CN102670959A - Anti-influenza Chinese herba preparation and preparation method thereof - Google Patents
Anti-influenza Chinese herba preparation and preparation method thereof Download PDFInfo
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- CN102670959A CN102670959A CN2012101368558A CN201210136855A CN102670959A CN 102670959 A CN102670959 A CN 102670959A CN 2012101368558 A CN2012101368558 A CN 2012101368558A CN 201210136855 A CN201210136855 A CN 201210136855A CN 102670959 A CN102670959 A CN 102670959A
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Abstract
The invention relates to anti-influenza Chinese herba preparation and preparation method thereof, wherein the anti-influenza Chinese herba preparation is made from eight tastes of Chinese herbal medicine which are cyrtomium rhizome, chrysanthemum, saposhnicovia divaricata, phillyrin, herba houttuyniae, rhizoma atractylodis, fortune eupatorium herb and radix ophiopogonis, and is suitable for symptom such as fever, headache, bodily pain and cough and the like caused by influenza, and has the effects of refrigerating, postoperative analgesia, anti-inflammation, relieving cough and relieving asthma and the like. The anti-influenza Chinese herba preparation does not have irritation, discomfort and side effect, is high in bioavailability, rapidly dilutes medicine, rapidly shows effect, is precise in treat therapy effect of nfluenza, rich in raw material sources and low in cost, does not have pollution during production process, and is suitable for industrial mass production.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to Chinese medicine preparation of a kind of influenza and preparation method thereof.
Background technology
Influenza is grippal abbreviation, and is popular on a large scale through regular meeting, brings many inconvenience for people's work and life.Current influenza has become society and has gone up a great problem, and the medicine that also is of no curative effect definite suppresses it.Influenza outbreak in recent years be scope wide, propagate fast, the cycle is long, be prone to the characteristics of recurrence after the drug withdrawal, not only bring the discomfort on the health, and cause very big economic loss to people.
Influenza is the acute respiratory infectious disease that is caused by influenza virus, and pathogen is first, second, the third three type influenza viruss, especially sees with the first type more.Virus is the small biology of nature, through the research course in surplus human 100 years, human viral characteristic and the virus and the mankind, natural mutual relation of progressively having disclosed.But, human understanding to virus still seldom to 95% of 5,000 kinds of viruses of natural boundary treaty, is still known nothing.This mainly is because the variability of virus lets human unpredictable.
Virus is through variation; Can obtain the characteristic that the past does not have, become can cross over species very soon, toxicity is stronger, the virus that infectiousness is higher; The influenza virus that we often say has eight genetic fragments; Each genetic fragment also has five subgenomic fragments, and these genetic fragments and the numerous rare and another kind of congenerous disease drug case of subgenomic fragment genetic fragment reprovision variations can be described as the virus that toxicity is stronger, infectiousness is higher; Make people's unpredictable, inhibition, eliminate it and be difficult to, the current popular sexuality is emitted and is become society and go up a great problem thus.Existing chemical drugs treatment influenza is not fully up to expectations, generally can only play some effects of improving symptom, and side effect is in various degree arranged, and the immune system of human body self is had injury.
The present invention is exactly the good medicine of resisiting influenza virus, and influenza virus is had unique curative effect, and the heating that the popularity flu causes, headache, general pain, pharyngalgia, cough, asthma etc. have the therapeutic effect that gets instant result.
Summary of the invention
The object of the present invention is to provide a kind of easy to use, onset is rapid, curative effect is high, the Chinese medicine preparation of the influenza that has no side effect and preparation method thereof.
For realizing above-mentioned purpose, the enforcement of technical scheme of the present invention is following:
A kind of Chinese medicine preparation of influenza, process that said Chinese medicine preparation raw materials of effective components is formed and parts by weight are:
20～40 parts of 30～50 parts of windproof 30～55 parts of Fructus Forsythiaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis
Processing said Chinese medicine preparation raw materials of effective components composition and parts by weight is:
25～35 parts of 35～42 parts of windproof 38～50 parts of Fructus Forsythiaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis
Processing said Chinese medicine preparation raw materials of effective components composition and parts by weight is:
30 parts of 38 parts of windproof 42 parts of Fructus Forsythiaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis
A kind of method for preparing of Chinese medicine preparation of influenza comprises following processing step:
(1) Rhizoma Osmundae is broken into Powdered, adds water, soaked overnight; At a simmer to surplus 100 milliliters of liquid, taking-up decocting liquid, cooling; Between the adjustment pH value 6～8, common filter paper filtering, filtrating concentrates and to obtain relative density is 1.15～1.23 clear paste.
