CN102670252B - Intracranial pressure non-invasive measuring method and system - Google Patents
Intracranial pressure non-invasive measuring method and system Download PDFInfo
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- CN102670252B CN102670252B CN2012101760046A CN201210176004A CN102670252B CN 102670252 B CN102670252 B CN 102670252B CN 2012101760046 A CN2012101760046 A CN 2012101760046A CN 201210176004 A CN201210176004 A CN 201210176004A CN 102670252 B CN102670252 B CN 102670252B
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Abstract
The invention discloses an intracranial pressure non-invasive measuring method. The method includes the following steps that step one, at least two ultrasonic sensors with a same specification are utilized to obtain a normal ultrasonic amplitude value and a phase reference signal; and step two, the ultrasonic sensors are arranged at temple positions of two sides of a head to be measured respectively, an incentive ultrasonic signal parameter which is same to that of the step one is utilized, the signal collected by the ultrasonic sensors is processed again and then transmitted to a computer, and an additional pressure value, namely an intracranial pressure can be detected by a differential demodulation method. Beside, the invention further discloses a system for intracranial pressure non-invasive measuring. By means of the intracranial pressure non-invasive measuring method and the system, the sensors are not required to be extended to the interior of a measured object (the head), and the ultrasonic wave is harmless to human body, so that a nondestructive ultrasonic testing for the measured object (the head) can be achieved, and the defect that the non-invasive testing for the measured object (the head) can not be achieved in terms of existing detection devices is overcome.
Description
Technical field
The present invention relates to the signal measurement analysis technical field, particularly a kind of intracranial pressure noninvasive measuring method, also relate to a kind of measuring system simultaneously.
Background technology
Ultrasonic technology, as a kind of nondestructiving detecting means, is widely used in the life medical treatment, food analysis, quality control, material science and geophysics field etc.Deformation can occur in object receiving force, and the quality because of object is certain again, so corresponding change can occur the density of object.Ultrasound wave propagation characteristic in object all has relation with parameters such as the material of object, density, hardness, temperature, in the situation that only consider object density, just can obtain the relation of object receiving force and hyperacoustic wavelength and phase place, utilize this theoretical relation that just can obtain intracranial pressure and ultrasound wave wavelength.Due to its excitation with to detect be all to carry out in the object outside, so ultrasound examination is a kind of noinvasive detection technique.The present invention proposes a kind of method and apparatus of brand-new detection intracranial pressure, has broad application prospects.
Ultrasonic sensor and ultrasonic signal capture card are the core apparatus that intracranial pressure noninvasive detects.Ultrasonic sensor utilizes piezoelectric effect and makes, it can be divided into shear wave sensor and Longitudinalwave sensor by wave mode, because its application is extensive, so the frequency of ultrasonic sensor does not wait from several ten thousand hertz to several megahertzes, and its shape also can change as required.Data acquisition card can be intuitively by ultrasound wave waveform and parameter display to computer, its frequency is generally more than 20 times of respective sensor frequency, could collect more accurately signal like this.In order to utilize better the computer analysis data, data acquisition card again must be compatible mutually with computer.This parameter to data acquisition card has certain requirement.
Traditional intracranial pressure detects and all need on head, punch, and in clinical practice, can bring certain misery to the patient, and so not only head is diminished wound but also can not repeatedly carry out, and the head wound infection in its later stage can directly cause patient death.Therefore current intracranial pressure detects detection method and the device of being badly in need of a kind of noinvasive and can repeatedly carrying out for a long time.
Summary of the invention
In view of this, one of purpose of the present invention is to provide a kind of intracranial pressure noninvasive measuring method, its sensor is without the inside that is deep into measuring object (head), and its ultrasound wave is harmless to human body, thereby has realized that measuring object (head) must can't harm ultrasound examination; Two of purpose of the present invention is to provide a kind of for the intracranial pressure nondestructive measurement system.
