CN102670323B - Mouse long bone distractor - Google Patents
Mouse long bone distractor Download PDFInfo
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- CN102670323B CN102670323B CN201210159667.7A CN201210159667A CN102670323B CN 102670323 B CN102670323 B CN 102670323B CN 201210159667 A CN201210159667 A CN 201210159667A CN 102670323 B CN102670323 B CN 102670323B
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- guide cylinder
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- arm
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Abstract
The invention relates to a mouse long bone distractor, comprising a traction screw rod, a first end cover, a guide cylinder, a second end cover, a movable fixer and a fixed fixer, wherein a strip-shaped hole is arranged at the side wall of the guide cylinder; supporting holes are arranged in the centers of the first end cover and the second end cover; the movable fixer is formed by a first connecting body and a first snap ring which is mounted on the first connecting body; a screw hole is arranged on the first connecting body; the fixed fixer is formed by a second connecting body and a second snap ring which is mounted on the second connecting body; and the components are combined in the following manner: the first end cover and the second end cover are respectively mounted at two ends of the guide cylinder, the traction screw rod is inserted into the guide cylinder, two ends of the traction screw rod are respectively located in the supporting holes of the first end cover and the second end cover, the first connecting body of the movable fixer is in threaded connection with the traction screw rod after passing through the strip-shaped hole of the guide cylinder and adopts an inner surface of the guide cylinder as a guide surface, and the fixed fixer is mounted at one end of the guide cylinder and is fixedly connected with the guide cylinder through the second connecting body of the fixed fixer.
Description
Technical field
The invention belongs to animal for research long bone stretch device, particularly a kind of experimental rat long bone Distraction Apparatus.
Background technology
Distraction osteogenesis refers to lateral osteotomy, retains soft tissue and adheres to and blood confession, progressively applies traction force bone section is retracted by special Distraction Apparatus by certain speed and frequency, makes spatium interosseum keep certain tension force, reaches the surgical technic that bone extends.Distraction osteogenesis has become long bone and cranio-maxillofacial hypoplasia, damaged critical treatment means, but the concrete biological mechanism of distraction osteogenesis is not very clear so far.Transgenic/knock out mice is the powerful of studying at present gene signal conduction, utilize transgenic/knock out mice can more in depth explore the biological mechanism of distraction osteogenesis at cell and molecular level, the distraction osteogenesis model of therefore setting up mice has very important using value.
About distraction osteogenesis zoopery, the Distraction Apparatus of existing structure is normally fixed on Distraction Apparatus on the long bone of animal or mandibular bone with screw and tests (sees " setting up mandibular distraction experimental animal model with goat ", recklessly wait quietly, clinical stomatology magazine, 2000, (01); " experimentation that distraction osteogenesis is repaired ' Bone Defect of Long Bones in conjunction with guiding skeletonization ", Xiao Yipeng, thesis for the doctorate, Military Surgeon Further Education College, PLA, 2010; " osteogenic factor NELL1 is the short osteogenetic research of cortex in rat femur distraction osteogenesis ", Xue Jing, thesis for the doctorate, Military Surgeon Further Education College, PLA, 2008), also have plenty of by tinsel Distraction Apparatus is fixed on the long bone of animal or mandibular bone and tests and (see " Activation of the hypoxia-inducible factor-1 α pathway accelerates bone regeneration ", Chao Wan etc., Proc Natl Acad Sci U S A, on January 15th, 2008, vol.105, no.2).Adopt and be screwed, for large volume animals such as monkey, sheep, dogs, the probability of success of the test is larger, but for the muroid animal (especially mice) of small size, because long bone diameter is too little, the one, fixing poor stability, the 2nd, may cause the medullary cavity total blockage of long bone, affect stretching effect, even cause the failure of an experiment.Employing tinsel is fixed, not only poor stability, and complex operation.
Summary of the invention
The object of the present invention is to provide a kind of Mus long bone Distraction Apparatus, to improve Distraction Apparatus fixing stability and success rate of experiment on Mus long bone, and simplify the operation.