(2) with all the other raw material decocte with water 3 times, each 1.5 hours, to filter, it is 1.15～1.23 clear paste that filtrating is concentrated into relative density.
(3) clear paste that obtains in blend step (1) and the step (2) continues to be concentrated into relative density more than or equal to 1.26 thick paste, adds adjuvant and promptly gets.
The present invention ties up under motherland's medicine and pharmacology theoretical direction, sums up through clinical observation for many years.Confirm that through a large amount of cases symptoms such as the heating that influenza virus is caused, headache, general pain, pharyngalgia, cough, asthma have unique definite curative effect.Chinese medicine preparation prescription of the present invention is by eight Chinese medicine compound formed of flavor Chinese medicines, and wherein Rhizoma Osmundae, Flos Chrysanthemi are monarch drug, and windproof, Fructus Forsythiae, Herba Houttuyniae are ministerial drug, and Rhizoma Atractylodis, Herba Eupatorii are adjuvant drug, and be messenger drug Radix Ophiopogonis.Rhizoma Osmundae heat-clearing and toxic substances removing, cooling blood for hemostasis, expelling wind and activating blood circulation in the side, Flos Chrysanthemi are the key medicine of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, and two medicines share, and are all monarch drug, gather the function that relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, lung qi dispersing bring down a fever altogether; Windproof have relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, expelling pathogenic factors from muscles by diaphoresis, sensible a loose effect of lung qi of nose, a surname of opening; Fructus Forsythiae is the article of clearing up internal heat by using drugs of bitter in taste and cold in nature; The pharmacological action that has antibiotic, heart tonifying, diuresis, town to tell; Herba Houttuyniae heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, three medicines share and are all ministerial drug, send out the function of lung qi, urinate detoxifcation, relieving the exterior syndrome by diaphoresis with the monarch drug compatibility to help its a surname; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, let out the drink expectorant, and Herba Eupatorii has Xin Xiang and walks to scurry, and the skin that looses, pass through a hair key, lung heat clearing expectorant, and two medicines share, and are all adjuvant drug, and two medicines principal drug assistance are altogether evacuated cold-evil, clearing away lung-heat to relieve cough; Be messenger drug Radix Ophiopogonis, can Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, relieving restlessness clears away heart-fire.All medicine 5 usefulness are played the suffering table that cools completely, the effect of removing heat from QI system with drugs of pungent flavor and cold nature altogether.
Medicine of the present invention is applicable to diseases such as upper respiratory tract infection that influenza causes, heating, headache, general pain, pharyngalgia, cough, asthma.Show that through pharmacodynamics test medicine of the present invention has good antitoxin, analgesic, antiinflammatory, eliminates the phlegm, antitussive effect.Clinically be used to treat influenza for many years, determined curative effect not only, and do not see toxic and side effects.
The present invention compared with prior art has following beneficial effect:
Chinese medicine preparation of the present invention has heat-clearing and toxic substances removing, anti-inflammatory analgesic, diaphoresis expelling pathogenic factors from muscles, the cough-relieving expectorant effect of washing and cough, relieving asthma, take behind this Chinese medicine preparation onset rapidly, determined curative effect, have no side effect and untoward reaction; Cheap; Taking convenience, all-ages, do not develop immunity to drugs.
Resisiting influenza virus test in the body:
Virus: with influenza virus A 1 hypotype Mus lung adapted strain FM1 (H1N1).Animal: 6 the week age mice, sex is identical.Positive control medicine: bitter sweet electuary.Virus virulence mensuration, drug toxicity mensuration, medicine antivirus test have been carried out.The result proves that this Chinese medicine preparation is effective to influenza virus in the body.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further elaboration.
Embodiment 1
Chinese medicine preparation raw materials of effective components of the present invention is formed and parts by weight are:
20～40 parts of 30～50 parts of windproof 30～55 parts of Fructus Forsythiaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis
The processing step of Chinese medicine preparation method for preparing of the present invention is:
(1) Rhizoma Osmundae is broken into Powdered, adds water, soaked overnight; At a simmer to surplus 100 milliliters of liquid, taking-up decocting liquid, cooling; Between the adjustment pH value 6～8, common filter paper filtering, filtrating concentrates and to obtain relative density is 1.15～1.23 clear paste.
