CN102670799A - Medicament or health-care food composition for improving gastrointestinal disturbance and preparation method and application thereof - Google Patents
Medicament or health-care food composition for improving gastrointestinal disturbance and preparation method and application thereof Download PDFInfo
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- CN102670799A CN102670799A CN2012101710259A CN201210171025A CN102670799A CN 102670799 A CN102670799 A CN 102670799A CN 2012101710259 A CN2012101710259 A CN 2012101710259A CN 201210171025 A CN201210171025 A CN 201210171025A CN 102670799 A CN102670799 A CN 102670799A
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Abstract
The invention provides a medicament or a health-care food composition for improving gastrointestinal disturbance. The medicament or health-care food composition is a preparation prepared from the following bulk pharmaceuticals in parts by weight: 1-5 parts of finger citron, 0.5-5 parts of perilla leaf and 10-30 parts of dandelion. The invention further provides a preparation method and an application of the composition. Due to the adoption of the medicament or health-care food composition for improving gastrointestinal disturbance, duodenum smooth muscle contraction can be suppressed, the gastritis symptom can be relieved, gastric cavity fullness, stuffiness and pain caused by peptic gastric ulcer or poor spleen and stomach functions, a definite effect is achieved, and novel medicament and health-care food options are provided clinically.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, belong to drug world.
Background technology
Functional gastrointestinal disorder; Claiming gastrointestinal neurosis again, is the general name of one group of gastrointestinal syndrome, cardinal symptom belch, anorexia, feel sick, burning sensation under the vomiting, xiphoid-process, food back be glutted or the like; Nervous and Mental Factors is the main inducing that primary disease takes place; Like the difficulty in nervous, anxiety, life and the work, worry, unexpected misfortune etc., all can disturb the normal activity of higher nerve, and then cause the gastrointestinal dysfunction.The also multiple chronic gastritis of the same trade, functional gastrointestinal disorder, peptic ulcer.
Theory of Chinese medical science thinks that The spleen and stomach provide the material basis of the acquired, source of generating QI and blood.Eating and drinking without temperance, cold-damp imbalance, pungent, the tobacco and wine of preference, surfeit delicious food savoury; Abuse chemical drugs, or work strain, it is irregular to work and rest, and chronic anxiety is melancholy; Mood is not smooth, and emotional maladjustment or the like all can impairing the spleen and stomach, causes the mechanism of qi retardance and above malaise symptoms occurs.
At present; Adopt the report of Chinese medicine functional gastrointestinal disorder more; Like the patent No.: 200510114943.8; This patent has been opened a kind of pharmaceutical composition of treating functional dyspepsia, and its component is following bulk drugs: Radix Linderae 11.65wt.%, Semen Arecae 11.65wt.%, Fructus Citri Sarcodactylis 9.30wt.%, Radix Curcumae 9.30wt.%, Lignum Aquilariae Resinatum 2.34wt.%, Herba Taraxaci 23.23wt.%, Concha Arcae (calcined) 23.23wt.%, Radix Codonopsis 9.30wt.%; This pharmaceutical composition can be treated functional dyspepsia, and it is glutted or distending pain is uncomfortable, belch, acid regurgitation, nausea and vomiting, lack of appetite are indigestion and loss of appetite, xerostomia, bitter taste, stool is smooth or symptom such as constipation to be mainly used in hold concurrently gastral cavilty due to the heat of stagnation of QI in spleen and stomach.Number of patent application: CN200410026434.5; This application provides a kind of pharmaceutical composition of treating functional dyspepsia and preparation method thereof; The prepared slices of Chinese crude drugs that Fructus Hordei Germinatus, Massa Medicata Fermentata, Semen Raphani, the Rhizoma Atractylodis Macrocephalae, Folium Perillae, Radix Glycyrrhizae Preparata, Cortex Magnoliae Officinalis, Herba Taraxaci, Rhizoma Corydalis are processed by standard with certain proportion; This pharmaceutical composition has that food stagnation removingization stagnates, the effect of invigorating the spleen to clear away damp pathogen, regulating QI to relieve pain, is the effectively specially medicine of treatment functional dyspepsia.