Mus long bone Distraction Apparatus of the present invention, formed by traction screw, the first end cap, guide cylinder, the second end cap, movable holder and fixed holder, the sidewall of guide cylinder is provided with bar hole, the centre of the first end cap and the second end cap is provided with support holes, movable holder is made up of the first connector and the first snap ring being arranged on this connector, on described the first connector, be provided with screw, fixed holder is made up of the second connector and the second snap ring being arranged on this connector; The compound mode of each member: the first end cap, the second end cap are arranged on respectively the two ends of guide cylinder, traction screw inserts guide cylinder, its two ends lay respectively in the support holes of the first end cap and the second end cap, the first connector of movable holder is threaded with traction screw through the bar hole on guide cylinder and taking the inner surface of guide cylinder as spigot surface, fixed holder is arranged on one end of guide cylinder, is connected by its second connector and guide cylinder.
Above-mentioned Mus long bone Distraction Apparatus, guide cylinder preferably drum body, matches with guide cylinder, and centered by the first connector of movable holder, position is provided with the Rotary-table of screw and the assembly of plate body.
Above-mentioned Mus long bone Distraction Apparatus, the first snap ring in its movable holder comprises the first night bolt, the first fixed arm, the first lever arm and the first control stick, one end of the first fixed arm is provided with jack and is connected with the plate body of composition the first connector, its other end is provided with the first hinge, one end of the first lever arm and the first hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the first fixed arm, make the first lever arm and the first fixed arm form annular solid (this annular solid is fixing on Mus long bone for Distraction Apparatus of the present invention), the first night bolt is arranged on the first connector and is positioned at the position corresponding with the zigzag draw-in groove of the first lever arm, the first control stick and the first night bolt are connected, operate the zigzag draw-in groove that the first control stick can make the first night bolt enter the zigzag draw-in groove of the first lever arm or depart from the first lever arm, realize locking or the unlatching of the first lever arm.Described the first fixed arm, the preferred arc body of the first lever arm, their the preferred serrated face of intrados.
Above-mentioned Mus long bone Distraction Apparatus, the second snap ring in its fixed holder comprises the second night bolt, the second fixed arm, the second lever arm and the second control stick, one end of the second fixed arm is provided with jack and is connected with the second connector, its other end is provided with the second hinge, one end of the second lever arm and the second hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the second fixed arm, make the second lever arm and the second fixed arm form annular solid (this annular solid is fixing on Mus long bone for Distraction Apparatus of the present invention), the second night bolt is arranged on the second connector and is positioned at the position corresponding with the zigzag draw-in groove of the second lever arm, the second control stick and the second night bolt are connected, operate the zigzag draw-in groove that the second control stick can make the second night bolt enter the zigzag draw-in groove of the second lever arm or depart from the second lever arm, realize locking or the unlatching of the second lever arm.Described the second fixed arm, the preferred arc body of the second lever arm, their the preferred serrated face of intrados.
The using method of Mus long bone Distraction Apparatus of the present invention: Distraction Apparatus is fixed on Mus long bone by the second snap ring in the first snap ring and fixed holder in movable holder, adjust zigzag draw-in groove on the first lever arm of the first snap ring insert the first fixed arm jack length and adjust zigzag draw-in groove on the second lever arm of the second snap ring and insert the length of the jack of the second fixed arm, the fixing on the Mus long bone of different sizes applicable to Distraction Apparatus, the first night bolt and the first control stick are for the unlatching of the first lever arm or the control of locking of the first snap ring, the second night bolt and the second control stick are for the unlatching of the second lever arm or the control of locking of the second snap ring, rotation traction traction screw rod, can make movable holder move, and realizes the stretching of Mus long bone.
The present invention has following beneficial effect:
1, by the second snap ring in the first snap ring and fixed holder in movable holder, Distraction Apparatus is fixed on Mus long bone, thereby can cause any harmful effect to the bone marrow in Mus long bone medullary cavity, the success of test is laid a good foundation.
2, compared with the fixed form of existing Distraction Apparatus on Mus long bone, not only more convenient operation, experiment difficulty reduces, and experimental period reduces, and can promote the post-operative recovery of Mus, ensures operation and stretching effect.
3, the structure of the second snap ring in the first snap ring and fixed holder in movable holder, not only ensure that Distraction Apparatus is fixed on the stability on Mus long bone, and be convenient to regulate the size of the annular solid that the first fixed arm and the first lever arm, the second fixed arm and the second lever arm form, to be applicable to the skeletonization stretching of Mus long bones of different sizes.
4, Distraction Apparatus volume of the present invention is little, simple in structure, is convenient to processing and fabricating, is conducive to promote the use of.
