CN102670325B - Electric control piston medicament injector and method - Google Patents

Electric control piston medicament injector and method Download PDF

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Publication number
CN102670325B
CN102670325B CN 201210123488 CN201210123488A CN102670325B CN 102670325 B CN102670325 B CN 102670325B CN 201210123488 CN201210123488 CN 201210123488 CN 201210123488 A CN201210123488 A CN 201210123488A CN 102670325 B CN102670325 B CN 102670325B
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chamber
gas
syringe
injection
port
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CN 201210123488
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Chinese (zh)
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CN102670325A (en
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王文
朱超
孙莉莉
高昌俊
每晓鹏
陈磊
董玉琳
李辉
张婷
武胜昔
李云庆
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中国人民解放军第四军医大学
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Abstract

本发明涉及一种电控活塞式药物注射器及方法,其特征是:该注射器至少包括注射器管体,注射器管体由密封口分割为活塞腔室和注射液室,注射液室有注射器出液口,活塞腔室通过活塞将腔体分为上腔和下腔,上腔和下腔分别有气输入/输出口和气输出/输入口;气输入/输出口即可以是气输入口,也可以是气输出口;同样,气输出/输入口即可以是气输出口,也可以是气输入口;所述的注射液室有注射器活塞,注射器活塞下端形成注射液室,注射液室通过注射器出液口吸入注射液。 The present invention relates to an electronically controlled piston and methods of the pharmaceutical syringe, characterized in that: the syringe body comprises at least a syringe barrel, the syringe tubular body is divided by a piston chamber sealing ports and injection chamber, injection fluid outlet chamber syringe , the piston chamber by the piston into an upper chamber and lower chamber, the upper and lower chambers respectively, the gas input / output port and air output / input port; gas input / output port which can be a gas input port, may be gas outlet; Similarly, gas output / input port which can be a gas outlet, the gas inlet may be; the injection chamber syringe plunger, the syringe plunger is formed lower injection chamber, the liquid chamber through the injection syringe intake port injection. 本发明的特点是组织损伤小,使用方便快捷,重复性好。 Features of the invention are tissue damage, easy to use and fast, good repeatability.

Description

电控活塞式药物注射器及方法 Electronically controlled piston and methods of the pharmaceutical syringe

技术领域 FIELD

[0001] 本发明涉及一种注射器,特别是一种电控活塞式药物注射器及方法,用于实验室进液量控制。 [0001] The present invention relates to an injector, in particular an electrically controlled piston and methods of the pharmaceutical syringe, into the laboratory for fluid loss control.

背景技术 Background technique

[0002] 神经科学的研究方兴未艾。 [0002] study neuroscience in the ascendant. 动物脑立体定位给药是神经科学研究中经常用到的实验方法。 Animal Stereotaxic positioning administration experimental method often used in neuroscience research. 如大脑核团定位注射束路追踪剂、活性药物、受体激动剂、受体拮抗剂等。 The brain nuclei positioned tract tracing agent injection, the active drug, receptor agonists, receptor antagonists. 这种显微操作要求注射量精确(0.1微升),注射速度恒定,重复性好,组织损伤小。 Such precise micromanipulation claim injection volume (0.1 l), the injection speed is constant, repeatable, less tissue damage. 传统的微量注射采用单手推动微量注射器活塞的方法进行,注射速度不能保持恒定,组织损伤大,影响实验结果的判读;且经常发生注射器针头堵塞,影响实验进程,操作精度无法满足上述要求。 Traditional single hand driven microinjection method is a micro syringe plunger, the injection speed can not be kept constant, large tissue damage, which affects the interpretation of experimental results; clog syringe needles and often affect progress of the experiment, operation accuracy can not meet the above requirements. 部分试剂需要电压离子导入,更增加了传统微量注射方法的操作复杂度。 Reagents required voltage iontophoresis, adds to the complexity of operation of a conventional microinjection method.

发明内容 SUMMARY

[0003] 本发明的目的是解决传统鼠大脑核团定位注射存在的上述问题,提供一种组织损伤小,使用方便快捷,重复性好的电控活塞式药物注射器及方法。 [0003] The object of the present invention to solve the above problems of the conventional injection Localization of rat brain nuclei present, there is provided a tissue damage, convenient to use, reproducible piston electrical control and the pharmaceutical syringe method.

