CN102670323A - Mouse long bone distractor - Google Patents
Mouse long bone distractor Download PDFInfo
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- CN102670323A CN102670323A CN2012101596677A CN201210159667A CN102670323A CN 102670323 A CN102670323 A CN 102670323A CN 2012101596677 A CN2012101596677 A CN 2012101596677A CN 201210159667 A CN201210159667 A CN 201210159667A CN 102670323 A CN102670323 A CN 102670323A
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Abstract
The invention relates to a mouse long bone distractor, comprising a traction screw rod, a first end cover, a guide cylinder, a second end cover, a movable fixer and a fixed fixer, wherein a strip-shaped hole is arranged at the side wall of the guide cylinder; supporting holes are arranged in the centers of the first end cover and the second end cover; the movable fixer is formed by a first connecting body and a first snap ring which is mounted on the first connecting body; a screw hole is arranged on the first connecting body; the fixed fixer is formed by a second connecting body and a second snap ring which is mounted on the second connecting body; and the components are combined in the following manner: the first end cover and the second end cover are respectively mounted at two ends of the guide cylinder, the traction screw rod is inserted into the guide cylinder, two ends of the traction screw rod are respectively located in the supporting holes of the first end cover and the second end cover, the first connecting body of the movable fixer is in threaded connection with the traction screw rod after passing through the strip-shaped hole of the guide cylinder and adopts an inner surface of the guide cylinder as a guide surface, and the fixed fixer is mounted at one end of the guide cylinder and is fixedly connected with the guide cylinder through the second connecting body of the fixed fixer.
Description
Technical field
The invention belongs to animal for research long bone stretch device, particularly a kind of experimental rat long bone stretching device.
Background technology
Distraction osteogenesis is meant cortical bone is cut, and keeps soft tissue and adheres to and the blood confession, progressively applies traction force through special stretching device by certain speed and frequency the bone section is retracted, and makes spatium interosseum keep certain force of strain, reaches the surgical technic that bone prolongs.Distraction osteogenesis has become long bone and cranio-maxillofacial hypoplasia, damaged critical treatment means, yet the concrete biological mechanism of distraction osteogenesis is not very clear so far.Transgenic/knock out mice is a strong instrument of studying the gene signal conduction at present; Utilize transgenic/knock out mice can more in depth explore the biological mechanism of distraction osteogenesis at cell and molecular level, the distraction osteogenesis model of therefore setting up mice has very important use value.
About the distraction osteogenesis zoopery; The stretching device of existing structure normally is fixed in the stretching device to make an experiment on long bone or the mandibular bone of animal with screw (to be seen " setting up lower jaw distraction osteogenesis experimental animal model with goat ", waits clinical stomatology magazine quietly recklessly; 2000, (01); " distraction osteogenesis combines the guiding skeletonization to repair the damaged experimentation of long bone bone ", Xiao Yipeng, thesis for the doctorate, Military Surgeon Further Education College, PLA, 2010; " osteogenic factor NELL1 is the short osteogenetic research of cortex in the rat femur distraction osteogenesis ", Xue Jing, thesis for the doctorate; Military Surgeon Further Education College, PLA; 2008), also have plenty of the stretching device to be fixed in make an experiment on long bone or the mandibular bone of animal and (see " Activation of the hypoxia-inducible factor-1 α pathway accelerates bone regeneration ", Chao Wan etc. through tinsel; Proc Natl Acad Sci U S A; On January 15th, 2008, vol.105, no.2).The employing screw is fixed, and for big volume animal such as monkey, sheep, dog, the probability of success of the test is bigger; But muroid animal (especially mice) for small size; Because the long bone diameter is too little, the one, fixation stability property is poor, and the 2nd, possibly cause the medullary cavity total blockage of long bone; Influence the stretching effect, even cause the failure of an experiment.The employing tinsel is fixed, not only poor stability, and complex operation.
Summary of the invention
The object of the present invention is to provide a kind of Mus long bone stretching device, improving the success rate of stretching device fixation stability property and experiment on the Mus long bone, and simplify the operation.
Mus long bone stretching device according to the invention; Constitute by traction screw, first end cap, guide cylinder, second end cap, movable holder and fixed holder; The sidewall of guide cylinder is provided with bar hole; The centre of first end cap and second end cap is provided with support holes; Movable holder is made up of first connector and first snap ring that is installed on this connector, and said first connector is provided with screw, and fixed holder is made up of second connector and second snap ring that is installed on this connector; The compound mode of each member: first end cap, second end cap are installed in the two ends of guide cylinder respectively; Traction screw inserts guide cylinder; Its two ends lay respectively in the support holes of first end cap and second end cap; First connector of movable holder passes that bar hole on the guide cylinder is threaded with traction screw and is spigot surface with the inner surface of guide cylinder, and fixed holder is installed in an end of guide cylinder, is connected through its second connector and guide cylinder.
