CN102688358B - Suppository for treating prostatitis and preparation method thereof - Google Patents
Suppository for treating prostatitis and preparation method thereof Download PDFInfo
- Publication number
- CN102688358B CN102688358B CN201210191464.6A CN201210191464A CN102688358B CN 102688358 B CN102688358 B CN 102688358B CN 201210191464 A CN201210191464 A CN 201210191464A CN 102688358 B CN102688358 B CN 102688358B
- Authority
- CN
- China
- Prior art keywords
- suppository
- parts
- treatment
- tamsulosin hydrochloride
- sanguis draxonis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a suppository for treating prostatitis and a preparation method thereof. The suppository is prepared from the following raw material drugs in parts by weight: 0.3 to 0.5 part of tamsulosin Hydrochloride, 5 to 15 parts of golden cypress, 5 to 15 parts of common andrographis herb, 0.4 to 1 part of dragon blood, and 100 parts of 36 type mixed fatty acid glyceride. The suppository is administrated from the anus, and is pushed into rectum for half finger; the dosage of the suppository for an adult is 5 to 8g per time and the suppository is taken 1 to 2 times everyday, 30 continuously administrated days are taken as a course of treatment, and the total effective rate in 30 cases with chronic prostatitis treated with the suppository for one course of treatment is 94.8 percent.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, related to a kind of prostatitis that is used for the treatment of, especially the urinary system obstacle being caused by prostatitis is had the fat-soluble suppository and preparation method thereof of the per anum administration of good curative effect.
Background technology
Prostatitis is the commonly encountered diseases of male urinary system, multiple disease.Long-term prostatitis likely causes uremic generation.Now, prostatitis sickness rate in China's middle-aging male is high, and the sickness rate of 60 years old above elderly men, more than 40%, has caused considerable influence to patient's life and health.Tamsulosin hydrochloride is a kind of one of prostatitic specific medicament for the treatment of, but its oral formulations toxic and side effects is stronger, when producing therapeutical effect to stomach irritation large-can cause gastric ulcer.Now mainly with the method for making enteric coatel tablets or slow releasing capsule, reduce the stimulation to stomach, but virtually also increased the cost of pharmacy.In Physiological Anatomy, prostatic position and large intestine end are close to, therefore this medicine is made to suppository is aided with cooling blood for hemostasis, the Chinese medicine of reducing swelling and alleviating pain, medicine arrives the mode by passive transport in focus, this method can effectively reduce the toxic and side effects of medicine, and improves curative effect, can alleviate again the difficult situation of " ten male nine hemorrhoid " simultaneously.
Summary of the invention
One of object of the present invention is to provide a kind of prostatitic fat-soluble suppository medicine for the treatment of, and this product can effectively be alleviated the symptom of hemorrhoid simultaneously; Two of object is to provide the preparation method of this medicine one of achieving the goal.
One of object of the present invention can be achieved by the following technical measures:
Treat a prostatitic suppository, it is the suppository of being made by the crude drug of following weight ratio:
Tamsulosin hydrochloride 0.3-0.5 part Cortex Phellodendri 5-15 part
Herba Andrographis 5-15 part Sanguis Draxonis 0.4-1 part
36 100 parts of type mixed fatty glycerides.
Described suppository, it is the suppository of being made by the crude drug of following weight ratio:
10 parts of 0.4 portion of Cortex Phellodendris of tamsulosin hydrochloride
0.6 part of 10 parts of Sanguis Draxonis of Herba Andrographis
36 100 parts of type mixed fatty glycerides.
The preparation method of the described prostatitic suppository for the treatment of, comprises the following steps:
The first step: choose Cortex Phellodendri, Herba Andrographis mixing, pulverizing, 95% (v/v) soak with ethanol according to parts by weight, amount of alcohol partly refers to be advisable with Myrrha, and immersion should surpass 24 hours, standby;
Second step: the crude drug of immersion is added to water heating and refluxing extraction 2 times, each 1-2 hour;
The 3rd step: the medicinal residues after above-mentioned water extraction are added to alcohol heating reflux and extract 2 times, each 1-2 hour;
The 4th step: above-mentioned second step, two kinds of extracting solution of the 3rd step are merged after reclaiming respectively solvent, and autoclaving sterilization, make extractum;
The 5th step: choose Sanguis Draxonis according to umber and pulverize, choose tamsulosin hydrochloride according to umber, then extractum, Sanguis Draxonis powder and tamsulosin hydrochloride and 36 type mixed fatty glycerides are mixed and made into suppository simultaneously;
Described method, adds in described the 3rd step to 60%-90% (v/v) ethanol that adds 5-8 times of medicinal residues weight in medicinal residues, twice of heating and refluxing extraction.