The objective of the invention is to be achieved through the following technical solutions:
The intracranial pressure noninvasive measuring method comprises the following steps:
Step 1: the ultrasonic sensor that adopts at least two same specifications, it is arranged at respectively to the temple position, both sides of the normal head of intracranial pressure, then set the ultrasonic signal parameter of excitation, be emitted in the ultrasonic signal of the excitation of propagating in head, the signal that ultrasonic sensor gathers imports computer after treatment into, obtains normal ultrasound wave amplitude and phase reference signal;
Step 2: the temple position, both sides that ultrasonic sensor is arranged at respectively to head to be measured, adopt the ultrasonic signal parameter of the excitation identical with step 1, the signal again ultrasonic sensor gathered imports computer after treatment into, when the change of intracranial pressure, ultrasound wave amplitude and the phase place at intracranial, propagated also can correspondingly change, by the difference demodulation method, draw the variation of ultrasound wave amplitude and phase place, just can detect the value of additonal pressure, i.e. intracranial pressure;
The result that step 1 records is as reference recording in computer, and intracranial pressure afterwards only needs repeating step two to get final product in measuring.
Further, described step 1 is triplicate at least, and the result according to repeatedly measuring, by the error analysis technology, obtain final normal ultrasound wave amplitude and phase reference signal.
Two of purpose of the present invention is achieved through the following technical solutions:
The intracranial pressure noninvasive measuring system, comprise
Supersonic generator, for being provided at the ultrasonic signal of the excitation that head propagates;
Ultrasonic sensor, quantity are at least two, are arranged on the both sides temple of head to be measured, the ultrasonic signal of propagating for being received in head;
Data acquisition card, be used to receiving the acquired signal of ultrasonic sensor output, and process;
Analyze main frame, carry out analyzing and processing for the signal after data acquisition card is processed, according to normal ultrasound wave amplitude and phase signal, the variation that draws ultrasound wave amplitude and phase place by the difference demodulation method, detect the value of additonal pressure, i.e. intracranial pressure.
Further, supersonic generator and ultrasonic sensor are made one, and namely ultrasonic sensor has the function of emission ultrasonic signal and received ultrasonic signal.
The invention has the beneficial effects as follows:
The invention provides a kind of intracranial pressure noninvasive measuring method and device of answering, the ultrasound wave that this device encourages can be at the internal communication of detected object (head), its sensor is without the inside that is deep into measuring object (head), its ultrasound wave is harmless to human body, thereby realized that measuring object (head) must can't harm ultrasound examination, overcome the shortcoming that existing checkout gear can not carry out the noinvasive detection to measuring object (head).
Other advantages of the present invention, target and feature will be set forth to a certain extent in the following description, and to a certain extent, based on to investigating hereinafter, will being apparent to those skilled in the art, or can be instructed from the practice of the present invention.Target of the present invention and other advantages can realize by following description and obtain.
The accompanying drawing explanation
In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention is described in further detail below in conjunction with accompanying drawing, wherein:
The device schematic diagram that Fig. 1 measures for the intracranial pressure noninvasive that the embodiment of the present invention provides;
The masterpiece that Fig. 2 provides for the embodiment of the present invention is for the object schematic diagram;
It is hyperacoustic propagation waveform distribution schematic diagram in the F situation that the detected object that Fig. 3 provides for the embodiment of the present invention (head) is subjected to additional force;
The detected object that Fig. 4 provides for the embodiment of the present invention (head) is subjected to the lower ultrasonic propagation distributed wave schematic diagram of additional force (F+ Δ F) effect.
Fig. 5 is subjected to additional force to be hyperacoustic acoustic pressure distribution schematic diagram in the F situation for the COMSOL analog detection object that utilizes that the embodiment of the present invention provides;
Fig. 6 for the embodiment of the present invention provide to utilize COMSOL analog detection object to be subjected to additional force be the acoustic pressure scattergram schematic diagram of the lower ultrasonic propagation of (F+ Δ F) effect.
The actual measurement that Fig. 7 provides for the embodiment of the present invention detects the graph of a relation of hyperacoustic amplitude and object receiving force.
The actual measurement that Fig. 8 provides for the embodiment of the present invention detects hyperacoustic the graph of a relation with object receiving force.
