CN102669156A - Application of compound carbonic anhydrase (CA)-074 methyl ester in preparation of gypsy moth imago attractant - Google Patents
Application of compound carbonic anhydrase (CA)-074 methyl ester in preparation of gypsy moth imago attractant Download PDFInfo
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- CN102669156A CN102669156A CN2012101303271A CN201210130327A CN102669156A CN 102669156 A CN102669156 A CN 102669156A CN 2012101303271 A CN2012101303271 A CN 2012101303271A CN 201210130327 A CN201210130327 A CN 201210130327A CN 102669156 A CN102669156 A CN 102669156A
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Abstract
The invention relates to an application of compound carbonic anhydrase (CA)-074 methyl ester displayed of chemical formula (I) in preparation of gypsy moth imago attractant. In the technical scheme, the compound CA-074 methyl ester is commoditized compound, is cheap, easy to get, simple in preparation method and extremely excellent in trap effect of gypsy moth imagoes, and has wide application prospect.
Description
Technical field
The present invention relates to the insect attractant field, be specifically related to the purposes of Compound C A-074 methyl esters in the preparation Gypsy moth adult worm attractant.
Background technology
Compound C A-074 methyl esters Chinese L-trans-Epoxysuccinic acid by name-Ile-Pro-OMe propionic aldehyde, English (L-trans-(Propylcarbamyl) oxirane-2-carbonyl)-L-proline methyl ester by name.As the product of Sigma company, CAS is numbered 147859-80-1, and the purposes of having stipulated this compound is for only supplying the scientific research purposes, not as medicine, the subsequent use medicine of family or other purposes.Reported first in 1992 inhibitor of CA-074 methyl esters as cathepsin B, can make the cathepsin B's inactivation optionally in people's Gingival Fibroblasts, the CA-074 methyl esters is explaining certain help is being arranged aspect cathepsin B's biological function.
Gypsymoth (Lymantria dispar L.) belongs to Lepidoptera Lymantriidae Euproctis, is a kind of common forest defoliator.Gypsymoth distributes extensively in China, the host plant of harm is of a great variety, and therefore development is of great practical significance for trapping and the control of gypsymoth.Prevent and treat in the method the numerous of gypsymoth, the attractant trapping is a kind of efficient, free of contamination method of preventing and treating, and modal attractant is the sex pheromone of gypsymoth itself.
Chinese patent CN 101810166 discloses a kind of Gypsy moth adult worm attractant and trapping device; Adopt several kinds of volatile ingredients in the Dahurian larch to carry out composite formation attractant; Gypsy moth adult worm is had trap effect preferably, but this attractant complicated component, cost are higher.
Summary of the invention
For overcoming defectives such as existing Gypsy moth adult worm attractant kind is few, with high costs, the purpose of this invention is to provide the purposes of a kind of compound in the preparation Gypsy moth adult worm attractant.
Purposes provided by the invention is: the purposes of the Compound C A-074 methyl esters shown in the chemical formula (I) in the preparation Gypsy moth adult worm attractant.
Attractant in the such use also comprises auxiliary agent, and auxiliary agent is the common auxiliary agent in insect attractant field or the combination of arbitrary proportion.
Preferably, said auxiliary agent is water or alcohols, hydro carbons, ester class, ethers, organic solvent of ketone.
Further preferably, said auxiliary agent is water or volatile organic solvent.More preferably volatile organic solvent.
Said volatile organic solvent most preferably is one or more in methyl alcohol, ethanol, propyl alcohol, isopropyl alcohol, methyl acetate, ethyl acetate, benzene,toluene,xylene, acetone, the ether.
The mass percent of Compound C A-074 methyl esters is 0.0001～50% in the said attractant, is preferably 0.001～30%, further is preferably 0.01～20%, most preferably is 0.05～10%.
Above-mentioned attractant preferably is placed in the insect trap and uses, and trapper can adopt existing insect trap arbitrarily, like tubbiness trapper, basin shape trapper etc.The preferred trapping of adopting the tubbiness trapper to be used for gypsymoth.At first attractant is processed by conventional method and lured core; To lure core to place on the trapper again, in the trapping of Gypsy moth adult worm, the content of active compound component CA-074 methyl esters is 0.1～10 milligram in the attractant usually; Preferred 0.5～3 milligram, and fully be dissolved in the volatile solvent.
