CN211658286U

CN211658286U - Micro-infusion device

Info

Publication number: CN211658286U
Application number: CN201921932385.XU
Authority: CN
Inventors: 王成尉; 刘福生; 彭士荣
Original assignee: Beijing Tiantan Hospital; Beijing Neurosurgical Institute
Current assignee: Beijing Tiantan Hospital; Beijing Neurosurgical Institute
Priority date: 2019-11-08
Filing date: 2019-11-08
Publication date: 2020-10-13
Anticipated expiration: 2029-11-08

Abstract

The utility model provides a micro infusion device, which comprises an injection needle head, an extension tube, a water stop valve, a flow limiter, an injector and a micro injection pump which are connected and communicated in sequence, wherein the water stop valve is arranged on the extension tube, the injector is fixed on the micro injection pump, and the injector comprises a needle cylinder and a piston handle; the pipe wall of the extension pipe is provided with volume scale marks, and the outer diameter of the extension pipe is 2.2-2.5 mm; the micro-injection pump comprises a pump body, a chip control assembly, a display input assembly, a driving assembly and a fixing assembly, wherein the chip control assembly, the display input assembly, the driving assembly and the fixing assembly are arranged in the pump body; the chip control assembly is electrically connected with the display input assembly and the driving assembly respectively, and the fixing assembly is used for fixing the injector; the driving assembly is used for driving the piston handle of the syringe to suck or advance so as to realize suction or infusion of the micro-infusion device. The micro-infusion device can automatically and accurately absorb or infuse micro-liquid samples, and has strong controllability.

Description

Micro-infusion device

Technical Field

The utility model relates to the technical field of medical equipment, especially, relate to a trace infusion device.

Background

Glioma is the most common intracranial tumor, and particularly malignant glioma has extremely high mortality rate and recurrence rate and great harm to human. Oncolytic viruses are used as a new method for treating tumors by selectively infecting and lysing tumor cells using natural viruses or viruses that have been genetically modified to achieve the goal of treating tumors. In clinic, a small amount of virus medicament is generally required to be accurately injected into the intracranial tumor body of a patient by virtue of an infusion device, and the existing infusion device has overlarge capacity and poor controllability in the infusion process, so that accurate micro-infusion cannot be realized.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model provides a micro-infusion device, micro-infusion device can absorb or infuse the trace liquid sample automatically, accurately, and the controllability is strong.

In a first aspect, the present invention provides a micro infusion device, comprising an injection needle, an extension tube, a water stop valve, a flow limiter, an injector and a micro injection pump, wherein the injection needle, the extension tube, the flow limiter and the injector are sequentially connected and communicated, the water stop valve is arranged on the extension tube, the injector is fixed on the micro injection pump, and the injector comprises a needle cylinder and a piston handle; the pipe wall of the extension pipe is provided with volume scale marks, and the outer diameter of the extension pipe is 2.2-2.5 mm; the micro-injection pump comprises a pump body, and a chip control assembly, a display input assembly, a driving assembly and a fixing assembly which are arranged in the pump body; the chip control assembly is electrically connected with the display input assembly and the driving assembly respectively, and the fixing assembly is used for fixing the injector; the driving assembly is used for driving the piston handle of the syringe to suck or advance so as to realize suction or infusion of the micro-infusion device.

Optionally, the syringe comprises a barrel and a plunger handle; the piston handle reciprocates in the syringe to realize suction or injection of the injector.

Optionally, the display input module is configured to input a tumor volume value, and the chip control module is configured to calculate an injection volume of the injector according to the tumor volume value.

In an embodiment of the present invention, the chip control module is used for controlling the operation of each module of the micro-infusion device to realize the control of the input and output of the liquid reagent.

Optionally, the micro infusion device further comprises a data receiving component, the data receiving component is electrically connected with the chip control component, and the data receiving component is used for receiving the tumor volume value provided by an external stereotaxic apparatus and transmitting the tumor volume value to the chip control component.

In an embodiment of the present invention, the display input module may be used as an input mode for directly setting the injection volume or the suction volume of the micro infusion device.

Optionally, the length of the extension tube is 150-.

Optionally, the volume scale mark comprises scale lines and scale value numbers, and the division value of the volume scale mark is 0.1 mL.