Via anum administration, enter the backward internal rectum of anus and push away again half finger, adult uses dosage of the present invention, each 5-8 gram, every day 1-2 time, being used in conjunction 30 days is a course for the treatment of, after the course for the treatment of, the total effective rate of this product treatment 30 Cases of Chronic Prostatitis is 94.8%.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1: get Cortex Phellodendri 500g, separately get Herba Andrographis 500g, after mixing, pulverize, add 5-10 to rise 95% (v/v) soak with ethanol 24 hours, the crude drug of immersion is added to water heating and refluxing extraction 2 times, each 1-2 hour; Medicinal residues after above-mentioned water extraction are added to ethanol (the 60%-90% ethanol of 5-8 times of medicinal residues weight) heating and refluxing extraction 2 times, each 1-2 hour (timing after boiling); Two parts solution reclaims respectively solvent, then mixes extractum; Get Sanguis Draxonis 40g and beat powder, cross 80 mesh sieves; Separately get tamsulosin hydrochloride 30g, with the appropriate suppository base mixed grinding melting, make suppository routinely.
Embodiment 2: get Cortex Phellodendri 1000g, separately get Herba Andrographis 1000g, after mixing, pulverize, add 10-15 to rise 95% (v/v) soak with ethanol 24 hours, the crude drug of immersion is added to water heating and refluxing extraction 2 times, each 1-2 hour; Medicinal residues after above-mentioned water extraction are added to alcohol heating reflux and extract 2 times, each 1-2 hour (timing after boiling); Two parts solution reclaims respectively solvent, then mixes extractum; Get Sanguis Draxonis 70g and beat powder, cross 80 mesh sieves; Separately get tamsulosin hydrochloride 40g, by the appropriate suppository base mixed grinding of extractum, Sanguis Draxonis and fusing, make suppository.
Embodiment 3: get Cortex Phellodendri 1500g, separately get Herba Andrographis 1500g, after mixing, pulverize, add 15-20 to rise 95% (v/v) soak with ethanol 24 hours, the crude drug of immersion is added to water heating and refluxing extraction 2 times, each 1-2 hour; Medicinal residues after above-mentioned water extraction are added to alcohol heating reflux and extract 2 times, each 1-2 hour (timing after boiling); Two parts solution reclaims respectively solvent, then mixes extractum; Get Sanguis Draxonis 100g and beat powder, cross 80 mesh sieves; Separately get tamsulosin hydrochloride 50g, by the appropriate suppository base mixed grinding of extractum, Sanguis Draxonis and fusing, make suppository.
Embodiment 4: get Cortex Phellodendri 500g, Herba Andrographis 500g makes mobile extract powder, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 40g, tamsulosin hydrochloride 30g and fusing, injection molding, cooling rear taking-up, make finished product, be used for the treatment of slight prostatitis with slight hemorrhoid person.
Embodiment 5: get Cortex Phellodendri 1000g, Herba Andrographis 1000g makes mobile extractum, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 70g, tamsulosin hydrochloride 40g and fusing, injection molding, cooling rear taking-up, makes the suppository of requirement, is used for the treatment of moderate prostatitis with moderate hemorrhoid person.
Embodiment 6: get Cortex Phellodendri 1500g, Herba Andrographis 1500g makes mobile extractum, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 100g, tamsulosin hydrochloride 50g and fusing, injection molding, cooling rear taking-up, make the suppository of requirement, be used for the treatment of moderate prostatitis with severe hemorrhoids person.
Embodiment 7: get Cortex Phellodendri 1000g, Herba Andrographis 1000g makes mobile extractum, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 60g, tamsulosin hydrochloride 30g and fusing, injection molding, cooling rear taking-up, makes finished product, is used for the treatment of slight prostatitis with slight hemorrhoid symptom.
