% | Qualified |
Microbial limit detects | Should be up to specification | Qualified |
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210195837 CN102703547B (en) | 2012-06-14 | 2012-06-14 | Method for producing glucose bulk drug for injection by using rice |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210195837 CN102703547B (en) | 2012-06-14 | 2012-06-14 | Method for producing glucose bulk drug for injection by using rice |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102703547A CN102703547A (en) | 2012-10-03 |
CN102703547B true CN102703547B (en) | 2013-09-25 |
Family
ID=46896593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 201210195837 Expired - Fee Related CN102703547B (en) | 2012-06-14 | 2012-06-14 | Method for producing glucose bulk drug for injection by using rice |
Country Status (1)
Country | Link |
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CN (1) | CN102703547B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103525887B (en) * | 2013-10-21 | 2015-09-09 | 诸城东晓生物科技有限公司 | A kind of crystalline dextrose production method of energy-conserving and environment-protective |
CN103725731B (en) * | 2013-12-30 | 2015-09-02 | 河南飞天农业开发股份有限公司 | Special crystalline dextrose of Sunmorl N 60S and preparation method thereof |
CN104498560A (en) * | 2014-12-23 | 2015-04-08 | 开封市四达农产品设备有限公司 | Liquefaction process and liquefaction equipment of glucose syrup |
CN104862428B (en) * | 2015-05-12 | 2018-01-16 | 华南理工大学 | The sugar-free grains enrichment and separation device and method of a kind of enzyme process starch sugar |
CN104928405A (en) * | 2015-05-22 | 2015-09-23 | 山东祥瑞药业有限公司 | Technique for extracting glucose from starch saccharified liquid |
CN107287110A (en) * | 2016-04-11 | 2017-10-24 | 天津职业技术师范大学 | Applied to the Predictive Control System in injection sugar production |
CN108251471A (en) * | 2017-12-09 | 2018-07-06 | 吉林中粮生化有限公司 | A kind of method of paddy sugaring |
CN108676827B (en) * | 2018-05-30 | 2020-12-29 | 湖南汇升生物科技有限公司 | Method for producing maltose raw material medicine for injection |
CN111500794A (en) * | 2020-04-15 | 2020-08-07 | 潍坊盛泰药业有限公司 | Production method of water-containing glucose |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101555508B (en) * | 2009-05-20 | 2012-05-30 | 万福生科(湖南)农业开发股份有限公司 | Method for preparing crystalline dextrose by rice |
CN101872677A (en) * | 2010-04-21 | 2010-10-27 | 东莞市艾炜特电子有限公司 | Current mutual inductor |
CN101831477A (en) * | 2010-05-21 | 2010-09-15 | 万福生科(湖南)农业开发股份有限公司 | Method for preparing rice into glucose for injection |
-
2012
- 2012-06-14 CN CN 201210195837 patent/CN102703547B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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CN102703547A (en) | 2012-10-03 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20151123 Address after: 415701 Changde city of Hunan province zoushi town unity Road community Guihua Road No. 1 Patentee after: Taoyuan Wanfu cereals and oils processing and Management Co.,Ltd. Address before: Guihua Road zoushi town of Taoyuan County in Hunan province Changde City, No. 1, 415700 Patentee before: Wanfu Biotechnology (Hunan) Agricultural Development Co.,Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180911 Address after: 100000 623 six, 3 building, 52 Zhongguancun South Street, Haidian District, Beijing. Patentee after: Beijing Jia Wo Zhen Cheng Technology Co.,Ltd. Address before: 415701 Guihua Road 1, Tuen Road community, Changde City, Hunan Patentee before: Taoyuan Wanfu cereals and oils processing and Management Co.,Ltd. |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130925 |