Optionally, the drive assembly includes step motor, transmission assembly and telescopic link, the telescopic link with the length direction of syringe is perpendicular, the telescopic link is equipped with a fixed clamp splice, fixed clamp splice is used for the centre gripping the piston handle of syringe, step motor passes through the transmission assembly drives the telescopic link carries out the back and forth concertina movement, in order to realize the piston handle is in the back and forth movement in the syringe.

Optionally, the injection needle and the extension tube are connected by a luer fitting. Through luer connects, can guarantee that syringe needle and extension tube link up closely, prevent to throw off. Wherein the luer connector comprises a luer male connector and a luer female connector which are in threaded connection with each other, the luer male connector is connected with the injection needle, and the luer female connector is connected with the extension tube.

Optionally, the flow restrictor comprises a pipe, a plastic ball is arranged in the pipe, and the diameter of the plastic ball is smaller than the inner diameter of the pipe; spiral bulges are arranged on the inner walls close to the two ports of the pipeline and used for blocking the plastic balls from flowing out from the two ends of the pipeline, and the two ends of the pipeline are respectively communicated with the extension pipe and the injector.

Optionally, the micro infusion device aspirates or infuses the liquid sample to an accuracy of 0.001 mL.

Optionally, the micro infusion device is operated by power supplied from an internal power source or an external power source.

The utility model discloses there is beneficial effect:

(1) the micro-infusion device comprises an injection needle head, an extension tube, a water stop valve, a flow limiter, an injector and a micro-injection pump, wherein the extension tube is provided with an obvious volume scale mark, so that the real-time monitoring of the infusion volume in the infusion process is facilitated; meanwhile, the micro-injection pump has the bidirectional functions of suction and injection, and the micro-infusion device can accurately suck or infuse the liquid sample with a micro volume.

(2) Trace infusion device can cooperate the stereotaxic apparatus of peripheral hardware to use, the tumour volume numerical value that acquires through the stereotaxic apparatus, trace infusion device basis tumour volume numerical value calculates the injection volume of syringe to the realization is to the accurate infusion of liquid sample.

Advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of embodiments of the invention.

Drawings

To more clearly illustrate the structural features and effects of the present invention, the following detailed description is given with reference to the accompanying drawings and specific embodiments.

FIG. 1 is a schematic diagram of a micro infusion device 100 according to an embodiment of the present invention;

fig. 2 is a schematic structural view of a micro-syringe pump according to an embodiment of the present invention.

Detailed Description

The following is a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the principle of the embodiment of the present invention, and these improvements and decorations are also considered as the protection scope of the embodiment of the present invention.

As shown in fig. 1 and 2, for the micro infusion device 100 provided by the present invention, the device comprises an injection needle 10, an extension tube 20, a water stop valve 30, a flow limiter 40, an injector 50 and a micro injection pump 60, wherein the injection needle 10, the extension tube 20, the flow limiter 40 and the injector 50 are connected and communicated in sequence, the water stop valve 30 is disposed on the extension tube 20, the injector 50 is fixed on the micro injection pump 60, and the injector 50 comprises a syringe 51 and a piston handle 52; the pipe wall of the extension pipe 20 is provided with volume scale marks, and the outer diameter of the extension pipe 20 is 2.2-2.5 mm.

The extension tube 20 and the flow restrictor 40 may be directly connected to each other, or may be connected to each other through a connection tube at one end. The flow restrictor 40 and the injector 50 may be directly connected or may be, but is not limited to, in communication via a one-end connection tube.

The micro-injection pump 60 comprises a pump body 61, a chip control assembly 62, a display input group 63, a driving assembly 64 and a fixing assembly 65, wherein the chip control assembly 62, the display input group 63, the driving assembly 64 and the fixing assembly 65 are arranged in the pump body; the chip control assembly 62 is electrically connected with the display input assembly 63 and the driving assembly 64 respectively, and the fixing assembly 65 is used for fixing the injector 50; the drive assembly 64 is used to drive the plunger shaft 52 of the syringe 50 to aspirate or advance to effect aspiration or infusion of the micro infusion device 100.

In this embodiment, the micro infusion device 100 is capable of sucking a liquid sample or reagent into the device through the injection needle 10, such as sucking the liquid sample into an extension tube or even into a syringe. The micro infusion device 100 is used for infusing a liquid sample or reagent in an extension tube into a target object, or infusing a liquid sample or reagent in a syringe into a target object through the flow restrictor 40, the extension tube 20 and the injection needle 10.