Can also add other reactive compound and Compound C A-074 methyl esters in the above-mentioned attractant and use as active component jointly, as having common attractant composition gypsymoth pheromones etc. now.
Technical scheme of the present invention provides the purposes of Compound C A-074 methyl esters in the preparation Gypsy moth adult worm attractant; Compound C A-074 methyl esters is commercial existing compound; The unification compound gets final product onset, and is cheap and easy to get, and the preparation method is easy; Trap effect for Gypsy moth adult worm is very good, has potential broad prospect of application in the Gypsy moth adult worm attractant field.
Embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1
In in July, 2010 to August Gypsy moth adult worm movable frequent period; Carried out one month by a definite date field trapping experiment; The amount of Compound C A-074 methyl esters with 0.5 milligram fully is dissolved in 15 microliter methanol; Adopt conventional method that it is adsorbed in rubber core and process and lure core, will lure core with the iron wire fixed suspension on commercially available tubbiness insect trap.Experiment is provided with 5 groups, is placed at random in the environment of different slope, heliotropism and different vegetation.
((+)-D) processes with same processing method and to lure core as control group to adopt business-like gypsymoth sex pheromone.As shown in table 1, number identical CA-074 methyl esters and gypsymoth sex pheromone in that to lay aspects such as place, environment very approaching.
Add up the quantity of Gypsy moth adult worm in trapper weekly; Concrete trapping quantity is as shown in table 1; And per two weeks are changed and once to lure core, at last the trapping total amount through calculating Gypsy moth adult worm and the trap effect of average magnitude analysis CA-074 methyl esters and gypsymoth sex pheromone weekly.
Table 1: in the field experiment weekly lure the borer population amount
| Numbering | July 22 | July 29 | August 5 | August 12 |
| (+)-D-1 | 7 | 11 | 11 | 3 |
| (+)-D-2 | 5 | 6 | 4 | 0 |
| (+)-D-3 | 7 | 11 | 4 | 1 |
| (+)-D-4 | 22 | 18 | 24 | 1 |
| (+)-D-5 | 2 | 1 | 1 | 0 |
| CA-074-1 | 10 | 23 | 13 | 6 |
| CA-074-2 | 22 | 77 | 24 | 1 |
| CA-074-3 | 8 | 26 | 17 | 3 |
| CA-074-4 | 33 | 157 | 22 | 5 |
| CA-074-5 | 10 | 52 | 18 | 0 |
Table 1 result shows that the trapping total amount of CA-074 methyl esters and average weekly trapping amount all are far longer than the trapping amount of gypsymoth natural sex pheromones.The CA-074 methyl esters has the effect of trapping gypsymoth, and trap effect is superior to gypsymoth natural sex pheromones.
Embodiment 2
In in July, 2011 to August Gypsy moth adult worm movable frequent period; Carried out one month by a definite date field trapping experiment; The amount of Compound C A-074 methyl esters with 2.5 milligrams fully is dissolved in the 30 microlitre acetone, adopts conventional method to process and lure core, be suspended on the commercially available tubbiness trapper.Experiment is provided with 5 groups, is placed at random in the environment of different slope, heliotropism and different vegetation.
((+)-D) processes with same processing method and to lure core as control group to adopt business-like gypsymoth sex pheromone.As shown in table 2, number identical CA-074 methyl esters and gypsymoth sex pheromone in that to lay aspects such as place, environment very approaching.
Add up the quantity of Gypsy moth adult worm in trapper weekly; Concrete trapping quantity is as shown in table 2; And per two weeks are changed and once to lure core, at last the trapping total amount through calculating Gypsy moth adult worm and the trap effect of average magnitude analysis CA-074 methyl esters and gypsymoth sex pheromone weekly.