Above-mentioned Mus long bone stretching device, guide cylinder preferably drum body is complementary with guide cylinder, and first connector of movable holder is that the centre is provided with the Rotary-table of screw and the assembly of plate body.
Above-mentioned Mus long bone stretching device; First snap ring in its movable holder comprises first night bolt, first fixed arm, first lever arm and first control stick; One end of first fixed arm is provided with jack and is connected with the plate body of forming first connector; Its other end is equipped with first hinge, and an end of first lever arm and first hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of first fixed arm; Make first lever arm and first fixed arm form annular solid (this annular solid is used for stretching device according to the invention fixing on the Mus long bone), first night bolt is installed on first connector and is positioned at the corresponding position of zigzag draw-in groove with first lever arm, and first control stick and first night bolt are connected; Operate the zigzag draw-in groove that first control stick then can make first night bolt get into the zigzag draw-in groove of first lever arm or break away from first lever arm, realize the locking or the unlatching of first lever arm.Said first fixed arm, the preferred arc body of first lever arm, the preferred serrated face of their intrados.
Above-mentioned Mus long bone stretching device; Second snap ring in its fixed holder comprises second night bolt, second fixed arm, second lever arm and second control stick; One end of second fixed arm is provided with jack and is connected with second connector; Its other end is equipped with second hinge, and an end of second lever arm and second hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of second fixed arm; Make second lever arm and second fixed arm form annular solid (this annular solid is used for stretching device according to the invention fixing on the Mus long bone), second night bolt is installed on second connector and is positioned at the corresponding position of zigzag draw-in groove with second lever arm, and second control stick and second night bolt are connected; Operate the zigzag draw-in groove that second control stick then can make second night bolt get into the zigzag draw-in groove of second lever arm or break away from second lever arm, realize the locking or the unlatching of second lever arm.Said second fixed arm, the preferred arc body of second lever arm, the preferred serrated face of their intrados.
The method for using of Mus long bone stretching device according to the invention: the stretching device is fixed on the Mus long bone through first snap ring in the movable holder and second snap ring in the fixed holder; Adjust the length that zigzag draw-in groove on second lever arm of length and adjustment second snap ring of jack that zigzag draw-in groove on first lever arm of first snap ring inserts first fixed arm inserts the jack of second fixed arm; Then applicable to stretching device fixing on the Mus long bone of different sizes; First night bolt and first control stick are used for unlatching or the control of locking of first lever arm of first snap ring, and second night bolt and second control stick are used for unlatching or the control of locking of second lever arm of second snap ring; The rotation traction traction screw rod then can make movable holder move, and realizes the stretching of Mus long bone.
The present invention has following beneficial effect:
1, through first snap ring in the movable holder and second snap ring in the fixed holder stretching device is fixed on the Mus long bone, thereby can cause any harmful effect, the success of test is laid a good foundation the bone marrow in the Mus long bone medullary cavity.
2, compare with the fixed form of existing stretching device on the Mus long bone, not only more convenient operation is tested difficulty and is reduced, and experimental period reduces, and can promote the post-operative recovery of Mus, guarantees operation and stretching effect.
3, the structure of second snap ring in first snap ring and the fixed holder in the movable holder; Guaranteed that not only the stretching device is fixed on the stability on the Mus long bone; And the size of being convenient to regulate first fixed arm and first lever arm, second fixed arm and the formed annular solid of second lever arm, to be applicable to the skeletonization stretching of the Mus long bone that difference is big or small.
4, stretching body according to the invention is long-pending little, simple in structure, is convenient to processing and fabricating, helps promoting the use of.
Description of drawings
Fig. 1 is the 3 dimensional drawing of Mus long bone stretching device according to the invention;
Fig. 2 is the profilograph of Fig. 1;
Fig. 3 is the A-A profile of Fig. 1;
Fig. 4 is the B-B profile of Fig. 1.
Among the figure, 1: traction screw, 2: the first end caps, 3: guide cylinder, 4: the second end caps, 5: movable holder, 5-1: first connector, 5-2: first night bolt, 5-3: first fixed arm, 5-4: first hinge, 5-5: first lever arm, 5-6: first control stick, 6: fixed holder, 6-1: second connector, 6-2: second night bolt, 6-3: second fixed arm, 6-4: second hinge, 6-5: second lever arm, 6-6: second control stick, 7: bar hole.
The specific embodiment
Through embodiment the structure of Mus long bone stretching device according to the invention is described further below.