Yet functional gastrointestinal disorder is a kind of chronic disease, needs long-term prescription.And in the compound recipe commonly used, flavour of a drug are more, and the patient treatment cost is higher.Therefore, develop the less compound medicine of a kind of flavour of a drug and consumption and seem particularly necessary.At present, also do not see the report that only Fructus Citri Sarcodactylis, Folium Perillae, Herba Taraxaci three flavor medical material compatibilities is used to improve gastrointestinal function.
Summary of the invention
Technical scheme of the present invention has provided a kind of medicine or health-care food composition, and another technical scheme of the present invention has provided the method for preparing and the purposes of this medicine or health-care food composition.
The invention provides a kind of medicine or health-care food composition, it is the preparation that is prepared from following raw materials by weight proportions:
Fructus Citri Sarcodactylis 1-5 part, Folium Perillae 0.5-5 part, Herba Taraxaci 10-30 part.
Further, it is the preparation that is prepared from following raw materials by weight proportions:
Fructus Citri Sarcodactylis 2-4 part, Folium Perillae 1-3 part, Herba Taraxaci 17-23 part.
Further preferably, it is the preparation that is prepared from following raw materials by weight proportions:
3 parts of Fructus Citri Sarcodactylis, 2 parts of Folium Perillaes, 20 parts of Herba Taraxacis.
Wherein, it is to be active component by the water of the primary crude drug of crude drug or crude drug or extractive with organic solvent, adds the preparation that acceptable accessories or complementary composition are prepared from.
Further, described preparation oral preparation.
Further, said oral formulations is tablet, granule, capsule, pill, oral liquid.
The present invention also provides above-mentioned preparation of compositions method, and it comprises the steps:
A, by prescription proportioning weighting raw materials;
B, with crude drug directly beat powder add water or organic solvent extraction after, add the preparation that acceptable auxiliary in pharmacy or the health food or complementary composition are prepared from.
The present invention also provides above-mentioned compositions to treat or prevention gastritis, the medicine of peptic gastric ulcer or the purposes in the health food in preparation.
The present invention also provide above-mentioned compositions in preparation treatment or prevention because stomach wrist distension, painful abdominal mass is vexed and the medicine of pain or the purposes in the health food.
The present invention also provides above-mentioned compositions to suppress the purposes in the excited medicine of duodenum smooth muscle in preparation.
Fructus Citri Sarcodactylis: relieving QI stagnancy in the stomach, the relieving distension pain relieving is the treatment stagnation of QI in spleen and stomach, feelings will is not smooth, irritated irritability, wrist abdominal distention is vexed, the good merchantable brand of pain.Modern study: these article contain compositions such as Hesperidin, bergapten, daucosterol.Gastrointestinal smooth muscle is had significant relieving spasm to stop pain effect, and can increase the blood flow of heart arteria coronaria, improve anoxia tolerance function and eliminate the phlegm, relieving asthma.
Folium Perillae: expelling cold and relieving exterior syndrome, regulating qi-flowing for harmonizing stomach except that being used for flu, also is usually used in stagnation of QI in spleen and stomach, the wrist distention and fullness in the abdomen.Ming Dynasty's " book on Chinese herbal medicine converge with speech " claim its " cold expelling gas, lung heat clearing gas, alleviating distention in middle-JIAO gas, antiabortive gas, following stagnation of QI, the gas that reduces phlegm, be control gas refreshing medicine also." modern study: these article contain compositions such as perillaldehyde, perilla ketone, perillanin.Folium Perillae can promote gastrointestinal peristalsis, makes motion of matter acceleration in the gastrointestinal and the appetizing relieving distension; And effects such as antibiotic, antiviral, analgesic, calmness are arranged.