Brief description of the drawings
Fig. 1 is the 3 dimensional drawing of Mus long bone Distraction Apparatus of the present invention;
Fig. 2 is the profilograph of Fig. 1;
Fig. 3 is the A-A profile of Fig. 1;
Fig. 4 is the B-B profile of Fig. 1.
In figure, 1: traction screw, 2: the first end caps, 3: guide cylinder, 4: the second end caps, 5: movable holder, 5-1: the first connector, 5-2: the first night bolt, 5-3: the first fixed arm, 5-4: the first hinge, 5-5: the first lever arm, 5-6: the first control stick, 6: fixed holder, 6-1: the second connector, 6-2: the second night bolt, 6-3: the second fixed arm, 6-4: the second hinge, 6-5: the second lever arm, 6-6: the second control stick, 7: bar hole.
Detailed description of the invention
Below by embodiment, the structure of Mus long bone Distraction Apparatus of the present invention is described further.
In the present embodiment, the structure of Mus long bone Distraction Apparatus as shown in Figure 1 and Figure 2, is made up of traction screw 1, the first end cap 2, guide cylinder 3, the second end cap 4, movable holder 5 and fixed holder 6.Guide cylinder 3 is cylinder, and its sidewall is provided with bar hole 7, so that the installation of movable holder 5 and motion, the centre of the first end cap 2 is provided with support holes, this support holes is through hole, and aperture matches with the diameter of traction screw 1 end (moving cooperation), and the centre of the second end cap 4 is provided with support holes, this support holes is blind hole, and aperture matches with the diameter of traction screw 1 end (moving cooperation), the structure of movable holder 5 is as Fig. 2, shown in Fig. 3, formed with the first snap ring being arranged on this connector by the first connector 5-1, centered by the first connector, position is provided with the Rotary-table of screw and the assembly of plate body, the external diameter of described Rotary-table matches with the internal diameter of guide cylinder 3 (moving cooperation), the first snap ring comprises the first night bolt 5-2, the first fixed arm 5-3, the first lever arm 5-5 and the first control stick 5-6, one end of the first fixed arm 5-3 is provided with jack and is connected with the plate body of composition the first connector 5-1, its other end is provided with the first hinge 5-4, one end of the first lever arm 5-5 and the first hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the first fixed arm 5-3, making the first lever arm and the first fixed arm form annular solid is fixed to Distraction Apparatus on Mus long bone, the first night bolt 5-2 is arranged on the first connector and is positioned at the position corresponding with the zigzag draw-in groove of the first lever arm, the first control stick 5-6 and the first night bolt 5-2 are connected, the first fixed arm 5-3, the first lever arm 5-5 is arc body, and their intrados is serrated face, the structure of fixed holder 6 is as Fig. 2, shown in Fig. 4, formed with the second snap ring being arranged on this connector by the second connector 6-1, the second connector 6-1 is plate body, the second snap ring comprises the second night bolt 6-2, the second fixed arm 6-3, the second lever arm 6-5 and the second control stick 6-6, one end of the second fixed arm 6-3 is provided with jack and is connected with the second connector 6-1, its other end is provided with the second hinge 6-4, one end of the second lever arm 6-5 and the second hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the second fixed arm 6-3, making the second lever arm and the second fixed arm form annular solid is fixed to Distraction Apparatus on Mus long bone, the second night bolt 6-2 is arranged on the second connector and is positioned at the position corresponding with the zigzag draw-in groove of the second lever arm, the second control stick 6-6 and the second night bolt 6-2 are connected, the second fixed arm 6-3, the second lever arm 6-5 is arc body, and their intrados is serrated face.
The compound mode of each parts or member: the first end cap 2, the second end cap 4 are arranged on respectively the two ends of guide cylinder 3, traction screw 1 inserts guide cylinder 3, its two ends lay respectively in the support holes of the first end cap and the second end cap, the first connector 5-1 of movable holder 5 is threaded with traction screw 1 through the bar hole on guide cylinder 3 and taking the inner surface of guide cylinder 3 as spigot surface, fixed holder 6 is arranged on one end of guide cylinder 3, is connected by its second connector 6-1 and guide cylinder 3.
