CN102698221B

CN102698221B - Traditional Chinese medicine for treating acute cholecystitis, preparation method and application

Info

Publication number: CN102698221B
Application number: CN2012101567871A
Authority: CN
Inventors: 高忠诚; 张连芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-05-09
Filing date: 2012-05-09
Publication date: 2013-07-31
Anticipated expiration: 2032-05-09
Also published as: CN102698221A

Abstract

The invention provides a traditional Chinese medicine for treating acute cholecystitis, which comprises the ingredients of agastache rugosus, codonopsis pilosula, liquorice, rheum officinale, ginger, capillary artemisia, rough gentian, radix gentianae, atractylodes, white paeony root, celandine, trichosanthes kirilowii maxim, waxgourd peel, rabdosia rubescens, eupatorium, semen brassicae, swertia mileensis, grifola and radix curcumae. According to the traditional Chinese medicine for treating acute cholecystitis and the preparation method of the traditional Chinese medicine provided by the invention, various defects caused by modern medicine can be overcome, so the curative effect is improved and the treatment time is shortened.

Description

A kind of Chinese medicine, preparation method and application for the treatment of acute cholecystitis

Technical field

The present invention relates to the pharmaceutical engineering technical field, relate in particular to a kind of Chinese medicine that is used for acute cholecystitis.

Background technology

Cholecystitis is with the pain over the hypochondriac region and take on the back radiation to the right, nausea and vomiting, and degradation is a main clinical manifestation under the appetite.For gallbladder because of antibacterial or other factors infect, cause gallbladder wall and neck of gallbladder congestion and edema, even and surrounding tissue stick together, bile excretion is obstructed, and neck of gallbladder and cystic duct shrink simultaneously, and bile is concentrated, be difficult for discharging, cause antibacterial and breed in a large number, increase the weight of the gallbladder inflammation.

Acute cholecystitis is a kind of in the cholecystitis, and it is clinically commonly encountered diseases, frequently-occurring disease, often merges cholelithiasis.Clinical symptoms shows as heating, upper right abdomen pain and tenderness, pain often is radiated to shoulder, omoplate portion and back, performances such as the companion feels sick, vomiting, slight jaundice and peripheral blood leucocyte counting increase, normal because cystic duct blocks, chemical irritation and the caused acute cholecystitis disease of bacterial infection sexually transmitted disease (STD) become.

Along with the change of dietary habit and living habit, acute cholecystitis becomes one of several principal diseases of the daily people of influence healthy and quality of life.Get to the bottom of sb.'s illness, modern medicine think block with infection be this pathogenetic two big principal element.Modern medicine adopts internal medicine spasmolytic function of gallbladder promoting, antibiotic Supporting Therapy except that to there being surgical operation indication patient to adopt the cholecystectomy radical cure to Most patients more in the treatment, and how not obvious curative effect is.

Acute cholecystitis belongs to Chinese medicine " gallbladder-distention " " hypochondriac pain " " stomachache " sick categories such as " jaundice ", the many and eating and drinking without temperance of its cause of disease, and disorder of emotion, factors such as overstrain are relevant.The thick greasy or unclean thing of surfeit delicious food and hungry full immoderate, long-pending humidifying expectorant of a specified duration are given birth to heat and are stopped up and hold back middle Jiao, so that liver and gall lose in catharsis, thereby gastral cavity side of body feeling of distension and oppression pain, nausea and vomiting; Or disorder of emotion, it is angry to be worried, the liver and gall dysfunction of acting as a pivot, bile is logical fall not smooth, stagnated QI transforming into fire, venation is become estranged, and satisfies into hypochondriac pain, gallbladder-distention." Ling Shu Miraculous Pivot or Divine Axis expands and discusses " said:

The gallbladder-distention person, distending pain in the hypochondrium, bitter in mouthful, sighing frequently

As seen the primary disease pathological characteristic is a dysfunction of SHAO YANG, and damp and hot malicious heresy is pented up three warmers, the gallbladder internal organs is logical fall not normal.According to primary disease clinical manifestation and the relevant dialectical clause of Zhang Zhongjing treatise on Febrile Diseases, primary disease can be summed up as Shaoyang disease, even few Yang Yangming combination of syndromes disease involving all three YANG meridians.Few sun is for regulating the hinge of whole body mechanism of qi, a variety of causes such as stagnation of QI due to depression of the liver close in damp and hot, and blood stasis is stagnated and caused the dysfunction of SHAO YANG bile excretion to be obstructed, gastrointestinal retention is obstructed, bile can not catharsis and deposit benefit very, even the whole body that overflows, and satisfies and sends out a primary disease, based on this, the present invention adopts the Chinese medicine acute cholecystitis, and with depressed liver-energy dispersing and QI regulating, the function of gallbladder promoting removing dampness is the Therapeutic Principle.