The specific embodiment
Hereinafter with reference to accompanying drawing, the preferred embodiments of the present invention are described in detail.Should be appreciated that preferred embodiment is only for the present invention is described, rather than in order to limit the scope of the invention.
The device schematic diagram that Fig. 1 measures for the intracranial pressure noninvasive that the embodiment of the present invention provides; The masterpiece that Fig. 2 provides for the embodiment of the present invention is for the object schematic diagram; It is that in the F situation, ultrasound wave is being propagated the waveform scattergram that the detected object that Fig. 3 provides for the embodiment of the present invention (head) is subjected to additional force; The detected object that Fig. 4 provides for the embodiment of the present invention (head) is subjected to the lower ultrasonic propagation distributed wave figure of additional force (F+ Δ F) effect.Fig. 5 is subjected to additional force to be hyperacoustic acoustic pressure distribution schematic diagram in the F situation for the COMSOL analog detection object that utilizes that the embodiment of the present invention provides; Fig. 6 for the embodiment of the present invention provide to utilize COMSOL analog detection object to be subjected to additional force be the acoustic pressure scattergram schematic diagram of the lower ultrasonic propagation of (F+ Δ F) effect.
A kind of intracranial pressure noninvasive measuring method provided by the invention, concrete enforcement comprises the following steps:
Step 1: the ultrasonic sensor that adopts two same specifications, it is arranged at respectively to the temple position, both sides of the normal head of intracranial pressure, then set the ultrasonic signal parameter of excitation, be emitted in the ultrasonic signal of the excitation of propagating in head, the signal that ultrasonic sensor gathers imports computer after treatment into, obtains normal ultrasound wave amplitude and phase reference signal;
Step 2: the temple position, both sides that ultrasonic sensor is arranged at respectively to head to be measured, adopt the ultrasonic signal parameter of the excitation identical with step 1, the signal again ultrasonic sensor gathered imports computer after treatment into, when the change of intracranial pressure, ultrasound wave amplitude and the phase place at intracranial, propagated also can correspondingly change, by the difference demodulation method, draw the variation of ultrasound wave amplitude and phase place, just can detect the value of additonal pressure, i.e. intracranial pressure;
The result that step 1 records is as reference recording in computer, and intracranial pressure afterwards only needs repeating step two to get final product in measuring.
In this method, sensor is placed on to object (the temple position of head), more is conducive to the propagation of ultrasonic signal.
To receive the intrinsic pressure of the detected normal measuring object of ultrasonic sensor (head) records as benchmark, intrinsic pressure normal with it measuring object (head) of the abnormal measuring object (head) that will detect again intrinsic pressure carries out difference demodulation contrast and draws the difference ultrasonic signal, thereby reflect the intrinsic pressure of measuring object (head), the many groups ultrasonic signal collected is carried out to the difference demodulation, just can draw the corresponding unique ultrasonic signal of a certain intrinsic pressure value of measuring object (head), the also intrinsic pressure value of this measuring object of unique reflection (head) of this ultrasonic signal conversely.
According to the design philosophy of said method, intracranial pressure noninvasive measuring system of the present invention, comprise
(1) supersonic generator, for being provided at the ultrasonic signal of the excitation that head propagates;
(2) ultrasonic sensor, quantity are at least two, are arranged on the both sides temple of head to be measured, the ultrasonic signal of propagating for being received in head;
(3) data acquisition card, be used to receiving the acquired signal of ultrasonic sensor output, and process;
(4) analyze main frame, carry out analyzing and processing for the signal after data acquisition card is processed, according to normal ultrasound wave amplitude and phase signal, the variation that draws ultrasound wave amplitude and phase place by the difference demodulation method, detect the value of additonal pressure, i.e. intracranial pressure.
In the present embodiment, supersonic generator and ultrasonic sensor are made one, and namely ultrasonic sensor has the function of emission ultrasonic signal and received ultrasonic signal.