In this embodiment, referring to fig. 2, the driving assembly 64 includes a stepping motor 641, a transmission assembly 642 and a telescopic rod 643, the telescopic rod 643 is perpendicular to the length direction of the syringe 50, the telescopic rod 643 is provided with a fixed clamping block 644, the fixed clamping block 644 is used for clamping the piston handle 52 of the syringe 50, and the stepping motor 641 drives the telescopic rod 643 to perform reciprocating telescopic movement through the transmission assembly 642 so as to achieve reciprocating movement of the piston handle 52 in the syringe 51 of the syringe 50.

In this embodiment, the transmission assembly 642 includes a transmission seat 645 and a screw rod 646, wherein the screw rod 646 is parallel to the length direction of the injector 50, and the stepping motor 641 is connected to the screw rod 646 through the transmission seat 645 and drives the screw rod to rotate through the transmission seat 645. And a gear transmission assembly or a belt transmission assembly is arranged in the transmission seat. The telescopic rod 643 is perpendicular to the length direction of the screw rod 646, a through hole is formed in one end of the telescopic rod 643, internal threads matched with the screw rod are arranged on the inner wall of the through hole, and the screw rod 646 penetrates through the through hole. When the screw 646 rotates clockwise or counterclockwise, the retractable rod 643 can reciprocate in the length direction of the screw 646, thereby driving the fixed clamp block 644 to reciprocate.

In this embodiment, the stepping motor 641 can rotate clockwise and counterclockwise to drive the screw 646 to rotate clockwise and counterclockwise. For example, the stepper motor 641 may further include two sub-stepper motors, one for clockwise rotation and the other for counterclockwise rotation.

In this embodiment, the plunger handle 52 reciprocates within the barrel 51 to effect aspiration or bolus injection of the syringe. Because the micro-syringe pump in the micro-infusion device 100 has the bidirectional functions of suction and injection, the micro-infusion device can accurately suck or infuse a micro-volume liquid sample.

In this embodiment, the fixing clamp 644 may be, but is not limited to, an integrally formed structure, and has a groove therein, and the groove is matched with the handle end of the piston handle 52. Alternatively, the fixed clamp 644 is composed of two movably connected clamp plates, wherein one clamp plate is provided with a notch for the handle of the piston handle 52 to pass through, and at the same time, the fixed clamp 644 can firmly clamp the handle end of the piston handle 52. When the telescopic rod 643 performs reciprocating telescopic motion, the fixed clamping block 644 can be driven to move together, so as to realize reciprocating telescopic motion of the piston handle 52 relative to the syringe 51.

In this embodiment, the display input module 63 is configured to input a tumor volume value, and the chip control module is configured to calculate an injection volume of the injector according to the tumor volume value.

In this embodiment, the chip control component 62 is used to control the operations of the components of the micro infusion device, so as to control the input and output of the liquid reagent.

In this embodiment, the display input module 63 has both a display screen for real-time display and an input module for facilitating manual input. When the display screen has touch performance, the input component can be fused to the display screen. The display input module 63 can directly input the numerical value to the module manually on one hand, and on the other hand, the display input module 63 can be controlled by the chip control module 62; the chip control module 62 can also regulate the numerical parameters in the display input module 63.

In this embodiment, the micro infusion device 100 further comprises a data receiving component electrically connected to the chip control component 62, and the data receiving component is configured to receive the tumor volume value provided by the peripheral stereotaxic apparatus and transmit the tumor volume value to the chip control component.

The stereotaxic apparatus is an existing common medical device, and can place a microelectrode, a puncture needle and other surgical instruments into a specific target point in the cranium under the coordination of an image positioning technology. Meanwhile, the stereotaxic apparatus can determine the position of the tumor, measure the volume value of the tumor and obtain the parameter data of the diameter, the size and the like of the tumor.

In the micro infusion device 100 of the present embodiment, the data receiving unit may transmit data to the display input unit 63 in addition to the chip control unit, and the data may be displayed on the display input unit 63.

In this embodiment, the display input module of the micro infusion device may be used as an input means for directly setting the injection volume or the aspiration volume of the micro infusion device.