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine that is used for the treatment of acute cholecystitis and preparation method thereof is provided, and it can overcome the various defectives that modern medicine brings, and improves curative effect, shortens treatment time.

Ask in order to solve above-mentioned technology, the invention provides a kind of Chinese medicine composition for the treatment of acute cholecystitis, it comprises: Herba Pogostemonis, Radix Codonopsis, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Artemisiae Scopariae, Radix Gentianae, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Herba Chelidonii, Fructus Trichosanthis, Exocarpium Benincasae, Rabdosia rubescens, Herba Eupatorii, Semen Sinapis Albae, Herba Swertiae Mileensis, Polyporus and Radix Curcumae.

Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is:

Herba Pogostemonis 5～15 weight portions, Radix Codonopsis 15～25 weight portions, Radix Glycyrrhizae 10～20 weight portions, Radix Et Rhizoma Rhei 5～15 weight portions, Rhizoma Zingiberis Recens 20～30 weight portions, Herba Artemisiae Scopariae 10～20 weight portions, Radix Gentianae 50～60 weight portions, Radix Glehniae 20～30 weight portions, the Rhizoma Atractylodis Macrocephalae 20～30 weight portions, the Radix Paeoniae Alba 20～30 weight portions, Herba Chelidonii 5～15 weight portions, Fructus Trichosanthis 10～20 weight portions, Exocarpium Benincasae 10～20 weight portions, Rabdosia rubescens 5～15 weight portions, Herba Eupatorii 5～15 weight portions, Semen Sinapis Albae 15～25 weight portions, Herba Swertiae Mileensis 15～25 weight portions, Polyporus 20～30 weight portions and Radix Curcumae 20～30 weight portions.

Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is more preferably:

Herba Pogostemonis 10～15 weight portions, Radix Codonopsis 20～25 weight portions, Radix Glycyrrhizae 15～20 weight portions, Radix Et Rhizoma Rhei 10～15 weight portions, Rhizoma Zingiberis Recens 25～30 weight portions, Herba Artemisiae Scopariae 15～20 weight portions, Radix Gentianae 55～60 weight portions, Radix Glehniae 25～30 weight portions, the Rhizoma Atractylodis Macrocephalae 25～30 weight portions, the Radix Paeoniae Alba 25～30 weight portions, Herba Chelidonii 10～15 weight portions, Fructus Trichosanthis 15～20 weight portions, Exocarpium Benincasae 15～20 weight portions, Rabdosia rubescens 10～15 weight portions, Herba Eupatorii 10～15 weight portions, Semen Sinapis Albae 20～25 weight portions, Herba Swertiae Mileensis 20～25 weight portions, Polyporus 25～30 weight portions and Radix Curcumae 25～30 weight portions.

Wherein, can further add Herba Hedyotidis Diffusae on the basis of above-mentioned Chinese medicine, the weight fraction of described Herba Hedyotidis Diffusae in described Chinese medicine is 15～25 weight portions.

Wherein, can further add Caulis Bambusae In Taenia on the basis of above-mentioned Chinese medicine, the weight fraction of described Caulis Bambusae In Taenia in described Chinese medicine is 20～30 weight portions.

Wherein, can further add Concha Ostreae and Endothelium Corneum Gigeriae Galli on the basis of above-mentioned Chinese medicine, described Concha Ostreae and the Endothelium Corneum Gigeriae Galli weight fraction in described Chinese medicine is Concha Ostreae 5～10 weight portions, Endothelium Corneum Gigeriae Galli 5～10 weight portions.