The specific embodiment of the invention is on ultrasonic propagation theoretical basis and the device of building, its theoretical for measuring object (head) while being subjected to additional force object deformation can occur, thereby change the density of object, Ultrasonic Wave Propagation Character also can correspondingly change so, utilize the difference demodulation method can obtain additional force (being intracranial pressure), its device is that main body forms by ultrasonic sensor (can receive and can launch) and the data acquisition card of two same models, its sensor is respectively in the relative both sides of measuring object (head), the ultrasonic signal parameter of its excitation is fixed constant, its additonal pressure is directly over measuring object (head).The frequency of data acquisition card is generally more than 20 times of respective sensor frequency, could collect more accurately signal like this.In order to utilize better the computer analysis data, data acquisition card must be compatible mutually with computer.
The device schematic diagram that Fig. 1 measures for intracranial pressure noninvasive that the embodiment of the present invention provides, the difference demodulation method of its demodulation method for carrying for the embodiment of the present invention, its checkout gear gets final product in object external stability.
Fig. 2 is the schematic diagram of object receiving force and Ultrasonic Wave Propagation Character relation, utilizes the difference demodulation method to detect the suffered additional force of measuring object (head), and principle is described in detail as follows:
In Fig. 2, the wave function of plane harmonic wave: y (x, t)=Acos[ω (t-
)+
] (1)
Compressional wave speed in solid:
(2), wherein E is the Young's modulus of solid, and ρ is the density of solid.
Solid Young's modulus: E=
(3), wherein F by area S, being held
The power be subjected to,
Deformation quantity for object under this power effect.
As shown in Figure 2, it is upper that additional force F acts on face S, and Δ L compressive deformation will occur object.Now cube density is:
（4）
The velocity of wave of ultrasound wave in object now
:
By formula (3), obtained:
(6)
Wherein
,, substitution (6) formula draws:
Can obtain the relation of additional force and ultrasound wave wavelength, can produce pressure P when ultrasound wave incides object, be acoustic pressure, and acoustic pressure corresponding to plane wave (1) formula
For:
The phase place that wherein can change
Amplitude for acoustic pressure
, wherein
For constant, have:
(9)
(9) formula substitution (6) formula is obtained:
When additional force is increased to F+ Δ F, by (10) formula, obtained:
（11）
By (10) formula and (11) formula, obtained:
By (12) formula, drawn the relation of additional force Δ F and twice of front and back sound pressure amplitude and phase place.
Waveform when Fig. 3 ultrasound wave when analog detection object (head) is subjected to additional force to be F is in theory propagated in object, Fig. 4 are the wave form varies of detected object (head) ultrasonic propagation while being subjected to additional force to be (F+ Δ F),
Its wavelength shortens, variation has also occurred in the ultrasound wave phase place of same point.
Fig. 5 is that when while utilizing COMSOL analog detection object to be subjected to additional force for F, in situation, ultrasound wave was propagated in object, acoustic pressure distributed, Fig. 6 hyperacoustic acoustic pressure scattergram when utilizing COMSOL analog detection object to be subjected to additional force to be (F+ Δ F), change has occurred in its ultrasound wave sound pressure amplitude scattergram, can draw the relation that it is subjected to additional force and ultrasound wave sound pressure amplitude
The actual measurement that Fig. 7 provides for the embodiment of the present invention detects the graph of a relation of hyperacoustic amplitude and object receiving force, can find out the variation relation of additional force with the ultrasound wave amplitude,
Additional force increases along with the increase of ultrasound wave amplitude.The actual measurement that Fig. 8 provides for the embodiment of the present invention detects hyperacoustic the graph of a relation with object receiving force can find out the variation relation of additional force with the ultrasound wave phase place,
Additional force increases along with the increase of ultrasound wave phase place.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, obviously, those skilled in the art can carry out various changes and modification and not break away from the spirit and scope of the present invention the present invention.Like this, if within of the present invention these are revised and modification belongs to the scope of the claims in the present invention and equivalent technologies thereof, the present invention also is intended to comprise these changes and modification interior.