Embodiment 8: get Cortex Phellodendri 1000g, Herba Andrographis 1000g makes mobile extractum, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 60g, tamsulosin hydrochloride 40g and fusing, injection molding, coldly goes rear taking-up, make the suppository of requirement, for versatility, treat.
Embodiment 9: gets Cortex Phellodendri 500g, Herba Andrographis 500g makes mobile extractum, mixs homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 40g, tamsulosin hydrochloride 30g and fusing, and injection molding, cooling rear taking-up, makes finished product, is used for the treatment of slight prostatitis.
Embodiment 10: get Cortex Phellodendri 500g, Herba Andrographis 500g makes mobile extractum, mix homogeneously with 36 type mixed fatty glycerides 10kg of Sanguis Draxonis powder 40g, tamsulosin hydrochloride 50g and fusing, and injection molding, cooling rear taking-up, makes finished product, is used for the treatment of moderate prostatitis.
Embodiment 11:
Adopt the prepared medicine of embodiment 9, carried out Clinical observation, via anum administration, enter the backward internal rectum of anus and push away again half finger, adult uses dosage of the present invention, each 5-8 gram, every day 1-2 time, being used in conjunction 30 days is a course for the treatment of, and after the course for the treatment of, the total effective rate of this product treatment 30 Cases of Chronic Prostatitis is 94.8%.1. clinical observation is evident in efficacy to the improvement of its main disease, as the effective percentage of pudendum distending pain, lower abdomen contracture, waist dull pain, dribbling urination and puckery pain all reaches 96.2%; 2. to the local sign curative effect of prostate, effective percentage tough and tenderness as hard in body of gland is respectively 82.1% and 90.8% (P < 0.01); 3. aspect reduction prostatic fluid leukocyte count, treated effect is 92.5%; 4. aspect increase lecithin, treatment group effective percentage is 93.0%.
In this product treatment chronic prostatitis process, after clinical experiment result shows to serve on three courses for the treatment of, its curative effect is comparatively satisfied.
During this product clinical trial, before and after treatment, blood, routine urinalysis, hepatic and renal function, electrocardiogram are showed no extremely.Illustrate that this medicine is harmless to people body-centered, liver, renal function.Clinically also without obvious adverse reaction.
Should be understood that, for those of ordinary skills, can be improved according to the above description or convert, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (4)
1. the prostatitic suppository for the treatment of, is characterized in that, it is the suppository of being made by the crude drug of following weight ratio:
Tamsulosin hydrochloride 0.3-0.5 part Cortex Phellodendri 5-15 part
Herba Andrographis 5-15 part Sanguis Draxonis 0.4-1 part
36 100 parts of type mixed fatty glycerides.
2. suppository as claimed in claim 1, it is the suppository of being made by the crude drug of following weight ratio:
10 parts of 0.4 portion of Cortex Phellodendris of tamsulosin hydrochloride
0.6 part of 10 parts of Sanguis Draxonis of Herba Andrographis
36 100 parts of type mixed fatty glycerides.