The present invention also provides above-mentioned preparation method of Chinese medicine, and it comprises:

The first step is mixed in proportion described component, puts into marmite and fries 20 minutes～40 minutes, is ground into smalls with pulverizer, is screened into 100 orders～200 purpose powder;

Second step, the determining alcohol that the powder quality that adding obtains with respect to the first step is 2～4 times is 70～80% ethanol, reflux 1～3 hour is extracted merge extractive liquid, 2～3 times, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, being recycled to does not have the alcohol flavor, and the medicinal residues that filtration obtains add the distilled water with respect to 4～8 times of filtering residue quality again, the each decoction 1～3 hour, decoct 2～3 times, filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure removes and desolvates, drying obtains and gets dry extract;

The 3rd step was broken into 200 orders～400 purpose powder with described dried cream powder, added various auxiliary additives and prepared needed various dosage form.

Wherein, when the dosage form of described Chinese medicine is syrup, described the 3rd step is for adding the water dissolution with respect to 2～3 times of powder qualities in the powder after pulverizing, regulate pH value to 7.0 with 40% sodium hydroxide solution, add correctives sucrose, antiseptic mix homogeneously subsequently, promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.

Wherein, when the dosage form of described Chinese medicine is capsule, described the 3rd step further be included in add in the powder of acquisition excipient, disintegrating agent mix, dry, pulverize, add fluidizer, in incapsulating at last, obtain capsule, described excipient is starch, dextrin, carboxymethyl starch, calcium hydrogen phosphate and other pharmaceutic adjuvants, and its weight content in described capsule is 5～60%; Described disintegrating agent is sodium carboxymethyl cellulose, hydroxypropyl cellulose and pharmaceutic adjuvant with water swelling, and its weight content in described capsule is 1～20%; Described fluidizer (lubricant) is that magnesium stearate, differential silica gel and other have the pharmaceutic adjuvant of fluidizer effect, and its weight content in described capsule is 0.1～5%.

The present invention also provides above-mentioned Chinese medicine composition, its application in the medicine that is used for the treatment of acute cholecystitis of the various dosage forms of preparation.

Beneficial effect of the present invention:

Chinese medicine that is used for the treatment of acute cholecystitis provided by the invention and preparation method thereof, it can overcome the various defectives that modern medicine brings, and improves curative effect, shortens treatment time.

The specific embodiment

The invention provides a kind of Chinese medicine composition for the treatment of acute cholecystitis, it comprises: Herba Pogostemonis, Radix Codonopsis, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Artemisiae Scopariae, Radix Gentianae, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Herba Chelidonii, Fructus Trichosanthis, Exocarpium Benincasae, Rabdosia rubescens, Herba Eupatorii, Semen Sinapis Albae, Herba Swertiae Mileensis, Polyporus and Radix Curcumae.

For the patient of hyperpyrexia, can on the basis of above-mentioned Chinese medicine, further add Herba Hedyotidis Diffusae, the weight fraction of described Herba Hedyotidis Diffusae in described Chinese medicine is 15～25 weight portions.

For the patient of nausea and vomiting, can on the basis of above-mentioned Chinese medicine, further add Caulis Bambusae In Taenia, the weight fraction of described Caulis Bambusae In Taenia in described Chinese medicine is 20～30 weight portions.

For patient with cholelithiasis, can on the basis of above-mentioned Chinese medicine, further add Concha Ostreae and Endothelium Corneum Gigeriae Galli, described Concha Ostreae and the Endothelium Corneum Gigeriae Galli weight fraction in described Chinese medicine is Concha Ostreae 5～10 weight portions, Endothelium Corneum Gigeriae Galli 5～10 weight portions.

Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.

The Chinese medicine composition syrup of embodiment 1 the present invention preparation

With Herba Pogostemonis 10g, Radix Codonopsis 20g, Radix Glycyrrhizae 15g, Radix Et Rhizoma Rhei 10g, Rhizoma Zingiberis Recens 25g, Herba Artemisiae Scopariae 15g, Radix Gentianae 55g, Radix Glehniae 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Paeoniae Alba 25g, Herba Chelidonii 10g, Fructus Trichosanthis 15g, Exocarpium Benincasae 15g, Rabdosia rubescens 10g, Herba Eupatorii 10g, Semen Sinapis Albae 20g, Herba Swertiae Mileensis 20g, Polyporus 25g and Radix Curcumae 25g mix, putting into marmite fried 30 minutes, be ground into smalls with pulverizer, be screened into 100 purpose powder, the determining alcohol that adds 1150g is 80% ethanol, reflux 3 hours, extract 3 times, merge extractive liquid,, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to and do not have the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 2000g again, the each decoction 2 hours, decoct 3 times, filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure removes and desolvates drying, obtain and get dry extract, dried cream powder is broken into 400 purpose powder, adds the water dissolution of 800g, regulate pH value to 7.0 with 40% sodium hydroxide solution, add 300g sucrose subsequently, 35g ethyl hydroxybenzoate mix homogeneously promptly gets syrup.

