CN102697866A - Ultrasonic extraction process for particles for removing urinary calculus - Google Patents
Ultrasonic extraction process for particles for removing urinary calculus Download PDFInfo
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- CN102697866A CN102697866A CN201210210971XA CN201210210971A CN102697866A CN 102697866 A CN102697866 A CN 102697866A CN 201210210971X A CN201210210971X A CN 201210210971XA CN 201210210971 A CN201210210971 A CN 201210210971A CN 102697866 A CN102697866 A CN 102697866A
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- clear paste
- ethanol
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- supersound extraction
- extractum
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Abstract
The invention relates to the field of natural medicines, in particular to an ultrasonic extraction process for particles for removing urinary calculus. By the process, an ultrasonic extraction technology is applied, the extraction efficiency is improved, and temperature is low; and the ultrasonic extraction process is short in time, low in cost and obvious in economic benefit.
Description
Technical field
The present invention relates to natural medicine field, be specifically related to a kind of ultrasonic extraction process of PAISHI KELI.
Background technology
" PAISHI KELI " is the seventies in last century, and on the basis of " the bright prescription of peaceful benevolent dispensary of peaceful favour " " BAZHENG SAN ", the calculus prescription of designing in conjunction with the meticulous screening study of clinical state of an illness characteristics comes by Shen Tongrentang Pharmaceutical Factory (applicant predecessor).The former lithagogue infusion that records 88 years versions of quality standard in Jiangsu Province of PAISHI KELI prescription records in Chinese Pharmacopoeia version in 2010 at present.Select the following traditional Chinese medicines material for use: Herba Glechomae, Semen Plantaginis (saline stir-fry), Caulis Akebiae, Radix Cynanchi Paniculati, Folium Pyrrosiae, Caulis Lonicerae, Talcum, Herba Dianthi, Semen Abutili and Radix Glycyrrhizae, decoct through water, be condensed into extractum, again extractum and pharmaceutic adjuvant are mixed and made into granule.
The contained composition of herbal raw material is quite complicated, and active ingredient is not only arranged, and also contains invalid element, and the quality that raw material extracts is directly connected to the therapeutic effect of finished medicines.At present, the common methods that the Chinese herbal medicine active ingredient is extracted has dipping (normal temperature dipping, warm macerating decoct) extraction method, macerate extraction method, reflux extraction etc., and extraction time is long, and extraction rate is also low; Experimentation proves for many years, uses the ultrasonic wave extraction equipment needed thereby simple, easy to operate, and extraction time is short, and extraction ratio is high, and energy-conservation, saving medical material need not heating, has the incomparable advantage of a lot of conventional method for distilling.
Ultrasonic extraction is a kind of novel physical extracting method, and is quick, efficient with it, less to effectively reaching the nutritional labeling influence, just receiving people's attention.Ultrasound wave is the mechanical wave that a kind of vibration frequency of in elastic fluid, propagating is higher than sound wave (20kHz), can produce and transmits powerful energy, gives medium (like solid granule or aggregate) acceleration greatly.When the energy of granule interior acceptance is enough to overcome the binding energy of structure; Solid particle (or aggregate) is broken (or depolymerization), thereby impels the stripping of effective ingredient in the cell: this energy is in liquid, when vibration is in rarefaction state; Liquid can tear very little hole; These holes are promptly closed in a flash, produce up to tens atmospheric instantaneous pressures when closed, promptly are called cavitation phenomenon.But this various materials of hole phenomenon refinement and manufacturing breast solution quicken the stripping of effective ingredient in the cell.In addition, hyperacoustic second order effect, like mechanical shock, emulsifying, spread, smash, diffusion that chemical effect etc. also can be quickened effective ingredient in the cell discharges and make it fully and solvent, be convenient to extract.
Ultrasonic technology has been widely used in fields such as industry, agricultural, medicine, health, national defence, is especially just receiving increasing attention in the application aspect the extraction medicinal herb components.
The application fetches rate of PAISHI KELI through ultrasound assisted extraction technique significantly improves than traditional handicraft and reaches 50-500%; Extraction time shortens, and medical material raw material treating capacity is big; The extraction temperature is low, saves energy consumption greatly, has also improved production security simultaneously; Extraction process operating cost is low, and overall economic efficiency is remarkable;
Summary of the invention
The present invention uses ultrasound assisted extraction technique, and extraction efficiency is high, the time is short, temperature is low, cost is low, remarkable in economical benefits.