In the present embodiment, structure such as Fig. 1, shown in Figure 2 of Mus long bone stretching device are made up of traction screw 1, first end cap 2, guide cylinder 3, second end cap 4, movable holder 5 and fixed holder 6.Guide cylinder 3 is a cylinder, and its sidewall is provided with bar hole 7, so that the installation of movable holder 5 and motion; The centre of first end cap 2 is provided with support holes; This support holes is a through hole, and the diameter of aperture and traction screw 1 end is complementary (movingly), and the centre of second end cap 4 is provided with support holes; This support holes is a blind hole, the diameter of aperture and traction screw 1 end be complementary (movingly); The structure of movable holder 5 such as Fig. 2, shown in Figure 3; Constitute with first snap ring that is installed on this connector by the first connector 5-1; First connector is that the centre is provided with the Rotary-table of screw and the assembly of plate body, and the internal diameter of the external diameter of said Rotary-table and guide cylinder 3 is complementary (movingly), and first snap ring comprises the first night bolt 5-2, the first fixed arm 5-3, the first lever arm 5-5 and the first control stick 5-6; The end of the first fixed arm 5-3 is provided with jack and is connected with the plate body of forming the first connector 5-1; Its other end is equipped with the first hinge 5-4, and the end of the first lever arm 5-5 and first hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of the first fixed arm 5-3; Make first lever arm and first fixed arm form annular solid the stretching device is fixed on the Mus long bone, the first night bolt 5-2 is installed on first connector and is positioned at the corresponding position of zigzag draw-in groove with first lever arm, and the first control stick 5-6 and the first night bolt 5-2 are connected; The first fixed arm 5-3, the first lever arm 5-5 are arc body, and their intrados is serrated face; The structure of fixed holder 6 such as Fig. 2, shown in Figure 4; Be made up of with second snap ring that is installed on this connector the second connector 6-1, the second connector 6-1 is a plate body, and second snap ring comprises the second night bolt 6-2, the second fixed arm 6-3, the second lever arm 6-5 and the second control stick 6-6; The end of the second fixed arm 6-3 is provided with jack and is connected with the second connector 6-1; Its other end is equipped with the second hinge 6-4, and the end of the second lever arm 6-5 and second hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of the second fixed arm 6-3; Make second lever arm and second fixed arm form annular solid the stretching device is fixed on the Mus long bone, the second night bolt 6-2 is installed on second connector and is positioned at the corresponding position of zigzag draw-in groove with second lever arm, and the second control stick 6-6 and the second night bolt 6-2 are connected; The second fixed arm 6-3, the second lever arm 6-5 are arc body, and their intrados is serrated face.
The compound mode of each parts or member: first end cap 2, second end cap 4 are installed in the two ends of guide cylinder 3 respectively; Traction screw 1 inserts guide cylinder 3; Its two ends lay respectively in the support holes of first end cap and second end cap; The first connector 5-1 of movable holder 5 passes that bar hole on the guide cylinder 3 is threaded with traction screw 1 and is spigot surface with the inner surface of guide cylinder 3, and fixed holder 6 is installed in an end of guide cylinder 3, is connected through its second connector 6-1 and guide cylinder 3.
Claims (10)
1. Mus long bone stretching device; It is characterized in that constituting by traction screw (1), first end cap (2), guide cylinder (3), second end cap (4), movable holder (5) and fixed holder (6); The sidewall of guide cylinder (3) is provided with bar hole (7); The centre of first end cap (2) and second end cap (4) is provided with support holes; Movable holder (5) is by first connector (5-1) and be installed in first snap ring formation on this connector, and said first connector (5-1) is provided with screw, and fixed holder (6) is by second connector (6-1) and be installed in second snap ring formation on this connector;
First end cap (2), second end cap (4) are installed in the two ends of guide cylinder (3) respectively; Traction screw (1) inserts guide cylinder (3); Its two ends lay respectively in the support holes of first end cap and second end cap; First connector (5-1) of movable holder (5) passes that bar hole (7) on the guide cylinder is threaded with traction screw (1) and is spigot surface with the inner surface of guide cylinder (3); Fixed holder (6) is installed in an end of guide cylinder (3), is connected through its second connector (6-1) and guide cylinder (3).
2. Mus long bone stretching device according to claim 1 is characterized in that guide cylinder (3) is a cylinder, and first connector of movable holder (5) is that the centre is provided with the Rotary-table of screw and the assembly of plate body.
3. Mus long bone stretching device according to claim 1 and 2; It is characterized in that first snap ring comprises first night bolt (5-2), first fixed arm (5-3), first lever arm (5-5) and first control stick (5-6); One end of first fixed arm (5-3) is provided with jack and is connected with the plate body of forming first connector (5-1); Its other end is equipped with first hinge (5-4), and an end of first lever arm (5-5) and first hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of first fixed arm (5-3); Make first lever arm and first fixed arm form annular solid, first night bolt (5-2) is installed on first connector and is positioned at the corresponding position of zigzag draw-in groove with first lever arm, and first control stick (5-6) is connected with first night bolt (5-2).