The Chinese medicinal composition capsules agent of embodiment 2 the present invention preparation

With Herba Pogostemonis 10g, Radix Codonopsis 20g, Radix Glycyrrhizae 15g, Radix Et Rhizoma Rhei 10g, Rhizoma Zingiberis Recens 25g, Herba Artemisiae Scopariae 15g, Radix Gentianae 55g, Radix Glehniae 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Paeoniae Alba 25g, Herba Chelidonii 10g, Fructus Trichosanthis 15g, Exocarpium Benincasae 15g, Rabdosia rubescens 10g, Herba Eupatorii 10g, Semen Sinapis Albae 20g, Herba Swertiae Mileensis 20g, Polyporus 25g and Radix Curcumae 25g mix, putting into marmite fried 30 minutes, be ground into smalls with pulverizer, be screened into 100 purpose powder, the determining alcohol that adds 1150g is 80% ethanol, reflux 3 hours, extract 3 times, merge extractive liquid,, filter and obtain alcohol extract, the alcohol extract concentrating under reduced pressure, be recycled to and do not have the alcohol flavor, filter the distilled water that the medicinal residues that obtain add 2000g again, the each decoction 2 hours, decoct 3 times, filter respectively, merging filtrate gets the water extract, water extract concentrating under reduced pressure, mix with the concentrated solution of the alcohol extract that obtains previously, further concentrating under reduced pressure removes and desolvates drying, obtain and get dry extract, dried cream powder is broken into 400 purpose powder, adds 300g starch, the 40g hydroxypropyl cellulose mixes, dry, pulverize, add the 3g magnesium stearate, in incapsulating at last, obtain capsule.

Embodiment 3 clinical experiments

1.1 basic clinical data

Select acute cholecystitis patient 240 examples in year October in May, 2008 to 2011, make a definite diagnosis, male's 108 examples wherein, women's 132 examples according to the diagnostic criteria of " practical internal medicine " (the 12nd edition); 15～79 years old age, average (34 ± 9) year; Stomachache, heating are all arranged, stomachache be positioned at right upper quadrant of the abdomen or xiphoid-process down and with feel sick, vomiter's 185 examples, 37.5～38.9 ℃ of person's 170 examples of body temperature, 39～39.9 ℃ of person's 170 examples of body temperature, body temperature person's 170 examples more than 40 ℃; Jaundice person's 129 examples appear, neutrophilic leukocyte rising person 198 examples.Be divided into treatment group and each 120 example of matched group by the table of random number method.Differences such as two groups of patient's sexes, age, symptom do not have significance (P＞0.05), have comparability.

1.2 diagnostic criteria

1. symptom is formulated in reference " clinical disease diagnosis is according to curing the improvement standard ": upper right abdomen constant pain, and paroxysmal increases the weight of, and shoulder radiation to the right, and the companion feels sick, vomits and heating; 2. sign: upper right abdominal pressure pain, muscle tonus, Fei Shi does not levy the positive, can lay one's hand on sometimes and enlargement gallbladder that tool is touched a tender spot; 3. blood test: total white blood cells and neutrophilic granulocyte counting significantly raise, and part has liver function change, serum total bilirubin slightly to increase; 4. ultrasound diagnosis: the gallbladder enlargement, cyst wall thickens, visible foreign matters ripple, light group, sound shadow.

1.3 get rid of the case standard

1. important organ dysfunction persons such as severe cardiac, liver, kidney are arranged; 2. gestation or women breast-feeding their children, allergic constitution person; 3. be associated with severe complication and be badly in need of the operative treatment person, as perforation of gallbladder, acute diffuse peritonitis or the pancreatitis of acute necrosis type etc.; 4. single calculus＞0.5cm person is pointed out in ultrasound diagnosis; 5. ultrasound diagnosis prompting neck of gallbladder does not obviously block the person; 6. be stomach most of excision, especially Billrath II formula person.