Claims (4)
1. a Mus long bone Distraction Apparatus, by traction screw (1), the first end cap (2), guide cylinder (3), the second end cap (4), movable holder (5) and fixed holder (6) form, it is characterized in that guide cylinder (3) is cylinder, the sidewall of guide cylinder is provided with bar hole (7), the centre of the first end cap (2) and the second end cap (4) is provided with support holes, movable holder (5) is by the first connector (5-1) and be arranged on the first snap ring formation on this first connector, described the first connector (5-1) is the assembly that plate body and centre are provided with the Rotary-table of screw, described the first snap ring comprises the first night bolt (5-2), the first fixed arm (5-3), the first lever arm (5-5) and the first control stick (5-6), one end of the first fixed arm (5-3) is provided with jack and is connected with the plate body of composition the first connector (5-1), its other end is provided with the first hinge (5-4), one end of the first lever arm (5-5) and the first hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the first fixed arm (5-3), make the first lever arm and the first fixed arm form annular solid, the first night bolt (5-2) is arranged on the first connector and is positioned at the position corresponding with the zigzag draw-in groove of the first lever arm, the first control stick (5-6) is connected with the first night bolt (5-2), fixed holder (6) is by the second connector (6-1) and be arranged on the second snap ring formation on this second connector,
The first end cap (2), the second end cap (4) is arranged on respectively the two ends of guide cylinder (3), traction screw (1) inserts guide cylinder (3), its two ends lay respectively in the support holes of the first end cap and the second end cap, first connector (5-1) of movable holder (5) is threaded with traction screw (1) through the bar hole (7) on guide cylinder and taking the inner surface of guide cylinder (3) as spigot surface, fixed holder (6) is arranged on one end of guide cylinder (3), be connected by its second connector (6-1) and guide cylinder (3).
2. Mus long bone Distraction Apparatus according to claim 1, it is characterized in that the first fixed arm (5-3), the first lever arm (5-5) are arc body, and their intrados is serrated face.
3. Mus long bone Distraction Apparatus according to claim 1 and 2, it is characterized in that the second snap ring comprises the second night bolt (6-2), the second fixed arm (6-3), the second lever arm (6-5) and the second control stick (6-6), one end of the second fixed arm (6-3) is provided with jack and is connected with the second connector (6-1), its other end is provided with the second hinge (6-4), one end of the second lever arm (6-5) and the second hinge are hinged, its other end is provided with zigzag draw-in groove, this end inserts the jack of the second fixed arm (6-3), make the second lever arm and the second fixed arm form annular solid, the second night bolt (6-2) is arranged on the second connector and is positioned at the position corresponding with the zigzag draw-in groove of the second lever arm, the second control stick (6-6) is connected with the second night bolt (6-2).
4. Mus long bone Distraction Apparatus according to claim 3, it is characterized in that the second fixed arm (6-3), the second lever arm (6-5) are arc body, and their intrados is serrated face.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159667.7A CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159667.7A CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102670323A CN102670323A (en) | 2012-09-19 |
| CN102670323B true CN102670323B (en) | 2014-09-24 |
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ID=46803330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210159667.7A Expired - Fee Related CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
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| Country | Link |
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| CN (1) | CN102670323B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29904696U1 (en) * | 1999-03-13 | 1999-06-02 | Aesculap Ag & Co Kg | Distractor for bone parts |
| CN201147362Y (en) * | 2008-01-08 | 2008-11-12 | 西安中邦钛生物材料有限公司 | Inferior maxilla column aspect one-way type embedded distractor |
| CN201602831U (en) * | 2009-10-29 | 2010-10-13 | 董方 | Split-type four-claw bone holding forceps |
| CN202051798U (en) * | 2011-05-04 | 2011-11-30 | 李红钢 | Bone-fracture opening repositor |
| CN202554158U (en) * | 2012-05-22 | 2012-11-28 | 四川大学 | Long bone drawing-stretching device for mice |
-
2012
- 2012-05-22 CN CN201210159667.7A patent/CN102670323B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29904696U1 (en) * | 1999-03-13 | 1999-06-02 | Aesculap Ag & Co Kg | Distractor for bone parts |
| CN201147362Y (en) * | 2008-01-08 | 2008-11-12 | 西安中邦钛生物材料有限公司 | Inferior maxilla column aspect one-way type embedded distractor |
| CN201602831U (en) * | 2009-10-29 | 2010-10-13 | 董方 | Split-type four-claw bone holding forceps |
| CN202051798U (en) * | 2011-05-04 | 2011-11-30 | 李红钢 | Bone-fracture opening repositor |
| CN202554158U (en) * | 2012-05-22 | 2012-11-28 | 四川大学 | Long bone drawing-stretching device for mice |
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| Publication number | Publication date |
|---|---|
| CN102670323A (en) | 2012-09-19 |
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