Table 2: in the field experiment weekly lure the borer population amount
| Numbering | July 22 | July 29 | August 5 | August 12 |
| (+)-D-1 | 9 | 10 | 12 | 4 |
| (+)-D-2 | 6 | 6 | 7 | 1 |
| (+)-D-3 | 7 | 15 | 5 | 1 |
| (+)-D-4 | 20 | 17 | 28 | 2 |
| (+)-D-5 | 3 | 2 | 3 | 0 |
| CA-074-1 | 12 | 27 | 19 | 8 |
| CA-074-2 | 29 | 58 | 37 | 5 |
| CA-074-3 | 11 | 22 | 17 | 2 |
| CA-074-4 | 43 | 127 | 26 | 4 |
| CA-074-5 | 14 | 61 | 15 | 1 |
Table 2 result shows that the trapping total amount of CA-074 methyl esters and average weekly trapping amount all are far longer than the trapping amount of gypsymoth natural sex pheromones.The CA-074 methyl esters has the effect of trapping gypsymoth, and trap effect is superior to gypsymoth natural sex pheromones.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (7)
1. the Compound C A-074 methyl esters shown in the chemical formula (I) is in the purposes of preparation in the Gypsy moth adult worm attractant.
2. purposes according to claim 1 is characterized in that said attractant also comprises auxiliary agent.
3. purposes according to claim 2 is characterized in that, said auxiliary agent is water or alcohols, hydro carbons, ester class, ethers, organic solvent of ketone.
4. purposes according to claim 3 is characterized in that, said organic solvent is a volatile organic solvent.
5. purposes according to claim 4 is characterized in that, said volatile organic solvent is one or more in methyl alcohol, ethanol, propyl alcohol, isopropyl alcohol, methyl acetate, ethyl acetate, benzene,toluene,xylene, acetone, the ether.
6. according to each described purposes of claim 1-5, it is characterized in that the mass percent of Compound C A-074 methyl esters is 0.0001～50% in the said attractant.
7. purposes according to claim 6 is characterized in that, the mass percent of Compound C A-074 methyl esters is 0.05～10% in the said attractant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210130327 CN102669156B (en) | 2012-04-27 | 2012-04-27 | Application of compound carbonic anhydrase (CA)-074 methyl ester in preparation of gypsy moth imago attractant |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210130327 CN102669156B (en) | 2012-04-27 | 2012-04-27 | Application of compound carbonic anhydrase (CA)-074 methyl ester in preparation of gypsy moth imago attractant |
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| CN102669156A true CN102669156A (en) | 2012-09-19 |
| CN102669156B CN102669156B (en) | 2013-09-11 |
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| CN 201210130327 Expired - Fee Related CN102669156B (en) | 2012-04-27 | 2012-04-27 | Application of compound carbonic anhydrase (CA)-074 methyl ester in preparation of gypsy moth imago attractant |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387188A (en) * | 2020-03-03 | 2020-07-10 | 菏泽学院 | Method for preventing gypsy moth based on methyl rosinate |
| CN111436433A (en) * | 2020-03-10 | 2020-07-24 | 菏泽学院 | Gypsy moth adult attractant and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06336428A (en) * | 1993-05-27 | 1994-12-06 | Takeda Chem Ind Ltd | Immunosuppressant |
| WO2006060473A2 (en) * | 2004-12-03 | 2006-06-08 | Mucosal Therapeutics Llc | Methods of treatment of injured or diseased joints with lubricin compositions |
| CN101810166A (en) * | 2010-02-08 | 2010-08-25 | 北京林业大学 | Gypsy moth adult worm attractant and trapping device |
-
2012
- 2012-04-27 CN CN 201210130327 patent/CN102669156B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06336428A (en) * | 1993-05-27 | 1994-12-06 | Takeda Chem Ind Ltd | Immunosuppressant |
| WO2006060473A2 (en) * | 2004-12-03 | 2006-06-08 | Mucosal Therapeutics Llc | Methods of treatment of injured or diseased joints with lubricin compositions |
| CN101810166A (en) * | 2010-02-08 | 2010-08-25 | 北京林业大学 | Gypsy moth adult worm attractant and trapping device |
Non-Patent Citations (1)
| Title |
|---|
| 齐兆生 等: "《农业昆虫学译丛 三》", 31 July 1981, 农业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111387188A (en) * | 2020-03-03 | 2020-07-10 | 菏泽学院 | Method for preventing gypsy moth based on methyl rosinate |
| CN111436433A (en) * | 2020-03-10 | 2020-07-24 | 菏泽学院 | Gypsy moth adult attractant and preparation method and application thereof |
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| Publication number | Publication date |
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| CN102669156B (en) | 2013-09-11 |
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