1.4 Therapeutic Method

Two groups of equal fasting, water (except the medicine) with the serious vomiter arrangement gastrointestinal decompression of still needing, give suitable fluid infusion, correct water, electrolyte disturbance, keep acid-base balance.The conventional antibacterials of using of matched group, based on the 3rd generation cephalosporin and quinolones, look the state of an illness and add and use the spasmolysis and analgesia medicine.The treatment group adopts the syrup of the embodiment of the invention 1 preparation.3 doses of every days.

1.5 observation item

The observation patient suffers from abdominal pain and disappears and abdominal distention remission time and other clinical symptoms and sign.

1.6 criterion of therapeutical effect

Symptom, sign are alleviated in clinical recovery: the 3d; Symptom, sign disappear in the 7d, and the every index of lab testing is all normal.Symptom, sign significantly alleviate in produce effects: the 7d, and every laboratory is an a little higher than normal value normally or only.Effectively: symptom, sign alleviate in the 7d, and every lab testing is significantly improved.Invalid: symptom, sign are not seen obvious improvement in the 7d, even worsen or change hands the art treatment.

1.7 statistical analysis

Use the SPSS10.0 statistical software.Measurement data with

Variance analysis and chi-square criterion are adopted in expression.

1.8 result

Two groups of clinical efficacies relatively see Table 1.The result shows that treatment group curative effect is better than matched group (P＜0.05).

Table 1 liang group clinical efficacy is n (%) relatively

Group	n	Recovery from illness	Produce effects	Effectively	Invalid	Effectively total
							The treatment group	120	93(77.5)	13(10.8)	11(9.2)	3(2.5)	117(97.5) ^*
Matched group	120	56(46.7)	18(15.0)	29(24.2)	17(14.2)	103(85.8)

Compare with matched group, ^*P＜0.05.

Two groups of stomachache disappears and the abdominal distention remission time relatively sees Table 2.The result shows that the treatment group all is shorter than matched group (P＜0.01).

Table 2 liang group stomachache disappearance and the comparison of abdominal distention remission time (h,

Group	n	The stomachache extinction time	The abdominal distention remission time
				The treatment group	120	50±12 ^**	45±12 ^**
Matched group	120	72±17	92±27

Compare with matched group, ^*P＜0.01.

Body temperature before and after two groups of treatments, numeration of leukocyte relatively the results are shown in Table 3.

Body temperature before and after the table 3 liang group treatment, numeration of leukocyte relatively

There is no untoward reaction in two groups of patient treatment processes and take place, hematuria routine and blood electrolyte, hepatic and renal function inspection, electrocardiogram are not all found obviously unusual before and after the treatment.

Model case

The Wang, the woman, 50 years old, on October 5th, 2010 went to a doctor.Upper right abdomen pain 2 days, the clothes antibiotic medicine does not have alleviation.Upper right angina abdominis, and take on the back radiation to the right, belching and acid regurgitation, bitter taste is vexed, and it is not well to defecate.38 ℃ of the temperature of having a medical check-up, spirit is withered, painful looks, upper right abdominal pressure pain is obvious, the murphy sign positive, red tongue yellow and greasy fur, stringy and rolling pulse.B ultrasonic prompting gallbladder 6.5cm * 4.5cm, wall thickness 0.5cm, crude.Be diagnosed as acute cholecystitis.Take the syrup of the embodiment of the invention 1 preparation, treat after 5 days upper right abdomen pain and obviously alleviate, no belching and acid regurgitation, stomach receive can, two just accent.Upper right abdomen pain disappears after 10 days, does not have the shoulder back pain, stomach receive can, two just transfer the white and thin fur soft pulse.B ultrasonic prompting gallbladder 5cm * 3cm, wall thickness 0.3cm is smooth.Follow up a case by regular visits to not recurrence in 1 year.