[0004] 本发明的目的是这样实现的,电控活塞式药物注射器,至少包括注射器管体,注射器管体由密封口分割为活塞腔室和第二注射液室,第二注射液室有注射器出液口,活塞腔室通过活塞将腔体分为上腔和下腔,上腔和下腔分别有气输入/输出口和气输出/输入口。 [0004] The object of the present invention is achieved, electrical control piston pharmaceutical syringe, the syringe comprising a tubular body at least, the tubular body of the syringe port is divided by a sealing piston chamber and a second injection chamber, the second chamber injection syringe the liquid outlet, the piston of the piston chamber through the cavity into an upper chamber and a lower chamber, upper and lower chambers respectively, the gas input / output port and air output / input port. 气输入/输出口即可以是气输入口,也可以是气输出口;同样,气输出/输入口即可以是气输出口,也可以是气输入口;所述的第二注射液室有注射器活塞,注射器活塞下端形成第一注射液室,第一注射液室通过注射器出液口吸入注射液。 Gas input / output port which can be a gas input port, an output port may be a gas; Similarly, the gas input / output port which can be a gas outlet, the gas inlet may be; the second injection syringe chamber plunger, the lower end of the piston forming a first syringe injection chamber, a first intake port injection liquid injection chamber via a syringe.

[0005] 所述的上腔有压力传感器接口,通过压力传感器接口连接压力传感器。 [0005] The upper chamber has a pressure sensor interface connected to a pressure sensor via a pressure sensor interface. 下腔有位移传感器接口,通过位移传感器接口连接位移传感器。 The chamber having a displacement sensor interface, the interface is connected via a displacement sensor displacement sensor.

[0006] 所述的气输入/输出口和气输出/输入口连接比例换向阀,比例换向阀连接气泵和气源。 [0006] The gas input / output port and air output / input port connected to proportional valve, proportional valve connected to an air pump and a gas source.

[0007] 为了使所述的气源纯净,气源输出通道上有过滤器,以防气源内的杂质进入上腔和下腔。 [0007] In order to clean the air, a filter output channels on the air, to prevent impurities in the source gas into the upper and lower chambers.

[0008] 电控活塞式药物注射方法,输液前,通过键盘给处理器输入进液量数据,或将进液量数据存入存贮器中;输液时,处理器控制气泵工作,处理器一边检测进气压力传感器的压力,一边控制比例换向阀开口度,控制活塞杆向下带动注射器活塞开始输液,注射器活塞在第二注射液室内移动,通过注射器出液口连接的气输出/输入口向注射体注液,同时,处理器检测位移传感器的位移量,控制进液量到设定值时,停止工作;退出活塞杆时,改变比例换向阀方向,处理器控制气泵工作,使比例换向阀处于退出输液状态。 [0008] The medication injection piston electrical control method, before infusion, the input to the processor via the keyboard into the liquid amount of data, or data is stored into the liquid amount memory; infusion, the processor controls the air pump, while the processor detecting the intake pressure of the pressure sensor, while the ratio of the opening degree of the control valve, the control rod drives the syringe piston starts downward infusion syringe plunger is moved in a second injection chamber, through the gas injector liquid outlet connected to the output / input port injection into the syringe body, at the same time, the processor detects the displacement amount of the displacement sensor, the control amount of the liquid feed to the set value, stops; exit of the piston rod, the direction of change proportional valve, the processor controls the air pump, that the ratio exit infusion valve in the state.

[0009] 本发明的优点是:由于将注射器内的注射器推杆与一个相配合的缸体内的活塞杆固定,使活塞杆与注射器推杆在一条运动轴线上,缸体进气口和缸体出气口分别通过比例换向阀与气源相通过,在气源与比例换向阀之间有气泵,缸体分别安装有位移传感器和进气压力传感器,前者用于检测进液量是否到位,后者用于控制进液量的速度。 [0009] The advantage of the present invention is that: since the syringe plunger within the syringe cylinder and a cooperating piston rod is fixed and the syringe plunger on the piston rod and an axis of movement, the cylinder and the cylinder intake port body outlet respectively proportional valve to a gas source through the phase between the gas source and the pump has proportional valve, the cylinder displacement sensor and the intake pressure sensors are respectively mounted on the former for detecting an intake fluid volume is in place , which is used to control the amount of liquid feed rate. 这样通过控制比例换向阀和检测位移传感器和气压力传感器的输出值,就能方便控制注射量,达到数字化控制的目的。 Thus by detecting the output value of the proportional valve and the displacement sensor and air pressure sensor, the injection quantity can be controlled easily, the purpose of digital control.

附图说明 BRIEF DESCRIPTION

[0010] 下面结合实施例附图对本发明作进一步说明: [0010] The following embodiments in conjunction with the accompanying drawings of the embodiments of the present invention is further described:

[0011] 图1是本发明注射器实施例结构示意图; [0011] FIG. 1 is a schematic structural view of a syringe embodiment of the present invention;

[0012] 图中,1、注射器管体;2、注射器活塞;3、第一注射液室;4、注射器出液口;5、活塞杆;6、位移传感器;7、压力传感器;8、比例换向阀;9、气泵;10、气源;11、气输入/输出口;12、气输出/输入口;13、密封口;14、活塞腔室;15、第二注射液室;16、上腔;17、下腔;18、活塞。 [0012] FIG, 1, the tubular body of the syringe; 2, syringe piston; 3, a first injection chamber; 4, the injector liquid outlet; 5, the piston rod; 6, a displacement sensor; 7, a pressure sensor; 8, the ratio valve; 9, an air pump; 10, gas source; 11, the gas input / output ports; 12, gas output / input port; 13, sealing ports; 14, piston chamber; 15, a second injection chamber; 16, the cavity; 17, lower cavity; 18, piston.