4. Mus long bone stretching device according to claim 3 it is characterized in that first fixed arm (5-3), first lever arm (5-5) are arc body, and their intrados is serrated face.
5. Mus long bone stretching device according to claim 1 and 2; It is characterized in that second snap ring comprises second night bolt (6-2), second fixed arm (6-3), second lever arm (6-5) and second control stick (6-6); One end of second fixed arm (6-3) is provided with jack and is connected with second connector (6-1); Its other end is equipped with second hinge (6-4), and an end of second lever arm (6-5) and second hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of second fixed arm (6-3); Make second lever arm and second fixed arm form annular solid, second night bolt (6-2) is installed on second connector and is positioned at the corresponding position of zigzag draw-in groove with second lever arm, and second control stick (6-6) is connected with second night bolt (6-2).
6. Mus long bone stretching device according to claim 3; It is characterized in that second snap ring comprises second night bolt (6-2), second fixed arm (6-3), second lever arm (6-5) and second control stick (6-6); One end of second fixed arm (6-3) is provided with jack and is connected with second connector (6-1); Its other end is equipped with second hinge (6-4), and an end of second lever arm (6-5) and second hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of second fixed arm (6-3); Make second lever arm and second fixed arm form annular solid, second night bolt (6-2) is installed on second connector and is positioned at the corresponding position of zigzag draw-in groove with second lever arm, and second control stick (6-6) is connected with second night bolt (6-2).
7. Mus long bone stretching device according to claim 4; It is characterized in that second snap ring comprises second night bolt (6-2), second fixed arm (6-3), second lever arm (6-5) and second control stick (6-6); One end of second fixed arm (6-3) is provided with jack and is connected with second connector (6-1); Its other end is equipped with second hinge (6-4), and an end of second lever arm (6-5) and second hinge are hinged, and its other end is provided with the zigzag draw-in groove; This end inserts the jack of second fixed arm (6-3); Make second lever arm and second fixed arm form annular solid, second night bolt (6-2) is installed on second connector and is positioned at the corresponding position of zigzag draw-in groove with second lever arm, and second control stick (6-6) is connected with second night bolt (6-2).
8. Mus long bone stretching device according to claim 5 it is characterized in that second fixed arm (6-3), second lever arm (6-5) are arc body, and their intrados is serrated face.
9. Mus long bone stretching device according to claim 6 it is characterized in that second fixed arm (6-3), second lever arm (6-5) are arc body, and their intrados is serrated face.
10. Mus long bone stretching device according to claim 7 it is characterized in that second fixed arm (6-3), second lever arm (6-5) are arc body, and their intrados is serrated face.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159667.7A CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159667.7A CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
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| Publication Number | Publication Date |
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| CN102670323A true CN102670323A (en) | 2012-09-19 |
| CN102670323B CN102670323B (en) | 2014-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210159667.7A Expired - Fee Related CN102670323B (en) | 2012-05-22 | 2012-05-22 | Mouse long bone distractor |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29904696U1 (en) * | 1999-03-13 | 1999-06-02 | Aesculap Ag & Co Kg | Distractor for bone parts |
| CN201147362Y (en) * | 2008-01-08 | 2008-11-12 | 西安中邦钛生物材料有限公司 | Inferior maxilla column aspect one-way type embedded distractor |
| CN201602831U (en) * | 2009-10-29 | 2010-10-13 | 董方 | Split-type four-claw bone holding forceps |
| CN202051798U (en) * | 2011-05-04 | 2011-11-30 | 李红钢 | Bone-fracture opening repositor |
| CN202554158U (en) * | 2012-05-22 | 2012-11-28 | 四川大学 | Long bone drawing-stretching device for mice |
-
2012
- 2012-05-22 CN CN201210159667.7A patent/CN102670323B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29904696U1 (en) * | 1999-03-13 | 1999-06-02 | Aesculap Ag & Co Kg | Distractor for bone parts |
| CN201147362Y (en) * | 2008-01-08 | 2008-11-12 | 西安中邦钛生物材料有限公司 | Inferior maxilla column aspect one-way type embedded distractor |
| CN201602831U (en) * | 2009-10-29 | 2010-10-13 | 董方 | Split-type four-claw bone holding forceps |
| CN202051798U (en) * | 2011-05-04 | 2011-11-30 | 李红钢 | Bone-fracture opening repositor |
| CN202554158U (en) * | 2012-05-22 | 2012-11-28 | 四川大学 | Long bone drawing-stretching device for mice |
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| Publication number | Publication date |
|---|---|
| CN102670323B (en) | 2014-09-24 |
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