Each component pharmacology is as follows in the Chinese medicine composition:

Herba Pogostemonis: acrid in the mouth, slightly warm in nature is returned lung, spleen, stomach warp, has dispelling summer-heat from superficies of the body, the effect of removing dampness to restore normal function of the stomach.Be used for summertime flu, the cold and heat headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, vomiting during pregnancy, nasal sinusitis, cards such as hands, tinea pedis, " medicine justice ": Herba Pogostemonis, its gas fragrance, the benefaction gastric qi, in transferring with this, stopping vomiting is told cholera, and with this fast gas, the dirt eliminating jailbird is vexed.And fragrant can and close the five internal organs, if incoordination between the spleen and stomach, the rib stomach of using and advance diet has the merit of the appetizing of being amusing.Hot energy tonneau nine orifices if haze miasma epidemic disease is used it, does not make in the exopathogen and invades, and the power of presiding over healthy energy is arranged.All all gas medicines, solely this body is gently warm in nature, can defend gas greatly, specially supports the lung stomach.But leaf belongs to sun, is the thing of generation, and its property is sharp and fragrant looses, and should not obey more.

Radix Codonopsis: sweet in the mouth, property is put down, go into lung, stomach warp, has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid, be used for weakness of the spleen and stomach, inappetence, diarrhea, fatigue and weakness, insufficiency of lung-QI, the cough with asthma of breathing hard, sound is humble, speech is unable, and gas Tianjin two is hindered, breathes hard thirsty, QI and blood deficiency, dizzy cardiopalmus, the unable card that waits of breathing hard, can increase body's immunity, delaying senility function is arranged, Radix Codonopsis is the key medicine of air making-up and spleen enlivening, contained saponin, inulin, micro-alkaloid, starch etc. have in various degree strong effect to the many internal organs of human body, can improve adaptability of human body.

Radix Glycyrrhizae: sweet in the mouth, property is flat, goes into 12 warps, and heat-clearing and toxic substances removing is arranged, and is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain is mainly used in invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong can play the QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.

Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, have and attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, antidotal effect, cure mainly the excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; The edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Cards such as scald.

Rhizoma Zingiberis Recens: acrid in the mouth, slightly warm in nature is returned lung, spleen, stomach warp, has the appetizing preventing or arresting vomiting, preventing phlegm from forming and stopping coughing, the effect of relieving the exterior syndrome by diaphoresis cures mainly Deficiency and coldness of spleen and stomach, loss of appetite, nausea and vomiting, or vomiting due to fluid-retention, the vomiting of disorder of stomach-QI; Wind and cold or cold-phlegm cough; Cold, fever with aversion to wind, the nasal obstruction headache waits card.

Herba Artemisiae Scopariae: acrid in the mouth, hardship, cold nature is returned spleen, stomach, liver, gallbladder meridian, cures mainly jaundice, dysuria, cards such as eczema pruritus, pharmaceutical research has function of gallbladder promoting, and liver function protecting is analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, effects such as coronary dilating.

Radix Gentianae: bitter in the mouth, cold in nature, return liver, gallbladder meridian, have heat clearing and damp drying; The effect of eliminating pathogen in the liver arresting convulsion has jaundice due to damp-heat; The urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; The hypochondriac pain bitter taste; The effect of calentura convulsion with spasms, " medicine justice ": the fire of the special eliminating pathogen in the liver gallbladder of Radix Gentianae, cure mainly the ophthalmalgia cervicodynia, pain in the hypochondrium, the infantile convulsion pathogen, infantile malnutrition, all genus Liver Channel pathogenic heats are for suffering from, and are wonderful with it.Its abnormal smells from the patient is thick and heavy and avale, kind clear damp-heat in lower-JIAO, if scroal abscess, inguinal bubo, primary sore, and urine is not smooth, and very swelling of man's sun, or light comes to a head, or the pain of itching in the stem, the woman is cloudy infirmityly to have a pain, or the living skin ulcer of itching, and goes into Decoction of Gentiana for Purging the Liver-fire with this to control it, and the power of all bitter cold prevailing over heat is also.Also can remove gastric heat, flat ascarid, the lid ascarid gets the bitter ear of promptly pacifying.

Radix Glehniae: cold nature, sweet in the mouth, little hardship have nourishing YIN and clearing away lung-heat, and the effect of reinforcing stomach reg fluid cures mainly cards such as lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound be thirsty.