The utility model discloses an in the embodiment, among the micro-infusion device, directly be in input tumour volume numerical value V1 in the demonstration input module, the chip control module can calculate the injection volume V2 of syringe according to this tumour volume numerical value V1, and wherein, the computational formula between V2 and the V1 is: v2 ═ V1/(4/3 ═ pi ═ R³) And R is the tumor radius. The data receiving component can receive the data of the tumor volume value V1 and the tumor radius provided by a peripheral stereotaxic apparatus.

In this embodiment, the injection needle 10 and the extension tube 20 are connected by a luer fitting 11, see fig. 1. Through the luer 11, the injection needle 10 can be tightly connected with the extension tube 20, and the disconnection is prevented.

Optionally, the luer connector comprises a luer male connector and a luer female connector which are mutually connected in a threaded manner, the luer male connector is connected with the injection needle, and the luer female connector is connected with the extension tube.

In this embodiment, the volume scale mark on the extension tube 20 includes a scale line and scale value numbers, and the division value of the volume scale mark is 0.1 mL. The division value of the volume scale mark can be regarded as the smallest grid volume value in the volume scale mark.

Optionally, the length of the extension tube is 150-. In this embodiment, the extension tube is very slender, the inner diameter of the extension tube is small, and the volume of the liquid sample or reagent contained in the extension tube per unit length is small, so that the suction or infusion state of the liquid sample or reagent can be observed in real time through the specific volume scale marks on the extension tube. Particularly, when a very small amount of liquid sample (for example, about 1 mL) needs to be sucked, the liquid sample only stays in the extension tube, and the specific volume value of the liquid sample cannot be known through the syringe; the extension tube in the micro-infusion device can be convenient for directly reading out the specific volume value of the liquid sample by virtue of the volume scale marks on the surface of the extension tube.

In one embodiment of the present invention, the length of the extension tube is 200 cm; the capacity of the extension tube is 2 mL. The extension tube is provided with a volume scale mark consisting of 200 scale marks, and the division value of the volume scale mark is 0.1 mL.

In this embodiment, still be equipped with the extension pipe fixation clamp on the extension pipe, the extension pipe fixation clamp cover is established on the extension pipe for it is fixed to make slender extension pipe realize. For example, the extension tube may be secured to the sterile dressing by the extension tube retaining clip.

Meanwhile, in the present embodiment, the micro infusion device includes an infusion mode and a suction mode, in which a liquid sample (e.g., a drug reagent, etc.) can be automatically sucked, and since the extension tube is slender, the micro infusion device can achieve that no air bubbles exist in the extension tube under the condition of controlling a certain suction rate.

In this embodiment, the flow rate of the liquid sample sucked or infused by the micro infusion device can be adjusted and controlled, and can be adjusted correspondingly according to the actual application. For example, when the infusion amount is relatively large, the flow rate can be increased appropriately.

In this embodiment, the extension tube is a medical thermoplastic polyurethane hose. The extension pipe has a high-permeability function, can be convenient for checking the flowing condition of liquid in real time, and does not influence the identification of volume scale marks.

In this embodiment, the micro infusion device is powered by an internal power source or an external power source. For example, in one embodiment, a lithium or other type of battery is provided within the micro-infusion device to provide for operation of the device. Alternatively, in another embodiment, the micro infusion device is provided with a power cord for connection to an external power source.

In this embodiment, the specification of the syringe may be adjusted based on the actual application. For example, the concentration may be, but is not limited to, 5mL, 10mL, 20mL, or the like.

In this embodiment, the actual size of the micro syringe pump can be adjusted according to the actual application. For example, the micro syringe pump may at least meet the normal aspiration and infusion of a corresponding gauge syringe.

Optionally, the micro-syringe pump may further be provided with other functional components, such as an alarm reminding component for reminding the completion of the infusion or aspiration mode, or an abnormal alarm of the syringe. The panel on one side of the pump body 61 of the micro-injection pump can be provided with a signal connection or signal output connection port for realizing the combination with other equipment or other function amplification.