Herba Taraxaci: heat-clearing and toxic substances removing, eliminating damp-heat protects the liver and is good for the stomach, and chronic gastritis, gastric ulcer, hyperlipemia and various infectious disease are had curative effect preferably.Qing Dynasty's " book on Chinese herbal medicine newly organized " points out: " Herba Taraxaci to low-priced and big merit is arranged, cherished common people and is not known to use it.Can pathogenic fire purging, do not decrease soil again, can grow clothes clothes and not hindering for a long time.Fire person that all systems sun is bright, all agent clothes greatly, fire moves back and gastric qi is spontaneous." modern study: these article contain compositions such as the black alcohol of Herba Taraxaci, choline phylloxanthin; and be rich in nutrient substance: contain sugar 11 grams, protein 3.6 grams, fat 1.7 grams, 115 milligrams of calcium, 115 milligrams in phosphorus, 12.4 milligrams of ferrum, Vc47 milligram in per 100 grams, 7.08 milligrams of carotene and riboflavin, thiamine, folic acid, vitamin B etc.Can obviously alleviate and to damage with gastric mucosa due to the ethanol, ulcer incidence rate and UI obviously descended, and have hepatic cholagogic, the enhancing human body immunity function.Effects such as resisting pathogenic microbes, anticancer and heart tonifying.
The kind warming middle-JIAO of regulating the flow of vital energy of Fructus Citri Sarcodactylis removes the pain relieving of expanding in the present composition; Folium Perillae circulation of qi promoting and blood assist Fructus Citri Sarcodactylis to be directed against main etiology and pathogenesis; Herba Taraxaci rushes down stomach-fire clearly, and the protection gastric mucosa opposes each other and yet also complement each other with Fructus Citri Sarcodactylis, Folium Perillae; Three's compatibility uses the effect both played Synergistic, makes the prescription cold and heat again and transfers, and character is gentle, has avoided the long-term drink product and causes body to be crossed trembling with fear wet phenomenon.
The present invention improves the medicine or the health-care food composition of functional gastrointestinal disorder; Can suppress the duodenum smooth muscle contraction; Can be used for slowing down the gastritis symptom; Can treat the not good enough and stomach wrist distension that causes of peptic gastric ulcer or spleen and stomach function, painful abdominal mass is vexed and pain, clear efficacy is for clinical a kind of new medicine and the health food of providing selected.
The specific embodiment
The preparation of embodiment 1 present composition
Get crude drug: Fructus Citri Sarcodactylis 30g, Folium Perillae 20g, Herba Taraxaci 200g, add 9 times of water gagings, soaked 1 hour, decocted 1 hour, add 8 times of water gagings again and decocted 1 hour, merge concentrated solution, the granulation packing gets final product.
The preparation of embodiment 2 present compositions
Get crude drug: Fructus Citri Sarcodactylis 10g, Folium Perillae 5g, Herba Taraxaci 100g, directly beat powder, encapsulated, get capsule.
The preparation of embodiment 3 present compositions
Get crude drug: Fructus Citri Sarcodactylis 50g, Folium Perillae 50g, Herba Taraxaci 300g, add 70% ethanol extraction, be concentrated into clear paste, add correctives etc., be prepared into oral liquid.
Below specify beneficial effect of the present invention through Test Example.
Test Example 1 pharmaceutical composition of the present invention is to the influence of duodenum smooth muscle
1, experiment material
Laboratory animal
Kunming mouse, reaching large bio tech ltd by Chengdu provides, the quality certification number: scxk (river) 2008-24
Experiment medicine and reagent
Prepared by the reagent thing: Fructus Citri Sarcodactylis 6g Folium Perillae 6g Herba Taraxaci 20g, decocting twice adds 9 times for the first time, adds 8 times in water for the second time, decocts 1h at every turn, processes granule.
Acecoline: Shanghai reagent three factories produce under the chemical reagent head factory of Shanghai: barium chloride: Chengdu chemical reagent factory, face with being formulated as 10% solution; Histamine phosphate: Shanghai uncle bio tech ltd tyrode's solution difficult to understand, collocation method is with reference to pertinent literature.