The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, return spleen, stomach warp, has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, be used for weakness of the spleen and stomach, lack of appetite distension, fatigue and weakness, have loose bowels, water-damp retention, phlegm retention, edema, cards such as exterior deficiency spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae have adjust gastrointestinal motility function, antiulcer, protect the liver, effects such as enhancing human body immunity function, anti-stress, enhancing hemopoietic function; Its dampness diuretic effect is relevant with diuresis; And antiabortive effect is relevant with the effect of inhibition uterine contraction.The Rhizoma Atractylodis Macrocephalae also has effects such as antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature is gone into liver, spleen channel, the joint venture of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing liver-YANG is mainly used in headache feeling of fullness in the head, vertigo and tinnitus, the irritated irritability of deficiecny of liver-YIN, excessive rising of liver-YANG; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of the wet resistance of deficiency of the liver stasis; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery stomachache; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the cards such as carpopedal spasm pain of supporting, and has antithrombotic to form and hepatoprotective effect, and dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus are had inhibitory action.

Herba Chelidonii: bitter in the mouth, cool in nature, attach to the lung and stomach meridians, have relieving spasm to stop pain, the effect of relieving cough and asthma cures mainly analgesia, cough-relieving, diuresis detoxifcation.Control gastrointestinal distress, jaundice, edema, the scabies skin ulcer is swollen, cards such as snake bite and insect sting.

Fructus Trichosanthis: cold in nature, sweet in the mouth, little hardship is returned lung, stomach, large intestine channel, has clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the effect of moisturizing laxation cures mainly the cough due to lung-heat, and the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, cards such as constipation.

Exocarpium Benincasae: sweet in the mouth, cool in nature, return spleen, small intestine meridian has the effect of inducing diuresis to remove edema, cures mainly the edema distension, dysuria, summer-heat is thirsty, cards such as oliguria with reddish urine.

Rabdosia rubescens: bitter in the mouth, sweet, cold nature, return lung, stomach, Liver Channel, has heat-clearing and toxic substances removing, the effect of promoting blood circulation and stopping pain cures mainly cards such as laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, joint rheumatalgia, snake bite and insect sting, can suppress first type, beta hemolytic streptococcus, staphylococcus aureus etc. effectively, thereby improve the human body resistance, reduce the leukocyte that causes because of inflammation rapidly and increase.

Herba Eupatorii: acrid in the mouth, property is flat, returns spleen, stomach, lung meridian has expelling summer-heat and damp, ward off dirty and in effect, cure mainly heat-damp in summer, the cold and heat headache is accumulate in moistening, the gastral cavity painful abdominal mass is not hungry, nausea and vomiting is sweet greasy in mouthful, disappears and truly waits card.

Semen Sinapis Albae: acrid in the mouth, warm in nature, return lung meridian, have warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral analgesic effect cures mainly warming spleen and stomach for dispelling cold, promoting the circulation of QI eliminating phlegm, the meridian dredging, detumescence poison.Control cold syndrome of the stomach and tell food, trusted subordinate's pain, lung cold cough, arthralgia aggravated by cold, sore throat, carbuncle of yin nature, the tuberculosis of bone and joint, cards such as traumatic injury, " herbal classic is dredged card ": Semen Sinapis Albae cloth kind is most in the autumn, adopt reality in early summer, to give birth to length, Cheng Zaidong gathers, and Yu Xiaqiu is anti-if do not have institute and person, hardly realizes to betide the winter, long being supported in the spring, all when its embryo, the autumn in summer then its search for the origin and the outcome of the development of things meeting also.Flavor hot must in the autumn to the greatest extent, the warm of gas must be in early summer, is that suffering is felt in water and being given birth to, temperature is pregnant educates in trembling with fear, temperature can not be from suffering, suffering can not be from temperature, then hot using warming therapy usefulness is all come together in water.So suffering person is logical, thus warm person send out, in the expectorant cold resistance, then difficult horizontal the reaching of gas and one in last behavior gas, difficult horizontal the reaching of gas, then the cold benefit of expectorant does not have institute and lets out, and only stay in chest and diaphragm, yellow hair is in face so hinder the mill of spleen to swing, a temperature and chest and diaphragm expectorant is cold sends out invariably more, one suffering and the mechanism of qi superinverse is declared logical invariably,, be not the power of drop-down all by horizontal soothing the liver merit, thus after be referred in the world it can be except that the expectorant the flesh side film, four joints are pain, also ear for this reason.The right all pains of all expectorant of must calling all can be controlled to be Yu, and lid also has boundary.The husband is greatly then hollow, little then solid, the permanent feelings of his thing.Only the anti-hollow of the little person of stem of Caulis et Folium Sinapis albee is real among the big person, still is that a class can be all usefulness for two kinds, and hollow person resembles the narrow air flue of expectorant, and middle real person resembles the swollen footpath of the heap soil or fertilizer over and around the roots tunnel of expectorant.Hereat in order in controlling, its card must be held concurrently and be gone up gas, and outside controlling, its card must doublely swell and ache, the time of then all expectorant joint and flesh side film outside, must in expectorant is arranged and outward for swell and ache for a long time by not empty person, just suitable therewith, be for its sorrowful territory can be also.