Claims (4)
1. intracranial pressure noninvasive measuring method is characterized in that: said method comprising the steps of:
Step 1: the ultrasonic sensor that adopts at least two same specifications, it is arranged at respectively to the temple position, both sides of the normal head of intracranial pressure, then set the ultrasonic signal parameter of excitation, be emitted in the ultrasonic signal of the excitation of propagating in head, the signal that ultrasonic sensor gathers imports computer after treatment into, obtains normal ultrasound wave amplitude and phase reference signal;
Step 2: the temple position, both sides that ultrasonic sensor is arranged at respectively to head to be measured, adopt the ultrasonic signal parameter of the excitation identical with step 1, the signal again ultrasonic sensor gathered imports computer after treatment into, when the change of intracranial pressure, ultrasound wave amplitude and the phase place at intracranial, propagated also can correspondingly change, by the difference demodulation method, draw the variation of ultrasound wave amplitude and phase place, just can detect the value of additonal pressure, i.e. intracranial pressure;
The result that step 1 records is as reference recording in computer, and intracranial pressure afterwards only needs repeating step two to get final product in measuring.
2. intracranial pressure noninvasive measuring method according to claim 1, it is characterized in that: described step 1 is triplicate at least, and the result according to repeatedly measuring, by the error analysis technology, obtain final normal ultrasound wave amplitude and phase reference signal.
3. intracranial pressure noninvasive measuring system, it is characterized in that: described system comprises
Supersonic generator, for being provided at the ultrasonic signal of the excitation that head propagates;
Ultrasonic sensor, quantity are at least two, are arranged on the both sides temple of head to be measured, the ultrasonic signal of propagating for being received in head;
Data acquisition card, be used to receiving the acquired signal of ultrasonic sensor output, and process;
Analyze main frame, carry out analyzing and processing for the signal after data acquisition card is processed, according to normal ultrasound wave amplitude and phase signal, the variation that draws ultrasound wave amplitude and phase place by the difference demodulation method, detect the value of additonal pressure, i.e. intracranial pressure.
4. intracranial pressure noninvasive measuring system as claimed in claim 3, it is characterized in that: described supersonic generator and ultrasonic sensor are made one, and namely ultrasonic sensor has the function of emission ultrasonic signal and received ultrasonic signal.
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| CN102973260B (en) * | 2012-11-30 | 2014-09-10 | 中国人民解放军第三军医大学生物医学工程与医学影像学院 | Noncontact magnetic sensing-type intracranial pressure monitoring device |
| CN103190930B (en) * | 2013-04-19 | 2014-10-29 | 重庆大学 | Intracranial pressure monitoring instrument based on ultrasonic wave acoustoelastic effect |
| CN110393518A (en) * | 2019-08-07 | 2019-11-01 | 西安市第四医院 | A kind of encephalic pressure detecting system |
| CN110507307B (en) * | 2019-08-30 | 2021-12-28 | 重庆博恩富克医疗设备有限公司 | Noninvasive intracranial pressure monitoring device and method |
| CN110507306B (en) * | 2019-08-30 | 2022-01-11 | 重庆博恩富克医疗设备有限公司 | Real-time noninvasive intracranial pressure monitoring system and method |
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| US8172769B2 (en) * | 2003-08-08 | 2012-05-08 | Virginia Commonwealth University | Method and apparatus for monitoring intra ocular and intra cranial pressure |
| CN2726531Y (en) * | 2004-08-05 | 2005-09-21 | 陕西一方科技发展有限公司 | Non-invasive intracranial pressure detector |
| US20060241438A1 (en) * | 2005-03-03 | 2006-10-26 | Chung-Yuo Wu | Method and related system for measuring intracranial pressure |
| CN100548212C (en) * | 2007-01-18 | 2009-10-14 | 北京大学人民医院 | Noninvasive intracranial pressure monitoring equipment |
| CN201426730Y (en) * | 2009-05-18 | 2010-03-24 | 重庆大学 | Intracranial pressure noninvasive comprehensive detection monitoring analyzer |
| CN102429651B (en) * | 2011-08-15 | 2013-10-30 | 重庆大学 | Multi-parameter-based intracranial pressure noninvasive detection method and device |
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