Experimental technique
1.1 influence to the stripped duodenum smooth muscle of rabbit
Get the rabbit head of fiercelying attack and cause death, cut open the belly rapidly, get the about 10cm of nearly pylorus end duodenum, place the vessel that fill cold tyrode's solution, cut off mesentery along intestinal wall, the segment that intestinal tube is cut into 1.5-2cm is subsequent use.Regulate constant temperature smooth muscle groove, make water temperature remain on (37 ± 0.5) ℃.Pressure transducer is connected with BL-420 biological function experimental system.Get one section of rabbit intestinal, a line is respectively worn at two ends, and wherein a line is fixed on the L type breather, puts into the bath of 50ml tyrode's solution, and fixed L type breather, and regulate constant temperature smooth muscle groove slowly feeds bubble (2 bubbles/S).The intestinal tube other end links to each other with pressure transducer, adds 1g load, opens BL-420 biological function experimental system, treat that the intestinal tube exercise recovery is normal after, write down one section intestinal tube normal activity curve, begin to drip administration.Receive the contained concentration of reagent thing to be respectively 1 * 10
-2G/ml, 2 * 10
-2G/ml, 4 * 10
-2G/ml (concentration is in the crude drug amount) drips 0.2ml, and barium chloride, histamine, acecoline dripping quantity are 0.2ml.Administering mode: normal myenteron is movable-receive reagent (writing down the influence of variable concentrations reagent respectively)-normal myenteron activity-tool drugs (acetylcholine, histamine, barium chloride)-receive reagent (ditto)-tool drugs (ditto) to normal myenteron.
Experimental result shows that the reagent thing that receives of variable concentrations has significant inhibitory effect to the stripped duodenum excitement of rabbit that barium chloride, acetylcholine, histamine cause, shows as frequency deceleration, and contractility reduces, and is a certain amount of effect relationship.Mean tension * 100% after suppression ratio (%)=(give mean tension after the tool drugs-give tool drugs before mean tension)/the give tool drugs.The result sees table 1,2,3.
Table 1 pair barium chloride causes the influence
of the stripped myenteron contraction of rabbit
Table 2 pair acetylcholine chloride causes the influence
of the stripped myenteron contraction of rabbit
Table 3 pair histamine causes the influence
of the stripped myenteron contraction of rabbit
Acetylcholine is the M cholinergic receptor agonist, can obvious excited gastrointestinal tract, and its shrinkage amplitude, tension force are increased, the gastrointestinal smooth muscle wriggling increases; Histamine can act on the H that is distributed on the intestines and stomach smooth muscle
1Receptor allows Na to open on the cell membrane
+, K
+, Ca
2+Penetrating ion channel causes the cell membrane depolarization, thereby makes voltage dependent channel open, Free Ca in the born of the same parents
2+Concentration increases, and then causes that gastrointestinal smooth muscle shrinks; Bacl
2Direct stimulating gastrointestinal mucosa is arranged, cause the effect that gastrointestinal smooth muscle shrinks.
Can know that to sum up this prescription can suppress the gastrointestinal smooth muscle motion, its mechanism possibly competed with acetylcholine, histamine, blocking-up M, H
1Receptor, and it is relevant directly to suppress the myenteron excitement.
The compositions of embodiment 1-3 preparation is carried out the Ergonomy test; Evidence, the present invention improve the medicine or the health-care food composition of functional gastrointestinal disorder, and it is excited to suppress the duodenum smooth muscle; Can be used for slowing down the gastritis symptom; The stomach wrist distension that treatment peptic gastric ulcer or spleen and stomach function is not good enough and cause, painful abdominal mass is vexed and pain, and clear efficacy provides a kind of new medicine and health food selection for clinical.
Claims (10)
1. a medicine or health-care food composition that improves functional gastrointestinal disorder, it is characterized in that: it is the preparation that is prepared from following raw materials by weight proportions:
Fructus Citri Sarcodactylis 1-5 part, Folium Perillae 0.5-5 part, Herba Taraxaci 10-30 part.
2. medicine according to claim 1 or health-care food composition is characterized in that: it is the preparation that is prepared from following raw materials by weight proportions:
Fructus Citri Sarcodactylis 2-4 part, Folium Perillae 1-3 part, Herba Taraxaci 17-23 part.