具体实施方式 Detailed ways

[0013] 如图1所示,至少包括注射器管体1,注射器管体1由密封口13分割为活塞腔室14和第二注射液室15,第二注射液室15有注射器出液口4,活塞腔室14通过活塞18将腔体分为上腔16和下腔17,上腔16和下腔17分别有气输入/输出口11和气输出/输入口 [0013] As shown in FIG 1, the syringe includes at least one tubular body, the tubular body of the syringe 1 by the sealing port 13 is divided into a second piston chamber 14 and the injection chamber 15, second chamber 15 with a syringe injection liquid outlet 4 the piston chamber 14 into an upper chamber and a lower chamber 16 through the cavity 18 of the piston 17, the chamber 16 and the lower gas chamber 17, respectively, an input / output port 11 and gas output / input port

12。 12. 气输入/输出口11即可以是气输入口,也可以是气输出口;同样,气输出/输入口12即可以是气输出口,也可以是气输入口;所述的第二注射液室15有注射器活塞2,注射器活塞2下端形成第一注射液室3,第一注射液室3通过注射器出液口4吸入注射液。 Gas input / output port 11 which can be a gas input port, an output port may be a gas; Similarly, the gas input / output port 12 which can be a gas outlet, the gas inlet may be; the second injection chamber 2 syringe plunger 15, syringe plunger 2 is formed a first lower injection chamber 3, a first injection syringe chamber 3 through the suction outlet port 4 injections.

[0014] 上腔16有压力传感器接口,通过压力传感器接口连接压力传感器7。 [0014] The upper chamber 16 has a pressure sensor interface, the interface connected to the pressure sensor 7 via a pressure sensor. 下腔17有位移传感器接口,通过位移传感器接口连接位移传感器6。 The lower chamber 17 with a displacement sensor interface, the interface is connected via a displacement sensor displacement sensor 6.

[0015] 气输入/输出口11和气输出/输入口12连接比例换向阀8,比例换向阀8连接气泵9和气源10。 [0015] The gas input / output port 11 and gas output / input port 12 connected to proportional valve 8, the proportional valve 89 and air pump 10 connected to the source.

[0016] 为了使气源10纯净,气源10输出通道上有过滤器,以防气源10内的杂质进入上腔16和下腔17。 [0016] In order to clean the gas source 10, a filter 10 outputs the air passage, to prevent impurities in the gas source 10 into the upper chamber 16 and lower chamber 17.

[0017] 输液工作时,通过键盘给处理器输入进液量数据,或将进液量数据存入存贮器中,处理器控制气泵9工作,处理器一边检测进气压力传感器7的压力,一边控制比例换向阀8开口度,控制活塞杆5向下带动注射器活塞2开始输液,注射器活塞2在第二注射液室15内移动,通过注射器出液口4连接的气输出/输入口12向注射体注液,同时,处理器检测位移传感器6的位移量,控制进液量到设定值时,停止工作。 When [0017] Infusion work input through a keyboard data to the processor enters the liquid volume, or into the liquid in the amount of data stored in memory, the processor controls the air pump 9 working, the processor while detecting the intake pressure sensor 7, 8 while controlling the opening degree of the proportional valve, the control piston 5 down to drive the syringe piston 2 starts infusion syringe piston 2 moves in the second injection chamber 15, via syringe outlet port 4 connected to the gas output / input port 12 injection into the syringe body, at the same time, the processor detects the displacement amount of the displacement sensor 6, the control advances to the set value when the amount of the liquid, stop working. 同时,处理单元控制报警电路工作。 Meanwhile, the processing unit controls the alarm circuit.

[0018] 退出活塞杆5时,改变比例换向阀8方向,处理器控制气泵9工作,使比例换向阀8处于退出输液状态。 [0018] 5 exit the piston rod, the direction of change proportional valve 8, the processor controls the pump 9 working, the proportional valve 8 is the infusion exit state.

[0019] 本实施例没有详细叙述的部件和结构属本行业的公知部件和常用结构或常用手段,这里不一一叙述。 [0019] member of the present embodiment and the configuration is not described in detail in the case of the industry commonly known structures or components and conventional means, not going to describe here.