Method for preparing of the present invention is following:
A, Herba Glechomae (15%, weight ratio) are used the drinking water supersound extraction, filter, and concentrate, and get clear paste A;
B, Herba Glechomae (85%, weight ratio) and other medical materials are used the drinking water supersound extraction, filter, and concentrate, and get clear paste B;
C, extractum B, precipitate with ethanol is got supernatant, concentrate clear paste C;
D, extractum A, clear paste C add the adjuvant spray drying and get granule.
The weight ratio of each Chinese crude drug in the preferred prescription:
The c step further comprises after filtrating is concentrated in above-mentioned: spissated filtrating is added ethanol, leave standstill, filter, decompression filtrate recycling ethanol further concentrates, and gets extractum.Wherein concentration of ethanol is preferred 40～80%, and concentration of ethanol all is weight percentage among the present invention.
Extract in above-mentioned a, the b step and doubly measure with the preferred 8-10 of drinking water, the supersound extraction plant capacity is preferred, 5000-6000W, and the supersound extraction time is 30-45 minute.
Above-mentioned pharmaceutic adjuvant is one or more in filler, disintegrating agent, diluent, binding agent, lubricant preferably.Preferred pharmaceutic adjuvant is starch and dextrin.In clear paste weight, the weight of starch and dextrin preferably accounts for 10%, 15% respectively.
In the finished product detection of PAISHI KELI, the composition that main luteolin is representative carries out assay.Be the selection test of the Several Factors of supersound extraction below:
One, the selection of supersound extraction power
Tested number 1,2,3 is represented the power draw with 4000W, 6000W, 8000W respectively in the following table, and the former extraction process of 4 representatives is extracted after 30 minutes the content of composition in the extractum
The demonstration test result of table 1 orthogonal test
The demonstration test presentation of results, after 6000W, 8000W supersound extraction, content of luteolin is higher.
Two, the selection of ultrasonic time:
Tested number 1,2,3 is represented the extraction time with 15min, 30min, 45min respectively in the following table, and power is the content that 6000W extracts composition in the extractum of back
Table 2 different time extracts result of the test
In conjunction with the mensuration result of each index, preferred 30min.
The specific embodiment
Embodiment 1
Medical material is by producing PAISHI KELI 1000kg:
Method for preparing:
1. Herba Glechomae 622.5kg is with drinking water supersound extraction 30min, and power is 6000W, filters, and concentrates, and gets clear paste;
2. Herba Glechomae 3527.5kg and other medical materials are with drinking water supersound extraction 30min, and power is 6000W, filter, and concentrate, and get clear paste;
3. the clear paste that 2 steps is obtained adds ethanol, makes to contain the alcohol amount and reach 70%, leaves standstill 24 hours, filters, and decompression filtrate recycling ethanol further is concentrated into relative density 1.10, extractum.
4. each extractum is merged, mixing, spray drying gets dry medicated powder.
Claims (1)
1. the ultrasonic extracting method of a PAISHI KELI is characterized in that comprising the following steps:
Method for preparing of the present invention is following:
A, Herba Glechomae (15%, weight ratio) are used the drinking water supersound extraction, filter, and concentrate, and get clear paste A;
B, Herba Glechomae (85%, weight ratio) and other medical materials are used the drinking water supersound extraction, filter, and concentrate, and get clear paste B;
C, extractum B, precipitate with ethanol is got supernatant, concentrate clear paste C;
D, extractum A, clear paste C add the adjuvant spray drying and get granule.
The weight ratio of each Chinese crude drug in the preferred prescription:
The c step further comprises after filtrating is concentrated in above-mentioned: spissated filtrating is added ethanol, leave standstill, filter, decompression filtrate recycling ethanol further concentrates, and gets extractum.Wherein concentration of ethanol is preferred 40～80%, and concentration of ethanol all is weight percentage among the present invention.
Extract in above-mentioned a, the b step and doubly measure with the preferred 8-10 of drinking water, the supersound extraction plant capacity is preferred, 5000-6000W, and the supersound extraction time is 30-45 minute.