Glioma is the most common intracranial tumor, and particularly malignant glioma has extremely high mortality rate and recurrence rate and great harm to human. Oncolytic viruses are used as a new method for treating tumors (including gliomas) by selectively infecting and lysing tumor cells with natural viruses or viruses that have been genetically modified to achieve the goal of treating tumors. However, as oncolytic viruses are limited by self conditions, targeting property, safety and oncolytic efficacy have certain limitations, and the requirements on the oncolytic virus dosage are also strict. In the present embodiment, the micro-infusion device can aspirate or infuse a micro amount of liquid sample or reagent, and thus, the micro-infusion device can be used for an oncolytic virus application for precisely controlling an oncolytic virus.

In this embodiment, the chip control component in the micro infusion device may be an integrated motherboard, and the integrated motherboard includes a semiconductor chip. The chip control assembly is used for calculating the injection volume of the injector according to the tumor volume numerical value. The program for calculating the injection volume by the chip control component can be different according to the tumor type and the medicament solubility or the type.

For example, in one embodiment, glioma cells are used as an example. About 10E9 tumor cells were present in a tumor 1cm in diameter, and the oncolytic virus-to-glioma cell IC50 was calculated at MOI of 0.01 (i.e. half of the tumor cells were killed, the ratio of virus to tumor cells was 0.01, i.e. 1 virus killed 50 tumor cells), while 10E8pfu of the oncolytic virus in 1mL was able to kill 5 × 10E9 tumor cells, in a reduced volume of 1.75cm in diameter; through the formula relation, the injection volume of the injector can be calculated according to the tumor volume numerical value.

It is to be noted that variations and modifications can be made on the above-described embodiment by those skilled in the art in light of the disclosure and description of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some equivalent modifications and variations of the present invention should be covered by the protection scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. A micro-infusion device is characterized by comprising an injection needle head, an extension tube, a water stop valve, a flow limiter, an injector and a micro-injection pump, wherein the injection needle head, the extension tube, the flow limiter and the injector are sequentially connected and communicated, the water stop valve is arranged on the extension tube, the injector is fixed on the micro-injection pump, and the injector comprises a needle cylinder and a piston handle; the pipe wall of the extension pipe is provided with volume scale marks, and the outer diameter of the extension pipe is 2.2-2.5 mm; the micro-injection pump comprises a pump body, and a chip control assembly, a display input assembly, a driving assembly and a fixing assembly which are arranged in the pump body; the chip control assembly is electrically connected with the display input assembly and the driving assembly respectively, and the fixing assembly is used for fixing the injector; the driving assembly is used for driving the piston handle of the syringe to suck or advance so as to realize suction or infusion of the micro-infusion device.

2. The micro-infusion device as claimed in claim 1, wherein the display input module is configured to input a tumor volume value, and the chip control module is configured to calculate the injection volume of the injector according to the tumor volume value.

3. The micro infusion device according to claim 2, further comprising a data receiving component electrically connected to the chip control component, wherein the data receiving component is configured to receive the tumor volume value provided by an external stereotaxic apparatus and transmit the tumor volume value to the chip control component.

4. The micro infusion device of claim 1, wherein the length of the extension tube is 150 and 250cm, and the volume of the extension tube is 1.5-2.5 mL.

5. The micro infusion device of claim 1, wherein the volume scale markings comprise tick marks and scale value digits, the volume scale markings having a division value of 0.1 mL.

6. The micro-infusion device according to claim 1, wherein the driving assembly comprises a stepping motor, a transmission assembly and a telescopic rod, the telescopic rod is perpendicular to the length direction of the injector, the telescopic rod is provided with a fixed clamping block, the fixed clamping block is used for clamping the piston handle of the injector, and the stepping motor drives the telescopic rod to perform reciprocating telescopic motion through the transmission assembly so as to realize the reciprocating motion of the piston handle in the injector.

7. The micro infusion device of claim 1, wherein the injection needle and the extension tube are connected by a luer fitting.

8. The micro infusion device of claim 1, wherein the flow restrictor comprises a tube having a plastic ball disposed therein, the plastic ball having a diameter less than an inner diameter of the tube; spiral bulges are arranged on the inner walls close to the two ports of the pipeline and used for blocking the plastic balls from flowing out from the two ends of the pipeline, and the two ends of the pipeline are respectively communicated with the extension pipe and the injector.

9. The micro infusion device of claim 1, wherein the micro infusion device aspirates or infuses a liquid sample to an accuracy of 0.001 mL.

10. The micro infusion device of claim 1, wherein the micro infusion device is electrically operated by an internal power source or an external power source.