(2) with all the other raw material decocte with water 3 times, each 1.5 hours, to filter, it is 1.15～1.23 clear paste that filtrating is concentrated into relative density.
(3) clear paste that obtains in blend step (1) and the step (2) continues to be concentrated into relative density more than or equal to 1.26 thick paste, adds adjuvant and promptly gets.
Embodiment 2
Chinese medicine preparation raw materials of effective components of the present invention is formed and parts by weight are:
25～35 parts of 35～42 parts of windproof 38～50 parts of Fructus Forsythiaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis
The Chinese medicine preparation method for preparing processing step of present embodiment is identical with embodiment 1.
Embodiment 3
Chinese medicine preparation raw materials of effective components of the present invention is formed and parts by weight are:
30 parts of 38 parts of windproof 42 parts of Fructus Forsythiaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis
The Chinese medicine preparation method for preparing processing step of present embodiment is identical with embodiment 1.
Chinese medicine preparation acute toxicity test in mice of the present invention:
Chinese medicine preparation of the present invention is carried out acute toxicity test in mice, can not find and once irritate the dosage that stomach causes dead mouse.Giving oral dose of 20 male and female half and half mices respectively is the Chinese medicine preparation of the present invention of 74.8 gram crude drug/kilograms, animal dead and abnormal response situation in 10 days after the observation administration.Result of the test shows: under this dosage, mice does not have dead and any toxic reaction.Animal hair color, diet, defecation, activity are all normal.Results suggest: the chmice acute per os maximum tolerated dose of Chinese medicine preparation of the present invention is 74.8 gram crude drug/kilograms, is equivalent to the clinical plan of people 99.7 times with dosage, the prompting drug safety.
Chinese medicine preparation mice of the present invention chronic toxicity test:
Chinese medicine preparation of the present invention is carried out the mice chronic toxicity test, take 12.6 gram crude drug/kilograms every day for respectively 20 male and female, half and half mice, once a day, continuous 90 days, mice body-mass index, organ coefficient, routine blood test, blood biochemistry detection index were all no abnormal.Main organs histopathologic examination does not also have pathology and changes.
Claims (4)
1. the Chinese medicine preparation of an influenza is characterized in that: process that said Chinese medicine preparation raw materials of effective components is formed and parts by weight are:
20～40 parts of 30～50 parts of windproof 30～55 parts of Fructus Forsythiaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis
2. the Chinese medicine preparation of a kind of influenza according to claim 1 is characterized in that: process that said Chinese medicine preparation raw materials of effective components is formed and parts by weight are:
25～35 parts of 35～42 parts of windproof 38～50 parts of Fructus Forsythiaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis
3. the Chinese medicine preparation of a kind of influenza according to claim 2 is characterized in that: process that said Chinese medicine preparation raw materials of effective components is formed and parts by weight are:
30 parts of 38 parts of windproof 42 parts of Fructus Forsythiaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis
4. the method for preparing of the Chinese medicine preparation of an influenza is characterized in that: comprise following processing step:
(1) Rhizoma Osmundae is broken into Powdered, adds water, soaked overnight; At a simmer to surplus 100 milliliters of liquid, taking-up decocting liquid, cooling; Between the adjustment pH value 6～8, common filter paper filtering, filtrating concentrates and to obtain relative density is 1.15～1.23 clear paste.
(2) with all the other raw material decocte with water 3 times, each 1.5 hours, to filter, it is 1.15～1.23 clear paste that filtrating is concentrated into relative density.
(3) clear paste that obtains in blend step (1) and the step (2) continues to be concentrated into relative density more than or equal to 1.26 thick paste, adds adjuvant and promptly gets.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210136855.8A CN102670959B (en) | 2012-04-30 | 2012-04-30 | Anti-influenza Chinese herba preparation and preparation method thereof |
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| CN201210136855.8A CN102670959B (en) | 2012-04-30 | 2012-04-30 | Anti-influenza Chinese herba preparation and preparation method thereof |
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| CN102670959A true CN102670959A (en) | 2012-09-19 |
| CN102670959B CN102670959B (en) | 2014-01-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105796872A (en) * | 2016-05-13 | 2016-07-27 | 孔伟 | Anti-influenza traditional Chinese medicine preparation |
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Non-Patent Citations (1)
| Title |
|---|
| 景姗等: "流行性感冒中医治疗概况", 《中国中医药信息杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796872A (en) * | 2016-05-13 | 2016-07-27 | 孔伟 | Anti-influenza traditional Chinese medicine preparation |
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