CN102670569A - Method for preparing absorbable minocyline drug diaphragm - Google Patents

Abstract

The invention relates to a method for preparing an absorbable minocyline drug diaphragm, which comprises the step of operating that 1 hydrochloric acid minocyline powder is dissolved into distilled water to obtain hydrochloric acid minocyline solution; 2 gelatin is added into the hydrochloric acid minocyline solution in water bath at 40 DEG C to be uniformly mechanically stirred away from light; 3 glycerin is further added in the water bath at 40 DEG C to go on to be uniformly stirred and obtain faint yellow viscous liquid; 4 the faint yellow viscous liquid is paved on a plate to be made into a diaphragm in room temperature, and a gel diaphragm which has a thickness of 0.5-0.6mm is obtained after solidifying; and 5 the gel diaphragm is frozen and dried to obtain the absorbable minocyline drug diaphragm. The method for preparing the absorbable minocyline drug diaphragm is simple in operation, excellent in controlling, environmental friendly and high in yield. The method for preparing the absorbable minocyline drug diaphragm is convenient to be applied in clinical, compared with similar products abroad, the absorbable minocyline drug diaphragm has excellent cost performance, and does not have obvious difference in effects of clinical application.

Description

A kind of method for preparing of absorbability minocycline medicine film

Technical field

The invention belongs to bio-pharmaceutical engineer technology domain, relate to the method for preparing of local application in the clinical oral materia medica.

Background technology

Periodontitis is a kind of by the cause a disease pathological changes of a kind of progressive irreversible destruction periodontal support tissue that dominant microflora causes of periodontal.Its sickness rate is high, and is ascendant trend gradually, and along with the increase at age, its sickness rate also increases gradually.Along with the aging of society, the ratio of periodontal in the clinical outpatient service of stomatology is also increasingly high.Drug therapy is occupied critical role as a kind of important foundation Therapeutic Method of periodontal in the treatment of periodontal disease.The oral systemic administration method that waits often causes the periodontal local drug concentration low, bad complication, and cause certain waste.Therefore,, can overcome the shortcoming that is administered systemically, become the topmost administering mode of present periodontal disease Drug therapy at pathological changes periodontal topical.Using antibacterials in the periodontal disease therapeutic at present mainly is the imidazoles antibacterials, like metronidazole, tinidazole, ornidazole; Tetracyclines.The example hydrochloric acid tetracycline, minocycline etc.The slow release formulation that periodontal uses mainly contains at present; Home-made metronidazole rod (starch fiber carrier), its storage time in periodontal pocket is short; The present domestic use of imported product mainly be the minocycline ointment of commodity Palio by name, its clinical application effect is good, and is easy to operate, but price is more expensive.

Minocycline not only has sensitivity to the dominant microflora of periodontitis, and can suppress the decomposition of connective tissue, suppresses the absorption of bone.Therefore, be a kind of comparatively ideal selection at the local use of periodontitis minocycline preparation.The Drug therapy of periodontitis is occupied bigger clinical technology proportion at China's basic hospital, and therefore, the periodontal topical pharmaceutical formulation of development of new has great demand.

Summary of the invention

In order to solve the more expensive problem of periodontitis Drug therapy Chinese medicine price, the present invention provides a kind of method for preparing of good, absorbability minocycline medicine film that product has good cost performance simple to operate, controlled.

Concrete operations step of the present invention is following:

1. diaphragm-operated method for preparing of absorbability minocycline medicine is characterized in that:

Raw materials used with the amount as follows:

Minocycline hydrochloride 0.2～0.5 gram

Gelatin 0.5～1 gram

2 milliliters of glycerol

8 milliliters of distilled water;

The preparation manipulation step is following:

(1). 0.2～0.5 gram minocycline hydrochloride is dissolved in 8 ml distilled waters, obtains minocycline hydrochloride solution;

(2). in minocycline hydrochloride solution, add 0.5～1 gram gelatin, water-bath under 40 ℃ of conditions of temperature, lucifuge, mechanical agitation are even;

(3). add 2 milliliters of glycerol again, water-bath under 40 ℃ of conditions of temperature continues to stir, and gets light yellow viscous liquid;

(4). with light yellow viscous liquid, bed board system film at room temperature solidifies that to obtain thickness be the gel diaphragm of 0.5～0.6mm;

(5). with the lyophilization of gel diaphragm, obtain absorbability minocycline diaphragm, cut apart, pack;

Aforesaid operations all carries out under the condition of lucifuge.