3. compositions according to claim 1 is characterized in that: it is the preparation that is prepared from following raw materials by weight proportions:
3 parts of Fructus Citri Sarcodactylis, 2 parts of Folium Perillaes, 20 parts of Herba Taraxacis.
4. according to any described compositions of claim 1-3; It is characterized in that: it is to be active component by the water of the primary crude drug of crude drug or crude drug or extractive with organic solvent, adds the preparation that acceptable accessories or complementary composition are prepared from.
5. compositions according to claim 4 is characterized in that: described preparation is an oral formulations.
6. compositions according to claim 5 is characterized in that: described oral formulations is tablet, granule, capsule, pill, oral liquid.
7. any described preparation of compositions method of claim 1-6, it comprises the steps:
A, by prescription proportioning weighting raw materials;
B, with crude drug directly beat powder add water or organic solvent extraction after, add the preparation that acceptable auxiliary in pharmacy or the health food or complementary composition are prepared from.
8. any described compositions of claim 1-6 is in preparation treatment or prevention gastritis, the medicine of peptic gastric ulcer or the purposes in the health food.
Any described compositions of claim 1-6 in preparation treatment or prevention because stomach wrist distension, painful abdominal mass is vexed and the medicine of pain or the purposes in the health food.
10. any described compositions of claim 1-6 suppresses the purposes in the excited medicine of duodenum smooth muscle in preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101710259A CN102670799A (en) | 2011-06-01 | 2012-05-29 | Medicament or health-care food composition for improving gastrointestinal disturbance and preparation method and application thereof |
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| CN201110146386.3 | 2011-06-01 | ||
| CN201110146386 | 2011-06-01 | ||
| CN2012101710259A CN102670799A (en) | 2011-06-01 | 2012-05-29 | Medicament or health-care food composition for improving gastrointestinal disturbance and preparation method and application thereof |
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| CN102670799A true CN102670799A (en) | 2012-09-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800668A (en) * | 2015-04-24 | 2015-07-29 | 福建德生百味保健食品有限公司 | Food, health product or drug combination with stomach nourishing function and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136452A (en) * | 1995-11-09 | 1996-11-27 | 来柏龄 | Primordial qi bag |
| CN1511569A (en) * | 2002-12-30 | 2004-07-14 | 郭浩山 | Method for producing stomach energy regulating medicine |
| CN1530033A (en) * | 2003-03-17 | 2004-09-22 | 刘小蓉 | Health food additive and products for drunkard |
| KR20090011984A (en) * | 2007-07-28 | 2009-02-02 | 전현철 | Drinking before and after drink sweet mongolian dandelion tea and drinking before and after drink sweet mongolian dandelion water |
| KR20100028190A (en) * | 2008-09-04 | 2010-03-12 | 김종심 | Dandelion processing method and dandelion juice |
-
2012
- 2012-05-29 CN CN2012101710259A patent/CN102670799A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136452A (en) * | 1995-11-09 | 1996-11-27 | 来柏龄 | Primordial qi bag |
| CN1511569A (en) * | 2002-12-30 | 2004-07-14 | 郭浩山 | Method for producing stomach energy regulating medicine |
| CN1530033A (en) * | 2003-03-17 | 2004-09-22 | 刘小蓉 | Health food additive and products for drunkard |
| KR20090011984A (en) * | 2007-07-28 | 2009-02-02 | 전현철 | Drinking before and after drink sweet mongolian dandelion tea and drinking before and after drink sweet mongolian dandelion water |
| KR20100028190A (en) * | 2008-09-04 | 2010-03-12 | 김종심 | Dandelion processing method and dandelion juice |
Non-Patent Citations (1)
| Title |
|---|
| 六木保健: "胃病常吃胃药危害大", 《HTTP://BLOG.SINA.COM.CN/S/BLOG_5ED501ED0100QNA7.HTML》, 2 March 2011 (2011-03-02), pages 1 - 4 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800668A (en) * | 2015-04-24 | 2015-07-29 | 福建德生百味保健食品有限公司 | Food, health product or drug combination with stomach nourishing function and preparation method thereof |
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Application publication date: 20120919 |