3. a preparation method for the prostatitic suppository for the treatment of as claimed in claim 1 or 2, is characterized in that, comprises the following steps:
The first step: choose Cortex Phellodendri, Herba Andrographis mixing, pulverizing, 95%v/v soak with ethanol according to parts by weight, amount of alcohol partly refers to be advisable with Myrrha, immersion should surpass 24 hours, standby;
Second step: the crude drug of immersion is added to water heating and refluxing extraction 2 times, each 1-2 hour;
The 3rd step: the medicinal residues after above-mentioned water extraction are added to alcohol heating reflux and extract 2 times, each 1-2 hour;
The 4th step: above-mentioned second step, two kinds of extracting solution of the 3rd step are merged after reclaiming respectively solvent, and autoclaving sterilization, make extractum;
The 5th step: choose Sanguis Draxonis according to umber and pulverize, choose tamsulosin hydrochloride according to umber, then extractum, Sanguis Draxonis powder and tamsulosin hydrochloride and 36 type mixed fatty glycerides are mixed and made into suppository simultaneously;
4. method according to claim 3, is characterized in that, adds to the 60%-90%v/v ethanol that adds 5-8 times of medicinal residues weight in medicinal residues, twice of heating and refluxing extraction in described the 3rd step.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210191464.6A CN102688358B (en) | 2012-06-11 | 2012-06-11 | Suppository for treating prostatitis and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210191464.6A CN102688358B (en) | 2012-06-11 | 2012-06-11 | Suppository for treating prostatitis and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102688358A CN102688358A (en) | 2012-09-26 |
CN102688358B true CN102688358B (en) | 2014-11-26 |
Family
ID=46854202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210191464.6A Expired - Fee Related CN102688358B (en) | 2012-06-11 | 2012-06-11 | Suppository for treating prostatitis and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102688358B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108619082A (en) * | 2018-06-05 | 2018-10-09 | 河南万仁药业有限公司 | It is a kind of to treat prostatitic suppository and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1927322A (en) * | 2006-09-08 | 2007-03-14 | 王广宇 | Liposoluble traditional medicine bougie for treating acute and chronic prostatitis, and manufacturing technique thereof |
CN101204387A (en) * | 2006-12-19 | 2008-06-25 | 北京德众万全药物技术开发有限公司 | Novel tamsulosin hydrochloride sustained release capsules |
-
2012
- 2012-06-11 CN CN201210191464.6A patent/CN102688358B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1927322A (en) * | 2006-09-08 | 2007-03-14 | 王广宇 | Liposoluble traditional medicine bougie for treating acute and chronic prostatitis, and manufacturing technique thereof |
CN101204387A (en) * | 2006-12-19 | 2008-06-25 | 北京德众万全药物技术开发有限公司 | Novel tamsulosin hydrochloride sustained release capsules |
Also Published As
Publication number | Publication date |
---|---|
CN102688358A (en) | 2012-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101292969B (en) | Application of butyric acid (butanoic acid) in preparing medicaments for treating anorectal diseases | |
CN102370765B (en) | Traditional Chinese medicine plaster for treating children's constipation and preparation method thereof | |
CN102370745A (en) | Haemorrhoids internal eliminating pill | |
CN102228520B (en) | Medicine for treating kidney calculus and preparation method thereof | |
CN100417402C (en) | Liposoluble traditional medicine bougie for treating acute and chronic prostatitis, and manufacturing technique thereof | |
CN101961449A (en) | Traditional Chinese medicine for treating tinea corporis | |
CN101433568A (en) | Extraction of burdock root aqueous extract and use | |
CN102688358B (en) | Suppository for treating prostatitis and preparation method thereof | |
CN103908611A (en) | Traditional Chinese medicine preparation for treating colon cancer and preparation method of traditional Chinese medicine preparation | |
CN102895620A (en) | Preparation technology and production method for integrated new formulation of licorice heart-draining decoction | |
CN101095868A (en) | Medicine composition for treating colitis and method of making the same | |
CN100353966C (en) | Chinese medicinal composition for treating hemorrhoid | |
CN100484541C (en) | Midicinal composition for treating hemorrhoids and preparation method thereof | |
CN101152166B (en) | Isoliquirtigenin gelling agent for treating hemorrhoids and method of preparing the same | |
CN102813720A (en) | Traditional Chinese medicine capsule for treating internal and external hemorrhoids | |
CN102210760A (en) | Application of Chinese medicinal component in preparation of medicament for treating chronic epididymitis | |
CN101618128B (en) | Medicine for treating hemorrhoid and preparation method thereof | |
CN102233039A (en) | Traditional Chinese medicine ointment used for treating hemorrhoid | |
CN114984160B (en) | Mongolian medicine for treating alcoholic liver disease | |
CN108619082A (en) | It is a kind of to treat prostatitic suppository and preparation method thereof | |
CN100560093C (en) | Capsule consisting of five kinds of ingredients for treating piles and preparation method thereof | |
CN105434808A (en) | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof | |
CN103479931A (en) | Medicine for treating haemorrhoids and preparation method thereof | |
CN100434081C (en) | Medicine for treating anal and bowel pile | |
CN100387264C (en) | Suppository of Chinese traditional medicine for improving intestine motivity and preparation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141126 Termination date: 20150611 |
|
EXPY | Termination of patent right or utility model |