Useful technique effect of the present invention is embodied in the following aspects:

1, method for preparing of the present invention is simple to operate, and is controlled good, environmental friendliness, and output is high;

2, method for preparing clinical practice of the present invention is convenient, belongs to the non-invasive therapy technology, is easy to promote;

3, medicine diaphragm of the present invention will soften in vivo, have good fitness with the periodontal pocket environment;

4, the new material of the present invention's acquisition is compared with external like product, has good cost performance, the clinical application effect no significant difference.

The specific embodiment

Below in conjunction with embodiment the present invention is done to describe further.

Embodiment 1:

The diaphragm-operated method for preparing of absorbability minocycline medicine comprises following operating procedure:

Raw materials used with the amount as follows:

Minocycline hydrochloride (purity 99%, Wuhan Yuancheng Technology Development Co., Ltd., China) 0.5 gram

Gelatin (Sigm-Aldrich company, the U.S.) 1 gram

2 milliliters of glycerol

8 milliliters of distilled water;

(1). 0.5 gram minocycline hydrochloride is dissolved in 8 ml distilled waters, obtains minocycline hydrochloride solution;

(2). in minocycline hydrochloride solution, add 1 gram gelatin, 40 ℃ of water-baths, lucifuge, mechanical agitation are even;

(3). add 2 milliliters of glycerol again, 40 ℃ of water-baths continue to stir, and obtain light yellow viscous liquid;

(4). with light yellow viscous liquid, at room temperature bed board system film solidifies the gel diaphragm that obtains the about 0.5mm of thickness;

(5). with the lyophilization of gel diaphragm, obtain absorbability minocycline medicine diaphragm, cut apart, pack;

Aforesaid operations all carries out under the condition of lucifuge;

(6) C ⁶⁰Sterilization, subsequent use.

Illustrate the clinical practice of absorbability minocycline medicine film below, range of application of the present invention is not limited thereto.

Give an example 1: be applied to the treatment of chronic periodontitis

Method for using:

Behind the periodontitis cacodontia cleaning tooth body, at a distance from wetting, dry up gingival sulcus.Above-mentioned minocycline diaphragm is placed in the periodontal pocket.

Give an example 2: be applied to the treatment of acute pericoronitis of the wisdom tooth

Acute pericoronitis of the wisdom tooth, at first after the flushing of conventional 3% hydrogen peroxide, the tooth body is placed into above-mentioned minocycline diaphragm in the hat week bag at a distance from wetting, dry up gingival sulcus.

Embodiment 2:

The method for preparing of absorbability minocycline medicine film comprises following operating procedure:

Raw materials used with the amount as follows:

Minocycline hydrochloride 0.2 gram

Gelatin 0.5 gram

2 milliliters of glycerol

8 milliliters of distilled water;

(1). 0.2 gram minocycline hydrochloride is dissolved in 8 ml distilled waters, obtains minocycline hydrochloride solution;

(2). in minocycline hydrochloride solution, add 0.5 gram gelatin, 40 ℃ of water-baths, lucifuge, mechanical agitation are even;

(3). add 2 milliliters of glycerol again, 40 ℃ of water-baths continue to stir, and obtain light yellow viscous liquid;

(4). with light yellow viscous liquid, at room temperature bed board system film solidifies the gel diaphragm that obtains the about 0.5mm of thickness;

(5). with the lyophilization of gel diaphragm, obtain absorbability minocycline medicine diaphragm, cut apart, pack;

Aforesaid operations all carries out under the condition of lucifuge;

(6) C ⁶⁰Sterilization, subsequent use.

Claims (1)

1. diaphragm-operated method for preparing of absorbability minocycline medicine is characterized in that:

Raw materials used with the amount as follows:

Minocycline hydrochloride 0.2～0.5 gram

Gelatin 0.5～1 gram

2 milliliters of glycerol

8 milliliters of distilled water;

The preparation manipulation step is following:

(1). 0.2～0.5 gram minocycline hydrochloride is dissolved in 8 ml distilled waters, obtains minocycline hydrochloride solution;

(2). in minocycline hydrochloride solution, add 0.5～1 gram gelatin, water-bath under 40 ℃ of conditions of temperature, lucifuge, mechanical agitation are even;

(3). add 2 milliliters of glycerol again, water-bath under 40 ℃ of conditions of temperature continues to stir, and gets light yellow viscous liquid;

(4). with light yellow viscous liquid, bed board system film at room temperature solidifies that to obtain thickness be the gel diaphragm of 0.5～0.6mm;

(5). with the lyophilization of gel diaphragm, obtain absorbability minocycline diaphragm, cut apart, pack;

Aforesaid operations all carries out under the condition of lucifuge.