Above-mentioned pharmaceutic adjuvant is one or more in filler, disintegrating agent, diluent, binding agent, lubricant preferably.Preferred pharmaceutic adjuvant is starch and dextrin.In clear paste weight, the weight of starch and dextrin preferably accounts for 10%, 15% respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210210971XA CN102697866A (en) | 2012-06-26 | 2012-06-26 | Ultrasonic extraction process for particles for removing urinary calculus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210210971XA CN102697866A (en) | 2012-06-26 | 2012-06-26 | Ultrasonic extraction process for particles for removing urinary calculus |
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| CN102697866A true CN102697866A (en) | 2012-10-03 |
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| CN201210210971XA Pending CN102697866A (en) | 2012-06-26 | 2012-06-26 | Ultrasonic extraction process for particles for removing urinary calculus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840526A (en) * | 2015-05-27 | 2015-08-19 | 南京同仁堂药业有限责任公司 | Calculus removing granules as well as preparation method and new application thereof |
| CN104983807A (en) * | 2015-06-22 | 2015-10-21 | 南京华宽信息咨询中心 | Preparation method and application of lithagogue granule solid beverage |
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| WO2007024510A2 (en) * | 2005-08-22 | 2007-03-01 | International Patent Holdings, Ltd. | Medicinal herbal composition for treating infection |
| CN1927230A (en) * | 2006-09-06 | 2007-03-14 | 成都信息工程学院 | Process for extracting and purifying resin from traditional Chinese medicine by ultrasonic |
| US20080166435A1 (en) * | 2006-12-29 | 2008-07-10 | Volodymyr Pylypchuk | Composition and methods of use of an immunomodulator |
| CN101219167A (en) * | 2008-01-22 | 2008-07-16 | 南京同仁堂药业有限责任公司 | Method for preparing capsule for expelling stone |
| CN101632707A (en) * | 2009-09-03 | 2010-01-27 | 辽宁鹿源参茸饮片有限公司 | Deer embryo ointment and preparation method thereof |
| CN102205000A (en) * | 2010-10-15 | 2011-10-05 | 江西普正制药有限公司 | Callicarpa nudiflora Hook. et Arn. extract, preparation method and application thereof |
| US20110250239A1 (en) * | 2010-04-09 | 2011-10-13 | Biofrontera Bioscience Gmbh | Pharmaceutical and/or cosmetic composition for treating the skin |
| CN102228520A (en) * | 2011-06-24 | 2011-11-02 | 郑素红 | Medicine for treating kidney calculus and preparation method thereof |
| CN102335300A (en) * | 2010-07-23 | 2012-02-01 | 李永春 | Stone decomposing and discharging medicament |
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2012
- 2012-06-26 CN CN201210210971XA patent/CN102697866A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007024510A2 (en) * | 2005-08-22 | 2007-03-01 | International Patent Holdings, Ltd. | Medicinal herbal composition for treating infection |
| CN1927230A (en) * | 2006-09-06 | 2007-03-14 | 成都信息工程学院 | Process for extracting and purifying resin from traditional Chinese medicine by ultrasonic |
| US20080166435A1 (en) * | 2006-12-29 | 2008-07-10 | Volodymyr Pylypchuk | Composition and methods of use of an immunomodulator |
| CN101219167A (en) * | 2008-01-22 | 2008-07-16 | 南京同仁堂药业有限责任公司 | Method for preparing capsule for expelling stone |
| CN101632707A (en) * | 2009-09-03 | 2010-01-27 | 辽宁鹿源参茸饮片有限公司 | Deer embryo ointment and preparation method thereof |
| US20110250239A1 (en) * | 2010-04-09 | 2011-10-13 | Biofrontera Bioscience Gmbh | Pharmaceutical and/or cosmetic composition for treating the skin |
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| CN102205000A (en) * | 2010-10-15 | 2011-10-05 | 江西普正制药有限公司 | Callicarpa nudiflora Hook. et Arn. extract, preparation method and application thereof |
| CN102228520A (en) * | 2011-06-24 | 2011-11-02 | 郑素红 | Medicine for treating kidney calculus and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840526A (en) * | 2015-05-27 | 2015-08-19 | 南京同仁堂药业有限责任公司 | Calculus removing granules as well as preparation method and new application thereof |
| CN104840526B (en) * | 2015-05-27 | 2018-01-12 | 南京同仁堂药业有限责任公司 | A kind of PAISHI KELI and preparation method thereof and medicinal usage |
| CN104983807A (en) * | 2015-06-22 | 2015-10-21 | 南京华宽信息咨询中心 | Preparation method and application of lithagogue granule solid beverage |
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Application publication date: 20121003 |