Herba Swertiae Mileensis: bitter in the mouth, cold in nature, return liver, gallbladder, urinary bladder channel has heat-clearing and toxic substances removing, the effect of dampness removing jaundice eliminating.Main jaundice due to damp-heat; The puckery pain of pyretic stranguria; Damp-heat dysentery; Leucorrhea with red and white discharge; Influenza; The malaria heating; Acute gastritis; Acute pharyngolaryngitis; Cards such as acute tonsillitis.

Polyporus: sweet in the mouth, light, property is flat, goes into kidney, urinary bladder channel, has the effect of promoting diuresis to eliminate damp pathogen, is mainly used in the edema of retention of water-damp, dysuria, and the having loose bowels, vomit of stagnation of dampness due to deficiency of the spleen; Cards such as the leucorrhea of damp invasion of lower energizer, nebulousurine.

Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, have regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the effect of promoting the function of the gallbladder to alleviate jaundice cures mainly the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, cards such as jaundice dark coloured urine.

Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, go into the heart, liver, spleen, large intestine channel has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen is used for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cards such as cancerous protuberance.

Caulis Bambusae In Taenia: sweet in the mouth, cold nature is gone into lung, stomach warp, the effect that removing heat-phlegm is arranged, relieves restlessness and prevents vomiting, being mainly used in lung meridian has heat, the cough ant phlegm of expectorant and accumulation of heat; The gallbladder fire is held expectorant under the arm, violates lung and disturbs the vexed of the heart, the palpitation with fear insomnia; Middle wind-phlegm fan, insufficiency of stomach is held the cards such as vomiting of heat under the arm.

Concha Ostreae: distinguish the flavor of, cold nature is returned liver, gallbladder, kidney channel, has suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect, cure mainly vertigo and tinnitus, brothers' chatter, palpitation and insomnia, dysphoria, infantile convulsion is demented, the scrofula goiter, the breast caking, spontaneous sweating, seminal emission frequent micturition, bleeding not during menses, acid regurgitation stomachache, cards such as eczema skin infection.

Endothelium Corneum Gigeriae Galli: sweet in the mouth, cold in nature, return spleen, stomach, small intestinal, urinary bladder channel, have promoting digestion and invigorating the stomach, the effect of arresting seminal emission cures mainly the food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, sore throat tonsillitis, cards such as ulcerative gingivitis aphtha.

This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment did, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.

Claims

1. Chinese medicine composition for the treatment of acute cholecystitis, it is characterized in that, make: Herba Pogostemonis, Radix Codonopsis, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Rhizoma Zingiberis Recens, Herba Artemisiae Scopariae, Radix Gentianae, Radix Glehniae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Herba Chelidonii, Fructus Trichosanthis, Exocarpium Benincasae, Rabdosia rubescens, Herba Eupatorii, Semen Sinapis Albae, Herba Swertiae Mileensis, Polyporus and Radix Curcumae by following raw medicinal material;

The ratio of weight and number of each raw medicinal material in the described Chinese medicine composition is:

2. Chinese medicine composition as claimed in claim 1 is characterized in that: the ratio of weight and number of each raw medicinal material in the described Chinese medicine composition is,

3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, comprising:

The first step is mixed in proportion described raw medicinal material, puts into marmite and fries 20 minutes～40 minutes, is ground into smalls with pulverizer, is screened into 100 orders～200 purpose powder;

4. the preparation method of the described Chinese medicine composition of claim 3, it is characterized in that: when the dosage form of described Chinese medicine is syrup, described the 3rd step is for adding the water dissolution with respect to 2～3 times of powder qualities in the powder after pulverizing, regulate pH value to 7.0 with 40% sodium hydroxide solution, add correctives sucrose, antiseptic mix homogeneously subsequently, promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, potassium sorbate 0.1～0.3%, ethyl hydroxybenzoate 0.01～0.05%.