Claims (1)

1.电控活塞式药物注射器,其特征是:至少包括注射器管体(1),注射器管体(I)由密封口( 13)分割为活塞腔室(14)和第二注射液室(15),第二注射液室(15)有注射器出液口(4),活塞腔室(14)通过活塞(18)将腔体分为上腔(16)和下腔(17),上腔(16)和下腔(17)分别有气输入/输出口(11)和气输出/输入口(12);气输入/输出口(11)即可以是气输入口,也可以是气输出口;同样,气输出/输入口(12)即可以是气输出口,也可以是气输入口;所述的第二注射液室(15)有注射器活塞(2),注射器活塞(2)下端形成第一注射液室(3),第一注射液室(3)通过注射器出液口(4)吸入注射液;所述的上腔(16)有压力传感器接口,通过压力传感器接口连接压力传感器(7);下腔(17)有位移传感器接口,通过位移传感器接口连接位移传感器(6);所述的气输入/输出口(11)和气输出/输入口(12)连接比例换向阀(8),比例换向阀(8 1. The electronically controlled medication syringe plunger, characterized in that: the body comprises at least a syringe barrel (1), the syringe tubular body (I) is divided by the sealing port (13) is a piston chamber (14) and a second injection chamber (15 ), the second injection chamber (15) with a fluid outlet of the syringe (4), the piston chamber (14) through (18) into the upper chamber of the piston cavity (16) and a lower chamber (17), the chamber ( 16) and a lower chamber (17), respectively the gas input / output port (11) and gas output / input port (12); gas input / output port (11) which can be a gas input port, may be a gas outlet; same gas output / input port (12) which can be a gas outlet, the gas inlet may be; the second injection chamber (15) with a syringe plunger (2), (2) forming the lower end of the first syringe plunger injection chamber (3), a first injection chamber (3) via syringe injection suction outlet port (4); said upper chamber (16) with a pressure sensor interface, the interface connected to the pressure sensor a pressure sensor (7) ; lower cavity (17) with a displacement sensor interface, the sensor interface is connected by the displacement a displacement sensor (6); proportional valve connected to the gas input / output port (11) and gas output / input port (12) (8), proportional directional valve (8 )连接气泵(9)和气源(10);为了使所述的气源(10)纯净,气源(10)输出通道上有过滤器,以防气源(10)内的杂质进入上腔(16)和下腔(17); 其原理是:通过键盘给处理器输入进液量数据,或将进液量数据存入存贮器中,处理器控制气泵工作,处理器一边检测进气压力传感器的压力,一边控制比例换向阀开口度,控制活塞杆向下带动注射器活塞开始输液,注射器活塞在第二注射液室内移动,同时,处理器检测位移传感器的位移量,控制进液量到设定值时,停止工作。 ) Connected to an air pump (9) and gas source (10); in order to make the gas source (10) of pure gas source with a filter (10) output channels, to prevent impurities in the air (10) into the upper chamber (16) and a lower chamber (17); the principle is: the processor through the keyboard to input data into the liquid amount, or the amount of data stored in memory into the liquid, the air pump control processor, the processor detecting the intake side pressure sensor, while the ratio of the opening degree of the control valve, the control rod drives the syringe piston starts downward infusion syringe plunger is moved in a second injection chamber, while the processor detects the displacement amount of the displacement sensor, the control amount into the liquid when the set value, stop working.
CN 201210123488 2012-04-25 2012-04-25 Electric control piston medicament injector and method CN102670325B (en)

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Citations (5)

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Publication number Priority date Publication date Assignee Title
US4327724A (en) * 1979-05-30 1982-05-04 Michael Birk Pneumatically operable injection device
EP0347190A1 (en) * 1988-06-14 1989-12-20 Vci Corporation Needleless vacuum-compression injector
CN1321096A (en) * 1999-09-17 2001-11-07 巴克斯特国际公司 Fluid dispenser with stabilized fluid flow
CN101784295A (en) * 2007-08-20 2010-07-21 马林克罗特公司 Fluid driven medical injectors
CN202589701U (en) * 2012-04-25 2012-12-12 中国人民解放军第四军医大学 Electrically-controlled piston type medicament injector

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327724A (en) * 1979-05-30 1982-05-04 Michael Birk Pneumatically operable injection device
EP0347190A1 (en) * 1988-06-14 1989-12-20 Vci Corporation Needleless vacuum-compression injector
CN1321096A (en) * 1999-09-17 2001-11-07 巴克斯特国际公司 Fluid dispenser with stabilized fluid flow
CN101784295A (en) * 2007-08-20 2010-07-21 马林克罗特公司 Fluid driven medical injectors
CN202589701U (en) * 2012-04-25 2012-12-12 中国人民解放军第四军医大学 Electrically-controlled piston type medicament injector

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